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*  DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES - Patent application
... plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic DNA regions are selected ... selectively amplifying a plurality of genomic DNA regions of the fetal and maternal genomic DNA of (b), wherein said genomic ... and total aneuploidy from segmental aneuploidy. Segmental aneuploidies can be caused by an intra-chromosomal event such as a ... Patent application title: DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES. Inventors: ...
  http://www.patentsencyclopedia.com/app/20120183963
*  Patent US6258540 - Non-invasive prenatal diagnosis - Google Patents
Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US20090170077 *. 29 Aug 2005. 2 Jul 2009. ... Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment. US20100113286 *. 5 May 2008. 6 May 2010. ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US8986966. 21 Mar 2007. 24 Mar 2015. The ... Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing. US9109256. 27 Oct 2005. 18 Aug 2015. ...
  http://www.google.ca/patents/US6258540
*  aneuploidy
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... AginganeuploidyATMbrca1brca2breast cancercancercell cycledna repairEd Parkkomenli-fraumeniMRNnon-dysjunctionp53progeriarecharge ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... aneuploidyautismdr parkfecundityfertilitypaternal agepronatlaismspermtelomerasetelomere ...
  http://www.rechargebiomedical.com/tag/aneuploidy/
*  stem cell theory of aging | Recharge Biomedical
Genomic entropy drives aneuploidy Ed Park, MD. 07/14/2017. age-related-diseases, aging, cancer, dr ed park, stem cell theory of ... Aginganeuploidybill andrewscancerchimerismchromothirpsisDr. Ed Parkgenetic driftmosicstem cellstelomere timebombstelomeres ... A body is a machine in turn made up of trillions of cellular machines, all exhibiting decreasing genomic integrity and ...
  http://www.rechargebiomedical.com/category/stem-cell-theory-of-aging/
*  About | mcb
Genomic approaches to studying cancer aneuploidy. Description :. Broad Institute Cambridge, Massachusetts Lecturer : ...
  http://www.weizmann.ac.il/mcb/
*  Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. - PubMed - NCBI
Tetraploidy constitutes a genomically metastable state that can lead to aneuploidy and genomic instability. Tetraploid cells ...
  https://www.ncbi.nlm.nih.gov/pubmed/24516128
*  KEGG PATHWAY: map05212
Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely ...
  http://www.genome.jp/dbget-bin/www_bget?path:map05212
*  Medical genetics - Wikipedia
Examples of chromosome abnormalities include aneuploidy, chromosomal rearrangements, and genomic deletion/duplication disorders ... used for identifying aneuploidy, genomic deletions or duplications, characterizing chromosomal translocations and determining ... Array comparative genomic hybridization is a new molecular technique that involves hybridization of an individual DNA sample to ... DNA sequencing is used to directly analyze the genomic DNA sequence of a particular gene. In general, only the parts of the ...
  https://en.wikipedia.org/wiki/Medical_Genetics
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cells use this mechanism to prevent aneuploidy or genomic instability, and hence cancers and other human diseases like birth ... In somatic cells, aneuploidy is associated with cancer but in gametes, aneuploidy leads to infertility, miscarriages or ... For reasons not fully understood, this reductional division is prone to errors and is more commonly the source of aneuploidy ... However, since blastocysts have on average 64 cells (containing 120-720 pg of genomic DNA), this method is not efficacious for ...
  https://www.jove.com/visualize/abstract/20927325/erk3-is-required-for-metaphase-anaphase-transition-mouse-oocyte
*  Plus it
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal ... The genomic identities of millions of DNA molecules per maternal plasma sample can be decoded in a sequencing run. The ... We found other aneuploidies besides trisomy 21 among the recruited pregnant women. For this study, we focused on the diagnostic ... However, massively parallel genomic sequencing is currently expensive. To determine its suitability as a first tier screening ...
  http://www.bmj.com/content/342/bmj.c7401
*  Selective analysis of cell-free DNA in maternal blood for evaluation of fetal trisomy - Sparks - 2012 - Prenatal Diagnosis -...
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal ... Screening for fetal aneuploidies at 11 to 13 weeks. Prenat Diagn 2011; 31(1): 7-15.. *Wiley Online Library , ... Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. National Institute of ... Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proc Natl Acad Sci USA 2008; 105(16): ...
  http://onlinelibrary.wiley.com/doi/10.1002/pd.2922/full
*  Methylation, Transcription, and Rearrangements of Transposable Elements in Synthetic Allopolyploids
... genome technologies and applications of genomic tools in plant breeding. In addition, the journal welcomes field review ... "Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic ... 55] detected genomic rearrangements in genes of the triticale polyploidy, as well as in retrotransposons. ... A comparison of the genomic distribution of Veju in the fifth (S5) generation of the synthetic allohexaploid and in the ~10,000 ...
  https://www.hindawi.com/journals/ijpg/2011/569826/
*  So what else is new?
Cancer cells have these common features, like genomic instability, aneuploidies, and loss of cell cycle control that we all ... Recent genomic sequencing on the popular 'Kyoto' HeLa line reveals known errors common to cancer cells like extra copies of ...
  https://freethoughtblogs.com/pharyngula/2013/03/20/so-what-else-is-new/comment-page-1/
*  DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs
DNA aneuploidy and mean nuclear genomic aberrations were associated with patients' age. In particular, DNA aneuploidy strongly ... Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs. PLoS One. 2015;10(11): ... The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic ... Relationship between genomic aberrations, age, and smoke habit, in OPMDs and OSCCs patients. To assess genomic aberrations and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5587305/
*  Breed-Predispositions to Cancer in Pedigree Dogs
R. Thomas, E. L. Seiser, A. Motsinger-Reif et al., "Refining tumor-associated aneuploidy through "genomic recoding" of ... A. R. Boyko, "The domestic dog: man's best friend in the genomic era," Genome Biology, vol. 12, no. 2, article 216, 2011. View ... L. L. Chu, G. R. Rutteman, J. M. C. Kong et al., "Genomic organization of the canine p53 gene and its mutational status in ... A. Y. Angstadt, A. Motsinger-Reif, R. Thomas et al., "Characterization of canine osteosarcoma by array comparative genomic ...
  https://www.hindawi.com/journals/isrn/2013/941275/ref/
*  Gene Report for G00001878 - Genes2Cognition Neuroscience Research Programme
Our findings suggest that the HTLV-I Tax oncoprotein targets TAX1BP2 causing genomic instability and aneuploidy. ... The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter.. ... but the causes of aneuploidy are incompletely understood. Here, we show that centrosome amplification is frequent in HTLV-I- ...
  http://www.genes2cognition.org/db/Gene/G00001878
*  Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary...
Defects in chromosome segregation play a critical role in producing genomic instability and aneuploidy, which are associated ... Aneuploidy. Introduction. Mitotic chromosome malsegregation produces aneuploidy and genome instability. An increasing number of ... Ford, J. H. ( 1985). A model for the mechanism of aneuploidy involving chromosome displacement. In Aneuploidy: Etiology and ... In Aneuploidy Etiology and Mechanisms (ed. V.L. Dellarco, P.E. Voytek and A. Hollaender), pp. 279 -289. Plenum Press, New York. ...
  http://jcs.biologists.org/content/115/3/507
*  Plus it
... we show that PTEN-null cells possess an underlying aneuploidy or genomic instability that is exacerbated by the effect of TTK ... An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-91. ... Genomic DNA was extracted from cell lines using the QIAamp DNA Blood Mini Kit (51104; Qiagen), according to the manufacturer's ... Gene expression and genomic profiles have been used to subclassify breast cancers. We investigated whether the patterns of ...
  http://cancerdiscovery.aacrjournals.org/content/1/3/260
*  Evolutionary Implications of Genome and Karyotype Restructuring in Nicotiana tabacum L | SpringerLink
Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic ... Turner TL, Hahn MW (2010) Genomic islands of speciation or genomic islands and speciation? Mol Ecol 19:848-850PubMedCrossRef ... Gaeta RT, Pires JC, Iniguez-Luy F, Leon E, Osborn TC (2007) Genomic changes in resynthesized Brassica napus and their effect on ... Liu B, Brubaker CL, Mergeai G, Cronn RC, Wendel JF (2002) Polyploid formation in cotton is not accompanied by rapid genomic ...
  https://link.springer.com/chapter/10.1007/978-3-642-31442-1_11
*  Competitor Analysis: Novel Mitotic Kinase Inhibitors
Main effectors of this process are mitotic spindles and centrosomes.157 Disruption of the process results in aneuploidy, and ... genomic instability renders the cellular condition optimal for apoptosis to occur. The rationale of targeting mitosis in cancer ...
  https://marketpublishers.com/report/medicine_pharmaceuticals_biotechnology/healthcare_equipment_services/competitor_analysis_novel_mitotic_kinase_inhibitors.html
*  Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes - Habermann,, Bündgen,, Gemoll,...
DNA aneuploidy has been identified as a prognostic factor in epithelial malignancies in general and in endometrial cancers in ... Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes : In addition to clinical ... Keywords:aneuploidy, endometrial carcinoma, genomic instability, comparative genomic hybridization, expression arrays, pathway ... Results:Comparative genomic hybridization revealed ploidyassociated specific, recurrent genomic imbalances. Gene expression ...
  http://www.youscribe.com/catalogue/documents/savoirs/genomic-instability-influences-the-transcriptome-and-proteome-in-2051911
*  Nuclear cyclin D1: An oncogenic driver in human cancer
... stabilized Cdt1 continually prime DNA re-replication during S phase and induces genomic instability characterized by aneuploidy ... Genomic Alterations: chromosomal translocations, gene amplification, and polymorphisms. Genomic alterations leading to aberrant ... Genomic instability in tumors harboring a nuclear cyclin D1/CDK4 kinase. *Targeting cyclin D/CDK activity as a therapeutic ... Genomic instability in tumors harboring a nuclear cyclin D1/CDK4 kinase. Despite the obvious involvement of cyclin D1 in many ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2874239/
*  Agilent Technologies Introduces Focused Exome Kit with Unparalleled Coverage, Speed, Flexibility for Disease Research on...
... a high-throughput oligonucleotide microarray for screening aneuploidy and other genomic aberrations in the 5- to 10-Mb range ... Agilent Technologies Introduces Microarray for Rapid Screening of Aneuploidy in Single Cells from Embryos. Jan. 12, 2015. ... streamlined analysis of genomic regions of interest. ...
  https://www.environmental-expert.com/news/agilent-technologies-introduces-focused-exome-kit-with-unparalleled-coverage-speed-flexibility-for-d-449523
*  Most recent papers with the keyword TTK | Read by QxMD
... whose tumor cells characteristically show a high level of aneuploidy and genomic instability. We tested our hypothesis that ... With the aim to identify a genomic biomarker to predict the response of tumor cells to TTK inhibitor therapy, we profiled a set ... However, how the E2F activators regulate mitosis to maintain genomic integrity is unclear. Centrosome amplification (CA) and ... The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1. ...
  https://www.readbyqxmd.com/keyword/110061