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*  Neuromuscular junction - Wikipedia
... in the case of neuromuscular diseases, tend to be humoral mediated, B cell mediated, and result in an antibody improperly ... Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy ... crayfish and fruit flies have a glutamatergic neuromuscular junction. AChRs at the skeletal neuromuscular junction form ... Finsterer J, Papić L, Auer-Grumbach M (October 2011). "Motor neuron, nerve, and neuromuscular junction disease". Curr. Opin. ...
  https://en.wikipedia.org/wiki/Neuromuscular_junction
*  Neuromuscular junction disease - Wikipedia
In each of these diseases, a receptor or other protein essential to normal function of the junction is targeted by antibodies ... Neuromuscular junction diseases can also be referred to as end plate diseases or disorders. Among neuromuscular diseases some ... Neuromuscular junction disease is a medical condition where the normal conduction through the neuromuscular junction fails to ... Immune-mediated diseases include a variety of diseases not only affecting the neuromuscular junction. Immune-mediated disorders ...
  https://en.wikipedia.org/wiki/Neuromuscular_junction_disease
*  Chiropractic Care of a Pediatric Patient with Myasthenia Gravis
Myasthenia gravis is a disease of the neuromuscular junction. Specifically, an autoimmune response occurs, wherein antibodies ... reduction of receptor antibodies, prevention of its binding at the neuromuscular junction, or the stimulation of T suppressor ... 19] In congenital MG, various components of the neuromuscular junction are dysfunctional as a result of a heterogeneous group ... Myasthenia gravis can also be associated with other autoimmune diseases (eg, Hashimoto disease). [31, 32]. Medical intervention ...
  http://www.chiro.org/cases/ABSTRACTS/Patient_with_Myasthenia_Gravis.shtml
*  Epiomic Epidemiology Series: Myasthemia Gravis Forecast in 26 Major Markets 2017-2027
... is one of the most significant diseases affecting the neuromuscular junction. The disorder is caused by auto-antibodies that ... Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and ... Crohn's disease. • Other forms of AI. This report is built using data and information sourced from the proprietary Epiomic ... These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.. MG ...
  https://finance.yahoo.com/news/epiomic-epidemiology-series-myasthemia-gravis-213500976.html
*  Juvenile Myasthenia Gravis: A Paediatric Perspective
As a multidisciplinary journal, basic science aimed at understanding the biology and mechanism of disease will be considered, ... as well as articles focusing on medical treatment of autoimmune diseases. ... Autoimmune Diseases is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and ... A. Vincent and M. I. Leite, "Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for ...
  https://www.hindawi.com/journals/ad/2011/404101/ref/
*  Ophthalmologic Manifestations of Myasthenia Gravis: Overview, Patient History, Physical Examination
... a disorder of neuromuscular transmission characterized by weakness and fatigability of skeletal muscles. The basic pathology of ... Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction in which circulating antibodies cause fluctuant ... Acetylcholine receptor antibody blood testing. Acetylcholine receptor antibody blood testing is specific but not sensitive for ... at the postsynaptic muscle membrane due to circulating anti-AChR antibodies [2] or, less commonly, to antibodies to muscle- ...
  https://emedicine.medscape.com/article/1216417-overview
*  Myasténia gravis. Myasthenia gravis MINIMONOGRAFIA - PDF
Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis. Curr Opin ... associated autoimmune diseases and antibodies against antogens at neuromuscular junction. Eur J Neurol 2006; 13 (Suppl.): ... Abstract Myasthenia gravis (MG) is defined as a disorder of the neuromuscular junction with fluctuating weakness of voluntary ... 2006; 183 (Suppl.): Newsom-Davis J. The emerging diversity of neuromuscular junction disorders. Acta Myol 2007; 16: Špalek P, ...
  http://docplayer.net/56062-Myastenia-gravis-myasthenia-gravis-minimonografia.html
*  eDucate | Myasthenia gravis
Vincent A, Leite MI Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia ... A neuromuscular disorder arising from autoimmune mediated injury of the post-synaptic neuromuscular junction and characterized ... Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction. Autoimmunity. 2010:5-6:353-70 ... of Pediatrics (Neuromuscular & Neurometabolic Disease), Hamilton Health Sciences-McMaster Children's Hospital, McMaster ...
  http://www.educatehealth.ca/pharmacist/neurology/neuromuscular/myasthenia-gravis.aspx
*  Ocular myasthenia - Wikipedia
Ocular myasthenia gravis (MG) is a disease of the neuromuscular junction resulting in hallmark variability in muscle weakness ... MG is an autoimmune disease where anomalous antibodies are produced against the naturally occurring acetylcholine receptors in ... At the neuromuscular junction, this electrical message is converted into a chemical message as acetylcholine is released from ... but has been shown to be helpful in young MG patients with acute disease within 3 years of disease onset, in patients with ...
  https://en.wikipedia.org/wiki/Ocular_myasthenia
*  Myasthenia - definition of myasthenia by The Free Dictionary
disease of the neuromuscular junction - a disease characterized by impairment of neuromuscular junctions ... The most common of such conditions is myasthenia gravis (MG), an autoimmune disorder in which an antibody-mediated, T-cell- ... Myasthenia gravis (MG) is a disease affecting the acetylcholine receptor in the neuromuscular junction.. Nonintubated video- ... autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune ...
  https://www.thefreedictionary.com/myasthenia
*  Myasthenia gravis: a clinical-immunological update. - Nuffield Department of Clinical Neurosciences
In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine kinase while the remainder of seronegative ... In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. ... is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. ... Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most ...
  https://www.ndcn.ox.ac.uk/publications/586481
*  Nervous system disease - Localization of neurological disease | Britannica.com
Localization of neurological disease: The nature and pattern of the symptoms and physical signs of neurological disease allow ... One symptom indicating muscular disease is weakness, usually symmetrical (that is, affecting both sides of the body) and mainly ... Disease of the neuromuscular junction. Myasthenia gravis is the most common disease of the neuromuscular junction. At this site ... In myasthenia gravis, receptors in the end-plate region are partially coated with an antibody, so that the acetylcholine ...
  https://www.britannica.com/science/human-nervous-system-disease/Localization-of-neurological-disease
*  A Pilot Trial To Assess The Feasibility And Efficacy Of SCIG In Patients With MG Exacerbation (SCIG-MG) - Full Text View -...
Neuromuscular Junction Diseases. Neuromuscular Diseases. Myasthenia Gravis. Autoimmune Diseases of the Nervous System. Nervous ... Autoimmune Diseases. Immune System Diseases. Immunoglobulins. Antibodies. Immunoglobulin G. Immunologic Factors. Physiological ... MG diagnosis will be based upon the clinical evaluation by a neuromuscular expert and meeting any two of the following ... Myasthenia Gravis (MG) Composite scores will be used to evaluate disease severity through a number of functional assessments, ...
  https://clinicaltrials.gov/ct2/show/study/NCT02774239?term=canada+and+neuromuscular&recr=Open&cntry1=NA%3ACA&rank=28
*  Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction with antibodies (abs) targeting the acetylcholine ... As MG course may be remarkably variable, we evaluated the possible use of FLCs as biomarkers of disease activity. Subjects and ... Further investigations are necessary to exploit their potential as reliable biomarkers of disease activity. ... in comparison with 20 sera from patients with systemic autoimmune rheumatic diseases and 18 from healthy blood donors, along ...
  https://www.hindawi.com/journals/jir/2018/9646209/abs/
*  Chapter 386. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction | Harrison's Principles of Internal Medicine,...
The anti-AChR antibodies reduce the number of available AChRs at neuromuscular junctions by three distinct mechanisms: (1) ... Myasthenia Gravis and Other Diseases of the Neuromuscular Junction." Harrison's Principles of Internal Medicine, 18e Longo DL, ... Myasthenia Gravis and Other Diseases of the Neuromuscular Junction. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, ... acetylcholine receptors (AChRs) at neuromuscular junctions due to an antibody-mediated autoimmune attack. Treatment now ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727203
*  Study to Evaluate Amifampridine Phosphate in Patients With MuSK-MG - Full Text View - ClinicalTrials.gov
Neuromuscular Junction Diseases. Neuromuscular Diseases. Autoimmune Diseases. Immune System Diseases. Antibodies. 3,4- ... Positive serologic test for anti-MuSK antibodies or anti-AChR antibodies as confirmed at Screening or by previous antibody test ... Autoimmune Diseases of the Nervous System. Nervous System Diseases. ... Condition or disease Intervention/treatment Phase Myasthenia Gravis, Generalized Drug: Amifampridine Phosphate Drug: Placebo ...
  https://clinicaltrials.gov/ct2/show/NCT03304054
*  What are peripheral nerves? - Neuromuscular Diseases
While the various neuromuscular diseases differ in their cause and symptoms, each in some way affects the muscles and the ... What are peripheral nerves? - Neuromuscular Diseases at BellaOnline ... Having a basic understanding of the nerve cells of the peripheral nervous system can improve understanding of neuromuscular ... In MG, the problem occurs at the neuromuscular junction. Antibodies block the receptors for the neurotransmitter acetylcholine ...
  http://www.bellaonline.com/articles/art174964.asp
*  Anaesthetic Considerations in Paediatric Myasthenia Gravis
As a multidisciplinary journal, basic science aimed at understanding the biology and mechanism of disease will be considered, ... as well as articles focusing on medical treatment of autoimmune diseases. ... Autoimmune Diseases is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and ... N. P. Hirsch, "Neuromuscular junction in health and disease," British Journal of Anaesthesia, vol. 99, no. 1, pp. 132-138, 2007 ...
  https://www.hindawi.com/journals/ad/2011/250561/
*  Myasthenia and Antisynthetase Antibody Syndrome: A Case Report in Togo - Myasthenia and Antisynthetase Antibody Syndrome: A...
We underlined the main difficulties of diagnostic and the management of Myasthenie and antisynthetase antibody syndrome in a 44 ... Myasthenia gravis is an autoimmune disease of the neuromuscular junction 1. It is a rare condition, with an estimated ... Depending on the antibody present, the clinical expression of the disease is different 6. Our patient was positive for PL7 ... Among rare neuromuscular junction conditions, autoimmune myasthenia gravis remains the most common cause. Its prevalence is ...
  https://oap-journals.com/jnrt/article/587
*  Clinical Medical Reviews and Case Reports Archives | Clinmed International Library
... is a neuromuscular junction disease, for which the most specific test is an increase in anti-acetylcholine receptor antibodies ... Abstract: A 55-year-old man with a two-year history of peripheral arterial disease (PAD) was urgently referred to rheumatology ... Giant Cell Arteritis of the Lower Limb Presenting as Peripheral Arterial Disease and Mantle Cell Lymphoma Two Years Later. ... He was scheduled for a balloon-angioplasty due to bilateral aortoiliac and femoro-popliteal disease and occlusion of the iliac ...
  https://clinmedjournals.org/archives_search.php?jid=cmrcr&volume=2&issue=6
*  Neuromuscular junction disease | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors |...
In each of these diseases, a receptor or other protein essential to normal function of the junction is targeted by antibodies ... Neuromuscular junction diseases. The neuromuscular junction is a specialized synapse between a neuron and the muscle it ... Neuromuscular junction disease is a medical condition where the normal conduction through the neuromuscular junction fails to ... Immune-mediated diseases include a variety of diseases not only affecting the neuromuscular junction. Immune-mediated disorders ...
  http://research.omicsgroup.org/index.php/Neuromuscular_junction_disease
*  New Light Shed On Muscle-weakening Disease Myasthenia Gravis By Researchers
Researchers report that an antibody to a protein critical to enabling the brain to talk to muscles has been identified as a ... they experienced classic symptoms of the disease along with clear evidence of degradation of the neuromuscular junction. LRP4 ... The finding that an antibody to LRP4 is a cause of the most common disease affecting brain-muscle interaction helps explain why ... The finding also shows that LRP4 is important, not only to the formation of the neuromuscular junction - where the brain and ...
  https://www.medindia.net/news/new-light-shed-on-muscle-weakening-disease-myasthenia-gravis-by-researchers-127825-1.htm
*  New cause found for muscle-weakening disease myasthe... ( Augusta Ga. An antibody to a prote...)
The finding also shows that LRP4 is important not only to the formati...,New,cause,found,for,muscle-weakening,disease, ... The finding that an antibody to LRP4 is a cause of the most common dis... You end up with patients who have no real diagnosis ... An antibody to a protein critical to enabling the brain ... ... not only to the formation of the neuromuscular junction where ... they experienced classic symptoms of the disease along with clear evidence of degradation of the neuromuscular junction. ...
  http://www.bio-medicine.org/biology-news-1/New-cause-found-for-muscle-weakening-disease-myasthenia-gravis-32419-1/
*  Plenary Sessions
Her research interests include models of neuromuscular junction and autoimmune CNS diseases, and the influence of maternal ... Her clinical interests are in the role of auto-antibodies to ion channels and receptors in peripheral and CNS disorders, and in ... He was a founder of the EU FP6 funded network of excellence for genetic neuromuscular diseases, TREAT-NMD, which he coordinated ... Professor Reilly is a co-director of both the UCL MRC Centre for Neuromuscular Diseases and the NIH Inherited Neuropathy ...
  http://www.icnmd2018.org/scientific-program/plenary-sessions/
*  Publikacje...
... and may play a role in neurodegeneration-induced glial plasticity at the neuromuscular junction. Neurobiology of Disease, 34: ... Popov B., Kaczmarek L., Antibody raised to the short sequence from the zinc-finger domain of the Egr-1 recognizes 102 kD ... Neurobiology of Disease, 45: 701-710, 2012. 2011. 200. Radwanska K. , Medvedev N.I., Pereira G.S., Engmann O., Thiede N., ... Neurobiology of Disease, 19: 283-292, 2005.. 115. Filipkowski R.K., Kiryk A., Kowalczyk A., Kaczmarek L. Genetic models to ...
  https://neurogene.nencki.gov.pl/?page_id=59