MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome | Annals of...
Membrane staining was performed with fluorescently labelled antibodies: anti-CD14 (APC/Cy7; BD Biosciences, California, USA), ... patients stratified in interferon (IFN) type I signature negative (IFNneg) (n=14) and IFN type I signature positive (IFNpos) (n ... Systemic increase in type I interferon activity in Sjogren's syndrome: a putative role for plasmacytoid dendritic cells. Eur J ... Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 2005;23:307-36. ...http://ard.bmj.com/content/early/2013/07/05/annrheumdis-2012-202552
OP0238 Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in...
OP0238 Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in ... OP0238 Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in ... Background MEDI-546 is an investigational human IgG1κ monoclonal antibody directed against subunit 1 of the type I interferon ... The proteomics study identified 8 proteins with decreased serum levels at day 56 among which 6 are type I IFN-inducible and 4 ( ...http://ard.bmj.com/content/73/Suppl_2/152.2
Interferon alpha WB Antibody | ProSpec
IFN-a WB Antibody- By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti- ... Type. Mouse Anti Human Monoclonal.. Introduction. IFN-alpha is produced by macrophages, IFN-alpha has antiviral activities and ... The antibody was can be used for Capture ELISA together with clone ProSpec's Mouse Anti Human IFN-A Neutralizing antibody. ... Antibody is shipped lyophilized at ambient temperature.. Storage Procedures. In lyophilized form, for long periods, store at ...https://www.prospecbio.com/Interferon-alpha_WB_Antibody
Anti-Interferon gamma antibody (ab9918) | Abcam
Rabbit polyclonal Interferon gamma antibody validated for WB, ELISA, Neut, sELISA and tested in Mouse. Referenced in 1 ... By product type. Primary antibodies. Secondary antibodies. ELISA, Matched Antibody Pairs and Multiplex Immunoassays. Cell and ... Custom antibody development. We offer world-leading antibody development platforms based on a proprietary RabMAb® rabbit ... This antigen affinity purified antibody, in conjunction with recommended pair as a detection antibody, allows the detection of ...http://www.abcam.com/interferon-gamma-antibody-ab9918.html
Cytokines as Drug Targets : Defence & Security : All
12:00 ANTIBODIES TO THE TYPE-1 INTERFERON. Dr Christopher Bebbington, Senior Director, Biology Research, Coulter Pharmaceutical ... Developing an antibody-based approach to target the receptor for type 1 interferons for treatment of autoimmune disorders and ... 10:20 DEVELOPING A LOW DOSAGE THERAPEUTIC INTERFERON. Dr Philip C Fox, Director, Research & Development, Amarillo Biosciences. ... Generating human antibodies using transgenic mouse technology *Developing ABX-IL8 using XenoMouse™ technology *ABX-IL8: moving ...http://www.smi-online.co.uk/defence/archive/1-2001/conference/cytokines-as-drug-targets
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The exact profile of type I interferon antibodies may indicate MG subtype and may hint at thymoma recurrence. ... In acute stroke, serum HSP-27 antibodies are elevated irrespective of stroke type and duration. In epilepsy, HSP-27 is induced ... Radioligand-binding assay reveals distinct autoantibody preferences for type I interferons in APS I and myasthenia gravis ... GBS patients had higher antibody levels than all other groups. No difference in antibody levels was found when comparing OMG ...https://www.jove.com/visualize?author=Nils+E+Gilhus
Interferon alpha-2 Antibody (Monoclonal, 17G6)
This antibody reacts with Human samples. Clone: 17G6. Supplied as 100 µL purified antibody (1 mg/ml) in HEPES with 0.15M NaCl, ... Interferon alpha-2 Monoclonal Antibody from Invitrogen for Western Blot and Immunoprecipitation applications. ... type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway negative regulation of T-helper ... interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha-2; Interferon alpha-A; interferon, alpha 2; LeIF ...https://www.thermofisher.com/antibody/product/Interferon-alpha-2-Antibody-17G6-Monoclonal/MA5-17263
JCI - Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector. Mol Ther. 2007;15(2):393-403.. View ... Functional role of type I and type II interferons in antiviral defense. Science. 1994;264(5167):1918-1921.. View this article ... Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Immunity. 2014;40(6):949-960.. View this article ... IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. ...https://www.jci.org/articles/view/78280
MATRIX: Measuring Neutralizing Antibodies in the Patients Treated With Interferon Beta 1a IM, in Mexico and Colombia - Full...
Study Type:. Interventional Study Design:. Allocation: Non-Randomized. Primary Purpose: Treatment. Official Title:. Measuring ... Antibodies. Interferon-beta. Interferon beta-1a. Antibodies, Blocking. Interferons. Immunologic Factors. Physiological Effects ... MATRIX: Measuring Neutralizing Antibodies in the Patients Treated With Interferon Beta 1a IM, in Mexico and Colombia (MATRIX). ... Neutralizing antibodies to Interferon beta 1a IM (Avonex) or IFN beta 1a IM biosimilar [ Time Frame: Day 1 ]. *Percentage of ...https://clinicaltrials.gov/ct2/show/NCT01556685
US5055289A - Interferon antibody therapeutic compositions having an extended serum half-life - Google Patents
The serum half-life of the interferon administered as the complex is substantially increased when compared to that of alpha- ... A complex of alpha-interferon with a monoclonal antibody complexes with the alpha-interferon without impairing its antiviral ... Antibody Drug US20090155286A1 (en) * 2004-10-07. 2009-06-18. Michel Gilliet. Type I interferon blocking agents for prevention ... Approximately 40 anti-alpha interferon monoclonal antibodies were employed to make interferon:antibody immune complexes which ...https://patents.google.com/patent/US5055289?oq=flatulence
Anti-Interferon regulatory factor 9 antibody (ab51639)
Rabbit polyclonal Interferon regulatory factor 9 antibody validated for WB, IHC, ICC/IF and tested in Human. Referenced in 1 ... By product type. Primary antibodies. Secondary antibodies. ELISA, Matched Antibody Pairs and Multiplex Immunoassays. Cell and ... Anti-Interferon regulatory factor 9 antibody. See all Interferon regulatory factor 9 primary antibodies. ... Anti-Interferon regulatory factor 9 antibody images. * Western blot - TF IRF9 antibody (ab51639) ...http://www.abcam.com/interferon-regulatory-factor-9-antibody-ab51639.html
Methods of Cancer Treatment | Breast Health 101 | Imaginis - The Women's Health & Wellness Resource Network
Monoclonal antibodies, interferon, interleukin-2 (IL-2) and several types of colony-stimulating factors (CSF, GM-CSF, G0CSF) ... For some types of cancer, doctors are studying whether it is beneficial to deliver the anticancer drugs directly to the ... In some cases, two or mores type of treatment will be used together to battle the cancer. Doctors who specialize in cancer ... Hormone Therapy: Some types of cancer, including most breast and prostate cancers, depend upon hormones to grow. For this ...http://www.imaginis.com/breast-health-101-cancer/methods-of-cancer-treatment-1
Esophageal Cancer Market is expected to grow with CAGR of 8.7 % and will lead to market size of US $1000.1 million by 2023 -...
Based on the type, the market has been segmented as monoclonal antibodies, interferons, interleukins, cancer growth inhibitors ... The two main sub-types of esophageal cancer are esophageal squamous-cell carcinoma which arises from the epithelial cells and ... 5 Global Esophageal Cancer Market, By Type. Continue………….. Related Report Global Liquid chromatography Instruments Market ... Information by Type (High pressure liquid chromatography, Liquid-solid chromatography, Chiral chromatography), by End User ( ...https://www.openpr.com/news/667937/Esophageal-Cancer-Market-is-expected-to-grow-with-CAGR-of-8-7-and-will-lead-to-market-size-of-US-1000-1-million-by-2023.html
Anti-Interferon regulatory factor 9 antibody [EPR3939] (ab109309)
Rabbit recombinant monoclonal Interferon regulatory factor 9 antibody [EPR3939] validated for WB, ICC, Flow Cyt and tested in ... By product type. Primary antibodies. Secondary antibodies. ELISA, Matched Antibody Pairs and Multiplex Immunoassays. Cell and ... Anti-Interferon regulatory factor 9 antibody [EPR3939]. See all Interferon regulatory factor 9 primary antibodies. ... Anti-Interferon regulatory factor 9 antibody [EPR3939] (Alexa Fluor® 488) (ab203318) *Anti-Interferon regulatory factor 9 ...http://www.abcam.com/interferon-regulatory-factor-9-antibody-epr3939-ab109309.html
New therapeutic target against persistent viral infections | EurekAlert! Science News
Type I interferons (IFN-I) are cytokines that were previously thought of as key contributors to the antiviral response, but ... 2016) Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection. Frontiers in ... Multiple type I interferon signalling pathways. IFN-I is synthesized by a large number of cells and triggers diverse responses ... Type I interferons (IFN-I) are cytokines that were previously thought of as key contributors to the antiviral response, but ...https://www.eurekalert.org/pub_releases/2017-01/indl-ntt011117.php
The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity | Cancer Research
Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors. J Exp Med 1983;158:2095-107. ... Functional role of type I and type II interferons in antiviral defense. Science 1994;264:1918-21. ... Enhanced tumor development in mice lacking a functional type I interferon receptor. J Interferon Cytokine Res 2002;22:457-62. ... Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 2006;25:361-72. ...http://cancerres.aacrjournals.org/content/71/7/2488
Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with...
Item Type:. Journal Article, refereed, original work. Communities & Collections:. 04 Faculty of Medicine , Epidemiology, ... Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with ... and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with interferon ... Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha ...http://www.zora.uzh.ch/id/eprint/111227/
Antibody Production Market worth $2.572 Billion by 2019: MarketsandMarkets
Protein Type (Monoclonal Antibodies, Interferon, Growth Hormone), End User (Academics Institutes, CROs) - Global Forecast to ... On the basis of types, this market is segmented into monoclonal and polyclonal antibodies. In 2014, the monoclonal antibodies ... The global antibody production market is segmented on the basis of products, types, technologies, end users, and regions. ... Browse 95 market data tables and 43 figures spread through 182 pages and in-depth TOC on "Antibody Production Market" ...https://pitchengine.com/pitches/f54b2526-00a7-41c2-ab22-a8c63bdb691b
Interferon alpha-inducible protein elisa and antibody
Recombinant Protein and Interferon alpha-inducible protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Wingless-Type Mmtv Integration Site Family, Member 9B (WNT9B... ELISA Kit. • infectious coryza (ic) ELISA Kit. more .... ... Custom Antibody. Antibody Matched Pairs. Antibody Peptide Pairs. Phospho Antibodies. Products by Disease. Products by Pathway. ... Interferon alpha-inducible protein 6 Recombinant. Interferon alpha-inducible protein 6 Antibody. Also known as Interferon alpha ...https://www.mybiosource.com/protein_family.php?root=interferon-alpha-inducible-protein
Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl...
1984) Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus ... 1998) Type I interferon-mediated stimulation of T cells by CpG DNA. J. Exp. Med. 188:2335-2342, pmid:9858519. ... 1999) Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4+ T cells from virus-induced ... 1999) Type I interferons keep activated T cells alive. J. Exp. Med. 189:521-530, pmid:9927514. ...http://jem.rupress.org/content/191/10/1777
The American Journal of Tropical Medicine and Hygiene | African and Asian Zika Virus Isolates Display Phenotypic Differences...
Last, the African isolate was , 10,000-fold more virulent than the Asian isolates in an interferon type I antibody blockade ... Last, the African isolate was , 10,000-fold more virulent than the Asian isolates in an interferon type I antibody blockade ...http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0685
Vetter Pharma International - Pharma Business review
... interferons and vaccines. Types of stopper, types of glass, and degree of siliconisation can all potentially interact with a ... Monoclonal antibodies, peptides, interferons and vaccines. Biotechnology drugs, in particular, are highly sensitive complex ... Vetter has extensive experience working with biotech substances, including monoclonal antibodies, peptides, ...https://www.pharmaceutical-business-review.com/suppliers/vetter_pharma_international
Patent US8137672 - Immunostimulatory regimen comprising administering type 1 interferon and ... - Google Patents
In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided ... A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least ... wherein the CD40 agonistic antibody or antibody fragment, the type 1 interferon and the viral antigen are comprised in the same ... wherein said type 1 interferon is selected from alpha interferon, beta interferon, omega interferon, tau interferon, zeta ...http://www.google.com.au/patents/US8137672
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
MEDI-545, an anti-interferon alpha monoclonal antibody, shows evidence of clinical activity in systemic lupus erythematosus. ... A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE. Johanna K Sandling,1 ... The type I IFN system is activated in SLE patients,5, 6 and an important role of the type I IFN system in the disease process ... Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3060320/
Scleroderma - Wikipedia
Anti-topoisomerase 1 antibodies, in turn, stimulate type I interferon production. Fibroblasts are recruited and activated by ... Mycosis fungoides, a type of cutaneous T cell lymphoma, a rare cancer that causes rashes all over the body. Nephrogenic ... Choctaw Native Americans are more likely than Americans of European descent to develop the type of scleroderma that affects ... Laboratory testing can show antitopoisomerase antibodies, like anti-scl70 (causing a diffuse systemic form), or anticentromere ...https://en.wikipedia.org/wiki/Scleroderma