Hybrids between Myeloma Cells and Thymocytes - An Attempt to Approach the Biological Function of Terminal Transferase |...
Sequences of the joining region genes for immunoglobulin heavy chain and their role in generation of antibody diversity, Proc. ... P. Early, H. Huang, M. Davis, K. Calame and L. Hood, An immunoglobulin heavy chain variable region gene is generated from three ... Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain, Proc. Natl. Acad. Sci. USA, 75: 1485 ... R.P. Perry, D.E. Kelley, C. Coleclough and J.F. Kearney, Organization and expression of immunoglobulins genes in fetal liver ...https://link.springer.com/chapter/10.1007/978-1-4684-8929-3_20
Grant Finder | Leukemia and Lymphoma Society
This process involves programmed formation and repair of DNA breaks in the antibody gene region. Failure to fix these breaks ... Project Title: Investigating The Roles Of Alternative End Joining In Immunoglobulin Class Switch Recombination ... Notch is a receptor that when activated by either ligand or mutation functions to regulate the expression of genes involved in ... In this context, we have identified mutations in the VAV1 gene in lymphoma samples from peripheral T-cell lymphoma patients. ...http://www.lls.org/grant-finder?field_grant_program_id_tid=All&field_grant_subprogram_id_tid=All&field_parameter_name_value=&field_organization_country_tid=All&field_work_state_tid=All&field_spending_year_value=&body_value=&page=8
Generation of xenogeneic antibodies - ABGENIX, INC.
... by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or ... These regions were then joined to the variable region encoding portion of other immunoglobulin genes from another species ... the diversity (D) region genes, followed by the joining (J. H. ) region genes and the constant (C. H. ) gene cluster. The size ... region of the kappa constant region, a thymidine kinase gene for negative selection, a neomycin resistance gene and a 3′ region ...http://www.freepatentsonline.com/y2004/0010810.html
Patent US6020153 - Chimeric antibodies - Google Patents
The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis ... The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or ... DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines ... processes for the preparation of these antibodies and their derivatives, ...http://www.google.com/patents/US6020153?dq=6734022
NAVER Academic | Comparative classification of leptospira serovars of the Pomona group by monoclonal antibodies and restriction...
Monoclonal antibodies (MCAs) were prepared to serovars of the Pomona group. The MCAs were directed against antigens of ... A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes Banerji ... Production of monoclonal antibodies: Strategy and tactics (1980) de St. Groth S.Fazekas et al. Journal of Immunological Methods ... Monoclonal antibody-recognizing cone visual pigment (1986) Szél Á et al. * Molecular characterization of synaptophysin, a major ...https://academic.naver.com/article.naver?doc_id=65300390
NAVER Academic | Granulocyte-specific monoclonal antibody inhibiting cytotoxicity reactions in the chicken
The antibody-dependent cellular cytotoxicity (ADCC) activity of purified granulocytes was also severely affected by treatment ... Monoclonal antibody (MAb) 10, specific for chicken granulocytes, is described for the first time. Treatment of peripheral blood ... A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes (1983) ... Animals, Antibodies, Monoclonal, Antibody-Dependent Cell Cytotoxicity, Antigens, Surface, Chickens, Cytotoxicity, Immunologic, ...https://academic.naver.com/article.naver?doc_id=65288563&page=2
PPT - Antibody structure and function PowerPoint presentation | free to download - id: 20efd9-ZWU2N
Aggregates formed by interaction of multivalent antibodies and multivalent ... - A free PowerPoint PPT presentation (displayed ... immunoglobulins*Imprecise joining of gene segments *Random nucleotide addition at joining regions ... Antibodies and hybridomas - Antibodies and hybridomas Presented by Nis giladi Antibodies Antibodies are the antigen binding ... Functions of immunoglobulins 52. Functions of immunoglobulins 53. (No Transcript) 54. Polyclonal vs. monoclonal antibodies* ...http://www.powershow.com/view/20efd9-ZWU2N/Antibody_structure_and_function_powerpoint_ppt_presentation
B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy | Journal of Translational...
Weigert M, Perry R, Kelley D, Hunkapiller T, Schilling J, Hood L. The joining of V and J gene segments creates antibody ... V gene (V), D gene (D), J gene (J) and constant regions (C). (2) Reverse transcription from isotype-specific primers (IgG, IgA ... Genomic rearrangement of variable (V), diversity (D) and joining (J) segments of immunoglobulin genes generates a diverse set ... Features of the immune repertoire, including V gene usage, relative isotype distribution and V gene region mutation frequency, ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1118-7
Patent US6303749 - Agouti and agouti-related peptide analogs - Google Patents
For example, it has been described that the homozygous deletion of the antibody heavy-chain joining region (JH) gene in ... The human immunoglobulin hinge and Fc region can be fused at either the N-terminus or C-terminus of the AGRP/ASP peptides using ... AGRP/ASP Antibodies. AGRP/ASP peptide may be used as an immunogen to generate anti-AGRP/ASP peptide antibodies. Such antibodies ... antibody. Methods for humanizing non-human antibodies are well known in the art. Generally, a humanized antibody has one or ...http://www.google.com/patents/US6303749?dq=5787449
ASMscience | Immunoglobulin Genes
Immunoglobulin class-switching recombination (CSR) occurs in or near the α switch region upstream of the μ gene and any one of ... IgA antibodies are the primary antibodies in saliva, tears, and colostrum and in the fluids of the gastrointestinal, ... Duplication of an immunoglobulin VH gene(s) results in some haplotypes' having identical immunoglobulin VH genes belonging to ... This marker can be used to examine for any tumor-derived immunoglobulin gene fragments amplified by PCR performed on genomic ...http://www.asmscience.org/content/book/10.1128/9781555815905.ch07
Analysis of the Immunoglobulin Light Chain Genes in Zebra Finch: Evolutionary Implications
... conserved RSS in the 4.5 kb region between the functional variable and constant region genes because the joining region gene is ... Keywords: immunoglobulin genes, cladistic molecular markers, antibody diversity, gene conversion, comparative genomics, ... the RSS sequences flanking the single functional variable region gene and the joining region gene are interrupted by a 23-bp ... Das S. Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2877555/
ImmunExplorer (IMEX): a software framework for diversity and clonality analyses of immunoglobulins and T cell receptors on the...
... or antibodies and T cell receptors (TR)) forms the basis for detailed analyses of the human adaptive immune system. For ... J rearranged regions, diversity analysis, primer efficiency, and various different visualization experiments. Using IMEX, ... IGH and TRB V domains are encoded by three different gene segments: variable (V), diversity (D) and joining (j); IGK, IGL and ... or generating lineage trees from immunoglobulin variable region gene sequences (e.g., IgTree). All those tools are based on ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0687-9
Antibody - Wikipedia
... to the desired constant region (γ, α or ε). This process results in an immunoglobulin gene that encodes an antibody of a ... These gene segments are then joined together using random genetic recombination to produce the paratope. The regions where the ... the Fab region of the antibody determines antigen specificity while the Fc region of the antibody determines the antibody's ... enables computational modeling of antibody variable regions. Rosetta Antibody is a novel antibody FV region structure ...https://en.wikipedia.org/wiki/Antibody
Indian Patents. 245386:'A DEIMMUNIZED MONOCLONAL ANTIBODY'
... made by taking the variable region genes for murine mAb B4 and joining them to the human immunoglobulin constant region genes, ... The antibody constant regions of the murine antibody are replaced by the human antibody constant regions in the final ... Construction of chlmeric B4 antibody genes and their expression by NSO cells. 1. Construction of chimeric antibody genes. [0070 ... Leder, P. Cloned human and mouse kappa immunoglobulin. constant and J region genes conserve homology in. functional segments. ...http://www.allindianpatents.com/patents/245386-a-deimmunized-monoclonal-antibody
US20030153504A1 - IL-16 antagonist peptides and DNA encoding the peptides - Google Patents
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of ... joined to constant regions of a human immunoglobulin. Chimeric antibodies and methods for their production are known in the art ... to produce murine-human chimeric immunoglobulin-encoding genes. Humanized antibodies can be made using a second approach, i.e ... A61K39/00-Medicinal preparations containing antigens or antibodies * A61K39/395-Antibodies; Immunoglobulins; Immune serum, e.g ...https://patents.google.com/patent/US20030153504A1/en
Antibodies against human CSF-1R - HOFFMANN-LA ROCHE INC.
CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. ... The present invention relates to antibodies against human CSF-1R ( ... Deletion of the Immunoglobulin Heavy-Chain Joining Region Blocks B-cell Development and Antibody Production" P Natl Acad Sci ... human chimeric antibodies are the product of expressed immunoglobulin genes comprising DNA segments encoding rat immunoglobulin ...http://www.freepatentsonline.com/9169323.html
Immunoglobulin heavy constant alpha 1 - Wikipedia
... and showed the genes were contained in three exons, each of which encodes a single region of the protein domain. The genes ... It encodes a constant (C) segment of Immunoglobulin A heavy chain. Immunoglobulin A is an antibody that plays a critical role ... a typical tertiary structure of the immunoglobulin fold class. The two beta sheets that comprise each beta-sandwich are joined ... 1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671-9. doi: ...https://en.wikipedia.org/wiki/Immunoglobulin_heavy_constant_alpha_1
DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch...
The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev. 18:1-11. [PubMed] ... region (Sμ) and one of the downstream S regions, and occurs by an end-joining type of recombination (1-3). Mammalian S regions ... The complete murine immunoglobulin class switch region of the α heavy chain gene-hierarchic repetitive structure and ... Nucleotide sequence and properties of the murine γ3 immunoglobulin heavy chain gene switch region: implications for successive ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2118644/?lang=en-ca
Immunoglobulins (IG) Gene Family | HUGO Gene Nomenclature Committee
Immunoglobulins: Immunoglobulins (IG) or antibodies are antigen receptors of the B cells of the adaptive immune response, ... There are four IG gene types, variable (V), diversity (D) (only for IGH), joining (J) and constant (C) genes which contribute ... or constant region, is encoded by a C gene. The combinatorial and junctional diversity together with IG somatic hypermutations ... IG are made of two identical heavy (H) chains and two identical light (kappa or lambda) chains, encoded by genes located in ...https://www.genenames.org/cgi-bin/genefamilies/set/348
Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires | Biology Direct |...
... and less frequently in the framework regions, of VH, Vκ, and Vλ gene segments, and involved motifs known to be preferred ... contributes to the affinity maturation of antibodies. We used repertoire cloning to examine human antibodies directed against 3 ... Clonal lineage analysis shows that these events occur through out the course of the somatic maturation of individual antibody ... Codon insertions and deletions were observed most often in the complementarity determining regions, ...https://0-biologydirect-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1745-6150-1-24
IGK@ - Wikipedia
... or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. ... is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies ( ... The immunoglobulin kappa locus contains the following genes: IGKC: immunoglobulin kappa constant IGKJ@: immunoglobulin kappa ... These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins. ...https://en.wikipedia.org/wiki/IGK@
The Use of Targeted Mutations in ES Cells to Create Novel Immunodeficient Mouse Models | Springer for Research & Development
Alt FW, Baltimore D (1982) Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of ... α chain genes (Davis and Bjorkman 1988; Malissen et al. 1992). Both Ig and TCR variable region genes are assembled by a common ... Alt FW, Blackwell TK, Yancopoulos GD (1987) Development of primary antibody repertoire. Science 238: 1079-1087PubMedCrossRef ... this process allows the initially expressed μ constant region gene to be replaced by a different downstream CH gene, while ...https://rd.springer.com/chapter/10.1007/978-3-642-78438-5_6
Genetic controller prepares immune system for diverse threats
The immunoglobulin gene locus has always served as a pioneering place to look at gene regulation because it s so complex and ... Alt suspects the region contains other regulatory elements, as well. There are many questions left to answer about how antibody ... and Joining (J). Hundreds of versions of the genes that encode these three segments are scattered throughout the genome, ... And now the immunoglobulin genes are providing us with a system to define how gene expression can be regulated over long ...https://medicalxpress.com/news/2011-09-genetic-immune-diverse-threats.html
Human genetics | biology | Britannica.com
... has illuminated the mechanisms by which a limited number of immunoglobulin genes can encode this vast number of antibodies. ... The mouse has more than 200 light-chain variable region genes, only one of which will be incorporated into the proximal ... Join Britannica's Publishing Partner Program and our community of experts to gain a global audience for your work! ... Recombinant DNA studies of immunoglobulin genes in mice have revealed that the light-chain genes are encoded in four separate ...https://www.britannica.com/science/human-genetics
IGHM Gene - GeneCards | IGHM Protein | IGHM Antibody
Immunoglobulin Heavy Constant Mu, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are ... No data available for DME Specific Peptides for IGHM Gene Domains & Families for IGHM Gene Gene Families for IGHM Gene. HGNC:. ... Summaries for IGHM Gene Entrez Gene Summary for IGHM Gene. * Immunoglobulins (Ig) are the antigen recognition molecules of B ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=IGHM