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*  Neutralizing antibody - Wikipedia
An example of a neutralizing antibody is diphtheria antitoxin, which can neutralize the biological effects of diphtheria toxin ... The difference between neutralizing antibodies and binding antibodies is that neutralizing antibodies neutralize the biological ... A neutralizing antibody (NAb) is an antibody that defends a cell from an antigen or infectious body by neutralizing any effect ... while single cell antibody cloning made it possible to produce large quantities of the antibodies for study. Low levels of ...
  https://en.wikipedia.org/wiki/Neutralizing_antibody
*  Jim (horse) - Wikipedia
... antibodies against diphtheria toxin). Jim produced over 30 quarts (7.5 US gallons) of diphtheria antitoxin in his career. ... "Jim" was the name of a former milk wagon horse, who was used to produce serum containing diphtheria antitoxin ( ... These failures in oversight led to the distribution of antitoxin that caused the death of 12 more children. This incident, and ...
  https://en.wikipedia.org/wiki/Jim_(horse)
*  Diphtheria antitoxin - Wikipedia
Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer ... Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by ... Diphtheria antitoxin was developed and came into medical use in the late 1800s. It is on the World Health Organization's List ... containing antibodies obtained from the blood of horses that have been immunized against diphtheria toxin. "Our Formulary , ...
  https://en.wikipedia.org/wiki/Diphtheria_antitoxin
*  Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants.
However, it is less certain whether the detection of antibodies in cerebrospinal fluid (c.s.f.) of infant ... The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several ... 0/Diphtheria Antitoxin; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Tetanus Antitoxin From MEDLINE®/PubMed®, a database of the U.S ... Diphtheria / immunology. Diphtheria Antitoxin / isolation & purification*. Female. Hemagglutination Tests. Humans. Immunity, ...
  http://www.biomedsearch.com/nih/Passive-transfer-antibodies-maternal-origin/47079.html
*  Side-chain theory - Wikipedia
He worked on antitoxins for diphtheria and their binding to antibodies in the blood. He hypothesised that antibodies bind to ... Antibody specificity exists for specific interaction with a given antigen. Antigen-antibody interaction occurs by precise ... The theory explains the interaction of antibodies and antigens in the blood, and how antibodies are produced. In 1891, Paul ... which would then be liberated into the blood stream as antibodies. According to Ehrlich, an antibody could be considered an ...
  https://en.wikipedia.org/wiki/Side-chain_theory
*  Health bulletin :: State Publications
This is diphtheria antitoxin. When a child has diphtheria this antitoxin, contain-ing the antibodies produced against the toxin ... A PASSIVE immunity may be ac-quired by borrowing some one else's antibodies. Diphtheria antitoxin is an example of this. If a ... If it is diphtheria it should have diph-theria antitoxin as soon as possible. Defects of the eyes, ears, nose or throat in ... If it is diphtheria it should have diph-theria antitoxin as soon as possible. Defects of the eyes, ears, nose or throat in ...
  http://digital.ncdcr.gov/cdm/compoundobject/collection/p249901coll22/id/257366/show/285767/rec/16
*  Environmental Health Perspectives - Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed...
Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors ... The observed antibody responses to diphtheria and tetanus toxoids in the two studies may therefore not be fully comparable. ... 1988), whereas antibodies against diphtheria toxoids were measured using a standard Vero cell-based neutralization assay ... 2006). At the 18-month examination of a subgroup of the cohort presented in this report, the diphtheria-specific antibody ...
  https://ehp.niehs.nih.gov/1001975/
*  Pertussis re-emergence in the post-vaccination era | BMC Infectious Diseases | Full Text
... that newborns born to mothers who received Tdap during pregnancy had significantly higher antibody titers to diphtheria anti-toxin ... Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum ... and for FHA at 18 months and lower geometric mean antibody concentrations for diphtheria at 7 months [51]. ... diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-13-151
*  Ion Transport and Bacterial Toxins | Annals of Internal Medicine | American College of Physicians
Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected ...
  http://annals.org/aim/article/681618/ion-transport-bacterial-toxins
*  922 - Diphtheria Antibody IgG - Viracor Eurofins
Your trusted lab partner for Diphtheria Antibody IgG testing, Viracor Eurofins delivers your results faster, when it matters ... The EIA is calibrated by reference to the WHO International Reference Diphtheria anti-toxin lot NIBSC 00/496. This test has not ... The recommended protective level of Diphtheria antitoxin IgG is greater than or equal to 0.10 IU/mL. ... such as Diphtheria, and determine vaccine-specific antibody concentrations in a serum sample 3-4 weeks post-immunization ...
  https://www.viracor-eurofins.com/test-menu/922-diphtheria-antibody-igg/
*  Alexander Glenny - Wikipedia
His scientific work focused on the mechanisms of antibody production and the prevention of diphtheria. In 1921 he and H. J. ... He worked on immunizations and antitoxins against diseases, including tetanus and diphtheria, and, later, chemical weapons. ... In 1925-6 he developed alum-precipitated diphtheria toxoid. He was elected Fellow of the Royal Society in 1944 and awarded the ... In the same paper they also briefly described the properties of diphtheria toxoid, which had been discovered by Glenny in 1904 ...
  https://en.wikipedia.org/wiki/Alexander_Glenny
*  Pharmaceutical Microbiology
An in vitro method is provided that is suitable for determining the potency of diphtheria antitoxin (antibodies against the ... If no or little diphtheria antitoxin is present, then diphtheria toxin induces cell death and the inability of cells to reduce ... The test is based on the ability of diphtheria antitoxin to neutralize the diphtheria toxin, decreasing its cytotoxic effect. ... Chapter 162 Diphtheria Antitoxin Potency Testing for Human Immune Globulins [This is a new chapter]. ...
  http://www.pharmamicroresources.com/2016_06_01_archive.html
*  Development of Jehovah's Witnesses doctrine - Wikipedia
Q: Are we to consider the injection of serums such as diphtheria toxin antitoxin and blood fractions such as gamma globulin ... into the blood stream, for the purpose of building up resistance to disease by means of antibodies, the same as the drinking of ...
  https://en.wikipedia.org/wiki/Development_of_Jehovah's_Witnesses_doctrine
*  Humoral immunity - Wikipedia
Ehrlich, with his friend Emil von Behring, went on to develop the diphtheria antitoxin, which became the first major success of ... Antibodies are synthesized and secreted by plasma cells that are derived from the B cells of the immune system. An antibody is ... Each antibody recognizes a specific antigen unique to its target. By binding their specific antigens, antibodies can cause ... Its aspects involving antibodies are often called antibody-mediated immunity. The study of the molecular and cellular ...
  https://en.wikipedia.org/wiki/Humoral_immunity
*  Magic bullet (medicine) - Wikipedia
Behring had been investigating antibacterial agents and discovered a diphtheria antitoxin. (For that discovery, Bering was the ... He speculated that these antibodies act as bullets fired from a gun to target specific microbes. But after further research, he ... Ehrlich was also nominated for that year.) From Behring's work, Ehrlich understood that antibodies produced in the blood could ... But Ehrlich's rationale was that the chemical structure called side chain forms antibodies that bind to toxins (such as ...
  https://en.wikipedia.org/wiki/Magic_bullet_(medicine)
*  Allocation bias Archives - The James Lind Library The James Lind Library
The quantity of diphtheria antitoxin required in the treatment of diphtheria. Archives of Paediatrics 17:823-827. View. ... Type I lobar pneumonia treated with concentrated pneumococcic antibody (Felton). The clinical course. JAMA 96:1465-1469.. View ... Use of diphtheria antitoxin in the treatment and prevention of diphtheria. JAMA 34: 902-904.. View. ... Does curative diphtheria serum act specifically through its anti-toxin content or non-specifically in human diphtheria]? ...
  http://www.jameslindlibrary.org/research-topics/allocation-bias-biases/
*  Acellular pertussis vaccine for adolescents
... the antitoxin against tetanus and diphtheria between the groups that received dT or Tdap. The level of antibodies against B. ... Maternal antibodies do not appear to influence the response to the vaccine against tetanus, diphtheria and acellular pertussis ... The majority of studies mentioned up to now used the presence of anti-pertussis antibodies (anti-toxoid, filamentous anti-toxin ... Unlike other immuno-preventable diseases, such as diphtheria and tetanus, in which the antibody titers associated with ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572006000400003&lng=en&nrm=iso&tlng=en
*  Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® - Full...
Percentage of Participants With Diphtheria Antitoxin Concentrations ≥ 0.1 IU/mL Pre- and Post-Vaccination With Adacel® or ... Geometric Mean Concentration of Antibody to Pertussis Antigens Pre- and Post-Vaccination With Adacel® or Boostrix®. [ Time ... Pertussis Tetanus Diphtheria Biological: ADACEL®:Tetanus, Reduced Diphtheria and Acellular Pertussis Adsorbed Biological: ... MedlinePlus related topics: Diphtheria Tetanus Tetanus, Diphtheria, and Pertussis Vaccines Whooping Cough ...
  https://clinicaltrials.gov/ct2/show/NCT00319553
*  Blood, Vaccines and Organ Transplants | AJWRB.org
"Are we to consider the injection of serums such as diphtheria toxin antitoxin and blood fractions such as gamma globulin into ... Yes. The antibodies that make up the shot are harvested from the blood of individuals who have become immunized or sensitized ... Then comes the antitoxin for other excuses, etc., until the children are full of the most deadly poisons known. Added to this ... "Serums or antitoxins are used. These are obtained from the blood of humans or animals that have already developed the ...
  http://ajwrb.org/blood-vaccines-and-organ-transplants?replytocom=1255
*  dentalaka: Gram positive bacteria
Acquired immunity to diphtheria -neutralizing antibody (antitoxin). • Toxoid - attenuated toxin. • Trivalent vaccine containing ... Induction of circulating, cross-reactive antibodies. • Some of the antibodies produced during infection by certain strains of ... Diphtheria toxin is absorbed and disseminated through lymph and blood to the susceptible tissues of the body. ... IgG antibodies against M protein promote phagocytosis - major mechanism of AMI to terminate Group A streptococcal infections ...
  http://dentalaka.blogspot.com/2011/05/gram-positive-bacteria.html
*  Niels Kaj Jerne - Wikipedia
"A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures". From 1943 to 1956 Jerne was a ... and to other antibodies that bind to the same site. The antibodies are in balance, until an antigen disturbs the balance, ... The antibody formation theory gave Jerne international recognition and in 1956 Jerne went to work for the World Health ... Firstly, instead of the body producing antibodies in response to an antigen, Jerne postulated that the immune system already ...
  https://en.wikipedia.org/wiki/Niels_Kaj_Jerne
*  Exotoxin - Wikipedia
For this reason antitoxin, anti-serum containing antibodies, is injected to provide passive immunity. Many exotoxins have been ... These retain their antigenic specificity and can be used to produce antitoxins and, in the case of diphtheria and tetanus ... "Primary immunization with a triple diphtheria-tetanus-whole cell pertussis vaccine in Iranian infants: an analysis of antibody ... A recombinant diphtheria exotoxin has been approved by the FDA for treatment of cutaneous T-cell lymphoma, an immune system ...
  https://en.wikipedia.org/wiki/Exotoxin
*  Antitoxin - Wikipedia
The use of diphtheria antitoxin for the treatment of diphtheria was regarded by The Lancet as the "most important advance of ... An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants ... Tetanus antitoxin is the protective antibody against Clostridium tetani, the bacterium that causes tetanus. The antibody ... use human antitoxin to treat humans). Antitoxins to diphtheria and tetanus toxins were produced by Emil Adolf von Behring and ...
  https://en.wikipedia.org/wiki/Antitoxin
*  Diphtheria toxin - Wikipedia
Diphtheria toxin was discovered in 1888 by Émile Roux and Alexandre Yersin. In 1890, Emil Adolf von Behring developed an anti- ... It uses diphtheria toxin (truncated by the cell binding domain) coupled to an antibody to CD3ε (UCHT1).[citation needed] ... Diphtheria Toxin at the US National Library of Medicine Medical Subject Headings (MeSH) How Diphtheria Toxin Works - Animation ... Diphtheria toxin has also been associated with the development of myocarditis. Myocarditis secondary to diphtheria toxin is ...
  https://en.wikipedia.org/wiki/Diphtheria_toxin
*  Evaluating Acceptability and Completeness of Overseas Immunization Records of Internationally Adopted Children | ELECTRONIC...
European sero-epidemiology network: standardization of the results of diphtheria antitoxin assays. Vaccine.2000;18 :3287- 3296 ... A previous analysis of antibody response after HB immunization among the adoptees in this study found detectable antibody to ... 22 ELISA assays for diphtheria antibodies are reliable in measuring sera with levels ,0.1 IU/mL but may overestimate some sera ... of children with written verification of 3 or more DTP vaccinations had antitoxin titers to diphtheria and tetanus, measured ...
  http://pediatrics.aappublications.org/content/109/2/e22.full