*  Vinpocetine - Wikipedia
Kindling models in rats has shown vinpocetine to exhibit anticonvulsant properties. The most pronounced anticonvulsant effects were observed in Pentylenetetrazole (PTZ)-kindled rats although there was also an effect on amygdala-kindled and neocortically-kindled rats.[8] Vinpocetine has also been shown to abolish [3H]Glu release after in vivo exposure to 4-aminopyridine (4-AP) which suggests an important mechanism for vinpocetine anticonvulsant activity.[9] Vinpocetine has been investigated in animal models as a potential anti-inflammatory agent.[10] [11] Vinpocetine inhibits the up-regulation of NF-κB by TNFα in various cell tests. Reverse transcription polymerase chain reaction also shows that it reduced the TNFα-induced expression of the mRNA of proinflammatory molecules such as interleukin-1 beta, monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1). In mice, vinpocetine reduced lipopolysaccharide inoculation induced polymorphonuclear neutrophil ...
*  Vinca Alkaloids and Platelet Function | Annals of Internal Medicine | American College of Physicians
To the editor: The recent article by Ahn and associates (1) reported the use of slow infusions of vinca alkaloids in vivo to load autologous platelets for the treatment of idiopathic thrombocytopenic purpura. Although serum vinblastine levels are shown, no data are given for levels achieved in the platelets. Under the conditions described, does the patients' platelet-rich plasma have a higher drug content than platelet-poor plasma? Does the alkaloid concentration achieved effect the function of the platelets?. We have shown a platelet dysfunction in patients treated with vincristine (2). The vinca alkaloid concentrations required for the disruption of microtubules and ...
*  Vinpocetine -- Ditch It - Brain Health - LONGECITY
Page 1 of 4 - Vinpocetine -- Ditch It - posted in Brain Health: I have come to the conclusion that vinpocetine should be eradicated from our supplement stashes. This is due in light of evidence brought about by 'dopamine' who is now posting more frequently on our boards.This is taken from M & M, a thread started by dopamine.Vinpocetine (ethyl apovincaminate) is a synthetic derivative of the alkaloid vincamine (from the periwinkle plant vinca minor) and has cerebral blood-flow...
*  Vinca alkaloid - Everything2.com
Vinca alkaloids are a family of anticancer alkaloids that include vinblastine, vincristine, vindesine, and vinorelbine. The first two chemicals occur na...
*  Enhanced anti-tumour effects of Vinca alkaloids given separately from cytostatic therapies.
In polychemotherapy protocols, that is for treatment of neuroblastoma and Ewing sarcoma, Vinca alkaloids and cell cycle-arresting drugs are usually administered on the same day. Here we studied whether this combination enables the optimal antitumour
*  Catharanthine Tartrate | 2468-21-5 | AvaChem Scientific
AvaChem Scientific offers Catharanthine Tartrate | 2468-21-5 for your research needs. Find product specific information including CAS, structure, protocols.
*  Role of vinpocetine in cerebrovascular diseases
Vinpocetine, chemically known as ethyl apovincaminate, is a vinca alkaloid that exhibits cerebral blood-flow enhancing and neuroprotective effects.
*  Role of vinpocetine in cerebrovascular diseases
Vinpocetine, chemically known as ethyl apovincaminate, is a vinca alkaloid that exhibits cerebral blood-flow enhancing and neuroprotective effects.
*  Microtubules and antineoplastic drugs]. - Semantic Scholar
Microtubules, which are composed of polymerized tubulin dimers, play an important role in various cell functions. For example, they maintain cell shape, form mitotic spindles in M phase of cell cycle, and carry an axonal transport in nerve cells. Microtubules have also been an important target of cancer chemotherapy. Vinca alkaloids depolymerize microtubules, the mechanisms of which action have extensively been investigated recently. Clinical trials of vinorelbine (navelbine), a new semisynthetic vinca alkaloid, are ongoing in Japan. One of advantages of the drug is reduced risk of neurotoxicity. Estramustine may act on microtubule-associated proteins (MAPs) as well as tubulin. It shows additive or synergistic cytotoxicity preclinically when used in combination with vinblastine. This combination was active against hormone-refractory prostate cancer. Another novel drug rhizoxin, which has a similar mechanism of action to that of vinca alkaloids, is also a ...
*  Plus it
In the present study, we evaluated the effect of PSC 833 on P-gp function both in vitro and in vivo. Increased cellular accumulation of VCR and VBL by HCT-15 cells, but not by COLO 205 cells, in the presence of PSC 833 (fig. 1) is attributed to the difference in the level of P-gp expression between the two cell lines (Iwahashi et al., 1993; Mano et al., 1997). These results were further supported by the efflux experiments from HCT-15 and COLO 205 cells (fig. 2); PSC 833 reduced the efflux of VCR from HCT-15 cells to a level comparable with that from COLO 205 cells, whereas the efflux of VCR from COLO 205 was unaffected by PSC 833. In addition, no significant effect of PSC 833 on the initial uptake of vinca alkaloids by both cell lines was observed (table 1). The half-maximum enhancement of the cellular uptake of vinca alkaloids by HCT-15 cells produced by PSC 833 was achieved at a concentration of 0.05 μM in the medium (fig. 3), which is comparable with previously reported ...
*  Cora® Cascade™ Magenta Vinca Flower Seeds
Sensational Vinca Cora® has transformed the way we can use Vinca in hot and humid climates, and now it's available in glorious trailing form! Cascade™ has all the disease resistance, heavy flowering, and lush foliage of its cousin, plus larger than ever blooms that resist fading and seem to last forever. Fill your flowerpots, hanging baskets, and windowboxes with this carefree annual!Just 6 to 8 inches high, Cascade™ spreads 32 to 36 inches wide, with flowers every inch of the way. The blooms are very evenly distributed, eliminating the 'bald spots' that plague some Vinca. And these flowers are a bit larger than most other Vincas', standing out brilliantly against glossy, dense green foliage. You can see the vigor in every leaf and bloom of Cascade™ -- it just looks healthy and ready to flourish!Cascade™ is perfect for containers of all kinds, particularly those high enough to show off its full ...
*  The Colors of Vinca | Home Guides | SF Gate
For a fast-growing groundcover with a profusion of flowers, many gardeners turn to vinca. The two species Vinca major and Vinca minor both thrive in U.S. Department of Agriculture plant hardiness ...
*  Q&A: Fuel Repatriation Project from Vinca Institute | IAEA
A conversation with Pablo Adelfang, Head of the IAEA´s Research Reactor Section:. What type of reactor is housed at Vinca? What type of fuel did it use and who supplied that fuel?. The research reactor at the Vinca Institute of Nuclear Sciences was a 6.5 MW heavy water reactor. It was a Soviet designed and supplied reactor. The fuel was also supplied by the Soviet Union, and was 80% Highly Enriched Uranium (HEU), although the reactor used 2% enriched uranium as well. The reactor and fuel were not of a very common design.. What type of activities were carried out in the Vinca reactor? How many years did it operate, and when was it shut down?. The reactor first went critical in 1959 and was shut down in 1984. While it was operational, it was used to carry out physics experiments, dosimetry work, some material irradiation, and radioisotope production.. What happened to the nuclear fuel when the reactor was shut down?. The spent fuel was stored at the reactor ...
*  Puzzles-Games.eu Search - vinca
vinca Puzzles-Games.eu. Play vinca puzzles games or send vinca puzzle game greeting ecards to your friends! Just upload an image and make your own puzzle game.
*  Vinca Plants | Garden Guides
Vinca is toxic. Every part of the plant--roots, stems, leaves and blossoms--causes symptoms if it is ingested. Vinca is harmful to dogs, cats, horses and humans. If any part of the plant is ...
*  Dainty Vinca major 'Bowles Mauve' from £11.95
Buy Vinca major 'Bowles Mauve' from Sarah Raven: Vinca major 'Bowles Mauve' is the best blue periwinkle and flowers for a long period. Pick yours today!
*  Vinblastine (Velban®, Alkaban AQ) | OncoLink
Vinblastine is a vinca alkaloid chemotherapy used in the palliative treatment of several types of lymphomas, testicular cancer and breast cancer.
*  vinorelbine
If you are cancer patients and have to receive chemotherapy agents such as taxanes (paclitaxol- Taxol and docetaxel-Taxotere), vinca alkaloids (vinorelbine-Navelbine) and platinum compounds (cisplatin, carboplatin - Paraplatin and oxaliplatin - Eloxatin), it is likely that you might experience chemotherapy … Continue reading →. ...
*  Plus it
Among the factors related to drug resistance, TUBB3 plays a prominent role in several tissues. Recently, Gan et al. (27) have shown that TUBB3 is overexpressed not only in cells treated with microtubule-interacting agents, such as taxanes and Vinca alkaloids, but also in cells resistant to DNA-damaging drugs such as cisplatin. Therefore, this finding suggests that TUBB3 represents an important factor of resistance and a main component of a survival program alas activated in drug-resistant patients.. This work was mainly aimed to identify a novel druggable pathway useful to block TUBB3 function in drug-resistant cells. So, we discovered that two TUBB3 isoforms exist in the cells. The first one is localized in the mitochondrion, is unglycosylated and unphosphorylated, and is not overexpressed in drug-resistant cells. During gel electrophoresis, mitochondrial TUBB3 exhibits a basic shift in the isoelectric point and a higher mobility, conferring to the isoform an apparently lower molecular ...
*  Iranian Culturebase : Herbalism(Vinca/)
... , Iran News, Complete Iranian History, Selection of comprehensive Glossary entries with Alphabetical index and Encyclopedic Reference
*  55 Vinca Way, Forrestfield for sale | Professionals Real Estate (Property ID 720094)
SCHMICKO!! - 55 Vinca Way, Forrestfield WA 6058 House for sale. These are the homes that Team Newland loves to present. This gorgeous and spacious 3x1 home is going to fly out the door so don't delay your inspectio...
*  39 Vinca St, Homosassa, FL 34446 - MLS# 752201 | CENTURY 21
Land for Sale: Land located at 39 Vinca St, Homosassa, FL 34446 on sale for $98,000. MLS# 752201. Great price for this lot in Oak Village of Sugarmill Woods.
*  Early Vinca Script, Old European, Bird Goddess Ki-Ri-Ke
... / 2004/5 Franz Gnaedinger, fgn(a)bluemail.ch, fg(a)seshat.ch, www.seshat.ch ...
*  1426 Vinca Place, Superior, CO 80027 | MLS 4201702 | Listing Information
See details for 1426 Vinca Place, Superior, CO 80027, 4 Bedrooms, 3 Full Bathrooms, 4118 Sq Ft., Price: $599,900, MLS#: 4201702, Courtesy: Staufer Team Real Estate, Provided by: REcolorado