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*  IJMS | Free Full-Text | Antibody Phage Display Libraries: Contributions to Oncology | HTML
This procedure resulted in a variant containing three amino acids changes in the CDR3 that increased binding affinity for the ... Usually the majority of such probes are obtained from peptides phage libraries once peptides present high affinity and ... Yip, Y.L.; Smith, G.; Koch, J.; Dubel, S.; Ward, R.L. Identification of epitope regions recognized by tumor inhibitory and ... that consists of a single human framework with diversity incorporated at 18 amino acid positions among VH and VL domains, ...
  http://www.mdpi.com/1422-0067/13/5/5420/htm
*  COMPOSITIONS AND METHODS FOR COMBINING REPORT ANTIBODIES - Patent application
... for Peptide Ligands with an Epitope Library, 249 Science 386 (1990); J. J. Devlin et al., Random Peptide Libraries: A Source of ... cassette of six amino acid residues. The hexapeptide modules fused to bacteriophage proteins provided a library for the ... 0054]Other methods, such as preparation of random peptide libraries or epitope libraries are well known in the art and may be ... proteins instead of peptides) that have multiple epitopes. Therefore, it will be appreciated that depending on the antigens and ...
  http://www.patentsencyclopedia.com/app/20080286881
*  Ole Lund - DTU
ArrayPitope: Automated Analysis of Amino Acid Substitutions for Peptide Microarray-Based Antibody Epitope Mapping Hansen, ...
  http://www.dtu.dk/english/service/phonebook/person?fr=11&id=5094&mr=10&qt=dtupublicationquery&tab=2
*  HSD17B4 MPF 2 Blocking Peptide - Gentaur.com
HSD17B4 MPF 2 Blocking Peptide is available 2 times from supplier Biovision at Gentaur.com shop ... Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 ... amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, ... You can block the antibody by the specific target amino acid sequence of peptide. ...
  https://gentaur.com/prod/hsd17b4-mpf-2-blocking-peptide/biovision/3104754679
*  Frontiers | Cell Wall Anchoring of the Campylobacter Antigens to Lactococcus lactis | Microbiology
First we constructed hybrid protein - CjaA antigen presenting CjaD peptide epitopes on its surface. We showed that specific ... To the best of our knowledge, this is the first attempt to employ LAB (Lactic Acid Bacteria) strains as a mucosal delivery ... First we constructed hybrid protein - CjaA antigen presenting CjaD peptide epitopes on its surface. We showed that specific ... In this work we tested the usefulness of Lactococcus lactis, the most extensively studied lactic acid bacterium, as a delivery ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.00165/full
*  PDB 1klu citation summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
Modification of the inhibitory amino acid for epitope peptide binding onto major histocompatibility complex class II molecules ... A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes. Pierce BG, Weng Z. Protein Sci. 22 35-46 ( ... Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes. Bordner AJ. PLoS ONE 5 e14383 ( ... A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Zavala-Ruiz ...
  http://www.ebi.ac.uk/pdbe/entry/pdb/1klu/citations
*  Antiproliferative and Apoptotic Effects of a Specific Antiprostate Stem Cell Single Chain Antibody on Human Prostate Cancer...
Briefly, peptides as epitopes (amino acids 50-64 and 67-81 of PSCA) were coated overnight on immunotubes (Nunc, Roskilde, ... was amino acids 67-81 of PSCA protein. This peptide also has immunogenic properties and is considered as an amino acid sequence ... Peptide I (TARIRAVGLLTVISK) was amino acids 50-64 of extracellular domain of PSCA molecule. It was reported that mAb 1G8 ... amino acids 46-85 [33]. Therefore, peptide I used in this study is in the recognition part of 1G8 antibody which has been ...
  https://www.hindawi.com/journals/jo/2013/839831/
*  Survivin as a Cancer Vaccine Target | OMICS International
Altered peptide ligands generated by substituting amino acids within a peptide epitope can markedly alter immune responses. ... 8.6 months) [78]. This anti-survivin vaccine peptide mixture (EMD640744) consists of five CTL epitope peptides, each with ... contains a large synthetic peptide with amino acid substitution designed to enhance MHC class I binding [25,57]. As a result ... collectively representing a large patient population in which the peptide should be immunogenic [25,57]. An amino acid ...
  https://www.omicsonline.org/open-access/survivin-as-a-cancer-vaccine-target-2157-7560.1000230.php?aid=26593
*  EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function |...
All epitope peptides are abbreviated to the first three amino acids throughout this text. The peptides were purchased from Alta ... Peptides and HLA class I tetramers. The following EBV-epitope peptides were used in this study: the A2-restricted epitopes GLC ... the lytic epitopes GLC and YVL and the latent epitope CLG) or one of three B8-restricted epitopes (the lytic epitope RAK and ... based on staining with HLA class I/peptide tetramers (15) and on peptide-induced cytokine release (16, 17), which allow epitope ...
  http://www.jimmunol.org/content/167/4/2019
*  Patent US7601814 - Reducing the immunogenicity of fusion proteins - Google Patents
... or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and ... Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional ... epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve ... amino acid of a first protein or peptide and the first (N-terminal) amino acid of a second protein or peptide in a fusion ...
  http://www.google.ca/patents/US7601814
*  US Patent # 7,422,746. Chemically programmable immunity - Patents.com
Geysen, H. Mario et al.; "Use of Peptide Synthesis to Probe Viral Antigens for Epitopes to a Resolution of a Single Amino Acid ... Xu, Wei et al.; "Anti-peptide aptamers recognize amino acid sequence and bind a protein epitope"; Proc. Natl. Acad. Sci. USA; ... amino-2'-deoxypyrimidines. Nucleic acids using these bases are much more stable in vivo than naturally occurring nucleic acids ... This peptide, or some part of it, functions as the second binding site. Methods for making the nucleic acid aptamers, which ...
  http://www.patents.com/us-7422746.html
*  Plus it
... tested a 105-amino acid synthetic MUC-1 peptide with five repeated immunodominant epitopes. In that study, 63 patients with ... Because most p53 mutations involve the alteration of a single amino acid, it follows that most of the p53 epitopes presented to ... Zaks T. Z., Rosenberg S. A. Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide specific cytotoxic T ... six patients with breast cancer were vaccinated four times with a 106-amino acid MUC-1 peptide with KLH and QS-21. The T-cell ...
  http://clincancerres.aacrjournals.org/content/9/9/3222
*  Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation
... was accessed by a synthetic peptide epitope radioimmunoassay corresponding to human CHGA amino acids 361 to 372. The CHGA ... Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372). Naturally Occurring Amino Acid Variant Gly364Ser ... In probing human genetic variation at CHGA, we discovered 3 naturally occurring amino acid substitution variants in the ... We discovered a naturally occurring amino acid substitution variant in the catestatin region Gly364Ser with an allele frequency ...
  http://circ.ahajournals.org/content/115/17/2271
*  Frontiers | Green Tea Catechin-Inactivated Viral Vaccine Platform | Microbiology
... crosslinked primarily with cysteine residues and thus preserved the major epitopes of the influenza hemagglutinin. In a mouse ... crosslinked primarily with cysteine residues and thus preserved the major epitopes of the influenza hemagglutinin. In a mouse ... a major anchor residue for epitope binding to MHC molecules, GT catechin epigallocatechin-3-gallate (EGCG) ... a major anchor residue for epitope binding to MHC molecules, GT catechin epigallocatechin-3-gallate (EGCG) ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.02469/full
*  Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer
... mapping experiments showed that the dendrimer induced immunoreactivity to more contiguous peptide epitopes along the amino acid ...
  https://kuscholarworks.ku.edu/handle/1808/13280
*  Peptide compositions for the treatment of HIV infection - Patent # 6447778 - PatentGenius
The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp120 principal neutralizing ... The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide ... of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. ... The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of ...
  http://www.patentgenius.com/patent/6447778.html
*  A Region of the N-terminal Domain of Meningococcal Factor H Binding Protein that Elicits Bactericidal Antibody across Antigenic...
Amino acid sequences of the phage-displayed peptides mimicking the JAR 4 epitope ... and that the respective distances between amino acids affecting the JAR 4 epitope and those of the epitopes of the second mAb ... The specific amino acids that flanked the DHK residues in the phage peptides, and contributed to JAR 4 binding to the phages, ... The objective of the present study was to identify amino acid residues in fHbp affecting the JAR 4 epitope. The long-term goals ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2673115/
*  Shoshana Levy | Stanford Medicine Profiles
... restricted peptide epitope of OVA (amino acids 257-264, SIINFEKL), or this class I-restricted epitope plus the adjacent class ... A nine-amino acid peptide from IL-1 beta augments antitumor immune responses induced by protein and DNA vaccines JOURNAL OF ... Six mAb were selected for their ability to bind synthetic peptides corresponding to amino acid residues 103-112 and 97-107 of ... Finally, the nucleic acid sequence of 38C-Id light chain was determined and, based on the corresponding amino acid sequence and ...
  https://med.stanford.edu/profiles/shoshana-levy?tab=teaching
*  Plus it
Experimental Design: Epitope-candidate peptides were predicted from the amino acid sequence of VEGFR1 based on their ... Epitope-candidate peptides were predicted from the amino acid sequence of VEGFR1 based on their theoretical binding affinities ... Synthetic peptides. The epitope-candidate peptides derived from VEGFR1 restricted to HLA-A*0201 (A2) and HLA-A*2402 (A24) were ... Peptide-specific CTL clones were also induced in vitro with these identified epitope peptides from peripheral blood mononuclear ...
  http://clincancerres.aacrjournals.org/content/12/19/5841
*  T Helper Subset Differentiation in the Absence of Invariant Chain | JEM
... littermates and incubated with varying amounts of the 18-amino acid peptide epitope of LACK (Peptide), soluble Leishmania ... amino acid peptide epitope, production of IL-2 in the supernatant (Fig. 5) was consistently enhanced using Ii −/−, as compared ... T cells from these mice recognize an 18-amino acid peptide epitope restricted by I-Ad from an immunodominant antigen, ... Splenocytes from Ii+ mice were incubated with varying amounts of the LACK peptide epitope (Peptide; 5 × 105 APCs/well), ...
  http://jem.rupress.org/content/185/1/31
*  Experimental Evolution: Foot-and-Mouth Disease Virus - Immunology and Evolution of Infectious Disease - NCBI Bookshelf
These antibody binding sites appear to be determined mostly by the amino acids in the GH peptide (a continuous epitope). ... Structural studies provide the three-dimensional location of amino acids. This allows one to analyze how particular amino acid ... Discontinuous epitopes occur when amino acid residues from widely separated sequence locations come together conformationally ... 2001). This loop has about 20 amino acids that contribute to several overlapping epitopes. ...
  https://www.ncbi.nlm.nih.gov/books/NBK2393/
*  Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies | Science
In this experiment, two gp41 2F5 epitope peptides, 2F5 amino acids 652 to 671 (QQEKNEQELLELDKWASLWN), and 2F5 amino acids 656 ... 2B). The amino acid sequence to which mAb 2F5 binds on HIV-1 gp41 includes amino acids 662 to 668 (Glu-Leu-Asp-Lys-Trp-Ala) (3 ... Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His ... E) demonstrates that both nominal 2F5 epitope peptides inhibited 2F5 mAb binding to cardiolipin, with IC50 of 2F5 652 to 671 ...
  http://science.sciencemag.org/content/308/5730/1906?ijkey=ea80581b8fc147d67208719cc59457d7fde16bd7&keytype2=tf_ipsecsha
*  Herpes simplex virus diagnostics - Chiron Corporation
... such as amino acids 111-116 of gG1 and amino acids 357-364, 553-572, 573-580 and 601-608, of gG2 type-specific peptide epitopes ... 153 amino acids), a linker of 2 amino acids (Met-Ala) and a HSV-1 gG1 polypeptide of 190 amino acids (FIG. 2C). The nucleotide ... Generally, an epitope consists of at least 5 such amino acids and, more usually, consists of at least 8-10 such amino acids. ... A truncated derivative of HSV-2 strain G VP16, VP16-2t, encoding amino acids 1-416 with the six-amino acid glu-epitope tag at ...
  http://www.freepatentsonline.com/5965354.html
*  Rindopepimut - Wikipedia
The vaccine consists of the EGFRv3-specific peptide (a 13-amino acid mutant vIII epitope) conjugated to the non-specific ... Rindopepimut (CDX-110) is an injectable peptide cancer vaccine which targets a mutant protein called EGFRvIII present in about ...
  https://en.wikipedia.org/wiki/Rindopepimut
*  Peptide amphiphile - Wikipedia
... a region of beta-sheet forming amino acids, and a peptide epitope designed to allow solubility of the molecule in water, ... "Synthetic lipidation of peptides and amino-acids - Monolayer structure and properties." doi:10.1021/ja00142a019 Hartgerink JD, ... multidomain peptides consisting nominally of alternating hydrophobic and hydrophilic amino acids, with terminal lysines self- ... acids and hydrophobic collapse of the tails to yield the formation of cylindrical micelles that present the peptide epitope at ...
  https://en.wikipedia.org/wiki/Peptide_amphiphile