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*  anti-CD47 antibody | GeneTex
CD47 molecule) for ICC/IF, IHC-P, WB. Anti-CD47 pAb (GTX53912) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance. ... Antigen Species. Human. Species Reactivity. Human, Mouse, Rat. Conjugation. Unconjugated. *. Storage Conditions: CD47 antibody ... ICC/IF analysis of U2OS cells using CD47 antibody (red) and DAPI (blue).. Top ... ICC/IF analysis of U2OS cells using CD47 antibody (red) and DAPI (blue).. Top ...
  http://www.genetex.com/CD47-antibody-GTX53912.html&utm_source=Newsletter&utm_medium=Email&utm_campaign=Newsletter_PD1macrophage
*  Innovent's Anti-CD47 Antibody IBI188 Receives IND Approval in China
Both in vitro and in vivo experiments showed that IBI188 can bind to the CD47 antigen on the surface of tumor cells, block the ... anti-OX40 mAb and anti-CD47 mAb. As one of the key targets in the field of anti-tumor immunotherapy, CD47 is regarded by many ... CD47 is one of the most important targets in the field of immuno-oncology. The development of anti-CD47 monoclonal antibody has ... "Emerging data suggests that CD47 antibody in combination with other treatments, including anti-PD-1 monoclonal antibodies, ...
  https://www.medindia.net/health-press-release/Innovents-Anti-CD47-Antibody-IBI188-Receives-IND-Approval-in-China-382999-1.htm
*  Anti-CD47 antibody may offer new route to successful cancer vaccination - Healthcanal.com : Healthcanal.com
This research shows that macrophages can be effective at antigen presentation and are powerful initiators of the CD8+T cell ... The researchers found that anti-CD47 antibodies, which can block the "don't-eat-me" signal and enable macrophages to engulf ... "Monitoring T-cell parameters in patients receiving anti-CD47 antibody may help us identify the immunological signatures that ... Home Cancers Anti-CD47 antibody may offer new route to successful cancer vaccination ...
  https://www.healthcanal.com/cancers/38840-anti-cd47-antibody-may-offer-new-route-to-successful-cancer-vaccination.html
*  Anti Human CD47 Antibody, clone BRIC126 - Mouse Anti-Human Monoclonal Antibody WB, IHC-F, FC, IP, Func - Buy Now! |Abgent
Mouse Anti-Human Monoclonal Antibody validated in WB, IHC-F, FC, IP, Func (ABD12912), Abgent ... Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6, CD47 ... home , Products , Primary Antibodies , Immunology , Anti Human CD47 Antibody, clone BRIC126 Anti Human CD47 Antibody, clone ... CD47, MER6. Target/Specificity Mouse anti human CD47 antibody, clone BRIC126 recognises the human CD47 cell surface ...
  http://www.abgent.com/products/ABD12912-Anti-Human-CD47-Antibody-clone-BRIC126-
*  Patent US20030211108 - Monoclonal antibody inducing apoptosis - Google Patents
... and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are ... useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having ... The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, ... The antigen expression of the obtained clones was examined using human IAP-recognizing anti-CD47 antibody (PharMingen), and the ...
  http://www.google.com/patents/US20030211108?dq=oakley+D523,461
*  Durable antitumor responses to CD47 blockade require adaptive immune stimulation | PNAS
2015) Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and ... D) Dose-response curves of B16F10 cell surface CD47 antagonism with the anti-mouse CD47 nanobody A4, anti-mouse CD47 antibody ... the anti-mouse CD47 antagonist antibody (miap301) alone or in combination with anti-TRP-1 and/or anti-PD-L1 antibodies failed ... Binding affinity and kinetics between anti-mouse CD47 nanobody A4, CV1, and anti-mouse CD47 antibody miap301 immobilized mouse ...
  http://www.pnas.org/content/113/19/E2646
*  lymphoma
Agents that block the anti-phagocytic signal CD47 can synergize with pro-phagocytic anti-tumor antigen antibodies to potently ... Agents that block the anti-phagocytic signal CD47 can synergize with pro-phagocytic. Posted on February 17, 2018 at 5:33 pm.. ... These findings serve as proof of principle for BsAb targeting of CD47 with tumor-associated antigens as …Read More ... with BsAbs reduced lymphoma burden and extended survival while recapitulating the synergistic efficacy of anti-CD47 and anti- ...
  http://researchhunt.com/tag/lymphoma/
*  Is CD47 an innate immune checkpoint for tumor evasion? | Journal of Hematology & Oncology | Full Text
... motifs and recruitment of Src homology 2 domain-containing tyrosine phosphatases to ultimately result in delivering an anti- ... One essential mechanism behind CD47-mediated immune evasion is that it can interact with signal regulatory protein-alpha (SIRPα ... Various solid and hematologic cancers exploit CD47 expression in order to evade immunological eradication, and its ... CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-016-0381-z
*  Molecular Characterization of Acute Myeloid Leukemia - Irving Weissman
2013) Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc ... dendritic cell presentation of tumor antigens) immune systems by examining the ability of various subsets of macrophages and ... We will test whether a blocking anti-CD47 antibody can overcome this effect and render them susceptible to immune clearance. ... Finally, we will examine whether CD47 expression (a 'don't eat me'signal) on leukemic cells renders them invisible to the ...
  http://grantome.com/grant/NIH/R01-CA086017-14
*  Anti-IL1RAP Antibodies and Their Use for Treating Human - CANTARGIA AB
... antibody heavy chains, antibody light chains, homodimers and heterodimers of antibody heavy and/or light chains, and antigen ... CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009; ... In addition, an antibody cocktail containing anti-CD34, anti-CD38 and anti-IL1RAP antibodies can be used for diagnostic ... In this study, we generate an anti-IL1RAP antibody and provide proof of concept that anti-IL1RAP antibodies targeting chronic ...
  http://www.freepatentsonline.com/y2017/0081414.html
*  CD47 - Wikipedia
Thus blocking CD47 with antibody turns off "don't eat me" signal and favors phagocytosis. Anti-CD47 antibody-mediated ... CD47 was first identified as a tumor antigen on human ovarian cancer in the 1980s. Since then, CD47 has been found to be ... March 2017). "Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for ... The mechanism of the anti-angiogenic activity of CD47 is not fully understood, but introduction of CD47 antibodies and TSP-1 ...
  https://en.wikipedia.org/wiki/CD47
*  Emil R. Unanue Laboratory| Publications
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. J Exp Med ... Commentary - Perspectives on anti-CD47 antibody treatment for experimental cancer. Proc Natl Acad Sci USA 110:10886-10887, 2013 ... Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants. J Immunol ... Autophagy in antigen presenting cells results in presentation of citrullinated peptides to CD4 T cells. J Exp Med 208:2625-2632 ...
  http://www.unanuelab.org/publications.html
*  CTLA-4 Limits Anti-CD20-Mediated Tumor Regression | Clinical Cancer Research
Several studies have indicated that anti-PD-1- or anti-CD47-mediated T-cell reactivation inside tumor tissues is essential for ... Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. ... To determine whether the cross-presentation function of APC is enhanced after anti-CD20 treatment, we transfected an antigen ... Anti-CTLA-4 was administered together with anti-CD20; as expected, the anti-CTLA-4 and anti-CD20 combined treatment had much ...
  http://clincancerres.aacrjournals.org/content/23/1/193
*  SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells | Clinical Cancer Research
Synergy was initially shown with blocking anti-CD47 antibodies and rituximab, an anti-CD20 antibody known to activate FcRs (7 ... S1A). The B6H12.2 anti-CD47 antibody has been extensively studied and served as a reference for robust CD47 binding (21). SIRPα ... Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PloS ONE 2015;10:e0137345. ... S2). All SIRPabodies bound CD47 on Raji cells as indicated by blocking of labeled anti-CD47 antibody (Supplementary Fig. S2A). ...
  http://clincancerres.aacrjournals.org/content/22/20/5109
*  CD47 Monoclonal Antibody SRF231 Is a Potent Inducer of Macrophage-Mediated Tumor Cell Phagocytosis and Reduces Tumor Burden in...
... prevents phagocytosis of CD47-expressing cells. CD47 was originally identified as a tumor antigen on human ovarian cancer and ... Tumor cell phagocytosis can be enhanced in the presence of opsonizing antibodies (e.g., anti-CD20 Ab) when co-administered with ... SRF231 is a fully human monoclonal antibody that binds with high affinity to human CD47 and blocks the CD47-SIRP▢ interaction. ... CD47 Monoclonal Antibody SRF231 Is a Potent Inducer of Macrophage-Mediated Tumor Cell Phagocytosis and Reduces Tumor Burden in ...
  http://www.bloodjournal.org/content/128/22/1843?sso-checked=true
*  Gentaur Molecular :Meretciel \ Canine Leukocyte surface antigen CD47,CD47 ELISA kit \ CC003
Canine Leukocyte surface antigen CD47,CD47 ELISA kit \ CC003 for more molecular products just contact us ... Canine Leukocyte surface antigen CD47,CD47 ELISA kit antibody storage GENTAUR recommends for long therm storage to freeze at - ... CD47 ELISA kit. http://mybiofast.com/ver.php?search=anti-&submit=Search ... Canine Leukocyte surface antigen CD47,CD47 ELISA kit. Related products : Canine Leukocyte surface antigen CD47,CD47 ELISA kit ...
  http://www.antibody-antibodies.com/product5893982-search-Canine_Leukocyte_surface_antigen_CD47,CD47_ELISA_kit.html
*  Calreticulin - Wikipedia
Calreticulin binds to antibodies in certain area of systemic lupus and Sjogren patients that contain anti-Ro/SSA antibodies. ... Hence antibodies that block CD47 might be useful as a cancer treatment. In mice models of myeloid leukemia and non-Hodgkin's ... but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen, but this was later ... "Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases". The Journal of ...
  https://en.wikipedia.org/wiki/Calreticulin
*  Apoptotic cell clearance: basic biology and therapeutic potential. - PubMed - NCBI
h. Targeting tumour cells with anti-CD47 blocking antibodies or soluble SIRPα variants inhibits CD47-SIRPα interaction and ... Strategies to degrade DAMPs (for example through the degradation of histone H3 by antigen presenting cells (APCs)) can improve ... The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as ... cell death accompanied with CRT and DAMPs exposure can promote DC-mediated engulfment and DC maturation to initiate an anti- ...
  https://www.ncbi.nlm.nih.gov/pubmed/24481336
*  Produktübersicht anti-CD36 Antikörper
... leukocyte differentiation antigen CD36 , scavenger receptor class B, member 3 , CD36 antigen like , CD36 antigen , GPIV , ... Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (zeige CD47 Antikörper)-dependent manner ... Mouse (Murine) Monoclonal CD36 Primary Antibody für IHC (p), IP - ABIN258619 : Febbraio, Podrez, Smith, Hajjar, Hazen, Hoff, ... anti-CD36 (CD36) Antikörper. Bezeichnung:. anti-CD36 Molecule (thrombospondin Receptor) Antikörper (CD36). Auf www.antikoerper- ...
  http://www.antikoerper-online.de/tlr-signalweg-pathway-21/cd36-antibody-2578/
*  Applications filed at May 24 2018 | INITIATOR COMPOSITION FOR FLUORINATED POLYMER AND METHOD FOR PRODUCING FLUORINATED...
THERAPEUTIC CD47 ANTIBODIES. Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as ... ANTI-CD19 ANTIBODIES AND METHODS OF USE THEREOF. The disclosure relates to monoclonal antibodies and antigen binding fragments ... ANTI-PD-1 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-PD-1 ANTIBODIES AND METHODS OF USING ANTI-PD-1 ANTIBODIES. Provided herein ... ANTI-GDF15 ANTIBODIES. Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies ...
  http://patents.com/ap-20180524-p91.html
*  Anti Bovine CD172a Antibody, clone DH59B | Bio-Rad Antibodies (formerly AbD Serotec)
... recognizes bovine CD172a also known as SIRP alpha or MyD-1 antigen. CD172a is a transmembrane signa ... The IgV domain of CD172a binds to CD47 (Hatherley et al. 2007).The binding domain of CD172a is analogous to that of ... Anti-idiotypic Antibodies Anti-Adalimumab Antibodies Anti-Alemtuzumab Antibodies Anti-Bevacizumab Antibodies Anti-Cetuximab ... Anti-Panitumumab Antibodies Anti-Rituximab Antibodies Anti-Tocilizumab Antibodies Anti-Trastuzumab Antibodies Anti-Ustekinumab ...
  https://www.bio-rad-antibodies.com/cow-bovine-cd172a-antibody-dh59b-mca6079.html
*  RHAG - Wikipedia
... and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), ... are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- ... The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so ... Dahl KN, Westhoff CM, Discher DE (Feb 2003). "Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual ...
  https://en.wikipedia.org/wiki/RHAG
*  Protocols and Video Articles Authored by Peggy P. Ho (Translated to Hebrew)
In contrast, blocking with a monoclonal antibody against CD47 in mice at the peak of paralysis worsens EAE severity and ... 2008 , Pubmed ID: 18826638 Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, ... These results were confirmed in SJL.B mice responding to MBP but not in B6 mice responding to the same antigen, suggesting that ... Depletion of Tregs with anti-CD25 antibodies prior to immunization with PLP139-151 rendered 30% of resistant B10.S mice to ...
  https://www.jove.com/author/Peggy++P._Ho?language=Hebrew
*  Anti Human CD172a Antibody, clone 4C7 | Bio-Rad
strong,Mouse anti Human CD172 antibody, clone 4C7,/strong, recognizes human Tyrosine-protein phosphatase non-receptor type ... Antibodies and Antigens for Diagnostic Assay Development and Research Endocrinology Antibodies Infectious Disease Testing ... 48 kDa single pass type 1 transmembrane glycoprotein and cell surface receptor for CD47.. Three isoforms of CD172a produced by ... Anti-idiotypic Antibodies Anti-Adalimumab Antibodies Anti-Alemtuzumab Antibodies Anti-Bevacizumab Antibodies Anti-Cetuximab ...
  https://www.bio-rad-antibodies.com/monoclonal/human-cd172a-antibody-4c7-mca5404.html
*  CD47, Functional Grade, clone: miap301, eBioscience™ 500μg; Functional Grade CD47, Functional Grade, clone: miap301,...
Functional Grade CD47, Functional Grade, clone: miap301, eBioscience™ Primary Antibodies... ... Custom Assays, Antibodies, Oligos Custom Assays, Antibodies, Oligos * Custom Assays, Antibodies, Oligos ... The monoclonal antibody miap301 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a ... CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 ...
  https://www.fishersci.co.uk/shop/products/cd47-rat-anti-mouse-clone-miap301-functional-grade-ebioscience-2/15278457