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*  Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia | EurekAlert! Science News
... an experimental monoclonal antibody-based drug, measurably inhibited the 'stemness' of chronic leukemia cancer (CLL) cells -- ... ROR1 appears to drive tumor growth and disease spread and scientists think that presents an excellent novel target for anti-cancer ... Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia Cirmtuzumab targets key cancer stem cell ... Phase I trial finds experimental drug safe in treating chronic lymphocytic leukemia. University of California - San Diego ...
  https://www.eurekalert.org/pub_releases/2018-06/uoc--pit053018.php
*  Phase I Trial Finds Experimental Drug Safe in Treating Chronic Lymphocytic Leukemia
ROR1 appears to drive tumor growth and disease spread and scientists think that presents an excellent novel target for anti-cancer ... Phase I Trial Finds Experimental Drug Safe in Treating Chronic Lymphocytic Leukemia. Cirmtuzumab targets key cancer stem cell ... an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic lymphocytic leukemia cancer (CLL ... "This is noteworthy as the patients who enrolled in the trial had leukemia that was getting worse and causing disruption of ...
  https://ucsdnews.ucsd.edu/pressrelease/phase_i_trial_finds_experimental_drug_safe_in_treating_chronic_lymphocytic
*  M√∂glichkeiten und Grenzen internistischer Behandlung Krebskranker | SpringerLink
On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother Rep 55: 1-111Google ... Skipper HE, Schabel FM, Wilcox WS (1964) Experimental evaluation of potential anticancer agents. XII. ...
  https://link.springer.com/chapter/10.1007/978-3-642-75831-7_8
*  Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3...
Quantitative evaluation of anticancer agent activity in experimental animals. Pharmacol Ther [A] 1: 411Google Scholar ... Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilion) ... A P388 leukemia resistant to NSC 370 147 (P388/NSC 370 147) was isolated and its in vivo cross-resistance profile was ... Ethyl Hydrate Leukemia Cancer Research Doxorubicin These keywords were added by machine and not by the authors. This process is ...
  https://link.springer.com/article/10.1007/BF00686251
*  PIs - Universit√§t Ulm
The Institute for Experimental Cancer Research mainly focuses on basic research on acute leukemias. We investigate the role of ... different factors in leukemia, as well as possible anti-cancer mechanisms. Therefore we use a broad spectrum of in vitro and in ... There is also a gene and biobank, an inpatient clinic for acutely neurologically ill patients, and an experimental section in ... These groups perform experimental research on the basic mechanisms of the diseases mentioned above. ...
  https://www.uni-ulm.de/med/cemma/members/pis/
*  Plus it
Experimental evaluation of potential anticancer agents. XII. On the criteria and kinetics associated with "curability" of ... Among those available for use was a murine leukemia induced by a carcinogen, Leukemia 1210 (L1210), described by Lloyd Law at ... By 1960, the L1210 leukemia system had been established as both the primary screen and the model for treating acute leukemia. ... Farber, Heinle, and Welch tested folic acid in leukemia and they came to the conclusion that it actually accelerated leukemia ...
  http://cancerres.aacrjournals.org/content/68/21/8643
*  Neoadjuvant Versus Adjuvant Chemotherapy in Invasive Bladder Cancer | Springer for Research & Development
On the criteria and kinetics associated with curability of experimental leukemia. Cancer Chemother Rep 35:1-9PubMedGoogle ... Skipper HE, Schabel FM, Wilcox WS (1964) Experimental evaluation of potential anticancer agents. XII. ...
  https://rd.springer.com/chapter/10.1007/978-3-642-84583-3_18
*  DIGITAL.CSIC: Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo
In experimental therapeutics for cancer, caspase-1 has been related to some anticancer activity. These observations led us to ... with spontaneous regression in neuroblastomas and with a good clinical response to chemotherapy in acute myeloid leukemia and ... The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. This observation raises the ... possibility that factors affecting caspase activation might be important determinants of anticancer drug sensitivity. Ectopic ...
  https://digital.csic.es/handle/10261/24781
*  Thymidine kinase in clinical chemistry - Wikipedia
Bazargan A, Tam CS, Keating MJ (2012). "Predicting survival in chronic lymphocytic leukemia". Expert Review of Anticancer ... The experimental method first developed by Gronowitz et al. used quantities of radioisotope much above those used in commercial ... Leukemias normally do not present major diagnostic difficulties, as the microscopic analysis of the cells in blood mostly give ... A very interesting case is the myelodysplastic syndrome: Some rapidly change to acute leukemia, whereas others remain indolent ...
  https://en.wikipedia.org/wiki/Thymidine_kinase_in_clinical_chemistry
*  Ferrocene - Wikipedia
Some ferrocenium salts exhibit anticancer activity, but no compound has seen evaluation in the clinic. An experimental drug was ... when derivatives bearing amine or amide groups were tested against lymphocytic leukemia. ... The anticancer activity of ferrocene derivatives was first investigated in the late 1970s, ... Babin, V. N., et al., "Ferrocenes as potential anticancer drugs. Facts and hypotheses", Russ. Chem. Bull. 2014, volume 63, 2405 ...
  https://en.wikipedia.org/wiki/Ferrocene
*  Molecules | Free Full-Text | Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling,...
Methods: In this study, we used the MV4-11 cell line, a FLT3 positive acute myeloid leukemia (AML) cell line that displays ... However, the mechanism of action (MOA) of ADR's anticancer and anti-drug-resistance activities remain elusive. ... multidrug resistance, as our experimental system. We first evaluated the effect of ADR on MV4-11 cell proliferation. Then, a ... among which leukemia cell lines exhibit the highest sensitivity to ADR. In particular, ADR was also reported to have reduced ...
  https://www.mdpi.com/1420-3049/22/9/1444
*  Frontiers | Drug Repositioning for Effective Prostate Cancer Treatment | Physiology
In addition to clinical assessments, VPA is still under experimental investigation regarding the numerous mechanisms of anti- ... and leukemia cell lines whereas there are numerous clinical trials that have considered anti-cancer activity of statins in ... Anti-cancer activity of digoxin may include intracellular decreased level of K+ and increased level of Na+ and Ca2+ and also ... Chan, K. K. W., Oza, A. M., and Siu, L. L. (2003). The statins as anticancer agents. Clin. Cancer Res. 9, 10-19. doi: 10.1158/ ...
  https://www.frontiersin.org/articles/10.3389/fphys.2018.00500/full
*  Oncology Expert Witness | ForensisGroup
... and anti-cancer drugs. I have additional knowledge of experimental therapeutics, toxic effects of chemicals (such as lead, ... I have experience with chronic myelogenous leukemia, hematologic malignancies, leukemia, lymphoma, multiple myeloma, cancer ... I have additional expertise in oncology, leukemia, stem cells, progenitor cells, leukemogensis, and the link between aging and ... I have over 10 years experience in hematology with a specialization in oncology, anemia, aplastic anemia, leukemia, blood ...
  https://www.forensisgroup.com/expert-witness/oncology/
*  Risk Assessment Expert Witness | ForensisGroup
... and anti-cancer drugs. I have additional knowledge of experimental therapeutics, toxic effects of chemicals (such as lead, ... benzene, and sewer gas), acute myelogenous leukemia (AML), nephrogenic systemic fibrosis (NSF), rhabdomyolysis; as well as, ...
  https://www.forensisgroup.com/expert-witness/risk-assessment/
*  THE DAIRY OF PATIENT NUMBER 96 - The Washington Post
Last fall, he decided to become part of a California research program to test a new experimental anti-cancer drug that has had ... announced a new drug that seemed to have a dramatic effect on hairy cell leukemia. It was a highly experimental drug -- only 12 ... I checked into the Scripps Clinic to become the 96th patient with hairy cell leukemia to undergo this experimental treatment. I ... Hairy-cell leukemia is a disease of the white blood cells, the key cells in the immune system that fight infections. ...
  https://www.washingtonpost.com/archive/lifestyle/wellness/1990/12/04/the-dairy-of-patient-number-96/651b088a-08f4-46f8-9aeb-a2a6165eb59c/
*  Anti-Cancer Drug Prevents, Reverses Cardiovascular Damage | EmaxHealth
An experimental anti-cancer drug can prevent -- and even reverse -- potentially fatal cardiovascular damage in a mouse model of ... which are being tested in people with myeloid leukemia, neurofibromatosis and other conditions. The team had previously found ... Building upon its past experiments in cells and mice, the NIH-led team examined the effects of an experimental cancer drug, ...
  https://www.emaxhealth.com/2/94/25413/anti-cancer-drug-prevents-reverses-cardiovascular-damage.html
*  Cancers | Free Full-Text | Genetic Interactions of STAT3 and Anticancer Drug Development | HTML
A number of STAT3 inhibitors have been evaluated for their antitumor activity in vitro and in vivo in experimental tumor models ... In fact, a major cause of failure of anticancer drug development is lack of efficacy. Genetic interactions among various cancer ... into mechanisms of cancer resistance to pathway-targeted therapies and strategies for development of more effective anticancer ... Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer ...
  http://mdpi.com/2072-6694/6/1/494/htm
*  Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)
... with newly diagnosed chronic myeloid leukemia (CML) in t ... 4. Received, for CML, any other systemic anticancer therapy, ... experimental therapy, or. radiation therapy with the exception of anagrelide or hydroxyurea. 5. Major surgery within 28 days ... Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC). Status:. Recruiting. Conditions:. Blood Cancer, Hematology ... Diagnosed with or received anticancer therapy for another primary malignancy within 3. years prior to entry (except for non- ...
  https://www.clinicaltrialsgps.com/search-clinical-trials/trial-32984/?Location=81549
*  The Law of the Sea in the Asian Pacific Region : James Crawford : 9780792327424
Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches Frederick A. Valeriote ... Biology and Therapy of Acute Leukemia Frederick A. Valeriote 09 Jan 2012 ...
  https://www.bookdepository.com/Law-Sea-Asian-Pacific-Region-James-Crawford/9780792327424
*  Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics
... that has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. ... Samples from 65 patients, 42 with acute lymphocytic leukemia (ALL) and 23 with acute myelocytic leukemia (AML) were tested with ... 2000 In: Leukemia, Vol. 14, no 4, p. 943-4.Article in journal (Refereed) Published Identifiers. urn:nbn:se:uu:diva-89994 (URN) ... 3. In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia. Open this publication in new window or ...
  http://www.diva-portal.org/smash/record.jsf?pid=diva2:161996
*  Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo | Clinical Cancer...
Experimental Design: We employed RS4;11 and MV4;11 cell lines, two acute leukemia models, to investigate acquired resistance ... Acquired resistance of tumor cells to anticancer drugs is a major cause of the failure of clinical cancer therapy. We have ... Acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) remain incurable with conventional chemotherapy, and ... The tumor suppressor p53 is another attractive therapeutic target for leukemia (16-21). In about 90% of leukemias, p53 retains ...
  http://clincancerres.aacrjournals.org/content/21/11/2558
*  Experimental Therapeutics Salt Lake City, Utah
Anticancer drug carrier design targeting MDR. Barnette, Phillip. e-mail. Acute childhood leukemia, therapeutic advances in ... Experimental Therapeutics Member Directory. The Experimental Therapeutics (ET) Program is organized to facilitate ... Prevention and treatment of Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) and Multiple Myeloma. ... Experimental therapeutics, clinical trials in oncology. Andtbacka, Robert. e-mail. Developing new modalities for the detection ...
  https://healthcare.utah.edu/huntsmancancerinstitute/research/cancer-center-research-programs/experimental-therapeutics.php
*  Zidovudine - Wikipedia
Society for Experimental Biology and Medicine. 216 (3): 358-369. doi:10.3181/00379727-216-44183. PMID 9402140. Fisher, J. W. ( ... This report attracted little interest from other researchers as the Friend leukemia virus is a retrovirus, and at the time, ... and anticancer agents, the leading work being done at the laboratory of Nobel laureates George Hitchings and Gertrude Elion, ... According to IARC, there is sufficient evidence in experimental animals for the carcinogenicity of zidovudine; it is possibly ...
  https://en.wikipedia.org/wiki/Zidovudine
*  New therapy treats autoimmune disease without harming normal immunity
Since 2011, though, experimental CAR T cell treatments for B cell leukemias and lymphomas-cancers in which patients' healthy B ... from the promising anti-cancer strategy by which T cells are engineered to destroy malignant cells in certain leukemias and ... "Our study effectively opens up the application of this anti-cancer technology to the treatment of a much wider range of ... The basic CAR T cell concept was first described in the late 1980s, principally as an anti-cancer strategy, but technical ...
  https://medicalxpress.com/news/2016-06-therapy-autoimmune-disease-immunity.html
*  Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells | SpringerLink
Anticancer Agents Med Chem. 2012;12:554-63.CrossRefPubMedGoogle Scholar ... Genistein induces apoptotic cell death associated with inhibition of the nf-kappab pathway in adult t-cell leukemia cells. Cell ... Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein. Neoplasia. ... Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of akt and nuclear ...
  https://link.springer.com/article/10.1007/s13277-013-1542-0