*  A Phase I Study of ABT-510 in Combination With Bevacizumab in Advanced Solid Tumors - Full Text View - ClinicalTrials.gov
... researchers have discovered that specific amino acid substitutions can greatly enhance these properties. From these efforts, ... a nine-amino acid synthetic peptide has emerged as a novel anti-angiogenesis agent. The peptide is soluble and stable in water ...
  https://clinicaltrials.gov/ct2/show/NCT00586092
*  Plus it
An unresolved question in evolutionary genetics concerns the importance of amino acid substitution versus promoter mutation in ... The first step in glucosinolate biosynthesis is the oxidation of the amino group to an oxime moiety by amino acid-specific ... A few amino acid substitutions can alter the ratio of products generated by a terpene synthase (Back and Chappell, 1996). The ... Amino acid comparison showed that the three genes are ∼60 to 70% similar to each other and ∼25% similar to other 2-ODD genes ( ...
  http://www.plantcell.org/content/13/3/681
*  An improved sequence-based prediction protocol for protein-protein interactions using amino acids substitution matrix and...
In this article, a sequence-based approach is proposed by combining a novel amino acid substitution matrix feature ... An improved sequence-based prediction protocol for protein-protein interactions using amino acids substitution matrix and ...
  http://ira.lib.polyu.edu.hk/handle/10397/65689
*  Substitution of disulphide bonds to hydrophobic amino acids in BACE1
... Halvarsson, Camilla Linköping University, Department of ... BACE1, disulphide bonds substitution, hydrophobic amino acids, protein purification, refolding time National Category Medical ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:280093
*  Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions - Dryad
Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions. Dryad Repository. ... Goldstein RA, Pollock DD (2017) Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions. Dryad ... Here we use parallels between amino acid substitutions and chemical reaction kinetics to develop an improved theory of protein ... Goldstein RA, Pollock DD (2017) Sequence entropy of folding and the absolute rate of amino acid substitutions. Nature Ecology ...
  http://datadryad.org/resource/doi:10.5061/dryad.7b8vb
*  Viruses | Free Full-Text | Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and...
We also tested a virus presenting a truncation of 109 amino acids at the C-terminal part of Env, a cytoplasmic tail partial ... Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. ... "Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism." ... Dufrasne, F.E.; Lombard, C.; Goubau, P.; Ruelle, J. Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) ...
  http://www.mdpi.com/1999-4915/8/10/285
*  RCSB PDB - 1LYF: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ...
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1LYF
*  Structure Cluster - 1LYG: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ... Acids Res. 2008 36: D419-D425 * [4] Alexandrov N., Shindyalov I. (2003). PDP: protein domain parser.. Bioinformatics 2003 Feb; ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1LYG
*  Sequence Similarity - 1LYE: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ...
  http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1LYE
*  Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 |...
Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 ...
  http://www.genetics.org/content/early/2015/05/04/genetics.115.175752
*  Sequence Similarity - 1C5I: HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID...
... a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase. ... HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF ...
  http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1C5I
*  Structure Cluster - 1LUV: CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE...
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion ... CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL ... Acids Res. 2008 36: D419-D425 * [4] Alexandrov N., Shindyalov I. (2003). PDP: protein domain parser.. Bioinformatics 2003 Feb; ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1LUV
*  Prediction modeling and statistical analysis of amino acid substitutions :: University of Southern California Dissertations and...
Prediction modeling and statistical analysis of amino acid substitutions. Page 1. Save page Remove page Previous. 1 of 148. ... Classifying and predicting amino acid substitutions are important in pharmaceutical and pathological research. We proposed a ... The overall area under ROC curve (AUC) scores is 86.6%. For the polygenic disease-associated amino acid substitutions, we ... PREDICTION MODELING AND STATISTICAL ANALYSIS FOR AMINO ACID SUBSTITUTIONS by Hua Yang A Dissertation Presented to the FACULTY ...
  http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/21662/rec/8
*  Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site | The...
Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site. Nico J ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ...
  http://www.jimmunol.org/content/164/4/1898.long
*  Eurosurveillance | Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced...
We believe that this report can contribute to a better understanding of the biological significance of amino acid substitutions ... During the 2012/13 epidemic season in Spain, two A(H1N1)pdm09 viruses bearing the specific Y155H substitution in the NA were ... The Y155H amino acid substitution in the neuraminidase gene (NA) has previously been associated with highly reduced inhibition ... Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced susceptibility to ...
  http://www.eurosurveillance.org/content/10.2807/1560-7917.ES2014.19.27.20849
*  Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids | JGP
Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids. Timothy J. Wilding, Elisabeth ... Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids ... Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines. J. Physiol. 520:337- ... Amino Acid Substitutions at the Q/R Site. Our previous work showed that homomeric recombinant kainate receptors formed by the ...
  http://jgp.rupress.org/content/132/1/85
*  A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with...
A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with ...
  http://dare.uva.nl/search?metis.record.id=136871
*  Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor
... Zhen Ma,‡§ ... Nucleic Acids Res. 2009;37:1174-1181. [PMC free article] [PubMed]. 12. Xiao Z, Donnelly PS, Zimmermann M, Wedd AG. Inorg. Chem ... Here we show that two "atom" substitutions of the Nε2 face of a Cu(I) coordinating histisine-61 allosterically uncouple Cu(I) ... More conservative substitutions of Glu81, i.e., with Gln, Asp or Asn, also give rise to significant decreases in ΔGc, to about ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2797707/
*  An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant...
An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ...
  http://www.plantphysiol.org/content/early/2012/09/24/pp.112.201061.short?keytype=ref&ijkey=zlDYtc5O4qcnday
*  Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand...
Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand- ... Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand- ... Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand- ... Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand- ...
  http://molpharm.aspetjournals.org/content/44/1/111
*  A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in...
A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in ... A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in ... A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in ... A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in ...
  http://www.biochemj.org/content/352/2/399
*  A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines | The EMBO Journal
A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines. Wolfgang Knecht ... The corresponding amino acids in the other kinases are marked with a black background. The conserved residues in all kinases ... Upon gene duplication of the progenitor kinase, only a limited number of single amino acid changes has taken place in each copy ... The triple mutant Dm‐dNK‐V84A/M88R/A110D, mimicking the amino acid residues found in dCK, showed higher catalytic efficiencies ...
  http://emboj.embopress.org/content/21/7/1873
*  Microbiology Society Journals | A single amino acid substitution affects multiple overlapping epitopes in the major antigenic...
Some amino acid replacements abolished one of the epitopes, whereas other replacements affected several epitopes in this region ... of nMAbs with synthetic peptides and with nMAb-resistant mutants of FMDV C-S8c1 carrying defined amino acid substitutions. The ... The conservative substitution His(146) → Arg, found in many nMAb-resistant mutants analysed, abolished the reactivity of the ... A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease ...
  http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-71-3-629