*  IJMS | Free Full-Text | Antibody Phage Display Libraries: Contributions to Oncology | HTML
This procedure resulted in a variant containing three amino acids changes in the CDR3 that increased binding affinity for the ... Usually the majority of such probes are obtained from peptides phage libraries once peptides present high affinity and ... Yip, Y.L.; Smith, G.; Koch, J.; Dubel, S.; Ward, R.L. Identification of epitope regions recognized by tumor inhibitory and ... that consists of a single human framework with diversity incorporated at 18 amino acid positions among VH and VL domains, ...
  http://www.mdpi.com/1422-0067/13/5/5420/htm
*  COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES - Patent application
... for Peptide Ligands with an Epitope Library, 249 Science 386 (1990); J. J. Devlin et al., Random Peptide Libraries: A Source of ... cassette of six amino acid residues. The hexapeptide modules fused to bacteriophage proteins provided a library for the ... 0054]Other methods, such as preparation of random peptide libraries or epitope libraries are well known in the art and may be ... proteins instead of peptides) that have multiple epitopes. Therefore, it will be appreciated that depending on the antigens and ...
  http://www.patentsencyclopedia.com/app/20080286881
*  Ole Lund - DTU
ArrayPitope: Automated Analysis of Amino Acid Substitutions for Peptide Microarray-Based Antibody Epitope Mapping Hansen, ...
  http://www.dtu.dk/english/Service/Phonebook/Person?fr=1&id=5094&mr=10&peer=0&ptype=all&qt=dtupublicationquery&tab=2
*  HSD17B4 MPF 2 Blocking Peptide - Gentaur.com
HSD17B4 MPF 2 Blocking Peptide is available 2 times from supplier Biovision at Gentaur.com shop ... Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 ... amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, ... You can block the antibody by the specific target amino acid sequence of peptide. ...
  https://gentaur.com/prod/hsd17b4-mpf-2-blocking-peptide/biovision/3104754679
*  Frontiers | Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis | Microbiology
First we constructed hybrid protein - CjaA antigen presenting CjaD peptide epitopes on its surface. We showed that specific ... To the best of our knowledge, this is the first attempt to employ LAB (Lactic Acid Bacteria) strains as a mucosal delivery ... First we constructed hybrid protein - CjaA antigen presenting CjaD peptide epitopes on its surface. We showed that specific ... In this work we tested the usefulness of Lactococcus lactis, the most extensively studied lactic acid bacterium, as a delivery ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.00165/full
*  PDB 1klu citation summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
Modification of the inhibitory amino acid for epitope peptide binding onto major histocompatibility complex class II molecules ... A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes. Pierce BG, Weng Z. Protein Sci. 22 35-46 ( ... Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes. Bordner AJ. PLoS ONE 5 e14383 ( ... A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Zavala-Ruiz ...
  http://www.ebi.ac.uk/pdbe/entry/pdb/1klu/citations
*  Survivin as a Cancer Vaccine Target | OMICS International
Altered peptide ligands generated by substituting amino acids within a peptide epitope can markedly alter immune responses. ... 8.6 months) [78]. This anti-survivin vaccine peptide mixture (EMD640744) consists of five CTL epitope peptides, each with ... contains a large synthetic peptide with amino acid substitution designed to enhance MHC class I binding [25,57]. As a result ... collectively representing a large patient population in which the peptide should be immunogenic [25,57]. An amino acid ...
  https://www.omicsonline.org/open-access/survivin-as-a-cancer-vaccine-target-2157-7560.1000230.php?aid=26593
*  EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function |...
All epitope peptides are abbreviated to the first three amino acids throughout this text. The peptides were purchased from Alta ... Peptides and HLA class I tetramers. The following EBV-epitope peptides were used in this study: the A2-restricted epitopes GLC ... the lytic epitopes GLC and YVL and the latent epitope CLG) or one of three B8-restricted epitopes (the lytic epitope RAK and ... based on staining with HLA class I/peptide tetramers (15) and on peptide-induced cytokine release (16, 17), which allow epitope ...
  http://www.jimmunol.org/content/167/4/2019
*  Patent US7601814 - Reducing the immunogenicity of fusion proteins - Google Patents
... or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and ... Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional ... epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve ... amino acid of a first protein or peptide and the first (N-terminal) amino acid of a second protein or peptide in a fusion ...
  http://www.google.ca/patents/US7601814
*  US Patent # 7,422,746. Chemically programmable immunity - Patents.com
Geysen, H. Mario et al.; "Use of Peptide Synthesis to Probe Viral Antigens for Epitopes to a Resolution of a Single Amino Acid ... Xu, Wei et al.; "Anti-peptide aptamers recognize amino acid sequence and bind a protein epitope"; Proc. Natl. Acad. Sci. USA; ... amino-2'-deoxypyrimidines. Nucleic acids using these bases are much more stable in vivo than naturally occurring nucleic acids ... This peptide, or some part of it, functions as the second binding site. Methods for making the nucleic acid aptamers, which ...
  http://www.patents.com/us-7422746.html
*  Plus it
... tested a 105-amino acid synthetic MUC-1 peptide with five repeated immunodominant epitopes. In that study, 63 patients with ... Because most p53 mutations involve the alteration of a single amino acid, it follows that most of the p53 epitopes presented to ... Zaks T. Z., Rosenberg S. A. Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide specific cytotoxic T ... six patients with breast cancer were vaccinated four times with a 106-amino acid MUC-1 peptide with KLH and QS-21. The T-cell ...
  http://clincancerres.aacrjournals.org/content/9/9/3222
*  Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation
... was accessed by a synthetic peptide epitope radioimmunoassay corresponding to human CHGA amino acids 361 to 372. The CHGA ... Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372). Naturally Occurring Amino Acid Variant Gly364Ser ... In probing human genetic variation at CHGA, we discovered 3 naturally occurring amino acid substitution variants in the ... We discovered a naturally occurring amino acid substitution variant in the catestatin region Gly364Ser with an allele frequency ...
  http://circ.ahajournals.org/content/115/17/2271
*  Frontiers | Green Tea Catechin-Inactivated Viral Vaccine Platform | Microbiology
... crosslinked primarily with cysteine residues and thus preserved the major epitopes of the influenza hemagglutinin. In a mouse ... crosslinked primarily with cysteine residues and thus preserved the major epitopes of the influenza hemagglutinin. In a mouse ... a major anchor residue for epitope binding to MHC molecules, GT catechin epigallocatechin-3-gallate (EGCG) ... a major anchor residue for epitope binding to MHC molecules, GT catechin epigallocatechin-3-gallate (EGCG) ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.02469/full
*  Peptide compositions for the treatment of HIV infection - Patent # 6447778 - PatentGenius
The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp120 principal neutralizing ... The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide ... of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. ... The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of ...
  http://www.patentgenius.com/patent/6447778.html
*  A Region of the N-terminal Domain of Meningococcal Factor H Binding Protein that Elicits Bactericidal Antibody across Antigenic...
Amino acid sequences of the phage-displayed peptides mimicking the JAR 4 epitope ... and that the respective distances between amino acids affecting the JAR 4 epitope and those of the epitopes of the second mAb ... The specific amino acids that flanked the DHK residues in the phage peptides, and contributed to JAR 4 binding to the phages, ... The objective of the present study was to identify amino acid residues in fHbp affecting the JAR 4 epitope. The long-term goals ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2673115/
*  Shoshana Levy | Stanford Medicine Profiles
... restricted peptide epitope of OVA (amino acids 257-264, SIINFEKL), or this class I-restricted epitope plus the adjacent class ... A nine-amino acid peptide from IL-1 beta augments antitumor immune responses induced by protein and DNA vaccines JOURNAL OF ... Six mAb were selected for their ability to bind synthetic peptides corresponding to amino acid residues 103-112 and 97-107 of ... Finally, the nucleic acid sequence of 38C-Id light chain was determined and, based on the corresponding amino acid sequence and ...
  https://med.stanford.edu/profiles/shoshana-levy?tab=teaching
*  T Helper Subset Differentiation in the Absence of Invariant Chain | JEM
... littermates and incubated with varying amounts of the 18-amino acid peptide epitope of LACK (Peptide), soluble Leishmania ... amino acid peptide epitope, production of IL-2 in the supernatant (Fig. 5) was consistently enhanced using Ii −/−, as compared ... T cells from these mice recognize an 18-amino acid peptide epitope restricted by I-Ad from an immunodominant antigen, ... Splenocytes from Ii+ mice were incubated with varying amounts of the LACK peptide epitope (Peptide; 5 × 105 APCs/well), ...
  http://jem.rupress.org/content/185/1/31
*  Herpes simplex virus diagnostics - Chiron Corporation
... such as amino acids 111-116 of gG1 and amino acids 357-364, 553-572, 573-580 and 601-608, of gG2 type-specific peptide epitopes ... 153 amino acids), a linker of 2 amino acids (Met-Ala) and a HSV-1 gG1 polypeptide of 190 amino acids (FIG. 2C). The nucleotide ... Generally, an epitope consists of at least 5 such amino acids and, more usually, consists of at least 8-10 such amino acids. ... A truncated derivative of HSV-2 strain G VP16, VP16-2t, encoding amino acids 1-416 with the six-amino acid glu-epitope tag at ...
  http://www.freepatentsonline.com/5965354.html
*  Patent US6451983 - Tumor necrosis factor antibodies - Google Patents
1984). "Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid" Proc. Natl. Acad ... except for certain amino acids as specified in Table 5.. Side chain protection chosen for the amino acids was removed ... 1. Overlapping peptides of 7 and 10 amino acid residues long were synthesized on polypropylene pins according to the method of ... The following peptides were synthesised and are described using the conventional three letter code for each amino acid with the ...
  http://www.google.co.uk/patents/US6451983
*  Frontiers | An Effective Way of Producing Fully Assembled Antibody in Transgenic Tobacco Plants by Linking Heavy and Light...
A sequence coding for a foot-and-mouth disease virus (FMDV) 2A peptide has been successfully used to link two or more genes, ... A sequence coding for a foot-and-mouth disease virus (FMDV) 2A peptide has been successfully used to link two or more genes, ... A Ebola epitope peptide (ATQVEQHHRRTDNDSTA), 17-amino acids corresponding to 401-417 region of the Zaire Ebola virus Mayinga ... The F2A peptide has 19 amino acids while some other 2A peptides have 18-22 amino acids. All of them are originated from various ...
  https://www.frontiersin.org/articles/10.3389/fpls.2018.01379/full
*  IL10R Alpha Blocking Peptide - Gentaur.com
IL10R Alpha Blocking Peptide is available 2 times from supplier fitzgerald at Gentaur.com shop ... or alpha protein sometimes glycoprotein present in blood.Peptides short amino acid chains or epitopes or blocking antagonists. ... The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, ... You can block the antibody by the specific target amino acid sequence of peptide. ...
  https://gentaur.com/prod/il10r-alpha-blocking-peptide/fitzgerald/1623584406
*  Autoimmune T-Cell Reactivity to Myelin Proteolipids and Glycolipids in Multiple Sclerosis
Some HLA types may be able to successfully present these epitopes, but in others, the amino acid differences may render the ... B. Bielekova, B. Goodwin, N. Richert et al., "Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99 ... DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope," Neurochemical ... This rapid concentration of peptide in the endosomes was facilitated through the presence of the palmitic acid, as fatty acids ...
  https://www.hindawi.com/journals/msi/2013/151427/
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
... marker DNA sequences which detect either directly or indirectly the identity of the codon encoding for the amino acid at ... Such antibodies and peptides encoded by said DNA sequences can be used therapeutically or prophylactically. ... DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated ... aspartic acid, and glutamic acid (the "I-DE" epitope) for leucine, glutamine, and lysine at amino acid positions 68, 71, and 72 ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  Hugh McDevitt | Stanford Medicine Profiles
... and immunization with these peptide epitopes indicate that the two amino acid substitutions within the I-A(beta) chain that ... Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells PROCEEDINGS OF THE ... We have generated transgenic mice on the NOD background expressing a T cell receptor (TCR)-specific for peptide epitope 286-300 ... The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and ...
  https://med.stanford.edu/profiles/hugh-mcdevitt
*  Rindopepimut - Wikipedia
The vaccine consists of the EGFRv3-specific peptide (a 13-amino acid mutant vIII epitope) conjugated to the non-specific ... Rindopepimut (CDX-110) is an injectable peptide cancer vaccine which targets a mutant protein called EGFRvIII present in about ...
  https://en.wikipedia.org/wiki/Rindopepimut