*  anti-CD47 antibody | GeneTex
CD47 molecule) for ICC/IF, IHC-P, WB. Anti-CD47 pAb (GTX53912) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance. ... Antigen Species. Human. Species Reactivity. Human, Mouse, Rat. Conjugation. Unconjugated. *. Storage Conditions: CD47 antibody ... ICC/IF analysis of U2OS cells using CD47 antibody (red) and DAPI (blue).. Top ... ICC/IF analysis of U2OS cells using CD47 antibody (red) and DAPI (blue).. Top ...
  http://www.genetex.com/CD47-antibody-GTX53912.html&utm_source=Newsletter&utm_medium=Email&utm_campaign=Newsletter_PD1macrophage
*  Anti-CD47 antibody may offer new route to successful cancer vaccination - Healthcanal.com : Healthcanal.com
This research shows that macrophages can be effective at antigen presentation and are powerful initiators of the CD8+T cell ... The researchers found that anti-CD47 antibodies, which can block the "don't-eat-me" signal and enable macrophages to engulf ... "Monitoring T-cell parameters in patients receiving anti-CD47 antibody may help us identify the immunological signatures that ... Home Cancers Anti-CD47 antibody may offer new route to successful cancer vaccination ...
  https://www.healthcanal.com/cancers/38840-anti-cd47-antibody-may-offer-new-route-to-successful-cancer-vaccination.html
*  Patent US20030211108 - Monoclonal antibody inducing apoptosis - Google Patents
... and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are ... useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having ... The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, ... The antigen expression of the obtained clones was examined using human IAP-recognizing anti-CD47 antibody (PharMingen), and the ...
  http://www.google.com/patents/US20030211108?dq=oakley+D523,461
*  Anti Human CD47 Antibody, clone BRIC126 - Mouse Anti-Human Monoclonal Antibody WB, IHC-F, FC, IP, Func - Buy Now! |Abgent
Mouse Anti-Human Monoclonal Antibody validated in WB, IHC-F, FC, IP, Func (ABD12912), Abgent ... Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6, CD47 ... home , Products , Primary Antibodies , Immunology , Anti Human CD47 Antibody, clone BRIC126 Anti Human CD47 Antibody, clone ... CD47, MER6. Target/Specificity Mouse anti human CD47 antibody, clone BRIC126 recognises the human CD47 cell surface ...
  http://www.abgent.com/products/ABD12912-Anti-Human-CD47-Antibody-clone-BRIC126-
*  Is CD47 an innate immune checkpoint for tumor evasion? | Journal of Hematology & Oncology | Full Text
... motifs and recruitment of Src homology 2 domain-containing tyrosine phosphatases to ultimately result in delivering an anti- ... One essential mechanism behind CD47-mediated immune evasion is that it can interact with signal regulatory protein-alpha (SIRPα ... Various solid and hematologic cancers exploit CD47 expression in order to evade immunological eradication, and its ... CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-016-0381-z
*  Molecular Characterization of Acute Myeloid Leukemia - Irving Weissman
2013) Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc ... dendritic cell presentation of tumor antigens) immune systems by examining the ability of various subsets of macrophages and ... We will test whether a blocking anti-CD47 antibody can overcome this effect and render them susceptible to immune clearance. ... Finally, we will examine whether CD47 expression (a 'don't eat me'signal) on leukemic cells renders them invisible to the ...
  http://grantome.com/grant/NIH/R01-CA086017-14
*  Anti-IL1RAP Antibodies and Their Use for Treating Human - CANTARGIA AB
... antibody heavy chains, antibody light chains, homodimers and heterodimers of antibody heavy and/or light chains, and antigen ... CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009; ... In addition, an antibody cocktail containing anti-CD34, anti-CD38 and anti-IL1RAP antibodies can be used for diagnostic ... In this study, we generate an anti-IL1RAP antibody and provide proof of concept that anti-IL1RAP antibodies targeting chronic ...
  http://www.freepatentsonline.com/y2017/0081414.html
*  CD47 - Wikipedia
Thus blocking CD47 with antibody turns off "don't eat me" signal and favors phagocytosis. Anti-CD47 antibody-mediated ... CD47 was first identified as a tumor antigen on human ovarian cancer in the 1980s. Since then, CD47 has been found to be ... March 2017). "Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for ... The mechanism of the anti-angiogenic activity of CD47 is not fully understood, but introduction of CD47 antibodies and TSP-1 ...
  https://en.wikipedia.org/wiki/CD47
*  Emil R. Unanue Laboratory| Publications
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. J Exp Med ... Commentary - Perspectives on anti-CD47 antibody treatment for experimental cancer. Proc Natl Acad Sci USA 110:10886-10887, 2013 ... Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants. J Immunol ... Autophagy in antigen presenting cells results in presentation of citrullinated peptides to CD4 T cells. J Exp Med 208:2625-2632 ...
  http://www.unanuelab.org/publications.html
*  CTLA-4 Limits Anti-CD20-Mediated Tumor Regression | Clinical Cancer Research
Several studies have indicated that anti-PD-1- or anti-CD47-mediated T-cell reactivation inside tumor tissues is essential for ... Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. ... To determine whether the cross-presentation function of APC is enhanced after anti-CD20 treatment, we transfected an antigen ... Anti-CTLA-4 was administered together with anti-CD20; as expected, the anti-CTLA-4 and anti-CD20 combined treatment had much ...
  http://clincancerres.aacrjournals.org/content/23/1/193
*  SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells | Clinical Cancer Research
Synergy was initially shown with blocking anti-CD47 antibodies and rituximab, an anti-CD20 antibody known to activate FcRs (7 ... S1A). The B6H12.2 anti-CD47 antibody has been extensively studied and served as a reference for robust CD47 binding (21). SIRPα ... Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PloS ONE 2015;10:e0137345. ... S2). All SIRPabodies bound CD47 on Raji cells as indicated by blocking of labeled anti-CD47 antibody (Supplementary Fig. S2A). ...
  http://clincancerres.aacrjournals.org/content/22/20/5109
*  Gentaur Molecular :Meretciel \ Canine Leukocyte surface antigen CD47,CD47 ELISA kit \ CC003
Canine Leukocyte surface antigen CD47,CD47 ELISA kit \ CC003 for more molecular products just contact us ... Canine Leukocyte surface antigen CD47,CD47 ELISA kit antibody storage GENTAUR recommends for long therm storage to freeze at - ... CD47 ELISA kit. http://mybiofast.com/ver.php?search=anti-&submit=Search ... Canine Leukocyte surface antigen CD47,CD47 ELISA kit. Related products : Canine Leukocyte surface antigen CD47,CD47 ELISA kit ...
  http://www.antibody-antibodies.com/product5893982-search-Canine_Leukocyte_surface_antigen_CD47,CD47_ELISA_kit.html
*  Calreticulin - Wikipedia
Calreticulin binds to antibodies in certain area of systemic lupus and Sjogren patients that contain anti-Ro/SSA antibodies. ... Hence antibodies that block CD47 might be useful as a cancer treatment. In mice models of myeloid leukemia and non-Hodgkin's ... but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen, but this was later ... "Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases". The Journal of ...
  https://en.wikipedia.org/wiki/Calreticulin
*  Produktübersicht anti-CD36 Antikörper
... leukocyte differentiation antigen CD36 , scavenger receptor class B, member 3 , CD36 antigen like , CD36 antigen , GPIV , ... Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (zeige CD47 Antikörper)-dependent manner ... Mouse (Murine) Monoclonal CD36 Primary Antibody für IHC (p), IP - ABIN258619 : Febbraio, Podrez, Smith, Hajjar, Hazen, Hoff, ... anti-CD36 (CD36) Antikörper. Bezeichnung:. anti-CD36 Molecule (thrombospondin Receptor) Antikörper (CD36). Auf www.antikoerper- ...
  http://www.antikoerper-online.de/tlr-signalweg-pathway-21/cd36-antibody-2578/
*  Anti Bovine CD172a Antibody, clone DH59B | Bio-Rad Antibodies (formerly AbD Serotec)
... recognizes bovine CD172a also known as SIRP alpha or MyD-1 antigen. CD172a is a transmembrane signa ... The IgV domain of CD172a binds to CD47 (Hatherley et al. 2007).The binding domain of CD172a is analogous to that of ... Anti-idiotypic Antibodies Anti-Adalimumab Antibodies Anti-Alemtuzumab Antibodies Anti-Bevacizumab Antibodies Anti-Cetuximab ... Anti-Panitumumab Antibodies Anti-Rituximab Antibodies Anti-Tocilizumab Antibodies Anti-Trastuzumab Antibodies Anti-Ustekinumab ...
  https://www.bio-rad-antibodies.com/cow-bovine-cd172a-antibody-dh59b-mca6079.html
*  RHAG - Wikipedia
... and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), ... are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- ... The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so ... Dahl KN, Westhoff CM, Discher DE (Feb 2003). "Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual ...
  https://en.wikipedia.org/wiki/RHAG
*  Protocols and Video Articles Authored by Peggy P. Ho (Translated to Hebrew)
In contrast, blocking with a monoclonal antibody against CD47 in mice at the peak of paralysis worsens EAE severity and ... 2008 , Pubmed ID: 18826638 Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, ... These results were confirmed in SJL.B mice responding to MBP but not in B6 mice responding to the same antigen, suggesting that ... Depletion of Tregs with anti-CD25 antibodies prior to immunization with PLP139-151 rendered 30% of resistant B10.S mice to ...
  https://www.jove.com/author/Peggy++P._Ho?language=Hebrew
*  CD47, Functional Grade, clone: miap301, eBioscience™ 500μg; Functional Grade CD47, Functional Grade, clone: miap301,...
Functional Grade CD47, Functional Grade, clone: miap301, eBioscience™ Primary Antibodies... ... Custom Assays, Antibodies, Oligos Custom Assays, Antibodies, Oligos * Custom Assays, Antibodies, Oligos ... The monoclonal antibody miap301 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a ... CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 ...
  https://www.fishersci.co.uk/shop/products/cd47-rat-anti-mouse-clone-miap301-functional-grade-ebioscience-2/15278457
*  Call for Abstracts
Antibody therapy. *. Cytokine therapy. *. Polysaccharide-K. *. Anti-GD2 antibodies. *. Immune checkpoints. *. Anti-CD47 ... Prostate screening tests comprises of Digital rectal exam (DRE) and Prostate-particular antigen (PSA) test. Screening builds ... Cancer Pharmacology & Anti-cancer Drug Delivery Cancer Pharmacology concentrates on creating exploratory ways to deal with the ... known as tumor-related antigens (TAAs); they are frequently proteins or different macromolecules. *. Cellular immunotherapy. ...
  http://worldcancer.alliedacademies.com/2017/call-for-abstracts
*  SITC 2016
423Anti-CD47 monoclonal antibody SRF231 is a potent inducer of macrophage-mediated tumor cell phagocytosis and has anti-tumor ... 43A tumor-penetrating recombinant protein anti-EGFR-iRGD enhances efficacy of antigen-specific CTL in gastric cancer in vivo. ... 200A novel anti-human LAG-3 antibody in combination with anti-human PD-1 (REGN2810) shows enhanced anti-tumor activity in PD-1 ... 156A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers. Add ...
  https://www.eventscribe.com/2016/SITC/aaSearchByPosterDaySession.asp?h=Browse%20by%20Poster%20Day
*  Development of Therapeutic Antibodies Targeting Human Acute Myeloid Leukemia Stem Cells | California's Stem Cell Agency
To show the antibodies were safe, we administered to regular mice large amounts of a comparable anti-mouse CD47 antibody on a ... The goal of this research proposal is to prepare therapeutic antibodies directed against AML stem cell-specific antigens for ... These antibodies bind to a protein called CD47 that is present on the outer surface of human leukemia cells. The anti-CD47 ... Since the anti-human CD47 antibody does bind to non-human primate CD47, safety studies for our candidate therapeutic need to be ...
  https://www.cirm.ca.gov/our-progress/awards/development-therapeutic-antibodies-targeting-human-acute-myeloid-leukemia-stem
*  Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. - Semantic Scholar
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.. *Diane Tseng ... Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells.. *D A Mitchell ... Capture and processing of exogenous antigens for presentation on MHC molecules.. *C Watts ... Calreticulin acts as an adjuvant to promote dendritic cell maturation and enhances antigen-specific cytotoxic T lymphocyte ...
  https://www.semanticscholar.org/paper/Calreticulin-displays-in-vivo-peptide-binding-and-Nair-Wearsch/55aafcd4eccb77b034f98fdd889c41b541e65d39
*  Binding of sCD23 to CD47+ and CD47− cell lines. CD4 | Open-i
CD47+ and CD47− cell lines were stained with two anti-CD47 mAbs (clone 10G2 and B6H12), anti-αv (CD51) ... Binding of sCD23 to CD47+ and CD47− cell lines. ... Antibodies, Monoclonal. *Antigens, CD47. *Cell Line. *Humans. * ... CD47+ and CD47− cell lines were stained with two anti-CD47 mAbs (clone 10G2 and B6H12), anti-αv (CD51) and anti-β3 (CD61) mAbs ... CD47+ and CD47− cell lines were stained with two anti-CD47 mAbs (clone 10G2 and B6H12), anti-αv (CD51) and anti-β3 (CD61) mAbs ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2132927_JCB9806057.f8&req=4
*  CD99 Signals Caspase-Independent T Cell Death | The Journal of Immunology
Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J. ... T cell lines were cultured with 1 μg/ml anti-CD99 mAbs Ad20 and MEM 131, anti-CD47 mAbs Ad22 and 2D3, or control mAbs TEPC 183 ... Anti-CD4 (IgG1-PerCP), anti-CD8 (IgG1-APC), anti-CD45RA (IgG1-FITC), anti-CD45RO (IgG2a-PE), and IgG1-PerCP, IgG1-APC, IgG1- ... CD99 signals T cell death independently of CD47 activation. Jurkat E6 cells were preincubated with 10 μg/ml anti-CD47 mAbs ...
  http://www.jimmunol.org/content/166/8/4931.long
*  Nelson Teng | Stanford Medicine Profiles
Anti-CD47 antibody therapy initiated on larger tumors inhibited tumor growth and prevented or treated metastasis, but ... Thus it is possible that the anti-DNA reactivity of V4-34-encoded monoclonal antibodies is mediated by the classic antigen- ... Monoclonal antibody 216 targeting was determined with an anti-idiotypic antibody to monoclonal antibody 216 and preliminary ... An Epstein-Barr virus (EBV)-transformed human B-cell line ( LB4r ) producing anti-Rhesus [Rho(D) antigen] antibody was fused ...
  https://med.stanford.edu/profiles/nelson-teng