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*  Alzforum: AlzRisk Risk Factor Discussion
Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment ... and non-selective agents (e.g., aspirin and other COX-1 inhibitors) are regularly prescribed to treat inflammatory and pain- ... Nonsteroidal antiinflammatory drugs and cognitive decline in the elderly. J Rheumatol. 1995;22(11):2142-7.. Scharf S, Mander A ... Etminan M, Gill S, Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review ...
  http://alzrisk.org/riskfactordoc.aspx?rfid=13
*  Peptic ulcer and non-steroidal anti-inflammatory agents. | Gut
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated ...
  http://gut.bmj.com/content/27/8/929
*  Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
All information about the latest scientific publications of the Clínica Universidad de Navarra. Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
  http://www.cun.es/en/research/scientific-publications/hypersensitivity-to-aspirin-and-other-nonsteroidal-anti-inflammatory-drugs-nsaids
*  Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs May Cut Risk of Esophageal Cancer in People with Barrett's Esophagus
Thomas L. Vaughan, M.D., M.P.H., and colleagues at Fred Hutchinson Cancer Research Center discovers Aspirin and other nonsteroidal anti-inflammatory drugs, such as ibuprofen, may significantly reduce the risk of esophageal cancer among people with Barrett's esophagus.
  http://www.fredhutch.org/en/news/releases/2005/11/aspirin_barretts.html
*  Prescriptions for Cyclooxygenase-2 Inhibitors and Other Nonsteroidal Anti-inflammatory Agents in a Medicaid Managed Care...
Objective. To determine whether race is a predictor of a patient's likelihood of being prescribed selective cyclooxygenase-2 inhibitors (COX-2s) versus other nonsteroidal anti-inflammatory agents (NSAIDs) in Medicaid managed care plans (MCO).. Design. All medical and prescription claims for Medicaid MCO enrollees receiving at least one prescription for a COX-2 or NSAID between January 2000 and June 2002 were retrieved. Selected for study were adults claiming at least one COX-2 prescription or NSAID prescription with a minimum 30 days of supply after June 2000; having 60 total days of supply or more over the study period was also required for study inclusion. The probability of being prescribed a COX-2 was estimated as a logistic function of patient age, gender, race, city/suburban/rural residence, and history of rheumatoid arthritis, osteoarthritis, chronic back pain, acute pains, gastrointestinal problems, use of ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2005.05011.x/full
*  A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury - No Study...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
  https://clinicaltrials.gov/ct2/show/results/NCT01140828
*  Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of Ophthalmology
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center's RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
  http://bjo.bmj.com/content/80/12/1117.1
*  Abstract: Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2...
Interaction with platelet function by non-steroidal anti-inflammatory drugs (NSAIDs) is related to the inhibition of cyclo-oxygenase-1 (COX-1). In pat
  http://www.prohealth.com/library/showarticle.cfm?libid=8374
*  Protection of Ischemia-Reperfusion Induced Cell Death by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Rat Retina |...
Abstract: : Purpose: The degeneration of retinal neurons results in loss of vision. It has been known that Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can protect the neuron from ischemic damage. The purpose of this study was to investigate the protective effect of NSAIDs in the rat retinal ischemia. Methods: Retinal ischemia in Sprague Dawley rats was induced by high intraocular pressure at 160 mmHg for 60 minutes after intra-ocular injection of saline, aspirin (5 to 20 mM), sulfasalazine (1 to 5 mM) or sulindac (0.01 to 0.1 mM). For morphological study, the retinas were embedded in epon 24 hours after ischemic injury. To determine neuronal survivorship in the retinal layers, the number of viable neurons was counted in 100µm X 25µm square and examined. Results: The intravitreal injections of aspirin, sulfasalazine or sulindac attenuated the ischemic neuronal degeneration in dose dependent. The protective effect of aspirin at ...
  http://iovs.arvojournals.org/article.aspx?articleid=2418307
*  Vitamin C Efficacy in Reducing Post Operative Pain - Full Text View - ClinicalTrials.gov
Opioids are the corner stone in the treatment of post operative pain. Because of the several side effects of opiods, non-steroidal anti-inflammatory drugs are usually added postoperatively to decrease the total requirements of opioids. However, non steroidal anti-inflammatory drugs have side effects of their own. Vitamin C, with virtually no side effects when used on short-term basis, has been shown to have promising analgesic effects in chronic pain and acute pain relief following orthopedic surgeries.. The investigators propose to assess the role of a prophylactic single dose (2g) of vitamin C in reducing the intensity of pain and the consumption of opioids in patients undergoing laparoscopic cholecystectomy at AUB-MC.. All eligible patients undergoing laparoscopic cholecystectomy at AUB-MC will be included in the study. Patients will be randomized into two groups to ...
  https://clinicaltrials.gov/ct2/show/NCT01322061
*  Wellington ICU Drug Book
As with other nonsteroidal anti-inflammatory drugs, borderline elevations of one or more liver function tests may occur in up to 15% of patients. These abnormalities may progress, may remain essentially unchanged, or may be transient with continued therapy. Severe hepatic reactions, including jaundice and cases of fatal hepatitis, have been reported with ibuprofen as with other nonsteroidal anti-inflammatory drugs. Although such reactions are rare, if abnormal liver tests persist or worsen, if clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc.), ibuprofen should be discontinued ...
  http://drug.wellingtonicu.com/F-K/I/Ibuprofen/
*  Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers - Tabular View -...
Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study ...
  https://clinicaltrials.gov/ct2/show/record/NCT00153712
*  Patent US6309630 - Non-steroidal anti-inflammatory ophthalmic suspensions - Google Patents
Compositions for topical ophthalmic application comprising an aqueous mixture of a non-steroidal anti-inflammatory agent. The compositions are formulated with a pH and concentration of agent chosen to maintain at least some of the therapeutic agent of the formulation in suspension.
  http://www.google.ca/patents/US6309630
*  Treatment and chemoprevention of NSAID-associated gastrointestinal com | TCRM
Treatment and chemoprevention of NSAID-associated gastrointestinal complications Edward J Frech1,2, Mae F Go1,21GI Section, George E Wahlen Department of Veterans Affairs Medical Center; 2Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, Utah, USAAbstract: The use of non-steroidal anti-inflammatory drugs has become ubiquitous worldwide and remains a common source of gastrointestinal morbidity. Antisecretory medications, particularly proton pump inhibitors, are effective in the treatment and prevention of NSAID-related gastrointestinal complications, including peptic ulcer disease and non-ulcer dyspepsia. A careful assessment of patients' risk factors for developing NSAID-related gastrointestinal complications should be undertaken prior to initiation of any NSAIDs. Patients who are considered at risk for developing gastrointestinal complications should receive concurrent ...
  https://www.dovepress.com/treatment-and-chemoprevention-of-nsaid-associated-gastrointestinal-com-peer-reviewed-article-TCRM
*  Torts Today: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or...
The U.S. Food and Drug Administration (FDA) is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke. Based on our comprehensive review of new safety information, we are requiring updates to the drug labels of all prescription NSAIDs. As is the case with current prescription NSAID labels, the Drug Facts labels of over-the-counter (OTC) non-aspirin NSAIDs already contain information on heart attack and stroke risk. We will also request updates to the OTC non-aspirin NSAID Drug Facts labels ...
  http://tortstoday.blogspot.com/2015/07/fda-strengthens-warning-that-non.html
*  Jen's RA Journey: February 2012
In ancient times, it was believed throughout the world that the root cause of ailments was the body's buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. It's important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you "leaky gut" which leads to worsening of disease. The intestinal tract's position and processes are integral in keeping your body healthy because it is the body's first line ...
  http://jensrajourney.blogspot.com/2012/02/
*  Jen's RA Journey: 2012
In ancient times, it was believed throughout the world that the root cause of ailments was the body's buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. It's important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you "leaky gut" which leads to worsening of disease. The intestinal tract's position and processes are integral in keeping your body healthy because it is the body's first line ...
  http://jensrajourney.blogspot.com/2012/
*  Plus it
OBJECTIVE: To evaluate the prophylactic effect of ranitidine 150 mg twice daily in patients requiring one of the following non-steroidal anti-inflammatory drugs: naproxen, piroxicam, diclofenac, and indomethacin. In addition, risk factors were studied in order to help in targeting of such treatment to specific groups of patients. DESIGN: Double blind, placebo controlled, randomised, parallel group with endoscopic assessments at 0, 4, and 8 weeks. SETTING: Multicentre outpatient study at secondary referral centres in five European countries. PATIENTS--297 patients with rheumatoid arthritis or osteoarthritis over the age of 18 without lesions in the stomach and duodenum at baseline endoscopy (after one week without taking non-steroidal anti-inflammatory drugs). Those taking other antirheumatic agents, concomitant ulcerogenic ...
  http://www.bmj.com/content/297/6655/1017
*  DJD | Cherrydown Vets
Drugs a) NSAIDs. The cornerstone of DJD treatment is Non Steroidal Anti-Inflammatory Drugs (NSAIDS). They have both anti-inflammatory and analgesic (pain killing) effects. All NSAIDs have the potential to cause side effects in some animals. These include: - Gastro-intestinal side effects such as vomiting and diarrhoea can occur. More seriously ulceration of the gastro-intestinal tract can occur. This causes vomit with blood in it, black tar like faeces (malaena), and can be fatal if left untreated. - Exacerbation of degradation of the articular cartilage by increasing cartilage breakdown or by reducing glycosaminoglycan synthesis. Thus, the drug that is most commonly used for treating DJD has been shown to speed up the progress and deterioration of the disease. - Kidney toxicity. Nsaids can be damaging to kidneys especially where there is existing kidney disease or when there is risk of low ...
  https://www.cherrydownvets.co.uk/news/tag/djd/
*  Study Links Long-term NSAID Use to Lower Colorectal Cancer Risk
Danish researchers conducted a population-based, case-control study that found an association between long-term, continuous use of low-dose aspirin and long-term use of nonaspirin nonsteroidal anti-inflammatory drugs and decreased colorectal cancer risk.
  http://www.aafp.org/news/health-of-the-public/20150902nsaidscrc.html
*  Drug treatment, Limb Joints, Other Areas of Pain
Although the disease cannot be cured, anti-inflammatory drugs, through pain reduction, often allow improvement in sleep and general well-being, resulting in a greater ability to carry out exercises. Analgesics themselves have a very little role, if any, in this condition. The symptoms-related inflammation and therefore non-steroidal anti-inflammatory drugs are appropriate. However, for those individuals who cannot tolerate non-steroidal anti-inflammatory drugs, usually with gastrointestinal complications, a pure analgesic may be the only alternative. This is why it is important to take this medication when the stomach contains food, to protect the stomach lining from any damage. However, these drugs are not habit-forming. There are over twenty different non-steroidal ...
  http://homepages.which.net/~ks.burrell/nassdb/nassdb_7.htm
*  Chondroitin
Clinical experience likewise suggests that some dogs and cats may appreciably benefit from chondroitin administration and others not at all. It is difficult to anticipate which animals are most likely to respond. Given the potential for benefit and the extremely low risk of any adverse side effects, chondroitin supplementation is always recommended for animals with joint pain. Where a benefit is seen, doses of more expensive and potentially deleterious drugs may be reduced, including the NSAIDs (non steroidal anti-inflammatory drugs) such as aspirin, carprofen and meloxicam. Because chondroitin protects mucosal barriers, it may not only enhance pain relief in animals administered NSAIDS, but help protect their intestinal tracts from ulcerations which are occasionally seen as a side effect of NSAID use.. Research in laboratory animals suggests that chondroitin dissolved in water before administration is more ...
  http://www.lifelearn-cliented.com/iframe.php?action=view&clinic=4305&rid=694&c=&print=1
*  Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure
Non-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the aetiology of acute renal failure (ARF), but epidemiological studies examining this association have produced disparate results. We conducted a case-control study using a purposebuilt record-linkage database for a population of 420 600 patients, resident in Tayside since May 1990. Patients (n = 207) hospitalized with a diagnostic code for ARF between 1990 and 1992 had their diagnosis validated by a renal physician. Six community controls and two hospital controls, matched for age and sex, were generated for each of these cases. Exposure to dispensed oral NSAIDs, topical NSAIDs and aspirin during the 90 days prior to the index date were investigated (recent exposure), as was exposure at any time since January 1989 (previous exposure). The most significant associations were modelled using conditional logistic regression. When community controls were used, recent exposure ...
  https://www.stir.ac.uk/research/hub/publication/4646
*  Nicox - NOblog: des news de NCX 4040
Nitric oxide-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs) are a promising class of compounds that cause cell cycle perturbations and induce apoptosis in cell lines from different tumors. We investigated the activity of a recently developed NO-NSAID (NCX 4040) in bladder cancer cell lines (HT1376 and MCR). Cells were treated with different drug concentrations for different exposure times. Cytostatic and cytocidal activity was tested by SRB assay and apoptosis was evaluated by TUNEL analysis, ANNEXIN V assay and fluorescence microscopy. To further investigate the cell death-inducing mechanisms of NCX 4040, we analyzed gp-170, caspase expression and mitochondrial membrane potential (Delta Psi) depolarization. NCX 4040 showed a striking cytocidal activity in both cell lines, reaching LC(50) at a 10-mu M and 50-mu M concentrations in HT1376 and in MCR cells, respectively, after an exposure of only 6 h followed by an 18-h washout. ...
  http://nicox.blogspot.com/2005/10/des-news-de-ncx-4040.html
*  Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat |...
The metabolic fate of nitric oxide (NO) released from nitroaspirin, benzoic acid, 2-(acetyloxy)-3-[(nitrooxy)methyl]phenyl ester (NCX 4016), the lead compound of a new class of NO-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs), has been studied in the rat following p.o. and i.p. administration of 100 mg/kg, by monitoring in plasma the bioactive storage forms of NO (S-nitrosothiols, RS-NO) and its oxidation products (nitrites/nitrates, NOx) by a chemiluminescent assay. In parallel, plasma was analyzed for unchanged drug and metabolites by reverse-phase HPLC. In orally treated rats, no unchanged drug is observed in the 0-24 h interval post-dosing, but only salicylic acid (SA), NOx and RS-NO. The time-course of SA formation parallels that of plasma NOx (plateau after 6 h). Nitrosothiols in plasma are detectable at 1 h, peak at 4 h post-administration, and decline thereafter. The results relative to i.p. administration show a more ...
  https://air.unimi.it/handle/2434/26733