Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia | EurekAlert! Science News
... an experimental monoclonal antibody-based drug, measurably inhibited the 'stemness' of chronic leukemia cancer (CLL) cells -- ... ROR1 appears to drive tumor growth and disease spread and scientists think that presents an excellent novel target for anti-cancer ... Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia Cirmtuzumab targets key cancer stem cell ... Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia. University of California - San Diego ...https://www.eurekalert.org/pub_releases/2018-06/uoc--pit053018.php
Möglichkeiten und Grenzen internistischer Behandlung Krebskranker | SpringerLink
On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother Rep 55: 1-111Google ... Skipper HE, Schabel FM, Wilcox WS (1964) Experimental evaluation of potential anticancer agents. XII. ...https://link.springer.com/chapter/10.1007/978-3-642-75831-7_8
Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3...
Quantitative evaluation of anticancer agent activity in experimental animals. Pharmacol Ther [A] 1: 411Google Scholar ... Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilion) ... A P388 leukemia resistant to NSC 370 147 (P388/NSC 370 147) was isolated and its in vivo cross-resistance profile was ... Ethyl Hydrate Leukemia Cancer Research Doxorubicin These keywords were added by machine and not by the authors. This process is ...https://link.springer.com/article/10.1007/BF00686251
PIs - Universität Ulm
The Institute for Experimental Cancer Research mainly focuses on basic research on acute leukemias. We investigate the role of ... different factors in leukemia, as well as possible anti-cancer mechanisms. Therefore we use a broad spectrum of in vitro and in ... There is also a gene and biobank, an inpatient clinic for acutely neurologically ill patients, and an experimental section in ... These groups perform experimental research on the basic mechanisms of the diseases mentioned above. ...https://www.uni-ulm.de/med/cemma/members/pis/
Neoadjuvant Versus Adjuvant Chemotherapy in Invasive Bladder Cancer | Springer for Research & Development
On the criteria and kinetics associated with curability of experimental leukemia. Cancer Chemother Rep 35:1-9PubMedGoogle ... Skipper HE, Schabel FM, Wilcox WS (1964) Experimental evaluation of potential anticancer agents. XII. ...https://rd.springer.com/chapter/10.1007/978-3-642-84583-3_18
DIGITAL.CSIC: Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo
In experimental therapeutics for cancer, caspase-1 has been related to some anticancer activity. These observations led us to ... with spontaneous regression in neuroblastomas and with a good clinical response to chemotherapy in acute myeloid leukemia and ... The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. This observation raises the ... possibility that factors affecting caspase activation might be important determinants of anticancer drug sensitivity. Ectopic ...https://digital.csic.es/handle/10261/24781
Molecules | Free Full-Text | Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling,...
Methods: In this study, we used the MV4-11 cell line, a FLT3 positive acute myeloid leukemia (AML) cell line that displays ... However, the mechanism of action (MOA) of ADR's anticancer and anti-drug-resistance activities remain elusive. ... multidrug resistance, as our experimental system. We first evaluated the effect of ADR on MV4-11 cell proliferation. Then, a ... among which leukemia cell lines exhibit the highest sensitivity to ADR. In particular, ADR was also reported to have reduced ...http://www.mdpi.com/1420-3049/22/9/1444
Oncology Expert Witness | ForensisGroup
... and anti-cancer drugs. I have additional knowledge of experimental therapeutics, toxic effects of chemicals (such as lead, ... I have experience with chronic myelogenous leukemia, hematologic malignancies, leukemia, lymphoma, multiple myeloma, cancer ... I have additional expertise in oncology, leukemia, stem cells, progenitor cells, leukemogensis, and the link between aging and ... I have over 10 years experience in hematology with a specialization in oncology, anemia, aplastic anemia, leukemia, blood ...https://www.forensisgroup.com/expert-witness/oncology/
THE DAIRY OF PATIENT NUMBER 96 - The Washington Post
Last fall, he decided to become part of a California research program to test a new experimental anti-cancer drug that has had ... announced a new drug that seemed to have a dramatic effect on hairy cell leukemia. It was a highly experimental drug -- only 12 ... I checked into the Scripps Clinic to become the 96th patient with hairy cell leukemia to undergo this experimental treatment. I ... Hairy-cell leukemia is a disease of the white blood cells, the key cells in the immune system that fight infections. ...https://www.washingtonpost.com/archive/lifestyle/wellness/1990/12/04/the-dairy-of-patient-number-96/651b088a-08f4-46f8-9aeb-a2a6165eb59c/
Thymidine kinase in clinical chemistry - Wikipedia
Bazargan A, Tam CS, Keating MJ (2012). "Predicting survival in chronic lymphocytic leukemia". Expert Review of Anticancer ... The experimental method first developed by Gronowitz et al. used quantities of radioisotope much above those used in commercial ... Leukemias normally do not present major diagnostic difficulties, as the microscopic analysis of the cells in blood mostly give ... A very interesting case is the myelodysplastic syndrome: Some rapidly change to acute leukemia, whereas others remain indolent ...https://en.wikipedia.org/wiki/Thymidine_kinase_in_clinical_chemistry
The Law of the Sea in the Asian Pacific Region : James Crawford : 9780792327424
Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches Frederick A. Valeriote ... Biology and Therapy of Acute Leukemia Frederick A. Valeriote 09 Jan 2012 ...https://www.bookdepository.com/Law-Sea-Asian-Pacific-Region-James-Crawford/9780792327424
Ferrocene - Wikipedia
Some ferrocenium salts exhibit anticancer activity, but no compound has seen evaluation in the clinic. An experimental drug was ... when derivatives bearing amine or amide groups were tested against lymphocytic leukemia. ... The anticancer activity of ferrocene derivatives was first investigated in the late 1970s, ... Babin, V. N., et al., "Ferrocenes as potential anticancer drugs. Facts and hypotheses", Russ. Chem. Bull. 2014, volume 63, 2405 ...https://en.wikipedia.org/wiki/Ferrocene
Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo | Clinical Cancer...
Experimental Design: We employed RS4;11 and MV4;11 cell lines, two acute leukemia models, to investigate acquired resistance ... Acquired resistance of tumor cells to anticancer drugs is a major cause of the failure of clinical cancer therapy. We have ... Acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) remain incurable with conventional chemotherapy, and ... The tumor suppressor p53 is another attractive therapeutic target for leukemia (16-21). In about 90% of leukemias, p53 retains ...http://clincancerres.aacrjournals.org/content/21/11/2558
Experimental Therapeutics Salt Lake City, Utah
Anticancer drug carrier design targeting MDR. Barnette, Phillip. e-mail. Acute childhood leukemia, therapeutic advances in ... Experimental Therapeutics Member Directory. The Experimental Therapeutics (ET) Program is organized to facilitate ... Prevention and treatment of Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) and Multiple Myeloma. ... Experimental therapeutics, clinical trials in oncology. Andtbacka, Robert. e-mail. Developing new modalities for the detection ...https://healthcare.utah.edu/huntsmancancerinstitute/research/cancer-center-research-programs/experimental-therapeutics.php
Cancers | Free Full-Text | Genetic Interactions of STAT3 and Anticancer Drug Development | HTML
A number of STAT3 inhibitors have been evaluated for their antitumor activity in vitro and in vivo in experimental tumor models ... In fact, a major cause of failure of anticancer drug development is lack of efficacy. Genetic interactions among various cancer ... into mechanisms of cancer resistance to pathway-targeted therapies and strategies for development of more effective anticancer ... Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer ...http://mdpi.com/2072-6694/6/1/494/htm
New therapy treats autoimmune disease without harming normal immunity
Since 2011, though, experimental CAR T cell treatments for B cell leukemias and lymphomas-cancers in which patients' healthy B ... from the promising anti-cancer strategy by which T cells are engineered to destroy malignant cells in certain leukemias and ... "Our study effectively opens up the application of this anti-cancer technology to the treatment of a much wider range of ... The basic CAR T cell concept was first described in the late 1980s, principally as an anti-cancer strategy, but technical ...https://medicalxpress.com/news/2016-06-therapy-autoimmune-disease-immunity.html
Ofatumumab/Methylprednisolone and Ofatumumab/Lenalidomide for Relapsed/Refractory Chronic Lymphocytic Leukemia/Small...
Concurrent use of other anti-cancer agents or treatments. *Known seropositive for or active viral infection with human ... Experimental: Immunotherapy Combination regimen consisting of high dose methylprednisolone combined with ofatumumab, followed ... Leukemia. Leukemia, Lymphoid. Leukemia, Lymphocytic, Chronic, B-Cell. Neoplasms by Histologic Type. Neoplasms. ... leukemia. lymphoma. consolidative therapy. combination regimen. Chronic Lymphocytic Leukemia (CLL). Small Lymphocytic Lymphoma ...https://clinicaltrials.gov/show/NCT01497496
Norman J. Lacayo, MD | Stanford Medicine Profiles
Idarubicin (IDA) is an anthracycline anticancer drug utilized in the treatment of acute leukemias. There are conflicting data ... Journal of experimental therapeutics & oncology Lacayo, N. J., Duran, G. E., Sikic, B. I. 2003; 3 (3): 127-135 Abstract. ... leukemia (AML), acute lymphoblastic leukemia (ALL), mixed phenotype acute leukemia (MPAL) and myelodysplastic syndrome (MDS). ... Acute leukemia subtypes included precursor B-cell acute lymphoblastic leukemia (ALL) (n=23), precursor T-cell ALL (n=6), and ...https://med.stanford.edu/profiles/norman-lacayo
Statins found to enhance efficacy of chemotherapy drug in blood cancers
Statins have shown promise as anticancer agents in experimental and epidemiologic research. However, any benefit that they ... Furthermore, in retrospective analyses of three clinical studies of chronic lymphocytic leukemia, background statin use was ... in primary leukemia and lymphoma cells but not in normal human peripheral blood mononuclear cells. By blocking mevalonate ... applicable only to certain cancers or in combination with specific anticancer drugs. We report that inhibition of 3-hydroxy-3- ...https://medicalxpress.com/news/2018-06-statins-efficacy-chemotherapy-drug-blood.html
Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances...
Experimental cell research. 2012;318:1946-58 34. Thomas X, Campos L, Le QH, Guyotat D. Heat shock proteins and acute leukemias ... Anti-cancer agents in medicinal chemistry. 2013;13:555-62 25. Wachsstock DH, Wilkins JA, Lin S. Specific interaction of ... Experimental cell research. 1999;249:161-76 54. Kang R, Chen R, Zhang Q. et al. HMGB1 in health and disease. Molecular aspects ... Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells. Cell stress & chaperones. 2008;13:357- ...http://www.medsci.org/v14p0284.htm
Patrick Andrew Brown, M.D.
Brown's research is focused on developing new therapies for childhood leukemia. Leukemia (cancer of the blood... ... Expertise: Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Blood Cancers, Chronic Myeloid Leukemia (CML), ... Advances in experimental medicine and biology. 2008 July 2008;630:1-18.. Goetze, S.; Lavely, W.C.; Ziessman, H.A.; Wahl, R.L. ... Anti-cancer drugs. 2007 Aug;18(7):809-816.. Brown, P.; Smith, F.O. Molecularly targeted therapies for pediatric acute myeloid ...https://www.hopkinsmedicine.org/profiles/results/directory/profile/0011816/patrick-brown?spec_disease=Non-Hodgkin
Engineered Immune Cells Produce Complete Response in Child with an Aggressive Pediatric Leukemia | SYS-CON BRASIL
The innovative experimental therapy used bioengineered T cells, custom-designed to multiply rapidly in the patient, and then ... CHOP Oncologist Achieves Potent Anticancer Effect with Engineered T Cell Therapy on First Use in Children-- ... "These engineered T cells have proven to be active in B cell leukemia in adults," said Grupp. "We are excited to see that the ... One of the nine responding patients is the 7-year-old with acute lymphoblastic leukemia (ALL). Grupp and Penn colleagues ...http://br.sys-con.com/node/2476774
Experimental Design: Anticancer efficacy was evaluated at the molecular target, cancer cells and nude mice. The mechanism was ... Results: IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon ... A, anticancer efficacy of IG-105 (100 or 275 mg/kg i.p., q2d), oxaliplatin (5 mg/kg i.p., q2d), and doxorubicin (1 mg/kg i.p., ... B, anticancer efficacy of IG-105 (100 or 200 mg/kg i.p., q2d) and paclitaxel (15 mg/kg i.p., q2d) against the MCF-7 xenograft ...http://clincancerres.aacrjournals.org/content/14/19/6218
Protocols and Video Articles Authored by Timothy C. Chambers
Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation' ... In this study, we sought to develop and characterize an experimental system in which to test the hypothesis that MTAs induce ... Pubmed ID: 25649768 BH3 mimetic drugs may be useful to treat acute lymphoblastic leukemia (ALL) but the sensitivity of primary ... Synthesis and Anticancer Activity of Sclerophytin-inspired Hydroisobenzofurans Bioorganic & Medicinal Chemistry Letters. , ...https://www.jove.com/author/Timothy+C._Chambers
Frontiers | Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical...
... to summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents.Data sources: a ... Objective: to summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents. Data ... In particular, twelve papers evaluated the effect of Citrus juices in in vitro experimental models, and eight in in vivo ones. ... Chemopreventive actions of blond and red-fleshed sweet orange juice on the Loucy Leukemia cell line. Asian Pac. J. Cancer Prev. ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00420/full