Advances in pharmacology. Volume 29, DNA topoisomerases: Topoisomerase-targeting drugs (eBook, 1994) [WorldCat.org]
Emphasis is placed on the molecular basis of drug action, both applied and experimental. ... Emphasis is placed on the molecular basis of drug action, both applied and experimental. This volume covers topoisomerase- ... Topoisomerases in Human Leukemia.D. Costin and M. Potmesil, Preclinical and Clinical Development of Camptothecins.Y. Pommier, A ... Tanizawa, and K.W. Kohn, Mechanisms of Topoisomerase I Inhibition by Anticancer Drugs.T. Andoh and K. Okada, Drug Resistance ...http://www.worldcat.org/title/advances-in-pharmacology-volume-29-dna-topoisomerases-topoisomerase-targeting-drugs/oclc/794594700
Withaferin A - Wikipedia
Yang, Huanjie; Shi, Guoqing; Dou, Q. Ping (2007). "The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound ... Indian Journal of Experimental Biology. 34 (10): 927-932. PMID 9055640. Stan, Silvia D.; Hahm, Eun-Ryeong; Warin, Renaud; Singh ... "Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 ... Lee, In-Chul; Choi, Bu Young (2016). "Withaferin-A-A Natural Anticancer Agent with Pleitropic Mechanisms of Action". ...https://en.wikipedia.org/wiki/Withaferin_A
Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia | Clinical Cancer Research
Experimental Design: Viral protein production, replication, and cytopathy were measured in human and murine ALL cells exposed ... In contrast to other viral-based anticancer therapies (30, 45), preexisting antiviral immunity increases the potency of iLOV. ... Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia. David P. Conrad, Jovian Tsang, ... Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia. David P. Conrad, Jovian Tsang, ...http://clincancerres.aacrjournals.org/content/19/14/3832
Fungal Endophytes from Anticancer Plants as Producers of the Antitumor Agent L-Asparaginase: A Look at Diversity, Ubiquity, and...
In recent years, endophytes from medicinal or anticancer plants have demonstrated the ability to produce... ... Pharmacological studies of anticancer, antiinflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals. J ... Masetti R, Pession A (2009) First-line treatment of acute lymphoblastic leukemia with pegasparaginase. Biologics 3:359-368 ... Gupta S, Zhang D, Yi J, Shao J (2004) Anticancer activities of Oldenlandia diffusa. J Herb Pharmacother 4:21-33CrossRefPubMed ...https://rd.springer.com/chapter/10.1007%2F978-981-10-8064-7_10
HuMax-CD20 in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients Failing Fludarabine and Alemtuzumab - Full Text View -...
... new anti-cancer treatment, and experienced death or progression after two or more missed visits in a row the endpoint was ... Leukemia. Leukemia, Lymphoid. Leukemia, Lymphocytic, Chronic, B-Cell. Neoplasms by Histologic Type. Neoplasms. ... MedlinePlus related topics: Chronic Lymphocytic Leukemia Leukemia Drug Information available for: Fludarabine Alemtuzumab ... Genetic and Rare Diseases Information Center resources: Chronic Lymphocytic Leukemia Leukemia, B-cell, Chronic ...https://clinicaltrials.gov/ct2/show/NCT00349349
Antibodies | Free Full-Text | Role and Redirection of IgE against Cancer | HTML
Conversely, experimental approaches implementing several strategies and engineered IgE formats built up a series of convincing ... reports from several laboratories are described herein in which a natural IgE link to cancer or the experimental redirection of ... Anticancer Res. 2006, 26, 1419-1424. [Google Scholar]. *von Wasielewski, R.; Seth, S.; Franklin, J.; Fischer, R.; Hübner, K.; ... Leukemia 2003, 17, 1428-1430. [Google Scholar] [CrossRef]. *Molin, D.; Edström, A.; Glimelius, I.; Glimelius, B.; Nilsson, G.; ...http://mdpi.com/2073-4468/2/2/371/htm
Integration of Different "-omics" Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the...
Cytotoxic Effect of Shikonin on U937 Leukemia Cells. The cytotoxic effect of shikonin against U937 leukemia cells was analyzed ... we used this experimental approach to show that the natural naphthoquinone shikonin strongly deregulates the IGF1R-Akt-mTOR ... combining an mTOR inhibitor and an IGF-1R inhibitor may be an appropriate strategy to enhance mTOR-targeted anticancer therapy ... especially in different types of leukemia . For example, in acute myelogenous leukemia (AML), the mTORC1-signaling pathway ...https://www.hindawi.com/journals/ecam/2013/818709/
Chaplin D. J., Hill S. A. Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br. J. Cancer ... Kerbel R. S. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents ... Leukemias are now also considered to be angiogenesis-dependent malignancies and have been shown to express VEGF (26, 27, 28) . ... Experimental and clinical studies have provided both direct and indirect evidence for the presence of hypoxic cells in tumors ( ...http://clincancerres.aacrjournals.org/content/9/6/1957
Books by Subject - Lane Medical Library - Stanford University School of Medicine
The Discovery of Anticancer Drugs Targeting Epigenetic Enzymes / A Ganesan -- Thienopyridyl and Direct-Acting P2Y Receptor ... Combining computational and experimental methods for identifying molecular targets of phytochemicals / Ann M. Bode and Zigang ... Promyelocytic leukemia gene retinoic acid receptor-alpha (PMI-RARA)translocation inhibitors -- Sipuleucel-T(Provenge®) -- ... This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer ...http://lane.stanford.edu/biomed-resources/ebsubjectbrowse.html?m=Pharmacology
Genes | Free Full-Text | A Reverse Transcriptase-Dependent Mechanism Is Essential for Murine Preimplantation Development | HTML
Indeed, we have found that RT inhibitors are endowed with powerful anti-cancer activity, both in in vitro experiments with ... That intuition has received ample experimental confirmation from recent findings indicating that typical embryonic genes are re ... tumorigenic cell lines, in ex vivo with human leukemia cells  and in in vivo assays with human cancer cells inoculated in ...http://www.mdpi.com/2073-4425/2/2/360/htm
A Scalable Method for Squalenoylation and Assembly of Multifunctional 64Cu-Labeled Squalenoylated Gemcitabine Nanoparticles
Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor. Mol Pharm. ... A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types. J Control ... Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. Small ... Polymer Prodrug Nanoparticles Based on Naturally Occurring Isoprenoid for Anticancer Therapy. Biomacromolecules. 2013;14:2837- ...http://www.ntno.org/v02p0387.htm
Selective glucocorticoid receptor modulator - Wikipedia
... are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer ... Moreover, in vitro a particular SEGRAM can promote apoptosis in prostate cancer and leukemia. In vivo studies in mice and rats ... Clinical trial number NCT01393639 NCT01393639 for "Study Comparing Doses Of An Experimental Glucocorticoid Compound To ... "Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562" (PDF). Biochemistry. ...https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator
Wiley Online Library: Search Results Page
Clinical and Experimental Pharmacology and Physiology. Volume 41, Issue 10, October 2014, Pages: 830-837, Nai-Jung Chiang, ... Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells. Cancer Science ... 2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by ...http://onlinelibrary.wiley.com/advanced/search/results?articleDoi=10.1111/j.1935-4940.2012.01269.x&scope=allContent&start=1&resultsPerPage=20
US7176302B2 - Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides - Google Patents
We have used three different kinds of human leukemic cell lines: ALL-1 (acute lymphocytic leukemia), BV173 and K562 (both are ... Clarenc et al., "Delivery of antisense oligonucleotides by poly(l-lysine) conjugation and liposome encapsulation," Anti-Cancer ... Preclinical Pharmacology/Experimental Therapeutics, 32:433, Abstract 2578, 1991. ... Growth inhibitor for leukemia cell comprising antisense oligonucleotide derivative to wilms tumor gene (WT1) ...https://patents.google.com/patent/US7176302B2/en
Experimental evidence in human AML suggests that, compared with the bulk population of leukemic blasts, the leukemia stem cells ... The identification of such targets and the development of anticancer agents will require a fuller understanding of normal stem ... The tumor-initiating cell is often used to mean the cell that causes a tumor (or leukemia) in xenograft models of human cancer ... Studies of acute myelogenous leukemia (AML) in the 1990s provide compelling evidence for the existence of a cancer stem cell ...http://cancerres.aacrjournals.org/content/66/19/9339
Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs |...
Tan DS, Gerlinger M, Teh BT, Swanton C (2010) Anti-cancer drug resistance: Understanding the mechanisms through the use of ... in a rat model for acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (DCK) gene. Ann Hematol 71(1):41 ... of the human deoxycytidine kinase gene enhances the cytotoxic and radiosensitizing effect of gemcitabine on experimental ...https://link.springer.com/article/10.1007%2Fs10549-011-1477-3
Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy
For an anti-cancer antibody agent to be successful, it must (a) be effective in the tumor microenvironment, and (b) reach the ... Although leukemia treatments involving mAbs have been in clinical use for years, this approach has not been as successful for ... Experimental Design. NCI-H226 (American Type Culture Collection or ATCC, Rockville, MD) is a human lung squamous carcinoma cell ... Most studies of anticancer drugs consider only cellular and/or genetic mechanisms at the level of the single cell. However, ...http://www.jcancer.org/v02p0507.htm
Ahcc: Uses, Side Effects, Interactions, Dosage, and Warning
Anticancer Drugs 1998;9(4):343-350. View abstract.. *Matuo, A., Yamada, M., Nakayama, K., Sudou, K., Yamada, K., Nakagawa, H., ... Congenital Malformations and Leukemia) by Active Hexose Correlated Compound, AHCC in Mice. Presented at the 19th International ... Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis. Eur.J Nutr ... Anticancer Drugs 2009;20(3):215-216. View abstract.. *Uno, K., Kosuna, K., Sun, B., Fujii, H., Wakame, K., Chikumaru, S., ...https://www.webmd.com/vitamins/ai/ingredientmono-1110/ahcc
Cellceutix CORP (Form: 10-Q, Received: 11/19/2012 10:01:37)
Based on the experimental studies results to date, the Company has decided to advance these drugs along the regulatory and ... The university wishes to test Kevetrin as a combination therapy for leukemia with drugs proprietary to one of the world s ... The Company has spent most of its efforts and resources on its anti-cancer compound, Kevetrin, for the treatment of certain ... The university wishes to test Kevetrin as a combination therapy for leukemia with drugs proprietary to one of the world s ...http://www.otcmarkets.com/edgar/GetFilingHtml?FilingID=8924833
IJMS | Free Full-Text | The Effect of Self-Assembling Peptide RADA16-I on the Growth of Human Leukemia Cells in Vitro and in...
In this study, we investigated the effect of RADA16-I on the growth of human leukemia cells in vitro and in nude mice. Self- ... MTT assay displayed that RADA16-I has no cytotoxicity for leukemia cells and human umbilical vein endothelial cells (HUVECs) in ... 3. Experimental Section. 3.1. Preparation of Peptide RADA16-I. The peptide RADA16-I (PuraMatrixTM, Ac-RADARADARADARADA-CONH2) ... the applications of many traditional anticancer drugs are generally accompanied with inefficiencies and severe side effects [1, ...http://www.mdpi.com/1422-0067/10/5/2136/htm
T-Cell Therapy Eradicates an Aggressive Leukemia in Two Children
"This study describes how these cells have a potent anticancer effect in children," said co-first author Stephan A. Grupp, M.D ... One of the patients, 7-year-old Emily Whitehead, was featured in news stories in December 2012 after the experimental therapy ... T-Cell Therapy Eradicates an Aggressive Leukemia in Two Children News Mar 26, 2013 ... The CTL019 therapy eliminates all B cells that carry the CD19 cell receptor: healthy cells as well as those with leukemia. ...https://www.technologynetworks.com/cell-science/news/tcell-therapy-eradicates-an-aggressive-leukemia-in-two-children-211212
Targeting Cancer Metabolism | Clinical Cancer Research
... are targeted by approved or experimental anticancer drugs (90).. Metabolomics is the quantitative assessment of endogenous ... Isocitrate dehydrogenase (IDH1/2) mutations have been found in leukemias, gliomas, prostate cancer, colon cancer, thyroid ... Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharm 2011;2:49. ... The earliest anticancer drugs focused on attacking cancer through selective toxicity toward proliferating cells. Several of the ...http://clincancerres.aacrjournals.org/content/18/20/5537.full
Protein-protein interaction activates and fuels leukemia cell growth | EurekAlert! Science News
... to accelerate the proliferation and spread of chronic lymphocytic leukemia cells, the most common form of blood cancer in ... Protein-protein interaction activates and fuels leukemia cell growth Findings also show how an experimental monoclonal antibody ... Because this protein was not found on normal adult tissues, these findings made ROR1 a new target for anti-cancer drug research ... some of which had the ability to reduce the survival of leukemia cells. They found ROR1 on leukemia cells but not on all normal ...https://www.eurekalert.org/pub_releases/2015-12/uoc--pia121815.php
Annual Report Division of Surgical Research. Department of Surgery. University Hospital Zurich Switzerland. Division of...
New strategies in anticancer therapy 癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 ... LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT ... In this experimental study we wanted to investigate whether donor and recipient treatment with NAC would reduce ischemia- ... 5 Experimental approach to chronic rejection of lung allograft in sensitized recipients W. Jungraithmayr, S. Arni, S. Hillinger ...http://docplayer.net/1908546-Annual-report-2008-division-of-surgical-research-department-of-surgery-university-hospital-zurich-switzerland-division-of-surgical-research.html
Oncology Research, Volume 11, pp
Anticancer Potential of Cleistanthin A Isolated From the Tropical Plant Cleistanthus collinus Chhalliyil P. Pradheepkumar and ... Attenuation of the Induced Differentiation of HL-60 Leukemia Cells by Mitochondrial Chaperone HSP70 Jian Xu,* Helen Hong Xiao ... Meinrad Peterlik, Department of General and Experimental Pathology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Tel: 43 1 ... Differences in Apoptosis Induced by Anticancer Drugs in Sublines (SKG-3a, SKG-3b) From a Human Uterine Cervical Epidermoid ...https://www.cognizantcommunication.com/cccSiteFiles/Oncology/oncabs.htm