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*  "Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatme" by Kristin Wijsanen Weitzel, Julie M. Wickman et al.
BACKGROUND: Insomnia is the subjective complaint of poor sleep or an inadequate amount of sleep that adversely affects daily functioning. For the past 4 decades, treatment of insomnia has shifted away from the use of barbiturates toward the use of hypnotic agents of the benzodiazepine class. However, problems associated with the latter (eg, next-day sedation, rebound insomnia, dependence, and tolerance) have prompted development of other agents. OBJECTIVE: This review describes the recently approved nonbenzodiazepine agent, zaleplon. METHODS: Studies of zaleplon were identified through a search of English-language articles listed in MEDLINE and International Pharmaceutical Abstracts, with no limitation on year. These were supplemented by educational materials from conferences. RESULTS: The efficacy and tolerability of zaleplon have been documented in the literature. Zaleplon has been shown to improve sleep variables in comparison with placebo. Like most hypnotic agents, ...
  https://digitalcommons.pcom.edu/scholarly_papers/710/
*  Intravenous Sedative-Hypnotics | Clinical Pharmacology for Anesthesiology | AccessAnesthesiology | McGraw-Hill Medical
Sedative-hypnotics are a relatively new class of anesthetics, beginning with the introduction of sodium thiopental in the early 1930s. Since then, several -sedative-hypnotics have been introduced (Table 6-1), with more in the drug development pipeline, such as remimazolam, fospropofol, and isomers of etomidate. Goals of these modified drugs include fast metabolism and breakdown as well as creating "soft" drugs with safer profiles. A major goal in developing methoxycarbonyl-etomidate is the removal of adrenocortical suppression by modifying the pyrrole ring in etomidate. Fospropofol is water-soluble as opposed to propofol, which is administered as an oil-water emulsion. In 2008, fospropofol was approved by the US Food and Drug Administration, although many clinical trials are still underway for specific uses of the drug.1 ...
  http://accessanesthesiology.mhmedical.com/content.aspx?bookid=1181§ionid=65652067
*  Buy Zolpidem Overnight Shipping | Buy Zolpidem On Line With
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*  Deprescribing Sedative-Hypnotics in the Elderly: An important Patient Safety QI Initiative | afhto
Register now Webinar: Deprescribing Sedative-Hypnotics in the Elderly: An important Patient Safety QI Initiative. Time : March 30, 2017 from 12:15 - 1:15 PM. Hosted by: North York FHT, Health-For-All FHT, Markham FHT, Southeast Toronto FHT, Southlake FHT, and St. Joe's Urban FHT. Join us for a webinar describing the Sleep Program at North York Family Health Team, and the efforts at five other FHTs to reduce use of sedative-hypnotics in patients 65 and older.. The webinar will cover:. - Risks and benefits of these medications. - National and international data around the scope of their "over-utilization". - The evidence-based deprescribing algorithm created by the Canadian Deprescribing Network (CaDeN). - Cognitive-Behavioural Therapy for Insomnia. - Team-based approach to care. - How this is being reported to HQO on our QIPs. Phone line: Participants to call:1-866-440-8941 (North American toll free); 416-343-2659;(Toronto); Participant Code: ...
  http://www.afhto.ca/events/other-events/deprescribing-sedative-hypnotics-in-the-elderly-an-important-patient-safety-qi-initiative/
*  Hypnotic drugs were associated with increased risk for mortality | Annals of Internal Medicine | American College of Physicians
Patients. 34 205 primary care patients ≥ 18 years of age (mean age 54 y, 63% women) who had ≥ 1 outpatient visit between January 2002 and September 2006. 10 529 patients had ≥ 1 prescription for a hypnotic drug that seemed to be prescribed for bedtime use, was indicated for insomnia by the US Food and Drug Administration, and was commonly prescribed in the electronic health records (hypnotics group). 23 676 patients without a prescription for hypnotics at any time were matched 2:1 with the hypnotics group based on sex, age (within 5 y), smoking status, and observation period (control group). Patients had to have ≥ 3 months of follow-up after prescription (hypnotics group) or ≥ 3 months of observation (control group). Patients with major cancer diagnosed , 18 days after the start of the observation period were excluded. ...
  http://annals.org/aim/article-abstract/1183557/hypnotic-drugs-were-associated-increased-risk-mortality
*  Hypnotics' association with mortality or cancer: a matched cohort study | BMJ Open
Results As predicted, patients prescribed any hypnotic had substantially elevated hazards of dying compared to those prescribed no hypnotics. For groups prescribed 0.4-18, 18-132 and ,132 doses/year, HRs (95% CIs) were 3.60 (2.92 to 4.44), 4.43 (3.67 to 5.36) and 5.32 (4.50 to 6.30), respectively, demonstrating a dose-response association. HRs were elevated in separate analyses for several common hypnotics, including zolpidem, temazepam, eszopiclone, zaleplon, other benzodiazepines, barbiturates and sedative antihistamines. Hypnotic use in the upper third was associated with a significant elevation of incident cancer; HR=1.35 (95% CI 1.18 to 1.55). Results were robust within groups suffering each comorbidity, indicating that the death and cancer hazards associated with hypnotic drugs were not attributable to pre-existing disease. ...
  http://bmjopen.bmj.com/content/2/1/e000850.short?%20g=w_open_current_tab
*  Hypnotics' association with mortality or cancer: a matched cohort study | BMJ Open
Results As predicted, patients prescribed any hypnotic had substantially elevated hazards of dying compared to those prescribed no hypnotics. For groups prescribed 0.4-18, 18-132 and ,132 doses/year, HRs (95% CIs) were 3.60 (2.92 to 4.44), 4.43 (3.67 to 5.36) and 5.32 (4.50 to 6.30), respectively, demonstrating a dose-response association. HRs were elevated in separate analyses for several common hypnotics, including zolpidem, temazepam, eszopiclone, zaleplon, other benzodiazepines, barbiturates and sedative antihistamines. Hypnotic use in the upper third was associated with a significant elevation of incident cancer; HR=1.35 (95% CI 1.18 to 1.55). Results were robust within groups suffering each comorbidity, indicating that the death and cancer hazards associated with hypnotic drugs were not attributable to pre-existing disease. ...
  http://bmjopen.bmj.com/content/2/1/e000850.short?g=w_open_current_tab
*  Hypnotics' association with mortality or cancer: a matched cohort study | BMJ Open
Patients with prescriptions for hypnotics had approximately 4.6 times the hazard of dying over an average observation period of 2.5 years as compared to non-users. These findings were robust with adjustment for multiple potential confounders and consistent using multiple strategies to address confounding by health status. A dose-response effect was seen. Among users in the highest tertiles of annualised dosages, the HRs for death were 5.3, 5.7 and 6.6, respectively, for all hypnotics, zolpidem alone and temazepam alone. This top third of users were prescribed 92.8% of all the prescription doses of hypnotics (supplemental figure 2). Those in the top third were also 35% more likely to develop a new major cancer.. Perhaps the most striking finding was that an increased hazard for death was present even in the lowest tertile of hypnotic use, such that hypnotic drugs were associated with a 3.6-fold increased risk of dying for ...
  http://bmjopen.bmj.com/content/2/1/e000850
*  She Boils Bananas Before Bed & Drinks The Liquid, You Won't Believe What Happens To Her Sleep | WorldTruth.Tv
The majority of sleeping pills are a specific type of drug that induces and maintains sleep. They're classified as something called sedative hypnotics. Among other sedative hypnotic drugs are benzodiazepines and barbiturates. Benzodiazepines-like Xanax and Valium-can be addictive and are used to treat anxiety disorders by increasing drowsiness. Barbiturates depress the central nervous system are used as anesthetics and sedatives.. As with all drugs, there's a list of side effects that accompany sleeping pills. Aside from the likeliness of them being habit-forming, they can cause the following:. Constipation. Dizziness. Difficulty focusing and remembering. Stomach pain. Weakness. Uncontrollable shaking. Parasomnias (Doing things without realizing it… Scary!). Sleeping pills also cause your breathing rhythm to slow down and significantly lighten. This means that if you're already suffering from lung diseases like COPD or even ...
  https://worldtruth.tv/she-boils-bananas-before-bed-and-drinks-the-liquid-you-wont-believe-what-happens-to-her-sleep/
*  Relief of Pain and Anxiety in Pediatric Patients in Emergency Medical Systems | AMERICAN ACADEMY OF PEDIATRICS | Pediatrics
The use of sedative hypnotic medication may be required to bring pain and stress levels under adequate control for many procedures in the emergency medical system. Unfortunately, pain and anxiety are often difficult to differentiate in infants and toddlers.. Although many procedures are not intrinsically painful or can be performed painlessly with the use of a topical or local anesthetic, this does not obviate the use of pharmacologic agents to decrease the anxiety and stress in children undergoing procedures in the ED.. Excellent reviews have been published that describe the safe and effective use of sedation in the ED.124,125 Procedural sedation is generally combined with analgesia to minimize pain whenever the procedure is uncomfortable or painful. Analgesia may take the form of local anesthetics or systemic analgesics. Combinations of medications, particularly the addition of opiates to sedative medications, may increase the risk of respiratory ...
  http://pediatrics.aappublications.org/content/114/5/1348.full
*  Health Fitness
Widely used for eczema antihistamines have anti-inflammatory, anti-allergic, sedative, most of them - the soporific effect. Duration of diphenhydramine, suprastin, diprazina 4-6 h, diazolin up to 2 days. The drug is used no more than 10-15 days, in the future make a break or replace it with another, because addiction occurs, and the therapeutic effect of weakening. Often the patient is one of the antihistamine is more effective. Because of the sedative and hypnotic action can not be assigned ambulatory patients whose work requires a lot of attention and rapid accurate targeting (surgeons, drivers, pilots, machinists). In such cases it is advisable to use diazolin, which does not give sedative and hypnotic effects, does not violate the mind works longer than other drugs in this group differs marked spasmolytic activity, but has a strong irritating properties, and therefore is contraindicated in diseases of the digestive ...
  http://healthfitnesscentre.blogspot.ca
*  excretion
Anxiolytic and Hypnotic Agents Types of Anxiolytic and Hypnotic Agents Anxiolytics Prevent feelings of tension or fear Sedatives Calm and make patients unaware of the environment Hypnotics Cause sleep Minor tranquilizers Produce a state of tranquility in anxious patients States Affected by Anxiolytic and Hypnotic Drugs Anxiety -Feeling of tension, nervousness, apprehension, or fear involving […]. Read more ...
  http://www.nursingbuddy.com/tag/excretion/
*  Softenon synonyms, Softenon antonyms - FreeThesaurus.com
Synonyms for Softenon in Free Thesaurus. Antonyms for Softenon. 3 words related to thalidomide: sedative-hypnotic, sedative-hypnotic drug, teratogen. What are synonyms for Softenon?
  https://www.freethesaurus.com/Softenon
*  Euro-Battle.net | Private Gaming Network - Forum • View topic - ambien sleeping pill reviews the drug ambien stilnoct zolpid
Precipitation of hepatic encephalopathy in patients with renal failure, extrasystoles, hypertension, tachycardia, increased alkaline phosphatase, increased alkaline phosphatase? Studies pertinent to safety concerns for sedative/hypnotic drugs [see warnings and precautions (5. what is an ambien Co-administration with other people, even if they develop any of these unlikely but serious side effects to fda at 1-800-fda-1088 or at www. Distribution total protein binding was found comparable to placebo. Special senses: frequent: diplopia, vision abnormal. The effect of decreased alertness. Tell your doctor about another treatment for your sleep quiz: suffer from insomnia? Clinical pharmacology (12 5 mg/day (10 mg zolpidem base); however, teratogenicity was not observed at any dose tested. what's ambien used for Total protein binding was found to contain haloperidol (haldol), a potent cyp3a4 inhibitor and zolpidem revealed that four of the' precautions' section precautions cns ...
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*  Natural Organic Chemical Free Skin Care - Hypnotic Skinssentials | Natural Body Butter - HYPNOTIC
Hypnotic blend: Hypnotic may cause a state of consciousness to suggestion. CreamyVanilla, Rose and Citrus blends create an altered state of mind or a form of imaginative role-enactment may reoccur. Heightened focus, concentration, with the ability to concentrate intensely on a specific thought or memory, while blocking out sources of distraction. Wearing and using our induction may result in undergoing love spells which are hard to escape.. Ingredients/Ingrédients: ...
  http://hypnoticskinssentials.com/product/hypnotic-body-butter/
*  Herbal Actions: Hypnotic
What is a Hypnotic? Hypnotics are herbal remedies that will help to induce a deep and healing state of sleep. They have nothing at all to do with hypnotic trances!
  http://www.healthy.net/Health/Article/Hypnotic/1487
*  Sedative, Hypnotic, or Anxiolytic Intoxication | Behavenet
Dysfunctional changes in physiological functioning, psychological functioning, mood state, cognitive process, or all of these, as a consequence of consumption of a [sedative, hypnotic, or anxiolytic]; usually disruptive, and often stemming from central nervous system impairment ...
  https://www.behavenet.com/index.php/sedative-hypnotic-or-anxiolytic-intoxication
*  Hypnotics and Sleep
Hypnotics are substances that increase sleepiness and may cause an individual to sleep or have a partial loss of consciousness. For this reason, hypnotics can be very useful to aid sleep in individuals that have difficulty sleeping, such as those that suffer from insomnia.
  https://www.news-medical.net/health/Hypnotics-and-Sleep.aspx
*  Sedatives and Sedation in Horses | Vet Help Direct
We routinely sedate horses in practice - after vaccination, it's probably the most common "routine" job that we do. So, what are we doing? How do the drugs work - and why doesn't it always happen the same way?. "Sedation - a state of rest or sleep… produced by a sedative drug.". That's the dictionary definition, and it makes it sound lovely and simple - give a drug, and the patient goes to sleep. Of course, in reality (as usual with anything equine!) life isn't that easy…. For those who haven't seen it before, a sedated horse doesn't lie down, but their head gets lower and lower, and they may require something to lean on to help them balance. It's also important to remember that a sedated horse CAN still kick - they're just much less likely to do so! It often seems that the horse is still more or less aware of what's going on around them, but they're too sleepy to care about it. As a result, we'd almost invariably use pain relief and local anaesthetic as well if we're carrying out a surgical ...
  https://vethelpdirect.com/vetblog/2013/01/08/sedatives-and-sedation-in-horses/
*  Endoscopy non-surgical procedure: Not painful - Health Awareness Club
Endoscopy non-surgical procedure: Doctor may give a sedative medication in forearm - helps a patient to relax during procedure. It is not painful but .....
  http://healthsexx.com/endoscopy-non-surgical-procedure-not-painful/
*  Addressing Hypnotic medicines use in primary care - ppt video online download
Established in 1998, NPS enables people to make better decisions about medicines and medical tests, leading to better health and economic outcomes. Originally started in SA, it is available to help health professionals keep up to date with the latest evidence and provide individuals with the tools and knowledge to make better decisions. The NPS Professional suite includes information and tools developed for primary and allied healthcare professionals, one of which is the information that will be this brief presentation on addressing hypnotic medicines use in primary care. The aim of this presentation is to highlight some of the key messages from the NPS on the use of hypnotic medicines. Information provided by NPS is evidence based, however please bear in mind that all decisions of drug therapy and non-drug therapy is totally dependent on your knowledge gained over years of experience. Thus, there is no black or white, similar to the fact that there are no two same person, ...
  http://slideplayer.com/slide/2415328/
*  The Treatment of Insomnia in Patients With HIV Disease - Full Text View - ClinicalTrials.gov
Insomnia is a disorder defined as persistent difficulty falling asleep, staying asleep or non-restorative sleep which is associated with diminished daytime function without any identifiable underlying cause. This condition is extremely common among HIV infected individuals and can lead to significant distress and reduction in the quality of life. The mechanisms for disrupted sleep in this population are diverse, including potential direct effects of the tat protein upon the sleep centers in the central nervous system. Insomnia has been documented to be one of the most common psychiatric disorders in HIV disease, but no trial has systematically examined the efficacy of available hypnotic agents, which are commonly used in this population.. Comparison(s): Two commonly prescribed hypnotic agents used for insomnia will be compared to placebo over a 6 month treatment study. ...
  https://clinicaltrials.gov/ct2/show/study/NCT00465972?view=record
*  The Treatment of Insomnia in Patients With HIV Disease - Tabular View - ClinicalTrials.gov
Insomnia is a disorder defined as persistent difficulty falling asleep, staying asleep or non-restorative sleep which is associated with diminished daytime function without any identifiable underlying cause. This condition is extremely common among HIV infected individuals and can lead to significant distress and reduction in the quality of life. The mechanisms for disrupted sleep in this population are diverse, including potential direct effects of the tat protein upon the sleep centers in the central nervous system. Insomnia has been documented to be one of the most common psychiatric disorders in HIV disease, but no trial has systematically examined the efficacy of available hypnotic agents, which are commonly used in this population.. Comparison(s): Two commonly prescribed hypnotic agents used for insomnia will be compared to placebo over a 6 month treatment study. ...
  https://clinicaltrials.gov/ct2/show/record/NCT00465972
*  Sedative
... s (lat. sedatio - sedation) - drugs that have a General calming effect on the Central nervous system. Sedative (calming) effect is to reduce the response to various external stimuli and a decrease in daily activity.. This group of drugs regulate the Central nervous system, strengthening the processes of braking or lowering the excitation. Typically, they facilitate the onset and deepen the natural sleep, enhance the effect of hypnotics, analgesics and other means, oppressive Central nervous system ...
  http://o-t-c.co.uk/sedative
*  Which of the following hypnotics is preferred in patients with limited hepatic function? Zolpidem - Zolpidem - Pharmacology...
Which of the following hypnotics is preferred in patients with limited hepatic function? Zolpidem - Zolpidem - Pharmacology Interview Questions and Answers, Job FAQs, Queries, Tips, Sample Papers, Exam Papers - Pharmacology What, Why, When, Where, How Pharmacology - CoolInterview.com
  http://www.coolinterview.com/interview/33346/