*  Neutralizing antibody - Wikipedia
An example of a neutralizing antibody is diphtheria antitoxin, which can neutralize the biological effects of diphtheria toxin ... The difference between neutralizing antibodies and binding antibodies is that neutralizing antibodies neutralize the biological ... A neutralizing antibody (NAb) is an antibody that defends a cell from an antigen or infectious body by neutralizing any effect ... while single cell antibody cloning made it possible to produce large quantities of the antibodies for study. Low levels of ...
  https://en.wikipedia.org/wiki/Neutralizing_antibody
*  Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants.
However, it is less certain whether the detection of antibodies in cerebrospinal fluid (c.s.f.) of infant ... The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several ... 0/Diphtheria Antitoxin; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Tetanus Antitoxin From MEDLINE®/PubMed®, a database of the U.S ... Diphtheria / immunology. Diphtheria Antitoxin / isolation & purification*. Female. Hemagglutination Tests. Humans. Immunity, ...
  http://www.biomedsearch.com/nih/Passive-transfer-antibodies-maternal-origin/47079.html
*  Jim (horse) - Wikipedia
... antibodies against diphtheria toxin). Jim produced over 30 quarts (7.5 US gallons) of diphtheria antitoxin in his career. ... "Jim" was the name of a former milk wagon horse, who was used to produce serum containing diphtheria antitoxin ( ... These failures in oversight led to the distribution of antitoxin that caused the death of 12 more children. This incident, and ...
  https://en.wikipedia.org/wiki/Jim_(horse)
*  Diphtheria antitoxin - Wikipedia
Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer ... Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by ... Diphtheria antitoxin was developed and came into medical use in the late 1800s. It is on the World Health Organization's List ... containing antibodies obtained from the blood of horses that have been immunized against diphtheria toxin. "Our Formulary , ...
  https://en.wikipedia.org/wiki/Diphtheria_antitoxin
*  Environmental Health Perspectives - Serum Concentrations of Antibodies Against Vaccine Toxoids in Children Exposed...
Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors ... The observed antibody responses to diphtheria and tetanus toxoids in the two studies may therefore not be fully comparable. ... 1988), whereas antibodies against diphtheria toxoids were measured using a standard Vero cell-based neutralization assay ... 2006). At the 18-month examination of a subgroup of the cohort presented in this report, the diphtheria-specific antibody ...
  https://ehp.niehs.nih.gov/1001975/
*  Pertussis re-emergence in the post-vaccination era | BMC Infectious Diseases | Full Text
... that newborns born to mothers who received Tdap during pregnancy had significantly higher antibody titers to diphtheria anti-toxin ... Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum ... and for FHA at 18 months and lower geometric mean antibody concentrations for diphtheria at 7 months [51]. ... diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-13-151
*  COMBINED IMMUNIZATION AGAINST DIPHTHERIA, TETANUS AND PERTUSSIS IN NEWBORN INFANTS | Original Articles | Pediatrics
After administration of a booster dose, however, diphtheria antibody production in the two age groups was comparable. ... "Older" children produced significantly higher diphtheria antitoxin titers after prophylactic injection than the newborn infants ... COMBINED IMMUNIZATION AGAINST DIPHTHERIA, TETANUS AND PERTUSSIS IN NEWBORN INFANTS Message Subject (Your Name) has sent you a ... Evaluation of antibody titers achieved by newborn infants after prophylactic injection of triple combined antigen reveals that ...
  http://pediatrics.aappublications.org/content/3/3/333
*  Health bulletin :: State Publications
This is diphtheria antitoxin. When a child has diphtheria this antitoxin, contain-ing the antibodies produced against the toxin ... A PASSIVE immunity may be ac-quired by borrowing some one else's antibodies. Diphtheria antitoxin is an example of this. If a ... If it is diphtheria it should have diph-theria antitoxin as soon as possible. Defects of the eyes, ears, nose or throat in ... If it is diphtheria it should have diph-theria antitoxin as soon as possible. Defects of the eyes, ears, nose or throat in ...
  http://digital.ncdcr.gov/cdm/compoundobject/collection/p249901coll22/id/257366/show/285767/rec/16
*  Ion Transport and Bacterial Toxins | Annals of Internal Medicine | American College of Physicians
Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected ...
  http://annals.org/aim/article/681618/ion-transport-bacterial-toxins
*  Side-chain theory - Wikipedia
He worked on antitoxins for diphtheria and their binding to antibodies in the blood. He hypothesised that antibodies bind to ... Antibody specificity exists for specific interaction with a given antigen. Antigen-antibody interaction occurs by precise ... The theory explains the interaction of antibodies and antigens in the blood, and how antibodies are produced. In 1891, Paul ... which would then be liberated into the blood stream as antibodies. According to Ehrlich, an antibody could be considered an ...
  https://en.wikipedia.org/wiki/Side-chain_theory
*  Pharmaceutical Microbiology
An in vitro method is provided that is suitable for determining the potency of diphtheria antitoxin (antibodies against the ... If no or little diphtheria antitoxin is present, then diphtheria toxin induces cell death and the inability of cells to reduce ... The test is based on the ability of diphtheria antitoxin to neutralize the diphtheria toxin, decreasing its cytotoxic effect. ... Chapter 162 Diphtheria Antitoxin Potency Testing for Human Immune Globulins [This is a new chapter]. ...
  http://www.pharmamicroresources.com/2016_06_01_archive.html
*  Humoral immunity - Wikipedia
... went on to develop the diphtheria antitoxin, which became the first major success of modern immunotherapy.[3] The presence and ... Antibody-antigen reaction[edit]. Now these antibodies will encounter antigens and bind with them. This will either interfere ... Its aspects involving antibodies are often called antibody-mediated immunity. The study of the molecular and cellular ... Antibodies[edit]. Main article: Antibody. Immunoglobulins are glycoproteins in the immunoglobulin superfamily that function as ...
  https://en.wikipedia.org/wiki/Humoral_immune_response
*  922 - Diphtheria Antibody IgG - Viracor Eurofins
Your trusted lab partner for Diphtheria Antibody IgG testing, Viracor Eurofins delivers your results faster, when it matters ... The EIA is calibrated by reference to the WHO International Reference Diphtheria anti-toxin lot NIBSC 00/496. This test has not ... The recommended protective level of Diphtheria antitoxin IgG is greater than or equal to 0.10 IU/mL. ... such as Diphtheria, and determine vaccine-specific antibody concentrations in a serum sample 3-4 weeks post-immunization ...
  https://www.viracor-eurofins.com/test-menu/922-diphtheria-antibody-igg/
*  Merck Announces Voluntary Recall of Certain Lots of PEDVAXHIB(R) and COMVAX(R). - Free Online Library
0.01 antitoxin units/mL to diphtheria and tetanus and 94.4% to 100% of 18 infants developed a (,=)4-fold rise in antibody to ... of 57 infants developed a 4-fold rise in antibody to diphtheria, 100% of 57 infants developed a 4-fold rise in antibody to ... The antibody responses are summarized below. Antibody Responses to COMVAX in Infants Not Previously Vaccinated with Hib or ... The antibody responses induced by each formulation of PedvaxHIB were similar. TABLE 2 shows antibody responses from this ...
  https://www.thefreelibrary.com/Merck+Announces+Voluntary+Recall+of+Certain+Lots+of+PEDVAXHIB
*  Comvax Vaccine - FDA prescribing information, side effects and uses
0.01 antitoxin units/mL to diphtheria and tetanus and 94.4% to 100% of 18 infants developed a ≥4-fold rise in antibody to ... of 57 infants developed a 4-fold rise in antibody to diphtheria, 100% of 57 infants developed a 4-fold rise in antibody to ... The antibody responses are summarized below.. Antibody Responses to COMVAX in Infants Not Previously Vaccinated with Hib or ... Table 2: Antibody Responses to COMVAX in Infants Previously Vaccinated with Hepatitis B Vaccine at Birth. Study ...
  https://www.drugs.com/pro/comvax-vaccine.html
*  Animal-rights groups fund diphtheria study to advance medicine, spare horses | Fox News
... effective treatment of infectious diphtheria in humans while sparing thousands of horses now being bled to produce antitoxins. ... To make the equine antitoxin, horses are repeatedly injected with diphtheria toxins, their immune systems develop antibodies ... But pharmaceutical companies have not been investing in diphtheria antitoxin research because affected regions generally can ... A product that's made with human antibody, as opposed to horse antibody, would be a good idea, assuming it's been appropriately ...
  http://www.foxnews.com/health/2016/11/23/animal-rights-groups-fund-diphtheria-study-to-advance-medicine-spare-horses.html
*  Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® - Full...
Percentage of Participants With Diphtheria Antitoxin Concentrations ≥ 0.1 IU/mL Pre- and Post-Vaccination With Adacel® or ... Geometric Mean Concentration of Antibody to Pertussis Antigens Pre- and Post-Vaccination With Adacel® or Boostrix®. [ Time ... Pertussis Tetanus Diphtheria Biological: ADACEL®:Tetanus, Reduced Diphtheria and Acellular Pertussis Adsorbed Biological: ... MedlinePlus related topics: Diphtheria Tetanus Tetanus, Diphtheria, and Pertussis Vaccines Whooping Cough ...
  https://clinicaltrials.gov/ct2/show/NCT00319553
*  Alexander Glenny - Wikipedia
His scientific work focused on the mechanisms of antibody production and the prevention of diphtheria. In 1921 he and H. J. ... He worked on immunizations and antitoxins against diseases, including tetanus and diphtheria, and, later, chemical weapons. ... In 1925-6 he developed alum-precipitated diphtheria toxoid. He was elected Fellow of the Royal Society in 1944 and awarded the ... In the same paper they also briefly described the properties of diphtheria toxoid, which had been discovered by Glenny in 1904 ...
  https://en.wikipedia.org/wiki/Alexander_Glenny
*  Development of Jehovah's Witnesses doctrine - Wikipedia
Q: Are we to consider the injection of serums such as diphtheria toxin antitoxin and blood fractions such as gamma globulin ... into the blood stream, for the purpose of building up resistance to disease by means of antibodies, the same as the drinking of ...
  https://en.wikipedia.org/wiki/Development_of_Jehovah's_Witnesses_doctrine
*  Humoral immunity - Wikipedia
Ehrlich, with his friend Emil von Behring, went on to develop the diphtheria antitoxin, which became the first major success of ... Antibodies are synthesized and secreted by plasma cells that are derived from the B cells of the immune system. An antibody is ... Each antibody recognizes a specific antigen unique to its target. By binding their specific antigens, antibodies can cause ... Its aspects involving antibodies are often called antibody-mediated immunity. The study of the molecular and cellular ...
  https://en.wikipedia.org/wiki/Humoral_immunity
*  Preventing Tetanus, Diphtheria, and Pertussis Among Adults: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular...
If tetanus and diphtheria antitoxin levels are each ,0.1 IU/mL, previous vaccination with tetanus and diphtheria toxoid vaccine ... The cutoff value for diphtheria was 2.56 IU/mL. A booster response for each antigen was defined as a fourfold rise in antibody ... 1994 indicated that the prevalence of immunity to diphtheria, defined as a diphtheria antitoxin concentration of ,0.1 IU/mL, ... The clinical management of diphtheria, including use of diphtheria antitoxin, and the public health response is reviewed ...
  https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5517a1.htm
*  Magic bullet (medicine) - Wikipedia
Behring had been investigating antibacterial agents and discovered a diphtheria antitoxin. (For that discovery, Bering was the ... He speculated that these antibodies act as bullets fired from a gun to target specific microbes. But after further research, he ... Ehrlich was also nominated for that year.) From Behring's work, Ehrlich understood that antibodies produced in the blood could ... But Ehrlich's rationale was that the chemical structure called side chain forms antibodies that bind to toxins (such as ...
  https://en.wikipedia.org/wiki/Magic_bullet_(medicine)
*  Evaluating Acceptability and Completeness of Overseas Immunization Records of Internationally Adopted Children | ELECTRONIC...
European sero-epidemiology network: standardization of the results of diphtheria antitoxin assays. Vaccine.2000;18 :3287- 3296 ... A previous analysis of antibody response after HB immunization among the adoptees in this study found detectable antibody to ... 22 ELISA assays for diphtheria antibodies are reliable in measuring sera with levels ,0.1 IU/mL but may overestimate some sera ... of children with written verification of 3 or more DTP vaccinations had antitoxin titers to diphtheria and tetanus, measured ...
  http://pediatrics.aappublications.org/content/109/2/e22.full
*  IDWeek 2015: Person Index C
Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in an animal model ... Do serum antibodies to Staphylococcus aureus PSMα3 protect against skin and soft-tissue infection? Evidence from a case-control ... Cytomegalovirus-Neutralizing Antibody Responses are Associated with Protection Against Fetal Loss, but not Placental ... Development of an Improved Antibody Detection EIA for use in Detection of Coccidioidomycosis ...
  https://idsa.confex.com/idsa/2015/webprogram/authorc.html
*  Task 4. The differentiating properties of corynebacteria
It is made according to the formula: X=10*A/B, where X is content of diphtheria antitoxin in assayed serum (IU), 10- titer of ... Task 7. The indirect hemagglutination test determine the antitoxin antibodies concentration in blood serum. ...
  http://doclecture.net/1-52938.html