Excitatory amino acid receptor antagonist - Wikipedia
An excitatory amino acid receptor antagonist, or glutamate receptor antagonist, is a chemical substance which antagonizes one ... Excitatory amino acid receptor agonist Excitatory amino acid reuptake inhibitor N-methyl-D-aspartate receptor antagonist MeSH ... Excitatory amino acid antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ... AP5 Barbiturates Dextromethorphan Dextrorphan Dizocilpine Ethanol Ibogaine Ifenprodil Ketamine Kynurenic acid Memantine Nitrous ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_antagonist
Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding...
Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ... Identification of Subunit- and Antagonist-Specific Amino Acid Residues in the N-Methyl-d-aspartate Receptor Glutamate-Binding ...http://jpet.aspetjournals.org/content/313/3/1066
Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists...
Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ... Roles of Amino Acids and Subunits in Determining the Inhibition of Nicotinic Acetylcholine Receptors by Competitive Antagonists ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931324
Booktopia - Advances in Pharmacology, Volume 46 by J. Thomas August, 9780120329472. Buy this book online.
Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists. Pharmacologic Therapy of Obsessive Compulsive Disorder. ... Quinolinic Acid in Neurological Disease: Opportunities for Novel Drug Discovery. Pharmacologic Management of Shock-Induced ...https://www.booktopia.com.au/advances-in-pharmacology-j-thomas-august/prod9780120329472.html
Dr Stephen Thompson - University of Plymouth
... the effects of ionotropic andmetabotropic excitatory amino acid receptor antagonists. Brain Res. 595 87-97. ... King,A.E., Thompson,S.W.N., Urban,L. and Woolf,C.J. (1988) An intracellularanalysis of amino acid induced excitations of deep ... Thompson,S.W.N. and Wall, P.D. (1996) The effect ofGABA and 5-HT receptor antagonists on rat dorsal root potentials. Neurosci. ... cooperation ofpeptides and excitatory amino acids? In CellularMechanisms of Sensory Processing (the Somatosensory System) Ed. L ...https://www.plymouth.ac.uk/staff/stephen-thompson
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their...
Lodge D, Johnson KM (1990) Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol Sci 11: 81-86PubMed ... NMDA Receptor Noradrenaline Release Kainate Receptor Excitatory Amino Acid Receptor Cortical Synaptosome These keywords were ... Structure-activity relationship in the development of excitatory amino acid receptor agonists and competitive antagonists. ... In conclusion, presynaptic NMDA receptors mediate stimulation of NA release. Ethanol probably acts at this receptor system. ...https://rd.springer.com/chapter/10.1007/978-3-7091-9175-0_16
d-Methadone Is Antinociceptive in the Rat Formalin Test | Journal of Pharmacology and Experimental Therapeutics
1992) Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur. J. Pharmacol. ... Pretreatment with a competitive NMDA receptor antagonist [e.g., APV[3-amino-5-phosphonovaleric acid] or a noncompetitive NMDA ... an NMDA receptor antagonist, but not by a non-NMDA or an NK-1 receptor antagonist (Okano et al., 1993). Table 1 demonstrates ... 1994) Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci. ...http://jpet.aspetjournals.org/content/283/2/648.long
Human Metabolome Database: Showing metabocard for Aminoadipic acid (HMDB0000510)
Kynurenic acid is a broad spectrum excitatory amino acid receptor antagonist. Recent studies have shown that aminoadipic acid ... This compound belongs to the class of chemical entities known as alpha amino acids. These are amino acids in which the amino ... A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. J ... Studies in rats indicate that aminoadipic acid (along with the 3 branched chain amino acid - Leu, Val and Ile) levels are ...http://www.hmdb.ca/metabolites/HMDB0000510
Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures. -...
... receptor-mediated mechanisms. The EPSPs were reversibly inhibited by approximately 50% during application of 30 microM NE. NE ... An analysis of the effects of excitatory amino acid receptor antagonists on evoked field potentials in the olfactory bulb.. *I ... Excitatory amino acid receptors and synaptic plasticity.. *G L Collingridge, W Singer ... Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors ...https://www.semanticscholar.org/paper/Noradrenergic-inhibition-of-synaptic-transmission-Trombley-Shepherd/902444d9402c060a675f9905b4ee04b5c554251d
Neurotransmitter Modulation of Neuronal Damage Following Cerebral Ischemia: Effects on Protein Ubiquitination | SpringerLink
Block, G.A., Pulsinelli, W.A. (1987) Excitatory amino acid receptor antagonists: Failure to prevent ischemic neuronal damage. J ... or post-treated with the non-competitive NMDA antagonist MK-801. In contrast, using an alpha 2-adrenergic receptor antagonist, ... Coyle, J.T., Bird, S.J., Evans, R.H., Gulley, R.L., Nadler, J.V., Nicklas, W.J., Onley, J.W. (1981) Excitatory amino acid ... In: Recent Advances in Excitatory Amino Acid Research ( Lehman, J. and Turski, L. eds.) Allan Liss Inc., N.Y. in press.Google ...https://link.springer.com/chapter/10.1007/978-1-4684-5562-5_34
Activation of NMDA Receptors in the Suprachiasmatic Nucleus Produces Light-Like Phase Shifts of the Circadian Clock In Vivo |...
1989) Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to ... Antagonists. Animals received 200 nl microinjections of 10 mm NMDA, 10 mm NMDA plus 10 mm 2-amino-5-phosphopentanoic acid (AP-5 ... by coinjection of the NMDA antagonist 2-amino-5-phosphopentanoic acid but were slightly attenuated by the non-NMDA antagonist 6 ... These two antagonists did not induce phase shifts when injected alone. Because activation of non-NMDA receptors is usually ...http://www.jneurosci.org/content/19/12/5124
Excitatory amino acid receptor ligand - Wikipedia
They include excitatory amino acid receptor agonists and excitatory amino acid receptor antagonists.. ... Excitatory amino acid receptor ligands are ligands of excitatory amino acid receptors (EAARs), also known as glutamate ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_ligand
Published Ahead-of-Print : Pediatric Emergency Care
Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside. Havali, ... Diagnostic Value of Serum Urokinase-Type Plasminogen Activator Receptor in Children With Acute Appendicitis. Oztan, Mustafa ...http://journals.lww.com/pec-online/toc/9000/00000
Muteins of the c5a anaphylatoxin, nucleic acid molecules encoding such muteins, and pharmaceutical uses of muteins of the c5a...
... which are C5a receptor antagonists, to nucleic acid molecules comprising a nucleotide sequence encoding such muteins of C5a ... The term "amino acid residue" as used herein refers to an amino acid either in the D or L form or to an amino acid mimetic that ... Such a mutein of the C5a anaphylatoxin is a mutein that is a C5a receptor antagonist, wherein the amino acid residue naturally ... 1. A mutein of the C5a anaphylatoxin which is a C5a receptor antagonist wherein the amino acid residue naturally occurring at ...http://www.freepatentsonline.com/y2006/0052294.html
HA-966 - Wikipedia
"Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice". European Journal of ... 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist ... The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ... HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (−)-HA-966 is a potent gamma-butyrolactone-like ...https://en.wikipedia.org/wiki/HA-966
CGP 39551 Supplier | CAS 127910-32-1 | CGP39551 | Tocris Bioscience
Potent, selective and competitive NMDA antagonist. Cited in 2 publications. ... D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal ... Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and ... Home / Pharmacology / Ion Channels / Ligand-gated Ion Channels / Glutamate (Ionotropic) Receptors / NMDA Receptors / NMDA ...https://www.tocris.com/products/cgp-39551_1409
Strychnine: A Potent Competitive Antagonist of α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors In Rat Hippocampal...
1994) A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal ... nicotinic acetylcholine receptor. α-BGT. α-bungarotoxin. CNS. central nervous system. GABA. γ-amino butyric acid. MEM. minimum ... 1991) Kinetic analysis of antagonist action at N-methyl-d-aspartic acid receptors: Two binding sites each for glutamate and ... 1990) Ligand-gated ion channels in the brain: The amino acid receptor superfamily. Neuron 5:383-392. ...http://jpet.aspetjournals.org/content/284/3/904
Selfotel - Wikipedia
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. Journal of ... receptor antagonists in pigeons: cross-tolerance between PCP-like compounds and competitive NMDA antagonists. Journal of ... PMID 11172782 Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain ... CGS 19755: a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant, anxiolytic and anti- ...https://en.wikipedia.org/wiki/Selfotel
Pharmacological Properties of Metabotropic Glutamate Receptors | SpringerLink
Metabotropic glutamate receptors (mGluRs) were initially discovered by their unique coupling mechanism and pharmacological ... Excitatory amino acid agonist-antagonist interactions at 2-amino-4-phosphonobutyric acid-sensitive quisqualate receptors ... Glutamate Receptor Xenopus Oocyte Metabotropic Glutamate Receptor Ionotropic Glutamate Receptor Ibotenic Acid These keywords ... and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. ...https://link.springer.com/chapter/10.1007/978-1-4757-2298-7_2
IL36RN - Interleukin-36 receptor antagonist protein - Homo sapiens (Human) - IL36RN gene & protein
... by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 ... Interleukin-36 receptor antagonist proteinAdd BLAST. 154. Amino acid modifications. Feature key. Position(s). Description ... Interleukin-36 receptor antagonist protein. Short name: IL-36Ra1 Publication. ,p>Manually curated information that is based on ... "Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.". Marrakchi S., Guigue P., Renshaw B.R., Puel ...http://www.uniprot.org/uniprot/Q9UBH0
Excitatory Amino Acid Neurotoxicity | Springer for Research & Development
The excitatory potency of the acidic amino acids glutamate and aspartate in various regions of the central nervous system (CNS ... Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. ... Structure-function studies on N-oxalyldiamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP ... The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989; 244(4906):798-800.PubMedCrossRef ...https://rd.springer.com/chapter/10.1007/978-1-4615-0123-7_1
Cholecystokinin B receptor - Wikipedia
"A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists". Nature. 362 ... type B gastrin/cholecystokinin receptor binding. • gastrin receptor activity. • cholecystokinin receptor activity. • peptide ... "A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity ... gastric acid secretion. • positive regulation of cytosolic calcium ion concentration. • cell surface receptor signaling pathway ...https://en.wikipedia.org/wiki/Cholecystokinin_B_receptor
Glutamatergic - Wikipedia
Examples include excitatory amino acid receptor agonists, excitatory amino acid receptor antagonists, and excitatory amino acid ... is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. ...https://en.wikipedia.org/wiki/Glutamatergic
Hudson B[au] - PubMed - NCBI
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection ... Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). ... Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4. ... Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Hudson+B&link_type=AUTHORSEARCH&cmd=search&term=Hudson+B%5Bau%5D&dispmax=50
Excitatory amino acid reuptake inhibitor - Wikipedia
... reuptake inhibitor Glycine reuptake inhibitor Excitatory amino acid receptor agonist Excitatory amino acid receptor antagonist ... An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory ... October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as ... neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs). Examples ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_reuptake_inhibitor