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*  Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission | Journal of Cell Science
2011). Focal adhesion kinase stabilizes the cytoskeleton. Biophys. J. 101, 2131-2138. doi:10.1016/j.bpj.2011.09.043. ... which lacks amino acids 916-983 of the exon 20 (Marg et al., 2010). This deletion disrupts the autoinhibition of vinculin and ... 2013). Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion ... 2005). Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol. Biol. ...
  http://jcs.biologists.org/content/128/18/3435
*  Vinculin Is Part of the Cadherin-Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin | JCB
... that an α-catenin mutant lacking the COOH-terminal 230 amino acids in Xenopus results in impaired blastomere adhesion and loss ... 9, a and a′), but also in focal adhesions. This was deduced from images as seen in Fig. 9 (a-c) and proven by double staining ... exposing actin-binding and protein kinase C phosphorylation sites. Biochem J 314:827-832, pmid:8615776.. ... 1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4:487- ...
  http://jcb.rupress.org/content/141/3/755
*  Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell Adhesion | JCB
... amino acid(s); Arf, ADP-ribosylation factor; CH, calponin homology; FAK, focal adhesion kinase; GST, glutathione S-transferase ... 8) localized weakly to focal adhesions after 12 h postplating (Fig. 9 A, k), confirming the presence of focal adhesion binding ... focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase ... 1996) The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J. Biol. Chem 271:31222- ...
  http://jcb.rupress.org/content/151/7/1435
*  Focal Adhesion Kinase
Amino acid sequence alignment showed that the ORF of "type":"entrez-nucleotide" attrs :"text":"R30128″ term_id :"936814″ term_ ... Aurora Kinases as Druggable Targets in Cancer Therapy » Focal Adhesion Kinase Menu Not Found. Skip to content *Home ... The amino acid sequence of LGD1069 "type":"entrez-nucleotide" attrs :"text":"R30128″ term_id :"936814″ term_text :"R30128″ ... text :"R30128″R30128 shared 56% LGD1069 identity with the predicted amino acid sequence of human ADK (Spychala et al. 1996 and ...
  http://www.exposed-skin-care.net/category/focal-adhesion-kinase/
*  Forms, Crosstalks, and the Role of Phospholipid Biosynthesis in Autophagy
ATG: autophagy-related protein; P: phosphate; AMPK: adenosine monophosphate kinase; FIP200: focal adhesion kinase family- ... It contains a large heavily glycosylated portion within the lumen, a ~20 amino acid transmembrane component, and ~12 amino acid ... focal adhesion kinase family interacting protein (FIP200), Unc-51-like kinase 1 (ULK1), and ATG-101 translocates to the ER ... L. Li and K. L. Guan, "Amino acid signaling to TOR activation: vam6 functioning as a gtr1 GEF," Molecular Cell, vol. 35, no. 5 ...
  https://www.hindawi.com/journals/ijcb/2012/931956/
*  Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J. Cell Biol. 149:741-754 ... the amino acid sensor is not an amino acid carrier or (ii) several amino acid transporters could be connected to a common ... They involve protein kinases mTORC1, activated by amino acid supplementation, and GCN2, activated by amino acid starvation. ... An amino acid response element (AARE) was identified in the promoters of these genes and can confer amino acid responsiveness ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2786873/?lang=en-ca
*  Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells
... a cytoplasmic tyrosine kinase related to focal adhesion kinase (FAK), in heregulin-mediated signal transduction in breast ... c-Abl was found to be associated with RAFTK through the region of RAFTK containing amino acids 419-1009. Site-directed ... Therefore, RAFTK serves as a mediator and an integration point between focal adhesion molecules in HRG-mediated signaling in ... c-Abl as well as with the focal adhesion molecules p130cas and paxillin. ...
  https://www.spandidos-publications.com/ijo/24/1/153
*  Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect...
Focal adhesion kinase (FAK) is a nonreceptor type tyrosine kinase composed of ∼1,030 amino acids that regulates integrin and ... Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 2000;19:5606-13. ... Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in ... Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect ...
  http://clincancerres.aacrjournals.org/content/14/14/4631
*  Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
... cell cycle control kinases, src family kinases, the EGF receptor and p92.sup.c-fps/fes based upon amino acid sequence motifs ... The isolated phosphopeptides are sequenced and an amino acid sequence motif for the phosphorylation site is determined based ... acids residues at each degenerate position. The invention also provides peptide substrates for protein kinase A, ... motif for a phosphorylation site of a protein kinase. In the method of the invention, a protein kinase is contacted with an ...
  http://www.patentgenius.com/patent/5532167.html
*  Yeast two-hybrid screening for angiostatin-binding prot | Open-i
Focal Adhesion Kinase 1. *Focal Adhesion Protein-Tyrosine Kinases. *Genes, Reporter. *Humans ... C) Binding of the 421 amino acid BIG3 sequence derived from yeast two-hybrid screening was verified by coprecipitation of GST- ... C) Binding of the 421 amino acid BIG3 sequence derived from yeast two-hybrid screening was verified by coprecipitation of GST- ... and in the presence of 50 mM 3-amino-1, 2,4-triazol. No growth was detected in yeast transfected with both the angiostatin-Gal4 ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199208_JCB0010121.f1&req=4
*  Pik3r2 - Phosphatidylinositol 3-kinase regulatory subunit beta - Mus musculus (Mouse) - Pik3r2 gene & protein
Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the ... a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- ... Phosphatidylinositol 3-kinase regulatory subunit betaAdd BLAST. 722. Amino acid modifications. Feature key. Position(s). ... focal adhesion Source: MGIInferred from direct assayi*25217619. *phosphatidylinositol 3-kinase complex Source: GO_Central ...
  https://www.uniprot.org/uniprot/O08908
*  The Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial...
We previously demonstrated binding of the 12 amino acid peptide of VEGFR-3 to the C-terminal, focal adhesion targeting (FAT) ... focal adhesion kinase. FAT. focal adhesion targeting domain. VEGFR-3. vascular endothelial growth factor receptor 3. ECM. ... RNA Interference Elucidates the Role of Focal Adhesion Kinase in HLA Class I-Mediated Focal Adhesion Complex Formation and ... Control of adhesion-dependent cell survival by focal adhesion kinase. Journal of Cell Biology. 1996;134:793-799. [PMC free ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2765121/
*  Curcumin Blocks RON Tyrosine Kinase-Mediated Invasion of Breast Carcinoma Cells | Cancer Research
... focal adhesion kinase, and mitogen-activated protein kinases which are involved in cell proliferation, tubular morphogenesis, ... The human recepteur d'origine nantais (RON) gene encodes a receptor tyrosine kinase (RTK) of 1,400 amino acids that belong to ... protein kinase C, protamine kinase, pp60c-src tyrosine kinase, p44/42 mitogen-activated protein kinase, and c-Jun-NH2-kinase ( ... RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol 2005; 12: 273-81. ...
  http://cancerres.aacrjournals.org/content/68/13/5185
*  Plus it
1992) PP 125 FAK, a structurally distinctive protein tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 89 ... 1987) The amino acid sequences of the myelin-associated glycoprotein: homology to the immunoglobulin gene superfamily. J Cell ... Adhesion of SCs to basal lamina is also required for myelin-specific gene expression and myelination (Carey and Todd, 1987; ... I. Ascorbic acid regulates basal lamina assembly and myelin formation. J Cell Biol 105:1023-1034. ...
  http://www.jneurosci.org/content/17/1/241
*  THY1 elisa kit | Human Thy-1 membrane glycoprotein ELISA Kit-NP 001298089.1
Human Thy-1 membrane glycoprotein ELISA Kit-NP_001298089.1 (MBS2883482) product datasheet at MyBioSource, ELISA Kits ... Biological Process: angiogenesis; cell-cell adhesion; cytoskeleton organization and biogenesis; focal adhesion formation; ... protein amino acid autophosphorylation; retinal cone cell development; T cell receptor signaling pathway ... Calcium-calmodulin dependent protein kinase II (CAMK2) ELISA Kit. • Vitamin C (VC) ELISA Kit. • a1-Antichymotrypsin (SERPINA1) ...
  https://www.mybiosource.com/prods/ELISA-Kit/Human/Thy-1-membrane-glycoprotein/THY1/datasheet.php?products_id=2883482
*  IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility | IOVS | ARVO Journals
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 ; 6: 56-68. ... is a 70-amino acid peptide belonging to a family of polypeptide trophic factors with mitogenic, differentiating, antiapoptotic ... and a mouse anti-phospo-focal adhesion kinase (p-FAK) antibody (Santa Cruz Biotechnology, Inc.). Secondary antibodies were ... of MMP-2 toward cellular protrusions and the partial colocalization with β1-integrin and phospo-focal adhesion kinase signals. ...
  https://iovs.arvojournals.org/article.aspx?articleid=2468289
*  Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance...
Epub 2015 Sep 1. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H. ... cell line was labeled with light amino acids and MCF7 tamoxifen-sensitive control (MCF7-CTRL) cell line was labeled with heavy ... Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance ... Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance ...
  https://www.ncbi.nlm.nih.gov/pubmed/26330541
*  Protocols and Video Articles Authored by Fu-Zhang Wang
Further, HHV-8 infection induced the integrin-mediated activation of focal adhesion kinase (FAK). These findings implicate a ... suggesting that the adhesion is mediated by the RGD amino acids of gB, which is independent of the heparin-binding domain of gB ... Adhesion induced by the gBdeltaTM was blocked by EDTA, thus suggesting the role of integrins in the observed adhesions. Focal ... of the receptors for its entry into the target cells via its gB interaction and induces the activation of focal adhesion kinase ...
  https://www.jove.com/author/Fu-Zhang_Wang
*  PTK2 - Wikipedia
"The role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase ... also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion- ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... A carboxy-terminal region of one hundred and fifty-nine amino acids, the focal adhesion targeting domain (FAT), has been shown ...
  https://en.wikipedia.org/wiki/PTK2
*  Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development | Journal of...
This is not unexpected since Dictyostelium does not contain obvious focal adhesion kinases or Src related kinase homologues. ... This phosphorylation site and surrounding amino acids are conserved in Dictyostelium and we therefore tested the importance of ... sites in Dictyostelium mostly since none of the classical components of focal adhesion sites such as focal adhesion kinase and ... Role of phosphorylation sites on focal adhesion kinetics. We measured the rate of formation of focal adhesion sites in ...
  http://jcs.biologists.org/content/118/18/4295
*  Tumstatin - Wikipedia
Tumstatin inhibits the activation of FAK (Focal Adhesion Kinase), Phosphoinositide 3-kinase (PI3-kinase), protein kinase B (PKB ... The 54-132 amino acid sequence of the tumstatin fragment binds both endothelial and melanoma cells but only inhibits ... The two proteins share 14% amino acid identity, making them very similar in structure. It has been proven to inhibit many types ... September 2008). "Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in ...
  https://en.wikipedia.org/wiki/Tumstatin
*  FERM, N-terminal (IPR018979) | InterPro | EMBL-EBI
Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins. ... The amino-acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association ... Janus tyrosine kinases (JAKs), cytoplasmic tyrosine kinases that are non-covalently associated with the cytoplasmic tails of ... Non-receptor tyrosine-protein kinase TYK2.. *Protein-tyrosine phosphatases PTPN3 and PTPN4, enzyme that appear to act at ...
  http://www.ebi.ac.uk/interpro/entry/IPR018979
*  Embryonal fyn-associated substrate - Wikipedia
The SH3 domain is a point of contact with polyproline sequences on focal adhesion kinase (FAK). or the related kinase PTK2B, ... A C-terminal domain (489-561 amino acids in human EFS) is highly conserved between family members at both primary amino acid ... A serine-rich domain encompassing a 4 α-helix bundle (amino acids 351-488 for human EFS). Although primary amino acid sequence ... amino acids 5-68 for human EFS). SH3 domains bind to proline-rich motif containing proteins. The amino acid sequences of the ...
  https://en.wikipedia.org/wiki/Embryonal_fyn-associated_substrate
*  Migration of MAE cells transfected with angiomotin or w | Open-i
Focal Adhesion Kinase 1. *Focal Adhesion Protein-Tyrosine Kinases. *Genes, Reporter. *Humans ... Amino Acid Sequence. *Angiostatins. *Animals. *Blood Vessels/growth & development/physiology. *Blotting, Northern ... Mentions: The localization of angiomotin in the leading edge of migrating cells and the effect of angiostatin on FAK kinase ... Mentions: The localization of angiomotin in the leading edge of migrating cells and the effect of angiostatin on FAK kinase ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199208_JCB0010121.f7&req=4
*  GSK-3: tricks of the trade for a multi-tasking kinase | Journal of Cell Science
Also known as cell adhesion kinase beta; focal adhesion kinase 2; protein tyrosine kinase 2 beta, cell adhsion kinase beta, ... activators of p70 ribosomal S6 kinase (p70S6K) such as amino acids, (Armstrong et al., 2001; Krause et al., 2002; Terruzzi et ... Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5). ... Armstrong, J. L., Bonavaud, S. M., Toole, B. J. and Yeaman, S. J. (2001). Regulation of glycogen synthesis by amino acids in ...
  http://jcs.biologists.org/content/116/7/1175?ijkey=aa5e6bf5983d0c651923d106d68885856536fc6a&keytype2=tf_ipsecsha