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*  PLOS ONE: Predicting the Functional Effect of Amino Acid Substitutions and Indels
... tools primarily focus on studying the deleterious effects of single amino acid substitutions through examining amino acid ... and multiple amino acid substitutions. This alignment-based score measures the change in sequence similarity of a query ... score as a new metric to predict the damaging effects of variations not limited to single amino acid substitutions but also in- ... approach to predict the functional effects of protein sequence variations including single or multiple amino acid substitutions ...
  https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0046688.g010
*  Feature-Based Classification of Amino Acid Substitutions outside Conserved Functional Protein Domains
PolyPhen-2 and SIFT had significantly lower accuracies in predicting the effects of amino acid substitutions outside CFDs than ... There are more than 500 amino acid substitutions in each human genome, and bioinformatics tools irreplaceably contribute to ... Feature-Based Classification of Amino Acid Substitutions outside Conserved Functional Protein Domains. Branislava Gemovic, ... are more suitable for the classification of amino acid substitutions outside CFDs than phylogeny-based tools. ...
  https://www.hindawi.com/journals/tswj/2013/948617/abs/
*  Comment on "Transitions to Asexuality Result in Excess Amino Acid Substitutions" | Science
Paland and Lynch (1) demonstrated this effect in Daphnia pulex by showing that the rates of amino acid replacement substitution ... Comment on 'Transitions to Asexuality Result in Excess Amino Acid Substitutions' Message Subject. (Your Name) has forwarded a ... A class of moderately deleterious amino acid substitutions has a higher probability of spreading to fixation in asexual ... the ratio of amino acid replacement to silent substitution in mitochondrial genes is higher in asexual lineages than in sexual ...
  http://science.sciencemag.org/content/313/5792/1389.2
*  Substitution of disulphide bonds to hydrophobic amino acids in BACE1
... Halvarsson, Camilla Linköping University, Department of ... BACE1, disulphide bonds substitution, hydrophobic amino acids, protein purification, refolding time National Category Medical ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:280093
*  The effects of amino acid substitution on apomyoglobin stability, folding intermediates, and holoprotein expression
... ... and helix propensity of the replacement amino acid. In most cases, once a range of amino acids has been correlated at a given ... "The effects of amino acid substitution on apomyoglobin stability, folding intermediates, and holoprotein expression." (2003) ... unfolding constants of the corresponding single mutants or from the amino acid properties of the substituted amino acid using ...
  https://scholarship.rice.edu/handle/1911/18562
*  Distribution of non-synonymous amino acid substitutions | Open-i
Distribution of non-synonymous amino acid substitutions across Odorant Receptor (OR) domains. a The white bars represent the ... Fig3: Distribution of non-synonymous amino acid substitutions across Odorant Receptor (OR) domains. a The white bars represent ... Fig3: Distribution of non-synonymous amino acid substitutions across Odorant Receptor (OR) domains. a The white bars represent ... 3) which covered between 19.3 % and 35.8 % of the OR amino acid sequence (Mean: 30.5 %; Additional file 1: Table S6). ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4552289_12862_2015_451_Fig3_HTML&req=4
*  Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions - Dryad
Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions. Dryad Repository. ... Goldstein RA, Pollock DD (2017) Data from: Sequence entropy of folding and the absolute rate of amino acid substitutions. Dryad ... Here we use parallels between amino acid substitutions and chemical reaction kinetics to develop an improved theory of protein ... Goldstein RA, Pollock DD (2017) Sequence entropy of folding and the absolute rate of amino acid substitutions. Nature Ecology ...
  http://datadryad.org/resource/doi:10.5061/dryad.7b8vb
*  Viruses | Free Full-Text | Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and...
We also tested a virus presenting a truncation of 109 amino acids at the C-terminal part of Env, a cytoplasmic tail partial ... Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. ... "Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism." ... Dufrasne, F.E.; Lombard, C.; Goubau, P.; Ruelle, J. Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) ...
  http://www.mdpi.com/1999-4915/8/10/285
*  RCSB PDB - 1LYF: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ...
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1LYF
*  Structure Cluster - 1LYG: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ... Acids Res. 2008 36: D419-D425 * [4] Alexandrov N., Shindyalov I. (2003). PDP: protein domain parser.. Bioinformatics 2003 Feb; ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1LYG
*  Sequence Similarity - 1LYE: DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF...
Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. ... DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59. ...
  http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1LYE
*  Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 |...
Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1. ... Evidence that the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 ...
  http://www.genetics.org/content/early/2015/05/04/genetics.115.175752
*  Sequence Similarity - 1C5I: HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID...
... a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase. ... HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF ...
  http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1C5I
*  RCSB PDB - 1C5H: HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION...
... a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase. ... HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF ...
  http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1C5H
*  Structure Cluster - 1LUV: CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE...
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion ... CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL ... Acids Res. 2008 36: D419-D425 * [4] Alexandrov N., Shindyalov I. (2003). PDP: protein domain parser.. Bioinformatics 2003 Feb; ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1LUV
*  RCSB PDB - 1LUW: CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE...
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion ... CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL ...
  http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1LUW
*  Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site | The...
Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site. Nico J ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ... Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site ...
  http://www.jimmunol.org/content/164/4/1898.long
*  Frontiers | The Amino Acid Substitution Q65H in the 2C Protein of Swine Vesicular Disease Virus Confers Resistance to Golgi...
A single amino acid substitution, Q65H, in the non-structural protein 2C was found to be responsible for increased resistance ... A single amino acid substitution, Q65H, in the non-structural protein 2C was found to be responsible for increased resistance ... Figure 7. The amino acid substitution Q65H in 2C confers resistance to GCA. IBRS-2 cells treated with 10 μM GCA for 30 min were ... The Amino Acid Substitution Q65H in the SVDV 2C Protein Also Confers Resistance to GCA. The production of SVDV was inhibited by ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.00612/full
*  Eurosurveillance | Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced...
We believe that this report can contribute to a better understanding of the biological significance of amino acid substitutions ... During the 2012/13 epidemic season in Spain, two A(H1N1)pdm09 viruses bearing the specific Y155H substitution in the NA were ... The Y155H amino acid substitution in the neuraminidase gene (NA) has previously been associated with highly reduced inhibition ... Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced susceptibility to ...
  http://www.eurosurveillance.org/content/10.2807/1560-7917.ES2014.19.27.20849
*  Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids | JGP
Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids. Timothy J. Wilding, Elisabeth ... Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids ... Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines. J. Physiol. 520:337- ... Amino Acid Substitutions at the Q/R Site. Our previous work showed that homomeric recombinant kainate receptors formed by the ...
  http://jgp.rupress.org/content/132/1/85
*  A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with...
A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with ...
  http://dare.uva.nl/search?metis.record.id=136871
*  Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive...
Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive ... residual activity suggests that the Pro304Arg substitution is less devastating to oxidase activity than the His303Asn mutation ...
  http://library.wur.nl/WebQuery/wurpubs/419904
*  Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor
... Zhen Ma,‡§ ... Nucleic Acids Res. 2009;37:1174-1181. [PMC free article] [PubMed]. 12. Xiao Z, Donnelly PS, Zimmermann M, Wedd AG. Inorg. Chem ... Here we show that two "atom" substitutions of the Nε2 face of a Cu(I) coordinating histisine-61 allosterically uncouple Cu(I) ... More conservative substitutions of Glu81, i.e., with Gln, Asp or Asn, also give rise to significant decreases in ΔGc, to about ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2797707/
*  An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant...
An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ... An amino acid substitution inhibits specialist herbivore production of an antagonist effector and recovers insect-induced plant ...
  http://www.plantphysiol.org/content/early/2012/09/24/pp.112.201061.short?keytype=ref&ijkey=zlDYtc5O4qcnday