*  Prostaglandin antagonist - Wikipedia
Prostaglandin antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ... A Prostaglandin antagonist is a hormone antagonist acting upon prostaglandin. NSAIDs inhibit cyclooxygenase and reduce ... prostaglandin synthesis. Corticosteroids inhibit phospholipase A2 production by boosting production of lipocortin, an inhibitor ...
  https://en.wikipedia.org/wiki/Prostaglandin_antagonist
*  Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils | Journal...
2005) Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. J Med Chem 48: 6174-6177. ... Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils. Chantal ... Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils. Chantal ... Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils. Chantal ...
  http://jpet.aspetjournals.org/content/320/1/173
*  A Live Imaging Cell Motility Screen Identifies Prostaglandin E2 as a T Cell Stop Signal Antagonist | The Journal of Immunology
... as novel T cell stop signal antagonists. The identification of PGs as stop signal antagonists is particularly surprising ... A Live Imaging Cell Motility Screen Identifies Prostaglandin E2 as a T Cell Stop Signal Antagonist. Andrew J. Wiemer, ... A Live Imaging Cell Motility Screen Identifies Prostaglandin E2 as a T Cell Stop Signal Antagonist ... A Live Imaging Cell Motility Screen Identifies Prostaglandin E2 as a T Cell Stop Signal Antagonist ...
  http://www.jimmunol.org/content/187/7/3663.long
*  US5445606A - Indicator for iontophoresis system - Google Patents
... parathyroid hormone antagonists; prostaglandin antagonists; pentigetide; protein C; protein S; renin inhibitors; thymosin alpha ... angiotensin II antagonist; antidiuretic hormone agonists; antidiuretic hormone antagonists; bradykinin antagonists; CD4; ... thrombolytics; TNF; vaccines; vasopressin antagonist analogs; alpha-1 anti-trypsin (recombinant); and TGF-beta. ... prostaglandins; proteins; peptides; psychostimulants; sedatives; and tranquilizers. ...
  https://patents.google.com/patent/US5445606
*  Patent US5639738 - Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic ... - Google Patents
... in an amount sufficient to block prostaglandin synthesis, (b) hyaluronic acid or a pharmaceutically acceptable salt thereof in ... Alan R. Liss, Inc., Modulation of Immunity in Cancer Patients by Prostaglandin Antagonists, Immunity to Cancer II , 1989, pp. ... Use of an ep2 or ep4 receptor antagonist and/or a cox-1 inhibitor for treating cervical cancer. ... Alan R. Liss, Inc., Modulation of Immunity in Cancer Patients by Prostaglandin Antagonists, Immunity to Cancer II, 1989, pp. ...
  http://www.google.ca/patents/US5639738
*  Frontiers | Asthma Endotypes and an Overview of Targeted Therapy for Asthma | Medicine
... and prostaglandin antagonists (CRTH2) (72). A general scheme to choose the appropriate monoclonal antibody based on simple ... Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled ... Such molecules include CXCR2 antagonists (79, 80), 5-lipoxygenase-activating protein inhibitors (81), anti-IL-17 (82), and anti ... Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo- ...
  https://www.frontiersin.org/articles/10.3389/fmed.2017.00158/full
*  Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.
... isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion ... Receptors, Prostaglandin / antagonists & inhibitors, genetics, metabolism*. Receptors, Prostaglandin E / antagonists & ... Furthermore, the decreased acid response was also attenuated by prior administration of the EP3- but not EP1- antagonist. ... Prostaglandin; 0/Receptors, Prostaglandin E; 0/SC 560; 0/Sulfones; 0/prostaglandin EP3 receptor; 0/rofecoxib; 363-24-6/ ...
  http://www.biomedsearch.com/nih/Involvement-prostaglandin-E-receptor-EP3/17928639.html
*  Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
5HT3 antagonists such as ondansetron and granisetron [28] as well as prostaglandin antagonists and 5HT2 and 5HT3 antagonists ... both of which can be blocked by 5HT3 antagonists. One of the early studies using granisetron (a 5HT3 antagonist) showed that 40 ... 5HT3 antagonists and IBS. Mechanistic studies. One of the earliest 5HT3 antagonists, granisetron, has been shown to reduce ... antagonist Cisapride. Motor neurones. Stimulates increased amplitude of oesphageal peristalsis contractions and lower ...
  http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2002.01612.x/full
*  Patent US5883135 - Composition, device, and method for enhanced electrotransport agent delivery - Google Patents
... parathyroid hormone antagonists, prostaglandin antagonists, pentigetide, protein C, protein S, renin inhibitors, thymosin alpha ... thrombolytics, TNF, vaccines, vasopressin antagonist analogs, alpha-1 antitrypsin (recombinant), and TGF-beta. ... angiotensin II antagonists, antidiuretic hormone agonists, antidiuretic hormone antagonists, bradykinin antagonists, CD4, ... prostaglandins; proteins; peptides; psychostimulants; sedatives and tranquilizers. ...
  http://www.google.com/patents/US5883135?dq=5,666,293
*  Patent US20040116859 - Prefillable intradermal delivery device - Google Patents
Prostaglandin antagonists, Prostaglandins, Recombinant soluble receptors, scopolamine, Serotonin agonists and antagonists, ... Sildenafil, Terbutaline, Thrombolytics, Tissue plasminogen activators, TNF-, and TNF-antagonist, the vaccines, with or without ... Growth hormone antagonists, Hirudin and Hirudin analogs such as hirulog, IgE suppressors, Insulin, insulinotropin and analogs, ... Dopamine agonists and antagonists, Enkephalins and other opioid peptides, Epidermal growth factors, Erythropoietin and analogs ...
  http://www.google.com/patents/US20040116859?dq=6,563,928
*  Patente US5423739 - Device and method for iontophoretic drug delivery - Google Patentes
... parathyroid hormone antagonists, prostaglandin antagonists, pentigetide, protein C, protein S, renin inhibitors, thymosin alpha ... thrombolytics, TNF, vaccines, vasopressin antagonist analogs, alpha-1 anti-trypsin (recombinant), and TGF-beta. ... angiotensin II antagonists, antidiuretic hormone agonists, bradykinin antagonists, CD4, ceredase, CS1's, enkephalins, FAB ... prostaglandins, proteins, peptides, psychostimulants, sedatives and tranquilizers. ...
  http://www.google.es/patents/US5423739
*  Patent US5857992 - Device and method of iontophoretic drug delivery - Google Patents
... parathyroid hormone antagonists, prostaglandin antagonists, pentigetide, protein C, protein S, renin inhibitors, thymosin alpha ... thrombolytics, TNF, vaccines, vasopressin antagonist analogs, alpha-1 anti-trypsin (recombinant) and interferon. ... angiotensin II antagonists, antidiuretic hormone agonists, antidiuretic hormone antagonists, bradykinin antagonists, CD4, ...
  http://www.google.com.au/patents/US5857992
*  Inflammatory Responses in Allergic Rhinitis: Traditional Approaches and Novel Treatment Strategies | The Journal of the...
Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, s-5751. J Pharmacol Exp Ther.. (2001). ;298: ... the leukotriene receptor antagonists provide effective symptomatic relief, compared with placebo. For example, pranlukast ... Prostaglandins, primarily PGD2, cause congestion and rhinorrhea.20,21 Kinins are released after allergen challenge; bradykinin ... Other mediators, including prostaglandins (PGs), kinins, and neuropeptides, have been found to be important in AR. ...
  http://jaoa.org/article.aspx?articleid=2092958
*  Atopic Dermatitis [2017]
5.1 Prostaglandin DP2 receptor antagonists 5.1.2 Fevipiprant (Novartis). 5.2 Galectin 3 inhibitors 5.2.1 GR-MD-02 (Galectin ... Fevipiprant (CRTH2 antagonist; Novartis) GR MD 02 (Galectin 3 inhibitor; Galectin) Anti-GATA3 gene therapy (Sterna Biologicals ...
  http://www.aarkstore.com/healthcare/631189/atopic-dermatitis-2017
*  Prostaglandin EP4 receptor - Wikipedia
... and selective prostaglandin EP4 receptor antagonist". Bioorganic & Medicinal Chemistry Letters. 27 (5): 1186-1192. doi:10.1016/ ... Inhibitory receptor antagonists for EP4, including grapiprant (CJ-023,423), ONO-AE3-208, GW627368X, AH23848, and ONO-AE2-227, ... Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans ... Prostaglandin E2 receptor 1 (EP1) Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 3 (EP3) Eicosanoid receptor ...
  https://en.wikipedia.org/wiki/Prostaglandin_EP4_receptor
*  Prostaglandin DP2 receptor - Wikipedia
"On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2 ... Setipiprant (ACT-129968), a selective, orally active antagonist of the (DP2) receptor, proved to be well-tolerated and ... DP2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate ... Prostaglandin DP1 receptor Prostaglandin receptors Prostanoid receptors Eicosanoid receptor GRCh38: Ensembl release 89: ...
  https://en.wikipedia.org/wiki/Prostaglandin_DP2_receptor
*  Setipiprant - Wikipedia
... orally available antagonist of the prostaglandin D2 receptor 2 (DP2). It was initially researched as a treatment for allergies ... doi: 10.1111/cea.12357 PMID 24964348 Norman P. Update on the status of DP2 receptor antagonists; from proof of concept through ... Prostaglandin DP2 receptor Fevipiprant Ramatroban Fretz H, Valdenaire A, Pothier J, Hilpert K, Gnerre C, Peter O, Leroy X, ... Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Science Translational ...
  https://en.wikipedia.org/wiki/Setipiprant
*  Sérgio Henrique Ferreira - Wikipedia
II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. ... In this area he described an antagonist of IL-1 that is now being developed as a model for a new class of analgesics. ... Prostaglandins, aspirin-like drugs and analgesia. Nature New Biology. vol. 240, p. 200-203. Ferreira, S. H. and Nakamura, M. ... Prostaglandins. vol. 18, p. 191-200. Ferreira, S. H., et al. 1988. Interleukin-1b as a potent hyperalgesic agent antagonized by ...
  https://en.wikipedia.org/wiki/S%C3%A9rgio_Henrique_Ferreira
*  Prostaglandin DP1 receptor - Wikipedia
Asapiprant (S-555739) and Laropiprant are selective receptor antagonists of DP1 whereas Vidupiprant is a receptor antagonist ... Prostaglandin receptors Prostanoid receptors Prostaglandin DP2 receptor Eicosanoid receptor GRCh38: Ensembl release 89: ... is primarily a receptor for prostaglandin D2 (PGD2). The receptor is a member of the Prostaglandin receptors belonging to the ... Prostaglandins & Other Lipid Mediators. 107: 48-55. doi:10.1016/j.prostaglandins.2013.07.001. PMID 23850788. Ferré S (2015). " ...
  https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
... an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity". Prostaglandins, leukotrienes, and essential fatty ... 12(S)-HETE and 12(R)-HETE bind to and act as Competitive antagonists of the Thromboxane receptor which mediates the actions of ... Based on the effects of LTB4 receptor antagonists, for example, leukotriene B4 receptor 2 mediates: the rise in cytosolic Ca2+ ... Yoshimoto, T; Takahashi, Y (2002). "Arachidonate 12-lipoxygenases". Prostaglandins & other lipid mediators. 68-69: 245-62. doi: ...
  https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
*  Prostaglandin - Wikipedia
... prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α). Examples of prostaglandin antagonists are: NSAIDs (inhibit ... a progesterone antagonist) To prevent closure of patent ductus arteriosus in newborns with particular cyanotic heart defects ( ... Prostaglandin E2 (PGE2) is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin H2, PGH2 ... "Prostaglandin F2alpha formation from prostaglandin H2 by Prostaglandin-F synthase (PGFS): crystal structure of PGFS containing ...
  https://en.wikipedia.org/wiki/Prostaglandin
*  Antiprogestogen - Wikipedia
... and the silent antagonist aglepristone. For medical abortion, mifepristone is combined with a prostaglandin (e.g., gemeprost). ... Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs ... Antiprogestogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiandrogens. ... Oct 2006). "Progesterone receptor antagonists". Curr Opin Investig Drugs. 7 (10): 882-90. PMID 17086932. Tang, OS.; Ho, PC. ( ...
  https://en.wikipedia.org/wiki/Antiprogestogen
*  Nicolas Bazan - Wikipedia
Prostaglandins 27:203-216, 1984 Birkle DL, Bazan NG: Effects of K+ depolarization on the synthesis of prostaglandins and ... "Platelet-activating factor antagonist inhibition of angiogenesis and tumor growth induced by basic fibroblast growth factor." ... is an endogenous neurotoxin and demonstrated neuroprotection by PAF antagonists. This included the finding that seizure-induced ... During that time, Bazan and his colleagues found prostaglandin D synthetase in the interphotoreceptor matrix and cloned its ...
  https://en.wikipedia.org/wiki/Nicolas_Bazan
*  Portopulmonary hypertension - Wikipedia
Prostaglandin PGE1 (Alprostadil) binds G-protein linked cell surface receptors that activate adenylate cyclase to relax ... 2005;128:164-8 Wilkins et al.Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. Am J ... endothelin receptor antagonists and agents capable of reversing the remodeling of pulmonary vasculature. Inhaled nitric oxide ... Prostacyclin and Prostaglandin E1: Molecular mechanisms and therapeutic utility. Prog Hemostasis Thrombosis 1991;10:307-37 Vane ...
  https://en.wikipedia.org/wiki/Portopulmonary_hypertension
*  Glaucoma medication - Wikipedia
Adrenergic antagonists (nonselective and selective Beta1-antagonists) Alpha 2 agonists Hyperosmotic agents Fotil is a ... Agents in common clinical use include: Prostaglandin analogs Parasympathomimetic (miotic) agents, including cholinergic and ... combination drug consisting of: Pilocarpine, a parasympathomimetic Timolol, a beta-adrenergic receptor antagonist Glaucoma ...
  https://en.wikipedia.org/wiki/Glaucoma_medication