*  VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer | Molecular Cancer Therapeutics
The mTOR signaling pathway has been suggested to be involved in multiple anticancer drug resistance mechanisms toward ... In contrast, as mutations in APC, MYCL1, or MYCN were associated with drug resistance these may provide genetic markers for ... Drug sensitivity profiling in the Genomics of Drug Sensitivity in Cancer cell line panel. To identify putative biomarkers of ... Interestingly, mutations of APC, MYCL1, or MYCN were correlated with drug resistance (Fig. 5A). ...
  http://mct.aacrjournals.org/content/12/2/151?rss=1
*  The Multiple Therapeutic Targets of A20 | Springer for Research & Development
A20 Expressing Tumors and Anticancer Drug Resistance Cleide Gonçalves da Silva, Darlan Conterno Minussi, Christiane Ferran, ... Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases ...
  https://rd.springer.com/book/10.1007%2F978-1-4939-0398-6
*  Measurement of Multiple Drug Resistance Transporter Activity in Putative Cancer Stem/Progenitor Cells | SpringerLink
Multiple drug resistance, mediated by the expression and activity of ABC-transporters, is a major obstacle to antineoplastic ... Tumorigenic stem and progenitor cells: implications for the therapeutic index of anti-cancer agents. J Control Release 2007;122 ... Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007;26:5674-5679.PubMedCrossRef ... Pre-existing multiple drug resistance ABCB1 activity ABCG2 activity Hoechst 33342 Rhodamine 123 Epithelial tumors Cancer stem ...
  https://link.springer.com/protocol/10.1007%2F978-1-59745-280-9_17
*  Frontiers | From antimicrobial to anticancer peptides. A review | Microbiology
... their use as anticancer peptides (ACPs) in cancer therapy either alone or in combination with other conventional drugs has been ... Strategies described for drug development and for increasing peptide selectivity towards specific cells while reducing toxicity ... As detailed studies on ACPs mechanisms of action are crucial for optimizing drug development, in this review we provide an ... As detailed studies on ACPs mechanisms of action are crucial for optimizing drug development, in this review we provide an ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2013.00294/full
*  New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. | Cancer Research
Enter multiple addresses on separate lines or separate them with commas.. You are going to email the following New daunorubicin ... Circumventing Drug Resistance New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. ... Anthracyclines are considered to be some of the most effective anticancer drugs for cancer therapy. However, drug resistance ... New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1270.1
*  Resistance to alkylating anticancer drugs: Role of the Nrf2-antioxidant system | Cancer Research
Enter multiple addresses on separate lines or separate them with commas.. You are going to email the following Resistance to ... Resistance to alkylating anticancer drugs: Role of the Nrf2-antioxidant system. Sarala Manandhar, Jeong-Min Cho, Hyun-Min Park ... Resistance to alkylating anticancer drugs: Role of the Nrf2-antioxidant system. Sarala Manandhar, Jeong-Min Cho, Hyun-Min Park ... Resistance to alkylating anticancer drugs: Role of the Nrf2-antioxidant system. Sarala Manandhar, Jeong-Min Cho, Hyun-Min Park ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/705
*  Application # 2012/0035268. SPHINGO-GUANIDINES AND THEIR USE AS INHIBITORS OF SPHINGOSINE KINASE - Patents.com
... multiple drug resistance gene inhibitor; multiple tumor suppressor 1-based therapy; mustard anticancer agent; mycaperoxide B; ... Other anti cancer drugs include, but are not limited to: 20-epi-1,25 dihydroxyvitamin D3; 5-ethynyluracil; abiraterone; ... Representative additional anti-cancer drugs are 5-fluorouracil and leucovorin. These two agents are particularly useful when ... Ceramide induces apoptosis in tumor cells and can enhance apoptosis in response to anti-cancer drugs, but can be further ...
  http://patents.com/us-20120035268.html
*  Abstract 5045: Overexpression of ABC transporters through HGF/c-MET activation results in anti-cancer drug resistance in SCLC |...
Abstract 5045: Overexpression of ABC transporters through HGF/c-MET activation results in anti-cancer drug resistance in SCLC. ... Enter multiple addresses on separate lines or separate them with commas.. You are going to email the following Abstract 5045: ... Upregulation of hepatocyte growth factor (HGF)/c-MET pathway causes drug resistance to anti-cancer agents such as epidermal ... Overexpression of ABC transporters through HGF/c-MET activation results in anti-cancer drug resistance in SCLC. [abstract]. In ...
  http://cancerres.aacrjournals.org/content/76/14_Supplement/5045
*  Abstract 3048: Study of mitochondria in multi-drug resistance and Polyphyllin D anti-cancer effect in hepatocellular carcinoma ...
Abstract 3048: Study of mitochondria in multi-drug resistance and Polyphyllin D anti-cancer effect in hepatocellular carcinoma ... which greatly hampers the efficacy of multiple kinds of structurally different drugs, during the course of treatment. Several ... Study of mitochondria in multi-drug resistance and Polyphyllin D anti-cancer effect in hepatocellular carcinoma. [abstract]. In ... Abstract 3048: Study of mitochondria in multi-drug resistance and Polyphyllin D anti-cancer effect in hepatocellular carcinoma ...
  http://cancerres.aacrjournals.org/content/75/15_Supplement/3048
*  Overview of the Classical Histone Deacetylase Enzymes and Histone Deacetylase Inhibitors
... pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter ... J. E. Bolden, M. J. Peart, and R. W. Johnstone, "Anticancer activities of histone deacetylase inhibitors," Nature Reviews Drug ... P. A. Marks, "The clinical development of histone deacetylase inhibitors as targeted anticancer drugs," Expert Opinion on ... W. K. Kelly and P. A. Marks, "Drug insight: Histone deacetylase inhibitors-development of the new targeted anticancer agent ...
  https://www.hindawi.com/journals/isrn/2012/130360/ref/
*  US5646126A - Sterol modified oligonucleotide duplexes having anticancer activity - Google Patents
There are known cancer cell lines having resistance to multiple drugs (multiple drug resistance, MDR). As far as the present ... including some cancer cell lines which have resistance to several established anticancer agents (cells with multiple drug ... as well as the naso-pharyngeal KB cell line with multiple drug resistance (KBMDR +) that are generally known to be relatively ... and to certain cancer cell lines with multiple drug resistance.. SUMMARY OF THE INVENTION. It has been discovered in accordance ...
  https://patents.google.com/patent/US5646126?oq=6819670
*  Antineoplastic resistance - Wikipedia
... is the ability of cancer cells to survive and grow despite different anti-cancer therapies, i.e. their multiple drug resistance ... Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of ... Epigenetic modifications in antineoplastic drug resistance play a major role in cancer development and drug resistance as they ... or the multiple drug resistance protein, is a phosphorylated and glycosylated membrane transporter that can shuttle drugs out ...
  https://en.wikipedia.org/wiki/Antineoplastic_resistance
*  Frontiers | Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent...
The presence of MK571 (inhibitor of MRP1 and Multidrug resistance protein 4 (MRP4) led to an enhanced effect of vincristine and ... Treatment with MK571, or specific MRP1 knockdown, did not have any effect on temozolomide drug response in these cells. These ... The presence of MK571 (inhibitor of MRP1 and Multidrug resistance protein 4 (MRP4) led to an enhanced effect of vincristine and ... Treatment with MK571, or specific MRP1 knockdown, did not have any effect on temozolomide drug response in these cells. These ...
  https://www.frontiersin.org/articles/10.3389/fnins.2015.00218/full
*  Plus it
... or melphalan but also to overcome drug resistance in multiple myeloma cells (25). ... Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5:769-84. ... The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res 2006;66:5781- ... The drug was reported to potentiate the action of anticancer agents such as bortezomib, dexamethasone, ...
  http://clincancerres.aacrjournals.org/content/15/12/4066
*  Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves
... ovarian expressing multiple drugs resistance phenotype), and OVCAR-3 (ovary)) were kindly provided by the National Cancer ... O. Trédan, C. M. Galmarini, K. Patel, and I. F. Tannock, "Drug resistance and the solid tumor microenvironment," Journal of the ... R. H. Shoemaker, "The NCI60 human tumour cell line anticancer drug screen," Nature Reviews Cancer, vol. 6, no. 10, pp. 813-823 ... A. Monks, D. Scudiero, P. Skehan et al., "Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured ...
  https://www.hindawi.com/journals/ecam/2015/948737/
*  Research and Markets: This Essential Report on Cancer Drug Resistance is Available Now. - Free Online Library
Care and treatment Drug therapy Cancer research Cancer treatment Drug resistance in microorganisms Microbial drug resistance ... This Essential Report on Cancer Drug Resistance is Available Now. by 'Business Wire'; Business, international Antimitotic ... novel drugs, drug combinations, multiple-targeting drugs, direct targeting and avoidance of resistance mechanisms, CSCs and ... Cancer Drug Resistance: Anticancer drugs fail to kill cancer cells for a number of reasons. These include kinetic factors, ...
  https://www.thefreelibrary.com/Research+and+Markets%3A+This+Essential+Report+on+Cancer+Drug+Resistance+...-a0185206196
*  ATP-binding cassette transporter - Wikipedia
... result in the development of resistance to multiple drugs such as antibiotics and anti-cancer agents. Hundreds of ABC ... Drug Resistance ATPase-1 (Drug RA1) (Putative) Drug Resistance ATPase-2 (Drug RA2) Macrolide Exporter (MacB) Peptide-4 Exporter ... The substrates that reverse the resistance to anticancer drugs are called chemosensitizers. Drug resistance is a common ... Bacterial drug resistance has become an increasingly major health problem. One of the mechanisms for drug resistance is ...
  https://en.wikipedia.org/wiki/ATP-binding_cassette_transporter
*  Efflux (microbiology) - Wikipedia
Some efflux systems are drug-specific, whereas others may accommodate multiple drugs with small multidrug resistance (SMR) ... Efflux pumps are one of the major causes of anticancer drug resistance in eukaryotic cells. They include monocarboxylate ... multiple drug resistance proteins (MDRs)- also referred as P-glycoprotein, multidrug resistance-associated proteins (MRPs), ... Antibiotic resistance. References[edit]. *^ Bay, Denice C.; Turner, Raymond J. (2016). Small Multidrug Resistance Efflux Pumps ...
  https://en.wikipedia.org/wiki/Efflux_%28microbiology%29
*  Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics - 1st Edition
8. Nanoparticles for Anti-Cancer Drug Delivery 'Targeting to Overcome Multiple Drug Resistance'. 9. Application Potential of ... Therapeutic Nanoparticles for Targeted Delivery of Anticancer Drugs: State-Of-The-Art and Future Trends. 14. Pulmonary ... Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers ... 5. Effect of Polymer-Based Nanoparticles on the Assay of Antimicrobial Drug Delivery Systems. 6. Nanometric Biopolymer Devices ...
  https://www.elsevier.com/books/multifunctional-systems-for-combined-delivery-biosensing-and-diagnostics/grumezescu/978-0-323-52725-5
*  PDCD2 | Cancer Genetics Web
The development of cross-resistance to many natural product anticancer drugs, termed multidrug resistance (MDR), is one of the ... Resistance to the broad spectrum of chemotherapeutic agents in cancer cell lines and tumors has been called multiple drug ... The development of cross-resistance to many natural product anticancer drugs, termed multidrug resistance (MDR), is a serious ... Drug resistant cancer cells exhibit different gene expression patterns depending on drug treatment, and each drug resistance ...
  http://www.cancerindex.org/geneweb/PDCD2.htm
*  Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese | IOVS | ARVO Journals
16 ABCC5 also provides resistance of anticancer drugs.17,18 The expression of ABCC5 was detected in multiple human tissues, ... The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated ... Furthermore, if multiple SNPs were found to be significant, logistic regression analyses were performed to adjust the ... Correction for multiple testing in haplotype association analysis was performed by using the permutation test (number of ...
  https://iovs.arvojournals.org/article.aspx?articleid=2649246
*  Inhibition of p-glycoprotein activity by limonin and other secondary metabolites from citrus species in human colon and...
... the occurrence of multiple drug resistance efficacy of anticancer compounds have been identified ( renders cells tolerant not ... Drug-resistant CEM/ADR5000 cell lines were maintained in the absence of doxorubicin and resistance wasstabilized by 5 µg/ml ... World Cancer triterpenoid drug amooranin overcomes multidrug resistance in human leukemia Report 2008. IARC Press, Lyon.. and ... Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S ...
  http://gotomydoctor.com/a/abcdef.uni-hd.de1.html
*  Tumors Feel the Deadly Sting of Nanobees
Too often, chemotherapy fails to cure cancer because some tumor cells develop resistance to multiple anticancer drugs. In most ... "Cancer cells can adapt and develop resistance to many anticancer agents that alter gene function or target a cell's DNA, but ... mechanism by which it kills cells is not likely to trigger the drug resistance that often develops with conventional anticancer ... Louis have created a potential new type of anticancer therapy with the potential to target a wide range of tumors. This work ...
  https://phys.org/news/2009-08-tumors-deadly-nanobees_1.html
*  Efflux (microbiology) - Wikipedia
Some efflux systems are drug-specific, whereas others may accommodate multiple drugs with small multidrug resistance (SMR) ... Efflux pumps are one of the major causes of anticancer drug resistance in eukaryotic cells. They include monocarboxylate ... multiple drug resistance proteins (MDRs)- also referred as P-glycoprotein, multidrug resistance-associated proteins (MRPs), ... "AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance ...
  https://en.wikipedia.org/wiki/Efflux_(microbiology)
*  Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by co-targeting MEK and IGF...
Drug resistance is a common problem associated with chronic treatment with anti-cancer drugs (Engelman and Janne, 2008; ... and consider the possibility that resistance to a drug can be linked to multiple mechanisms. Understanding the mechanisms ... Effective strategies to overcome anti-cancer drug resistance are sorely needed and can only be developed by understanding the ... Acquired resistance to anticancer agents is frequently encountered in clinical practice. Resistance to kinase inhibitors is ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3026446/