CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells
Because tumor cells have evolved mechanisms to shed NKG2DLs to escape antitumor immunity, we first determined whether the ... silencing CEACAM1 expression in tumor cells enhances NKG2D-mediated antitumor immunity via increased NKG2DL on the tumor cells. ... CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. Zhangguo Chen,1 Lanfen Chen,1 ... In so doing, this study demonstrates that CEACAM1 attenuates antitumor immunity by disabling NKG2DL function on tumor cells. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3244030/?lang=en-ca
Natural T Cell Immunity against Cancer | Clinical Cancer Research
Immune escape mechanisms might hamper the effectiveness of natural antitumor immunity. Possible mechanisms include immune ... due to tumor escape mechanisms. An alternate hypothesis is that the evasion of tumor cells, especially in lymph nodes, is a ... Marincola F. M., Jaffee E. M., Hicklin D. J., Ferrone S. Escape of human solid tumors from T cell recognition: molecular ... There is clear evidence that tumor patients are able to generate TAA-specific T cell immunity spontaneously. Whereas the ...http://clincancerres.aacrjournals.org/content/9/12/4296
T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications
However, this cell subpopulation, hypothetically supporting the anti-tumor immunity, appears to be functionally impaired, as ... then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. ... β-related tumor protection strategy to enhance antitumor immunity," Blood, vol. 99, no. 9, pp. 3179-3187, 2002. View at ... Interestingly, in the only case of spontaneous remission ever reported in HL, a specific impairment of the anti-EBV immunity ...https://www.hindawi.com/journals/ah/2011/501659/
Retinoid Signaling in Cancer and Its Promise for Therapy | OMICS International
The presence of high numbers of Tregs leads to impaired anti-tumor immunity and immune escape; the secretion of TGF-β as well ... Ongoing research into the role of RA signaling in cancer cells, anti-tumor immune response, and the tumor microenvironment will ... in combination with the anti-estrogen acolbifene prevented tumor formation. When tumors were allowed to form, rexinoid/ ... Tumor immunity and retinoic acid. Vitamin A deficiency is associated with defects in immune function [151,152]; supplementation ...https://www.omicsonline.org/retinoid-signaling-in-cancer-and-its-promise-for-therapy-2157-2518-S7-006.php?aid=20426
Melanoma stem cells' evasive talents - Healthcanal.com : Healthcanal.com
"To my knowledge, this study provides the first evidence that cancer stem cells escape and down-regulate host antitumor immunity ... initially provoking anti-tumor attacks, as evidenced by patients whose brown-black skin tumors seem to have partly dissolved ... Although the immune system initially responds to melanoma and mounts anti-tumor attacks, these assaults are generally ... Tumors Heat Up: New method for more effective photothermal tumor therapy with infrared light ...https://www.healthcanal.com/cancers/4958-melanoma-stem-cells-evasive-talents.html
Frontiers | Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity | Immunology
This justifies the increased interest of the use of activated NK cells in anti-tumor immunotherapy in the clinic. The in vivo ... Recent data offer some clues on the mechanism that could explain the important role of PKCtheta in NK cell-mediated anti-tumor ... This justifies the increased interest of the use of activated NK cells in anti-tumor immunotherapy in the clinic. The in vivo ... Recent data offer some clues on the mechanism that could explain the important role of PKCtheta in NK cell-mediated anti-tumor ...https://www.frontiersin.org/articles/10.3389/fimmu.2012.00187/full
Melanoma stem cells' evasive talents
Although the immune system initially responds to melanoma and mounts anti-tumor attacks, these assaults are generally ... ... "To my knowledge, this study provides the first evidence that cancer stem cells escape and down-regulate host antitumor immunity ... initially provoking anti-tumor attacks, as evidenced by patients whose brown-black skin tumors seem to have partly dissolved ... Although the immune system initially responds to melanoma and mounts anti-tumor attacks, these assaults are generally ...https://medicalxpress.com/news/2010-01-melanoma-stem-cells-evasive-talents.html
Antigenic escape - Wikipedia
"Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches". ... This can be achieved when the tumor recruits immunosuppressive cell subsets into the tumor's environment. Such cells include ... Antigenic escape occurs when the immune system is unable to respond to an infectious agent. This means that the response ... Antigenic escape is not only crucial for resistance of a host's natural immune response, but also for the resistance against ...https://en.wikipedia.org/wiki/Antigenic_escape
Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy | The...
6A). Previous studies demonstrated that tumors induce suppressor cells to escape the attack by the immune system (22, 23). ... Tumor-specific CD4+ T cells are essential for antitumor immunity after CPA treatment. To determine whether the transfer of CD4+ ... Anti-tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution. Eur. ... In previous studies, we demonstrated that TDLNs played a pivotal role in the development of antitumor immunity (9, 19). Tumor- ...http://www.jimmunol.org/content/195/2/726
Cancer Stem Cell News: January 2010
Evidence that CSC escape and down-regulate host antitumor immunity [FriendFeed entry] http://bit.ly/5vWN8n http://bit.ly/5wgRBV ... Labels: brain cancer, brain tumors, CD133, glioblastoma, glioma stem cells, immunity, STAT3, T cell response ... Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link? By Isabelle Germano, Victoria Swiss ... The degree of diversity correlated with clinically relevant breast tumor subtypes and in some tumors was markedly different ...http://cancerstemcellnews.blogspot.com/2010_01_01_archive.html
Centre de biophysique moléculaire - UPR 4301 - MicroRNAs and Tumor Vasculature Normalization : Impact on Anti-Tumor Immune...
... and leaky blood vessels created in the process of angiogenesis allow tumor cells to escape and extricate anti-cancer immunity. ... MicroRNAs and Tumor Vasculature Normalization : Impact on Anti-Tumor Immune Response. * Missions to Mars : Characterisation of ... MicroRNAs and Tumor Vasculature Normalization : Impact on Anti-Tumor Immune Response. Archivum Immunologiae et Therapiae ... Stable tumor vessel normalization with pO increase and endothelial PTEN activation by inositol trispyrophosphate brings novel ...http://cbm.cnrs-orleans.fr/spip.php?article6429
Induction of Active Immunity in Cancer Patients Undergoing Passive Immunotherapy with Antitumor Antibodies
... of immune escape are being investigated including cellular reprogramming and recruitment of regulatory T cells into the tumor ... Animal model studies suggest that anti-tumor antibodies prevent tumor growth by inducing anti-tumor immune responses, but ... Induction of Active Immunity in Cancer Patients Undergoing Passive Immunotherapy with Antitumor Antibodies Raphael Clynes, M.D ... Does Anti-Tumor Antibody Treatment Improve Immune Responses and Outcomes of Breast Cancer?. This consortium will determine ...http://www.dana.org/Media/GrantsDetails.aspx?id=38715
JCI Insight - C3d regulates immune checkpoint blockade and enhances antitumor immunity
Despite expression of immunogenic polypeptides, tumors escape immune surveillance by engaging T cell checkpoint regulators and ... and amplifies antitumor T cell responses, allowing immunity to reverse or even to prevent tumor growth. C3d enhances antitumor ... 9) tumor cells. (. H. ) Immunofluorescence analysis of frozen sections of C3d+ or C3d- lymphoid tumors stained with anti-CD8 ... Free C3d in tumor cells enhances resistance of mice to tumors by promoting adaptive immunity. ...https://insight.jci.org/articles/view/90201/figure/1
Construction and Characterization of Bispecific Costimulatory Molecules Containing a Minimized CD86 (B7-2) Domain and Single...
... in the induction of specific antitumor immunity and cannot prevent possible tumor recurrence if disseminated tumor cells escape ... Yang G., Hellström K. E., Hellström I., Chen L. Antitumor immunity elicited by tumor cells transfected with B7-2, a second ... molecules on tumor cells can result in the activation of tumor specific T lymphocytes and induce protective antitumor immunity ... molecules on tumor cells can result in the activation of tumor-specific T lymphocytes and induce protective antitumor immunity ...http://clincancerres.aacrjournals.org/content/6/11/4314
Defect in recruiting effector memory CD8+T-cells in malignant pleural effusions compared to normal pleural fluid | BMC Cancer |...
It is widely admitted that T cells and NK cells are key players in anti-tumour immunity, although progressing tumours can ... which may be involved in the escape of tumor cells from immune response. Further studies are needed to characterize which ... PleuraEffusionTumorMesotheliomaImmunityLymphocytes. Background. Malignant pleural effusions (MPE) are a common consequence of ... Natural killer cells are also a very important component of the anti-tumor immune response. In accordance with previous reports ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-324
The Antitumor Immunity of Ipilimumab: (T-cell) Memories to Last a Lifetime? | Clinical Cancer Research
The question of how this patient's tumor escaped after induction of a seemingly effective antitumor immune response underscores ... The Antitumor Immunity of Ipilimumab: (T-cell) Memories to Last a Lifetime?. Michael A. Postow, Margaret K. Callahan and Jedd D ... The Antitumor Immunity of Ipilimumab: (T-cell) Memories to Last a Lifetime? ... The Antitumor Immunity of Ipilimumab: (T-cell) Memories to Last a Lifetime? ...http://clincancerres.aacrjournals.org/content/18/7/1821
Extranodal NK/T-Cell Lymphoma: Toward the Identification of Clinical Molecular Targets
One way for an NKTCL tumor cell to escape anti-EBV immunity is to lower its expression of EBV antigens, particularly LMPs ... The list includes a number of oncogenes or tumor suppressor genes associated with many other tumors. TP53 is a well-known tumor ... The cell of origin of these tumors has been debated. Indeed, the identification of CD3 expression in tumor cells in necrotic ... It is downregulated in multiple human cancers and maps to a prominent tumor-suppressor region of LOH in many tumors including ...https://www.hindawi.com/journals/bmri/2011/790871/
Tumor-related interleukins: old validated targets for new anti-cancer drug development
... and escape from the host immune response and conventional anti-cancer therapy [12, 13]. On the other hand, adaptive immunity is ... In contrast, anti-inflammatory cytokines (IL-2, IL-15, and IL-21) usually activate the antitumor immunity and interfere with ... IL-15 mediates anti-tumor effects after cyclophosphamide injection of tumor-bearing mice and enhances adoptive immunotherapy: ... Tumor-related interleukins: old validated targets for new anti-cancer drug development. Sarra Setrerrahmane1 and Hanmei Xu. 1,2 ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5606116/
Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia | Cancer Research
Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated ... An important argument for this approach is that responses to multiple epitopes should reduce or prevent immune escape (i.e., ... However, a limiting step in the development of tumor vaccines or adoptive immunotherapy is the identification of tumor antigens ... which have already been shown to elicit tumor-specific immunity in other diseases ( 22). This list also features at least one ...http://cancerres.aacrjournals.org/content/65/21/10050
Adiponectin receptor signaling on dendritic cells blunts antitumor immunity. - Nuffield Department of Surgical Sciences
Dendritic cells (DC) that interact with T cells represent a crucial site for the development of tolerance to tumor antigens, ... Together, our findings reveal novel insights into how DC-tolerizing signals evolve in cancer to promote immune escape. ... which are sufficient to blunt antitumor immunity. Mechanistic investigations of ligand-receptor interactions on DCs revealed ... Immune escape is a fundamental trait of cancer. ... which are sufficient to blunt antitumor immunity. Mechanistic ...https://www.nds.ox.ac.uk/publications/485711
Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come. ecancermedicalscience - The open...
... cancer cells can escape immune system surveillance . In fact, PD-L1, expressed on the surface of tumour and infiltrating ... PD-L1 checkpoint inhibitors are monoclonal antibodies that disrupt PD-1/PD-L1-mediated signalling restoring antitumour immunity ... 30. Yu HA, Arcila ME, and Rekhtman N, et al (2013) Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI ... Therefore, appropriate tumour sampling is essential not only for histological subtyping but also for accurate tissue genotyping ...http://ecancer.org/journal/11/full/787-non-small-cell-lung-cancer-treatment-r-evolution-ten-years-of-advances-and-more-to-come.php
CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity | Cancer Research
... or isolated from tumor ascites [tumor-associated lymphocytes (TAL)], using anti-CD25 mAb in combination with anti-CD127 mAb as ... but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. ... RNA was extracted from ovarian tumor specimens, cells isolated from tumor ascites, tumor cell lines, and monocytes using the ... associated with efficient antitumor responses, should be specifically targeted to enhance antitumor immunity. ...http://cancerres.aacrjournals.org/content/72/17/4351
Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers | Cancer...
Evading antitumor immunity is a hallmark for the development and progression of cancer (44). One such mechanism used by tumors ... Tumor cells respond to the presence of TILs by developing counteracting mechanisms to escape immune surveillance. Spranger and ... tumors compared with ER+ tumors (Supplementary Fig. S5A) and in basal-like tumors compared with other subtypes and normal ... tumors than in ER+ tumors, notably in basal-like subtype compared with luminal subtype breast tumors. Although ...http://cancerimmunolres.aacrjournals.org/content/5/4/330.full
LXR Agonism Depletes MDSCs to Promote Antitumor Immunity | Cancer Discovery
The Kyn-AhR Pathway Upregulates PD-1 to Promote Tumor Immune Escape ... LXR Agonism Depletes MDSCs to Promote Antitumor Immunity Message Subject (Your Name) has forwarded a page to you from Cancer ...http://cancerdiscovery.aacrjournals.org/content/8/3/263.1
Assessment of cytokine mRNA expression profiles in tumor microenvironment and peripheral blood mononuclear cells of patients...
... anti-tumor immunity, NK-cell cytotoxicity, cytokines, Th1, Th2, T regulatory response, inflammation, tumor microenvironment ... We explored: 1) tumor escape from cytotoxicity by exosome-mediated modulation of the NK-cell receptors NKG2D and DNAM-1; 2) ... responses promoting tumorigenesis and T-regulatory cell priming that suppress anti-tumor immunity. In addition, we studied ... Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:1133365
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