Excitatory amino acid receptor antagonist - Wikipedia
An excitatory amino acid receptor antagonist, or glutamate receptor antagonist, is a chemical substance which antagonizes one ... Excitatory amino acid receptor agonist Excitatory amino acid reuptake inhibitor N-methyl-D-aspartate receptor antagonist MeSH ... Excitatory amino acid antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ... AP5 Barbiturates Dextromethorphan Dextrorphan Dizocilpine Ethanol Ibogaine Ifenprodil Ketamine Kynurenic acid Memantine Nitrous ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_antagonist
Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding...
Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ...http://jpet.aspetjournals.org/content/313/3/1066
Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists...
Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931324
Dr Stephen Thompson - University of Plymouth
... the effects of ionotropic andmetabotropic excitatory amino acid receptor antagonists. Brain Res. 595 87-97. ... King,A.E., Thompson,S.W.N., Urban,L. and Woolf,C.J. (1988) An intracellularanalysis of amino acid induced excitations of deep ... Thompson,S.W.N. and Wall, P.D. (1996) The effect ofGABA and 5-HT receptor antagonists on rat dorsal root potentials. Neurosci. ... cooperation ofpeptides and excitatory amino acids? In CellularMechanisms of Sensory Processing (the Somatosensory System) Ed. L ...https://www.plymouth.ac.uk/staff/stephen-thompson
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their...
Lodge D, Johnson KM (1990) Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol Sci 11: 81-86PubMed ... NMDA Receptor Noradrenaline Release Kainate Receptor Excitatory Amino Acid Receptor Cortical Synaptosome These keywords were ... Structure-activity relationship in the development of excitatory amino acid receptor agonists and competitive antagonists. ... In conclusion, presynaptic NMDA receptors mediate stimulation of NA release. Ethanol probably acts at this receptor system. ...https://rd.springer.com/chapter/10.1007/978-3-7091-9175-0_16
d-Methadone Is Antinociceptive in the Rat Formalin Test | Journal of Pharmacology and Experimental Therapeutics
1992) Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur. J. Pharmacol. ... Pretreatment with a competitive NMDA receptor antagonist [e.g., APV[3-amino-5-phosphonovaleric acid] or a noncompetitive NMDA ... an NMDA receptor antagonist, but not by a non-NMDA or an NK-1 receptor antagonist (Okano et al., 1993). Table 1 demonstrates ... 1994) Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci. ...http://jpet.aspetjournals.org/content/283/2/648.long
Human Metabolome Database: Showing metabocard for Aminoadipic acid (HMDB0000510)
Kynurenic acid is a broad spectrum excitatory amino acid receptor antagonist. Recent studies have shown that aminoadipic acid ... This compound belongs to the class of chemical entities known as alpha amino acids. These are amino acids in which the amino ... A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. J ... Studies in rats indicate that aminoadipic acid (along with the 3 branched chain amino acid - Leu, Val and Ile) levels are ...http://www.hmdb.ca/metabolites/HMDB0000510
Neurotransmitter Modulation of Neuronal Damage Following Cerebral Ischemia: Effects on Protein Ubiquitination | SpringerLink
Block, G.A., Pulsinelli, W.A. (1987) Excitatory amino acid receptor antagonists: Failure to prevent ischemic neuronal damage. J ... or post-treated with the non-competitive NMDA antagonist MK-801. In contrast, using an alpha 2-adrenergic receptor antagonist, ... Coyle, J.T., Bird, S.J., Evans, R.H., Gulley, R.L., Nadler, J.V., Nicklas, W.J., Onley, J.W. (1981) Excitatory amino acid ... In: Recent Advances in Excitatory Amino Acid Research ( Lehman, J. and Turski, L. eds.) Allan Liss Inc., N.Y. in press.Google ...https://link.springer.com/chapter/10.1007/978-1-4684-5562-5_34
Activation of NMDA Receptors in the Suprachiasmatic Nucleus Produces Light-Like Phase Shifts of the Circadian Clock In Vivo |...
1989) Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to ... Antagonists. Animals received 200 nl microinjections of 10 mm NMDA, 10 mm NMDA plus 10 mm 2-amino-5-phosphopentanoic acid (AP-5 ... by coinjection of the NMDA antagonist 2-amino-5-phosphopentanoic acid but were slightly attenuated by the non-NMDA antagonist 6 ... These two antagonists did not induce phase shifts when injected alone. Because activation of non-NMDA receptors is usually ...http://www.jneurosci.org/content/19/12/5124
Excitatory amino acid receptor ligand - Wikipedia
They include excitatory amino acid receptor agonists and excitatory amino acid receptor antagonists.. ... Excitatory amino acid receptor ligands are ligands of excitatory amino acid receptors (EAARs), also known as glutamate ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_ligand
Published Ahead-of-Print : Pediatric Emergency Care
Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside. Havali, ... Diagnostic Value of Serum Urokinase-Type Plasminogen Activator Receptor in Children With Acute Appendicitis. Oztan, Mustafa ...http://journals.lww.com/pec-online/toc/9000/00000
HA-966 - Wikipedia
"Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice". European Journal of ... 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist ... The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ... HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (−)-HA-966 is a potent gamma-butyrolactone-like ...https://en.wikipedia.org/wiki/HA-966
Selfotel - Wikipedia
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. Journal of ... receptor antagonists in pigeons: cross-tolerance between PCP-like compounds and competitive NMDA antagonists. Journal of ... PMID 11172782 Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain ... CGS 19755: a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant, anxiolytic and anti- ...https://en.wikipedia.org/wiki/Selfotel
Strychnine: A Potent Competitive Antagonist of α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors In Rat Hippocampal...
1994) A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal ... nicotinic acetylcholine receptor. α-BGT. α-bungarotoxin. CNS. central nervous system. GABA. γ-amino butyric acid. MEM. minimum ... 1991) Kinetic analysis of antagonist action at N-methyl-d-aspartic acid receptors: Two binding sites each for glutamate and ... 1990) Ligand-gated ion channels in the brain: The amino acid receptor superfamily. Neuron 5:383-392. ...http://jpet.aspetjournals.org/content/284/3/904
Glutamatergic - Wikipedia
Examples include excitatory amino acid receptor agonists, excitatory amino acid receptor antagonists, and excitatory amino acid ... is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. ...https://en.wikipedia.org/wiki/Glutamatergic
IL36RN - Interleukin-36 receptor antagonist protein - Homo sapiens (Human) - IL36RN gene & protein
... by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 ... Interleukin-36 receptor antagonist proteinAdd BLAST. 154. Amino acid modifications. Feature key. Position(s). Description ... Interleukin-36 receptor antagonist protein. Short name: IL-36Ra1 Publication. ,p>Manually curated information that is based on ... "Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.". Marrakchi S., Guigue P., Renshaw B.R., Puel ...http://www.uniprot.org/uniprot/Q9UBH0
Excitatory Amino Acid Neurotoxicity | Springer for Research & Development
The excitatory potency of the acidic amino acids glutamate and aspartate in various regions of the central nervous system (CNS ... Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. ... Structure-function studies on N-oxalyldiamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP ... The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989; 244(4906):798-800.PubMedCrossRef ...https://rd.springer.com/chapter/10.1007/978-1-4615-0123-7_1
Hudson B[au] - PubMed - NCBI
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection ... Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). ... Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4. ... Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Hudson+B&link_type=AUTHORSEARCH&cmd=search&term=Hudson+B%5Bau%5D&dispmax=50
Glutamate Receptors - Glutamate Receptor Summary Report | CureHunter
Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ... Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They ... Glutamate Receptors: Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. ... ion channels, and metabotropic receptors which act through second messenger systems. ...http://www.curehunter.com/public/keywordSummaryD017470.do
Effects of Laparotomy on Spontaneous Exploratory Activity and Conditioned Operant Responding in the Rat:A Model for...
Zahn PK, Umali E, Brennan TJ: Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat ... Pogatzki EM, Zahn PK, Brennan TJ: Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the ... 26 Amino acid release is increased in the cord after this procedure, and non-N -methyl-d-aspartate antagonists attenuate the ... Yamamoto T, Sakashita Y: The role of the spinal opioid receptor like1 receptor, the NK-1 receptor and cyclooxygenase-2 in ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1942891
Excitatory amino acid reuptake inhibitor - Wikipedia
... reuptake inhibitor Glycine reuptake inhibitor Excitatory amino acid receptor agonist Excitatory amino acid receptor antagonist ... An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory ... October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as ... neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs). Examples ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_reuptake_inhibitor
CO2 that also contained 2 mm kynurenic acid, an excitatory amino acid receptor antagonist. SPNs within the IML were targeted, ... but not the glycine receptor antagonist strychnine (Stry) or the GABAB receptor antagonist CGP55458A (D). ... Strychnine is considered as a selective glycine receptor antagonist; however, it may cross-react on GABA-A receptors when ... Metabotropic GABAB receptors are also expressed in SPNs (Whyment et al., 2004); therefore, the effect of the GABAB antagonist ...http://www.jneurosci.org/content/28/47/12445
1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES - Patent application
5,153,196 to be excitatory amino acid receptor antagonists. These compounds were synthesized from 1,2-diaminobenzenes which ... myristic acid, behenic acid, pentadecanoic acid, linoleic acid, elaidic acid, brasidic acid, erucic acid or oleic acid, which ... for example palmitic acid, lauric acid, tridecanoic acid, margaric acid, stearic acid, arachidic acid, ... 0220] Exemplary acid addition salts include acetates (such as those formed with acetic acid or trihaloacetic acid, for example ...http://www.patentsencyclopedia.com/app/20120302564
Evidence of GLP-1-Mediated Neuroprotection in an Animal Model | Peripheral Neuropathy | Nervous System
Amino acid sequences for GLP-1, Ex4 and the GLP-1 receptor antagonist, Exendin (9-39). The purple shading represents the amino ... A control group was infused with a scrambled inactive, 30-amino acid peptide (n = 12; designated: IAP). Incisions were sutured ... a competitive antagonist of the GLP-1 receptor (Figure 1), infused at a rate of 0.24 nM/ kg/min in combination with 3.5 GLP-1 ( ... specifically due to the PSS sequence at the beginning of the 9-amino acid tail), is more potent at maintaining plasma insulin ...https://www.scribd.com/document/82447108/Evidence-of-GLP-1-Mediated-Neuroprotection-in-an-Animal-Model
Spinal Adenosine Receptor Activation Reduces Hypersensitivity after Surgery by a Different Mechanism Than after Nerve Injury |...
Zahn PK, Umali E, Brennan TJ: Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat ... methyl-D-aspartate receptor antagonists 24 and neurokinin-1 receptor antagonists 25 are effective in this model. Further, ... Yamamoto T, Sakashita Y: The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in ... Zahn PK, Brennan TJ: Lack of effect of intrathecally administered N -methyl-d-aspartate receptor antagonists in a rat model for ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1943070
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