Iminosugar - Wikipedia
Anti-cancer and anti-viral activity was subsequently observed for swainsonine-a mannose analogue-and castanospermine-a glucose ... DNJ was modified to produce two derivatives now used as medicines, N-hydroxyethyl-DNJ (miglitol) for diabetes and N-butyl-DNJ ( ... Although the early compounds had biological activities due to glycosidase inhibition, an increasing number are being shown to ... Amino sugar Watson AA, Fleet GW, Asano N, Molyneux RJ, Nash RJ (2001). "Polyhydroxylated alkaloids-natural occurrence and ...https://en.wikipedia.org/wiki/Iminosugar
Molecules | Free Full-Text | Marine Natural Products as Models to Circumvent Multidrug Resistance
This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated ... during the last decades concerning their synthesis and MDR-inhibiting activities will help medicinal chemists develop potential ... to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure. The ATP binding cassette ... Multidrug resistance (MDR) to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure ...http://www.mdpi.com/1420-3049/21/7/892
Peganum harmala - Wikipedia
"Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent". Phytochemistry. 66 ... "Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities". ... Further mechanistic studies indicate that beta-carboline derivatives inhibit DNA topoisomerases and interfere with DNA ... "The beta-carboline alkaloids present in medicinal plants, such as Peganum harmala and Eurycoma longifolia, have recently drawn ...https://en.wikipedia.org/wiki/Peganum_harmala
NIH Guide: CANCER DRUG DISCOVERY: DIVERSITY GENERATION AND SMART ASSAYS
... vinca alkaloids, taxanes and camptothecin derivatives). The current state of the relevant science and technology suggests now, ... Drug development activities, such as large-scale production of an agent, are beyond the scope of the RFA. HEALTHY PEOPLE 2000 ... Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: ... Since the discovery of new anticancer agents may result from these P01 projects, it is essential that applicants provide plans ...https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-97-006.html
Α-Hederin - Wikipedia
One of the derivatives of alpha-hederin, kalopanaxsaponin-I, was found to possess anticancer activity. • Alpha-hederin also, in ... 1f), saponin (a potential anticancer agent), vitamins (riboflavin, thiamin, niacin, pyridoxine, folic acid, and vitamin E), and ... A literature search has revealed that a lot more studies have been recently carried out related to the anticancer activities of ... 1d), isoquinoline alkaloids (nigellicimine and nigellicimine-N-oxide, Fig. 1e), alpha-hederin (a water-soluble pentacyclic ...https://en.wikipedia.org/wiki/%CE%91-Hederin
Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells | BMC...
In this study we examined the anticancer effect of Daucus carota oil extract (DCOE) fractions on the human breast ... These results suggest that the pentane-based fractions of DCOE possess potential anti-cancer activity that is mainly mediated ... vinca alkaloids, epipodophyllotoxins, taxanes, and camptothecin derivatives . ... DCOE has been shown to have an antioxidant and anticancer activities against breast and colon cancer cell lines . ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-387
Halogenated Indole Alkaloids from Marine Invertebrates
Aplysinopsins have the potential to influence monoaminooxidase (MAO) and nitric oxide synthase (NOS) activities. They have also ... This section reports a compilation of the 13C chemical shifts of the halogenated marine indole alkaloids derivatives, ... These results demonstrate the potential of aplycianins structure as a scaffold for anticancer drug discovery . ... Frederich M, Tits M, Angenot L. Potential antimalarial activity of indole alkaloids. Trans R Soc Trop Med Hyg. 2008;102:11-19. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2885079/
Gelsemine - Wikipedia
In addition, gelsemine has been noted to have anti-inflammatory and anti-cancer activities. Recent research on gelsemine has ... Liu, Z.-J. & Lu, R.-R. (1988). "Gelsemium Alkaloids". The Alkaloids: Chemistry and Pharmacology (review). The Alkaloids. Vol. ... Pharmacological research has suggested gelsemine activities to have potential related to the treatment of anxiety, and in ... with ongoing research including attempts to identify safer derivatives and analogs to make use of gelsemine's beneficial ...https://en.wikipedia.org/wiki/Gelsemine
Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and...
... anticancer, and anti-inflammatory properties. The inhibitory activities of licorice extract in hCB1 receptor-expressing Chem-1 ... "Unsaturated fatty alcohol derivatives of olive oil phenolic compounds with potential low-density lipoprotein (LDL) antioxidant ... This was the first study showing that naturally occurring alkaloids are also source of CB1 receptor antagonists and this could ... and opioid receptor activities, rutin may be a potential multitargeted polypharmacological agent in prevention and treatment of ...https://www.hindawi.com/journals/ecam/2015/238482/
Caltech engineers build mini drug-producing biofactorie... ( PASADENA Calif.-- Researchers at the...)
BIA molecules exhibit a wide variety of pharmacological activities in...,Caltech,engineers,build,mini,drug-producing, ... By expanding to nonnatural alkaloids, we can search for molecules that provide enhanced activities, new activities, and not be ... Other BIAs have shown anticancer, antioxidant, antimalarial, and anti-HIV potential. "There are estimated to be thousands of ... a related area of research will be to examine more closely the pharmacological activities of these metabolites and derivatives ...http://www.bio-medicine.org/biology-news-1/Caltech-engineers-build-mini-drug-producing-biofactories-in-yeast-4479-1/
Marine Drugs | Free Full-Text | Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance |...
Aplysinopsins have the potential to influence monoaminooxidase (MAO), and nitric oxide synthase (NOS) activities. They were ... Two aplysinopsin derivatives 3 and 4, were found in extracts from both P. melanobrachia and T. coccinea. In turn, compounds 5, ... Anticancer  Antiplasmodial . 3. Dercitus sp. sponge Caribbean  Tubastrea coccinea coral Hawaii  Phestilla ... Anticancer [2,10] Antimicrobial  Inhibitor of development of fertilized sea urchin eggs  Induces symbiosis between sea ...http://mdpi.com/1660-3397/7/2/166/htm
Plant sources of anti-cancer agents - Wikipedia
Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or ... been discovered in screening programs and developed as chemotherapy drugs Some plants that indicate potential as an anticancer ... Cardenas, ME; Cruz, MC; Del Poeta, M; Chung, N; Perfect, JR; Heitman, J (1999). "Antifungal activities of antineoplastic agents ... Catharanthus roseus Vinca alkaloids were originally manufactured by extracting them from Catharanthus (Madagascar Periwinkle). ...https://en.wikipedia.org/wiki/Plant_sources_of_anti-cancer_agents
Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line | BMC Complementary...
In fact, at least 60 % of the currently used anticancer agents, such as paclitaxel or the vinca alkaloids, vincristine and ... This is consistent with the goal of potential anticancer drugs, in which a primary characteristic is to induce apoptosis. ... The study of new natural products with anticancer activity is important to synthesize new chemical derivatives based on ... to determine their specific anticancer activities using various assays. ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1136-7
Marine Drugs | Free Full-Text | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the...
... in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good ... The outstanding biological activities of these marine alkaloids have attracted the attention of numerous research groups ... anticancer drugs) [1,2]. Quinoline core is a common structural motif among many marine alkaloids [3,4]. For example, the ... Xiang, P.; Jie, H.; Zhou, Y.; Yang, B.; Wang, H.-J.; Hu, J.; Hu, J.; Yang, S.-Y.; Zhao, Y.-L. 5-Methoxyquinoline derivatives as ...http://www.mdpi.com/1660-3397/15/9/276/htm
Protocols and Video Articles Authored by Thomas P. Fondy (Translated to Italian)
In spite of the availability of such potential anti-neoplastic agents, there has yet to be an effective microfilament-directed ... The Real Deal: Using Cytochalasin B in Sonodynamic Therapy to Preferentially Damage Leukemia Cells Anticancer Research. May, ... These combinations could increase the likelihood of obtaining clinically useful activities with microfilament-directed agents ... and a variety of natural products and semi-synthetic derivatives are available to exploit these differences in vitro. ...https://www.jove.com/author/Thomas++P._Fondy?language=Italian
Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents | Open Access Journals
Marine natural products are valuable sources that could produce potential chemotherapeutic agents, and marinederived organisms ... alkaloids, polyketides and terpenes, have demonstrated antimicrobial and antiviral activities [13,14]. Most of marine-derived ... The role of new eudesmane-type sesquiterpenoid and known eudesmane derivatives from the red alga Laurenciaobtusa as potential ... Their ethyl acetate extract and isolated compounds were explored for antibacterial, anticancer, and antiviral (HCV) activities ...https://www.omicsonline.org/open-access/red-sea-microbial-diversity-for-antimicrobial-and-anticancer-agents-2155-9929-1000267.php?aid=66387
Molecules | Free Full-Text | Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways...
... anticancer potential against lung cancer cells was previously demonstrated [23,24]: treatment of lung cancer cells with ... Miyake, K.; Tezuka, Y.; Awale, S.; Li, F.; Kadota, S. Canthin-6-one alkaloids and a tirucallanoid from eurycoma longifolia and ... E. longifolia is rich in quassinoids, triterpenes, squalene derivatives, biphenylneolignans, canthin-6-ones and β-carboline ... we describe here anti-inflammatory and anti-leukemic activities of two compounds from E. longifolia with differential NF-κB ...http://www.mdpi.com/1420-3049/19/9/14649/htm
Endophytic Fungi as Novel Resources of natural Therapeutics
and its antifungal, anticancer and anti-metastatic activities. Sustainable Chemical Processes. 2014; 2:8. [ Links ] ... anticancer, antidiabetic and antimicrobial effects to test the potential effects of fungal endophytes, but very few scientists ... 143 Zhang G, Sun S, Zhu T, Lin Z, Gu J, Li D, Gu Q. Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. ... 160 Lai D, Brötz-Oesterhelt H, Müller WE, Wray V, Proksch P. Bioactive polyketides and alkaloids from Penicillium citrinum, a ...http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100430&lng=en&tlng=en
Antimicrobial Compounds from Tree Endophytes | SpringerLink
Gu W, Ding H (2008) Two new tetralone derivatives from the culture of Xylaria hypoxylon AT-028. Chin Chem Lett 19:1323-1326 ... Cheng Z-S, Pan J-H, Tang W-C et al (2009) Biodiversity and biotechnological potential of mangrove-associated fungi. J For Res ... Govindachari TR, Viswanathan N (1972) Alkaloids of Mappia foetida. Phytochemistry 11: 3529-3531CrossRefGoogle Scholar ... Huang Z, Cai X, Shao C et al (2008) Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic ...https://link.springer.com/chapter/10.1007/978-94-007-1599-8_17
trypanosoma brucei rhodesiense
The compounds are also potential anticancer agents.. ... *Water-Soluble and Metabolically Stable Calpain Inhibitors as ... This is the first detailed study on the antiprotozoal potential of marine bromopyrrole alkaloids... ... The 43 isoxazole derivatives were assayed against Trypanosoma brucei rhodesiense (T. brucei rhodesiense) STIB900, Plasmodium ... Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were ...http://www.labome.org/topics/organisms/animals/invertebrates/protozoa/sarcomastigophora/mastigophora/zoomastigophora/kinetoplastida/trypanosomatina/trypanosoma/trypanosoma-brucei-rhodesiense-2179.html
Most Cited Articles ::: Letters in Drug Design & Discovery
A Series of 2,4(1H,3H)-Quinazolinedione Derivatives: Synthesis and Biological Evaluation as Potential Anticancer Agents. , 2016 ... Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways. , 2016 ... Accumulation Effects of 3-N-Benzyloxycarbonyl-β-aminobutyric Salicylate on the Alkaloids in Catharanthus roseus Cells. , 2016; ... Recent Developments in the Synthesis and Applications of Anticancer Amonafide Derivatives. A Mini Review. , 2016; 13(1): 47-63. ...https://benthamscience.com/journals/letters-in-drug-design-and-discovery/most-cited-articles/
Barbiturate and thiobarbiturate compounds for use in cancer therapy - NUHOPE LLC
... as potential cancer treatments when combined with indole (Palwinder et al., "Design, synthesis and anticancer activities of ... Some barbiturate derivatives have been proposed as possible modulators of apoptosis and therefore possible anti-cancer agents ( ... alkaloids, and topoisomerase inhibitors. ... Other CC-I derivatives (Formulae V, IX, XIX, XX, XXI, and XXII ... The term "derivatives" refers to molecules derived from the compounds described herein. Such derivatives may, for example, be ...http://www.freepatentsonline.com/9878998.html
Medicinal fungi - Wikipedia
Penicillium is a potential source of the leukemia medicine asparaginase. Some countries have approved Beta-glucan fungal ... Zmitrovich IV (2015). "Anti-cancer metabolites of Basidiomycota and their molecular targets. A review" (PDF). Vestnik Permskogo ... Nagaraj, G.; Uma, MV.; Shivayogi, MS.; Balaram, H. (January 2001). "Antimalarial activities of peptide antibiotics isolated ... Antibiotics retapamulin, tiamulin, and valnemulin are derivatives of the fungal metabolite pleuromutilin. Plectasin, ...https://en.wikipedia.org/wiki/Medicinal_fungi
Marine Drugs | Free Full-Text | Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of...
In Vitro Anticancer Activity Assays. 3.7.1. Cell Lines. Eight cancer cell lines were used to assess the anticancer activity of ... MH inoculated plates were incubated for 18-20 h at 37 °C. Potential synergism was recorded when the halo of an antibiotic disk ... Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus ... and Simplicillium lanosoniveum), this is the first report of the isolation of hydroxypyrrolidine alkaloids from A. candidus. ...http://www.mdpi.com/1660-3397/16/4/119/htm
... tested cancer cell lines and that most demonstrated more potent inhibitory activities compared with the commercial anticancer ... Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models. Some 19 ... In the present study, we have evaluated the potential activity of the resin-oil of Pinus elliottii and its major compound ... Interestingly, Catharanthus roseus, a host species for pharmaceutically valuable terpenoid indole alkaloids, exhibited a very ...http://www.uef.fi/en/web/finechem/dehydroabietic-acid