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*  Prenatal diagnosis of fetal aneuploidies: post-genomic developments | Genome Medicine | Full Text
... the long elusive goal of non-invasive prenatal diagnosis for fetal aneuploidies can finally be attained. ... Prenatal diagnosis of fetal aneuploidies and chromosomal anomalies is likely to undergo a profound change in the near future. ... Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal ... This was indeed the case and, in both studies, all cases of aneuploidy could be reliably distinguished from euploid controls [ ...
  https://0-genomemedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/gm171
*  DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES - Patent application
... plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic DNA regions are selected ... selectively amplifying a plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic ... and total aneuploidy from segmental aneuploidy. Segmental aneuploidies can be caused by an intra-chromosomal event such as a ... Patent application title: DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES. Inventors: ...
  http://www.patentsencyclopedia.com/app/20120183963
*  Patent US6258540 - Non-invasive prenatal diagnosis - Google Patents
Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US20090170077 *. 29 Aug 2005. 2 Jul 2009. ... Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment. US20100113286 *. 5 May 2008. 6 May 2010. ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US8986966. 21 Mar 2007. 24 Mar 2015. The ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US9109256. 27 Oct 2005. 18 Aug 2015. ...
  http://www.google.ca/patents/US6258540
*  aneuploidy
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... AginganeuploidyATMbrca1brca2breast cancercancercell cycledna repairEd Parkkomenli-fraumeniMRNnon-dysjunctionp53progeriarecharge ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... aneuploidyautismdr parkfecundityfertilitypaternal agepronatlaismspermtelomerasetelomere ...
  http://www.rechargebiomedical.com/tag/aneuploidy/
*  stem cell theory of aging | Recharge Biomedical
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... A body is a machine in turn made up of trillions of cellular machines, all exhibiting decreasing genomic integrity and ...
  http://www.rechargebiomedical.com/category/stem-cell-theory-of-aging/
*  Chromosomes trapped in micronuclei are liable to segregation errors | Journal of Cell Science
2011). Aneuploidy drives genomic instability in yeast. Science 333, 1026-1030. doi:10.1126/science.1206412. ... 2011). Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40. doi: ... 2015). Short- and long-term effects of chromosome mis-segregation and aneuploidy. Nat. Rev. Mol. Cell Biol. 16, 576-576. doi: ... 2016). The presence of extra chromosomes leads to genomic instability. Nat. Commun. 7, 10754. doi:10.1038/ncomms10754. ...
  http://jcs.biologists.org/content/131/13/jcs214742
*  About | mcb
Genomic approaches to studying cancer aneuploidy. Description :. Broad Institute Cambridge, Massachusetts Lecturer : ...
  http://www.weizmann.ac.il/mcb/
*  Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. - PubMed - NCBI
Tetraploidy constitutes a genomically metastable state that can lead to aneuploidy and genomic instability. Tetraploid cells ...
  https://www.ncbi.nlm.nih.gov/pubmed/24516128
*  GB2533006B - Systems and methods to detect copy number variation - Google Patents
Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment US20090053719A1 (en) 2007-08-03. 2009-02-26. ... Methods for targeted genomic analysis WO2014107548A1 (en) 2013-01-05. 2014-07-10. Foundation Medicine, Inc.. System and method ... Systems and methods for detection of genomic copy number changes JPWO2014148557A1 (en) 2013-03-19. 2017-02-16. 凸版印刷株式会社. Egfr ... Genomic analysis method US6629040B1 (en) 1999-03-19. 2003-09-30. University Of Washington. Isotope distribution encoded tags ...
  https://patents.google.com/patent/GB2533006B/en
*  US20060019278A1 - Marker for prenatal diagnosis and monitoring - Google Patents
Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment CA2737643A1 (en) 2008-09-20. 2010-03-25. Hei- ... Rapid aneuploidy detection JP2015522293A (en) 2012-07-19. 2015-08-06. アリオサ ダイアグノスティックス インコーポレイテッドAriosa Diagnostics,Inc.. ... Simultaneous determination of aneuploidy and fetal fraction US20110151442A1 (en) 2011-06-23. Direct Molecular Diagnosis of ... Processes and kits for identifying aneuploidy US9163282B2 (en) 2010-05-18. 2015-10-20. Natera, Inc.. Methods for non-invasive ...
  https://patents.google.com/patent/US20060019278A1/en
*  KEGG PATHWAY: map05212
Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely ...
  http://www.genome.jp/dbget-bin/www_bget?path:map05212
*  Medical genetics - Wikipedia
Examples of chromosome abnormalities include aneuploidy, chromosomal rearrangements, and genomic deletion/duplication disorders ... used for identifying aneuploidy, genomic deletions or duplications, characterizing chromosomal translocations and determining ... Array comparative genomic hybridization is a new molecular technique that involves hybridization of an individual DNA sample to ... DNA sequencing is used to directly analyze the genomic DNA sequence of a particular gene. In general, only the parts of the ...
  https://en.wikipedia.org/wiki/Medical_Genetics
*  Dog and human cancers | Philosophical Transactions of the Royal Society B: Biological Sciences
2011 Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non ... Genomic analysis of canine GBMs reveals a very similar pattern [11]. The comparison of genomic changes in canine versus human ... Initial genomic investigation of these aggressive urothelial neoplasms, as part of the larger ongoing work by the Sea Lion ... Genomic analyses of human gliomas reveal increasing molecular complexity as the clinical tumour stage progresses, along with ...
  http://rstb.royalsocietypublishing.org/content/370/1673/20140231
*  Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system...
Ehlers JP, Worley L, Onken MD, Harbour JW (2008) Integrative genomic analysis of aneuploidy in uveal melanoma. Clin Cancer Res ... it will prove interesting to determine whether these genomic alterations are also of prognostic significance in MT-CNS. ...
  https://link.springer.com/article/10.1007%2Fs11060-015-2052-2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cells use this mechanism to prevent aneuploidy or genomic instability, and hence cancers and other human diseases like birth ... In somatic cells, aneuploidy is associated with cancer but in gametes, aneuploidy leads to infertility, miscarriages or ... For reasons not fully understood, this reductional division is prone to errors and is more commonly the source of aneuploidy ... However, since blastocysts have on average 64 cells (containing 120-720 pg of genomic DNA), this method is not efficacious for ...
  https://www.jove.com/visualize/abstract/20927325/erk3-is-required-for-metaphase-anaphase-transition-mouse-oocyte
*  Evaluation of Patients With Unresolved Chromosome Abnormalities - Full Text View - ClinicalTrials.gov
There is a range of genomic aberrations from aneuploidy down to single base pair deletions or inserts. Present technology uses ... Confirmation of SKY results will be performed by standard FISH, genomic content mapping, and other standard techniques. ...
  https://www.clinicaltrials.gov/ct2/show/NCT00001639
*  Plus it
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal ... The genomic identities of millions of DNA molecules per maternal plasma sample can be decoded in a sequencing run. The ... We found other aneuploidies besides trisomy 21 among the recruited pregnant women. For this study, we focused on the diagnostic ... However, massively parallel genomic sequencing is currently expensive. To determine its suitability as a first tier screening ...
  http://www.bmj.com/content/342/bmj.c7401
*  Noninvasive Prenatal Testing/Noninvasive Prenatal Diagnosis: the Position of the National Society of Genetic Counselors |...
2008). Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in ... Noninvasive prenatal diagnosis Aneuploidy screening Prenatal diagnosis Down syndrome Trisomy 13 Trisomy 18 Trisomy 21 Monosomy ... Fan, H. C., Blumenfeld, Y. J., Chitkara, U., Hudgins, L., & Quake, S. R. (2008). Noninvasive diagnosis of fetal aneuploidy by ... Genome-Wide Fetal Aneuploidy Detection by Maternal Plasma DNA Sequencing. Obstetrics and Gynecology, 119(5), 1-13.Google ...
  https://link.springer.com/article/10.1007/s10897-012-9564-0
*  Shimmel K - PubMed - NCBI
Genomic and Functional Approaches to Understanding Cancer Aneuploidy.. Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, ...
  https://www.ncbi.nlm.nih.gov/pubmed/?term=Shimmel%20K
*  Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through...
Overexpression of cyclin E can induce G2/M cell cycle arrest, aneuploidy and genomic instability (Bartkova et al., 2005; Keck ... 2I), G2/M cell cycle arrest and aneuploidy (Fig. 2J), that are similar to what we observed in the parental MDA-MB-231 cells ( ... J) Loss of Drp1 induces G2/M cell cycle arrest and aneuploidy in MDA-MB-231 ρ0 cells. Cell cycle distribution was determined by ... et al. (2005). Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907- ...
  http://jcs.biologists.org/content/125/23/5745
*  Aneuploidy Analysis | Thermo Fisher Scientific - MX
These large genomic imbalances can now be detected by Low-Pass Whole Genome Sequencing using Ion ReproSeq PGS kits and Ion ... Low-pass whole-genome aneuploidy workflow features:. *Uses as little as a single cell's DNA as input, followed by whole-genome ... Cells that do not contain an exact diploid set are called aneuploid (Figure 1). Common types of aneuploidy are monosomy (the ... ANEUPLOIDY ANALYSIS. Detection by low-pass whole-genome sequencing with Ion Reporter Software ...
  https://www.thermofisher.com/mx/en/home/life-science/sequencing/next-generation-sequencing/ion-torrent-next-generation-sequencing-workflow/ion-torrent-next-generation-sequencing-data-analysis-workflow/ion-reporter-software/aneuploidy-analysis.html
*  Frontiers | DNA Sequence Analysis in Clinical Medicine, Proceeding Cautiously | Molecular Biosciences
Gene mapping and initial genome sequencing data enabled the development of microarrays to analyze genomic variants. The goal of ... Gene mapping and initial genome sequencing data enabled the development of microarrays to analyze genomic variants. The goal of ... Delineation of underlying genomic and genetic factors in a specific disease may be valuable in establishing a definitive ... Delineation of underlying genomic and genetic factors in a specific disease may be valuable in establishing a definitive ...
  https://www.frontiersin.org/articles/10.3389/fmolb.2017.00024/full
*  Publications | Page 3 | Broad Institute
Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Taylor AM, Shih J, Ha G, et al. Genomic and Functional ... Approaches to Understanding Cancer Aneuploidy. Cancer Cell. 2018;33(4):676-689.e3. doi:10.1016/j.ccell.2018.03.007. ...
  https://www.broadinstitute.org/publications/view/3564?page=2
*  Methylation, Transcription, and Rearrangements of Transposable Elements in Synthetic Allopolyploids
... genome technologies and applications of genomic tools in plant breeding. In addition, the journal welcomes field review ... "Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic ... 55] detected genomic rearrangements in genes of the triticale polyploidy, as well as in retrotransposons. ... A comparison of the genomic distribution of Veju in the fifth (S5) generation of the synthetic allohexaploid and in the ~10,000 ...
  https://www.hindawi.com/journals/ijpg/2011/569826/