*  DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES - Patent application
... plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic DNA regions are selected ... selectively amplifying a plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic ... and total aneuploidy from segmental aneuploidy. Segmental aneuploidies can be caused by an intra-chromosomal event such as a ... Patent application title: DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES. Inventors: ...
  http://www.patentsencyclopedia.com/app/20120183963
*  Patent US6258540 - Non-invasive prenatal diagnosis - Google Patents
Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US20090170077 *. 29 Aug 2005. 2 Jul 2009. ... Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment. US20100113286 *. 5 May 2008. 6 May 2010. ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US8986966. 21 Mar 2007. 24 Mar 2015. The ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US9109256. 27 Oct 2005. 18 Aug 2015. ...
  http://www.google.ca/patents/US6258540
*  aneuploidy
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... AginganeuploidyATMbrca1brca2breast cancercancercell cycledna repairEd Parkkomenli-fraumeniMRNnon-dysjunctionp53progeriarecharge ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... aneuploidyautismdr parkfecundityfertilitypaternal agepronatlaismspermtelomerasetelomere ...
  http://www.rechargebiomedical.com/tag/aneuploidy/
*  stem cell theory of aging | Recharge Biomedical
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... A body is a machine in turn made up of trillions of cellular machines, all exhibiting decreasing genomic integrity and ...
  http://www.rechargebiomedical.com/category/stem-cell-theory-of-aging/
*  Chromosomes trapped in micronuclei are liable to segregation errors | Journal of Cell Science
2011). Aneuploidy drives genomic instability in yeast. Science 333, 1026-1030. doi:10.1126/science.1206412. ... 2011). Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40. doi: ... 2015). Short- and long-term effects of chromosome mis-segregation and aneuploidy. Nat. Rev. Mol. Cell Biol. 16, 576-576. doi: ... 2016). The presence of extra chromosomes leads to genomic instability. Nat. Commun. 7, 10754. doi:10.1038/ncomms10754. ...
  http://jcs.biologists.org/content/131/13/jcs214742
*  About | mcb
Genomic approaches to studying cancer aneuploidy. Description :. Broad Institute Cambridge, Massachusetts Lecturer : ...
  http://www.weizmann.ac.il/mcb/
*  Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. - PubMed - NCBI
Tetraploidy constitutes a genomically metastable state that can lead to aneuploidy and genomic instability. Tetraploid cells ...
  https://www.ncbi.nlm.nih.gov/pubmed/24516128
*  KEGG PATHWAY: map05212
Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely ...
  http://www.genome.jp/dbget-bin/www_bget?path:map05212
*  Medical genetics - Wikipedia
Examples of chromosome abnormalities include aneuploidy, chromosomal rearrangements, and genomic deletion/duplication disorders ... used for identifying aneuploidy, genomic deletions or duplications, characterizing chromosomal translocations and determining ... Array comparative genomic hybridization is a new molecular technique that involves hybridization of an individual DNA sample to ... DNA sequencing is used to directly analyze the genomic DNA sequence of a particular gene. In general, only the parts of the ...
  https://en.wikipedia.org/wiki/Medical_Genetics
*  Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system...
Ehlers JP, Worley L, Onken MD, Harbour JW (2008) Integrative genomic analysis of aneuploidy in uveal melanoma. Clin Cancer Res ... it will prove interesting to determine whether these genomic alterations are also of prognostic significance in MT-CNS. ...
  https://link.springer.com/article/10.1007%2Fs11060-015-2052-2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cells use this mechanism to prevent aneuploidy or genomic instability, and hence cancers and other human diseases like birth ... In somatic cells, aneuploidy is associated with cancer but in gametes, aneuploidy leads to infertility, miscarriages or ... For reasons not fully understood, this reductional division is prone to errors and is more commonly the source of aneuploidy ... However, since blastocysts have on average 64 cells (containing 120-720 pg of genomic DNA), this method is not efficacious for ...
  https://www.jove.com/visualize/abstract/20927325/erk3-is-required-for-metaphase-anaphase-transition-mouse-oocyte
*  Evaluation of Patients With Unresolved Chromosome Abnormalities - Full Text View - ClinicalTrials.gov
There is a range of genomic aberrations from aneuploidy down to single base pair deletions or inserts. Present technology uses ... Confirmation of SKY results will be performed by standard FISH, genomic content mapping, and other standard techniques. ...
  https://www.clinicaltrials.gov/ct2/show/NCT00001639
*  Plus it
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal ... The genomic identities of millions of DNA molecules per maternal plasma sample can be decoded in a sequencing run. The ... We found other aneuploidies besides trisomy 21 among the recruited pregnant women. For this study, we focused on the diagnostic ... However, massively parallel genomic sequencing is currently expensive. To determine its suitability as a first tier screening ...
  http://www.bmj.com/content/342/bmj.c7401
*  Shimmel K - PubMed - NCBI
Genomic and Functional Approaches to Understanding Cancer Aneuploidy.. Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, ...
  https://www.ncbi.nlm.nih.gov/pubmed/?term=Shimmel%20K
*  Frontiers | DNA Sequence Analysis in Clinical Medicine, Proceeding Cautiously | Molecular Biosciences
Gene mapping and initial genome sequencing data enabled the development of microarrays to analyze genomic variants. The goal of ... Gene mapping and initial genome sequencing data enabled the development of microarrays to analyze genomic variants. The goal of ... Delineation of underlying genomic and genetic factors in a specific disease may be valuable in establishing a definitive ... Delineation of underlying genomic and genetic factors in a specific disease may be valuable in establishing a definitive ...
  https://www.frontiersin.org/articles/10.3389/fmolb.2017.00024/full
*  Publications | Page 3 | Broad Institute
Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Taylor AM, Shih J, Ha G, et al. Genomic and Functional ... Approaches to Understanding Cancer Aneuploidy. Cancer Cell. 2018;33(4):676-689.e3. doi:10.1016/j.ccell.2018.03.007. ...
  https://www.broadinstitute.org/publications/view/3564?page=2
*  Methylation, Transcription, and Rearrangements of Transposable Elements in Synthetic Allopolyploids
... genome technologies and applications of genomic tools in plant breeding. In addition, the journal welcomes field review ... "Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic ... 55] detected genomic rearrangements in genes of the triticale polyploidy, as well as in retrotransposons. ... A comparison of the genomic distribution of Veju in the fifth (S5) generation of the synthetic allohexaploid and in the ~10,000 ...
  https://www.hindawi.com/journals/ijpg/2011/569826/
*  Herrero J[au] - PubMed - NCBI
Aneuploidy screening by array comparative genomic hybridization improves success rates of in vitro fertilization: A multicenter ... Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Herrero+J%5Bau%5D&dispmax=50
*  So what else is new?
Cancer cells have these common features, like genomic instability, aneuploidies, and loss of cell cycle control that we all ... Recent genomic sequencing on the popular 'Kyoto' HeLa line reveals known errors common to cancer cells like extra copies of ...
  https://freethoughtblogs.com/pharyngula/2013/03/20/so-what-else-is-new/comment-page-1/
*  DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs
DNA aneuploidy and mean nuclear genomic aberrations were associated with patients' age. In particular, DNA aneuploidy strongly ... Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs. PLoS One. 2015;10(11): ... The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic ... Relationship between genomic aberrations, age, and smoke habit, in OPMDs and OSCCs patients. To assess genomic aberrations and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5587305/
*  Breed-Predispositions to Cancer in Pedigree Dogs
R. Thomas, E. L. Seiser, A. Motsinger-Reif et al., "Refining tumor-associated aneuploidy through "genomic recoding" of ... A. R. Boyko, "The domestic dog: man's best friend in the genomic era," Genome Biology, vol. 12, no. 2, article 216, 2011. View ... L. L. Chu, G. R. Rutteman, J. M. C. Kong et al., "Genomic organization of the canine p53 gene and its mutational status in ... A. Y. Angstadt, A. Motsinger-Reif, R. Thomas et al., "Characterization of canine osteosarcoma by array comparative genomic ...
  https://www.hindawi.com/journals/isrn/2013/941275/ref/
*  AKC Canine Health Foundation
... aneuploidy) of dog chromosomes 6, 15, 16, and 18. Objective: In this project the researchers will use molecular cytogenetics to ... Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non- ... Home > Research > Research Portfolio > The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma ... 613: The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma. Grant Status: Closed ...
  http://www.akcchf.org/research/research-portfolio/0613.html
*  Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary...
Defects in chromosome segregation play a critical role in producing genomic instability and aneuploidy, which are associated ... Aneuploidy. Introduction. Mitotic chromosome malsegregation produces aneuploidy and genome instability. An increasing number of ... Ford, J. H. ( 1985). A model for the mechanism of aneuploidy involving chromosome displacement. In Aneuploidy: Etiology and ... In Aneuploidy Etiology and Mechanisms (ed. V.L. Dellarco, P.E. Voytek and A. Hollaender), pp. 279 -289. Plenum Press, New York. ...
  http://jcs.biologists.org/content/115/3/507
*  Plus it
... we show that PTEN-null cells possess an underlying aneuploidy or genomic instability that is exacerbated by the effect of TTK ... An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-91. ... Genomic DNA was extracted from cell lines using the QIAamp DNA Blood Mini Kit (51104; Qiagen), according to the manufacturer's ... Gene expression and genomic profiles have been used to subclassify breast cancers. We investigated whether the patterns of ...
  http://cancerdiscovery.aacrjournals.org/content/1/3/260