*  SMART: WD40 domain annotation
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W- ... Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. ... Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as ... several proteins with WD-repeats are able to fold into globular proteins in a rabbit reticulocyte lysate. One protein, beta ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=WD40&START=34&END=73&E_VALUE=4.11e-10&TYPE=SMART&BLAST=NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG
*  WD40 repeat - Wikipedia
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, ... WD40 domain-containing proteins have 4 to 16 repeating units, all of which are thought to form a circularised beta-propeller ... The blades interlock so that the last beta strand of one repeat forms with the first three of the next repeat to form the 3D ... Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ...
  https://en.wikipedia.org/wiki/WD40_repeat
*  Recombinant Human TBLR1 / TBL1XR1 protein (ab153511) | Abcam
TBL1XR1 protein. Ab153511 is a full length protein produced in Wheat germ and has been validated in WB, ELISA. Abcam provides… ... Transducin beta like 1X related protein 1. *Transducin beta-like 1X-related protein 1 ... Belongs to the WD repeat EBI family.. Contains 1 F-box-like domain.. Contains 1 LisH domain.. Contains 8 WD repeats. ... Recombinant Human TBLR1 / TBL1XR1 protein. See all TBLR1 / TBL1XR1 proteins and peptides. ...
  https://www.abcam.com/recombinant-human-tblr1--tbl1xr1-protein-ab153511.html
*  Cells | Free Full-Text | Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein | HTML
The interaction between Mule and Mcl-1 can be modulated by other Bcl-2 family proteins, while recognition of Mcl-1 by the other ... Ubiquitination of Mcl-1, that targets it for proteasomal degradation, allows for rapid elimination of the protein and ... Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of multiple cell lineages and that is ... E3 ubiquitin-ligases and deubiquitinase is influenced by phosphorylation of specific residues in Mcl-1. The protein kinases and ...
  http://www.mdpi.com/2073-4409/3/2/418/htm
*  Cell cycle Role of SCF complex in cell cycle regulation
... beta-transducin repeat containing protein ( TrCP ) or F-box protein FBW7 ( FBXW7 )) and RING-box protein 1. The Cullin 1/ RING- ... Ubiquitin, a small protein of 76 amino acids is found in all eukaryotic cells. In the Ubiquitin -dependent pathway, the ... Chk1, RING-box protein 1, UBE1, CDC34, CDC25A, CKS1, Wee1, beta-TrCP, NEDD8, p27KIP1, Cul1/Rbx1 E3 ligase, APC/hCDH1 complex, ... Ubiquitin-lake protein NEDD8 charged surface residues mediates activation of Cullin 1/ RING-box protein 1, which is needed to ...
  http://pathwaymaps.com/maps/706/
*  SMART: GGL domain annotation
Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. ... The transducin gamma subunit is very hydrophilic and acidic; it has 19 acidic and 11 basic amino acids as well as three ... several proteins with WD-repeats are able to fold into globular proteins in a rabbit reticulocyte lysate. One protein, beta ... PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX. 3ah8. Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=dummy&DOMAIN=GGL
*  IGF2BP1 Antibody
... beta-actin andbeta-transducin repeat-containing protein, and regulating theirtranslation. Two transcript variants encoding ... KLH conjugated synthetic peptide between 508-534 amino acids from the C-terminal region of human IGF2BP1 ... Protein Aliases: Coding region determinant-binding protein; CRD-BP; CRDBP; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding ... IGF2BP1 is a member of the insulin-like growthfactor 2 mRNA-binding protein family. The protein encoded by thisgene contains ...
  https://www.thermofisher.com/antibody/product/IGF2BP1-Antibody-Polyclonal/PA5-23968
*  G beta-gamma complex - Wikipedia
The amino acid sequence contains 7 WD repeat motifs of about 40 amino acids, each highly conserved and possessing the Trp-Asp ... Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... Nevertheless, recent in vivo findings demonstrate the necessity of the transducin Gβγ complex in the functioning of rod ... August 1992). "Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound ...
  https://en.wikipedia.org/wiki/G_beta-gamma_complex
*  Structural Biochemistry/Protein Evolution - Wikibooks, open books for an open world
WD40 domains were first discovered in bovine beta-transducin, a subunit of the trimeric G protein transducin complex. It ... Each of the proteins formed would consist of a domain with the characteristic length of amino acids being 100. Further ... WD40 Domain (WD- Repeat)[edit]. WD40 domain is one of the most abundant domains and is one of the most active domains of the ... Protein Evolution[edit]. Protein evolution is a key indicator of the progression of proteins through time. These studies have ...
  https://en.wikibooks.org/wiki/Structural_Biochemistry/Protein_Evolution
*  Arrestin C-terminal-like domain (IPR011022) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... two domains of antiparallel beta-sheets connected through a hinge region and one short alpha-helix on the back of the amino- ... It interacts with photo-activated phosphorylated rhodopsin, inhibiting or 'arresting' its ability to interact with transducin [ ...
  http://www.ebi.ac.uk/interpro/entry/IPR011022
*  The Role of PPAR in the Transcriptional Control by Agonists and Antagonists
TBL1 is a 6 WD-40 repeat-containing protein (also known as beta-transducin repeat) that was identified as a subunit of the SMRT ... PPARγ2 has 30 additional amino acids at the N-terminus in humans [20] and is generated from the same gene by mRNA splicing [21 ... transducin β-like 1 (TBL1), TBL1-related protein (TBLR1), and G protein pathway suppressor 2 (GPS2), forming a functional ... J. Li, J. Wang, J. Wang et al., "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3," ...
  https://www.hindawi.com/journals/ppar/2012/362361/
*  Anti-TBLR1 antibody (ab97398) | Abcam
Transducin beta like 1X related protein 1 antibody. *Transducin beta-like 1X-related protein 1 antibody ... Belongs to the WD repeat EBI family.. Contains 1 F-box-like domain.. Contains 1 LisH domain.. Contains 8 WD repeats. ... Recombinant fragment containing a sequence corresponding to a region within amino acids 210-484 of Human TBLR1 (NP_078941). ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ...
  http://www.abcam.com/tblr1-antibody-ab97398.html
*  Identification and characterization of endonuclein binding proteins: evidence of modulatory effects on signal transduction and...
The recombinant protein was immobilized to a column and by affinity chromatography several interacting proteins were purified ... The interacting proteins were identified as; Tax interaction protein 1 (TIP-1), Aα fibrinogen transcription factor (P16/SSBP1 ... immunoglobulin heavy chain binding protein (BiP), human ER-associated DNAJ (HEDJ/DNAJB11), endonuclein interaction protein 8 ( ... Using the cDNA encoding human endonuclein, we have expressed and purified the recombinant protein from Escherichia coli using ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-10-34
*  GNB3 Gene - GeneCards | GBB3 Protein | GBB3 Antibody
Protein Coding), G Protein Subunit Beta 3, including: function, proteins, disorders, pathways, orthologs, and expression. ... G-protein beta WD-40 repeat signature * Beta G-protein (transducin) signature ... 340 amino acids. Molecular mass:. 37221 Da. Quaternary structure:. *G proteins are composed of 3 units, alpha, beta and gamma. ... Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 3 2 3 * Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=GNB3&simap=8
*  SMART: Secondary literature for RPOL9 domain
... an RNP-type RNA-binding domain that contacts the pre-mRNA and transducin repeats characteristic of G-protein beta-subunits. ... 33 amino acids) were longer than that (3 amino acids) of TRA1 and the N-terminus of NOR1 protein contained proline-rich ... This domain, described also in eIF4G and NMD2 proteins, is thought to be involved in protein-protein and also in protein--RNA ... Menin, the 610-amino acid nuclear protein encoded by MEN1, binds to the transcription factor JunD and can repress JunD-induced ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=RPOL9
*  Tle1 - Transducin-like enhancer protein 1 - Mus musculus (Mouse) - Tle1 gene & protein
View protein in PROSITE. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. ... Transducin-like enhancer protein 1Add BLAST. 770. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex. R-MMU-3769402. Deactivation of the beta-catenin ... View protein in PROSITE. PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. ...
  http://www.uniprot.org/uniprot/Q62440
*  GNB4 - Guanine nucleotide-binding protein subunit beta-4 - Homo sapiens (Human) - GNB4 gene & protein
The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector ... G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. ... View protein in PROSITE. PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. ... Guanine nucleotide-binding protein subunit beta-4Add BLAST. 339. Amino acid modifications. Feature key. Position(s). ...
  http://www.uniprot.org/uniprot/Q9HAV0
*  Mothers against decapentaplegic homolog 4 - Wikipedia
... inhibition and also generate a phosphodegron used as a docking site by the ubiquitin E3 ligase Beta-transducin Repeat ... The SMAD proteins are homologs of both the Drosophila protein MAD and the C. elegans protein SMA. The name is a combination of ... SMAD4 is a 552 amino-acid polypeptide with a molecular weight of 60.439 Da. SMAD4 has two functional domains known as MH1 and ... It also belongs to the Darwin family of proteins that modulate members of the TGFβ protein superfamily, a family of proteins ...
  https://en.wikipedia.org/wiki/Mothers_against_decapentaplegic_homolog_4
*  Patente US8093043 - β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing ... - Google Patentes
In certain embodiments, the invention relates to inhibitors of at least one of β-TrCP1/2 or RSK1/2 proteins that sensitize ... beta-transducin repeat containing protein 1) paralogous gene product, called β-TrCP2 (beta-transducin repeat containing protein ... Human Cdc25A (cell division cycle 25A protein) has been sequenced and is a 524 amino acid long protein according to GenBank ... A "β-transducin repeat containing protein" or "β-TrCP" herein is a protein belonging to the family of F-box proteins containing ...
  http://www.google.es/patents/US8093043?hl=es&dq=flatulence
*  TLE6 Gene - GeneCards | TLE6 Protein | TLE6 Antibody
Protein Coding), Transducin Like Enhancer Of Split 6, including: function, proteins, disorders, pathways, orthologs, and ... Protein attributes for TLE6 Gene. Size:. 572 amino acids. Molecular mass:. 63473 Da. Quaternary structure:. *Component of the ... Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling ... Contrary to other WD repeat Groucho/TLE family members, does not contain any identifiable Q, GP, CcN or SP domains. Only the C- ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=TLE6
*  William Weis | Stanford Medicine Profiles
We have determined the crystal structure of a 15 amino acid beta-catenin binding repeat from APC bound to the armadillo repeat ... Siah-1-interacting protein (SIP), Skp1, transducin beta-like 1 (TBL1), and adenomatous polyposis coli (APC). Given the ... Plakoglobin and beta-catenin are homologous armadillo repeat proteins found in adherens junctions, where they interact with the ... APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats. ...
  https://med.stanford.edu/profiles/william-weis
*  Molecular strategies for modulating Wnt signaling | ПРЕЦИЗИОННАЯ ОНКОЛОГИЯ
... bone morphogenetic proteins, and Hedgehog proteins). This review will summarize the research surrounding currently available ... secreted Frizzled-Related Proteins (sFRPs), and Wnt Inhibitory Factor-1 (WIF-1), along with others which may act via indirect ... The protein ligase beta-transducin repeat containing E3 ubiquitin protein ligase (βTrcP) is recruited to the complex where it ... These relatively small proteins (~350-400 amino acids and approximately 40kDa) are lipid modified in the endoplasmic reticulum ...
  http://cancerlink.ru/carcinogenesis/molecular-strategies-modulating-wnt-en/
*  INDIVIDUALIZED CANCER TREATMENTS - Patent application
... protein 3 201867_s_at transducin (beta)-like 1X-linked TBL1X 495656 AW968555 202000_at NADH dehydrogenase (ubiquinone) 1 NDUFA6 ... 70 kDa protein 1B NOL5A 200875_s_at nucleolar protein 5A (56 kDa with KKE/D repeat) CSE1L 201112_s_at CSE1 chromosome ... at oxysterol binding protein-like 2 OSBPL2 20q13.3 40201_at dopa decarboxylase (aromatic L-amino acid decarboxylase) DDC 7p11 ... at ribosomal protein S7 RPS7 2p25 34772_at coronin, actin binding protein, 2B CORO2B 15q23 34800_at leucine-rich repeats and ...
  http://www.patentsencyclopedia.com/app/20100305058
*  Prolactin Receptor cDNA ORF Clone,Mouse | SinoBiological
... by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein ... Prolactin Receptor cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information **Sino Biological guarantees 100% sequence ... beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast ... Protein expression is influenced by many factors that may vary between experiments or laboratories.** ...
  http://kr.sinobiological.com/Mouse-PRLR-Gene-cDNA-Clone-full-length-ORF-Clone-expression-ready-N-FLAG-tagged-p88846.html
*  KEGG BRITE: KEGG Orthology (KO) - Cricetulus griseus (Chinese hamster)
G protein subunit gamma transducin 2 100762552 Grk2; G protein-coupled receptor kinase 2 100761290 Adrbk2; beta-adrenergic ... SH3 and multiple ankyrin repeat domains protein K15009 SHANK; SH3 and multiple ankyrin repeat domains protein K15009 SHANK; SH3 ... L-amino-acid oxidase [EC:1.4.3.2] K03334 IL4I1; L-amino-acid oxidase [EC:1.4.3.2] K03334 IL4I1; L-amino-acid oxidase [EC:1.4. ... 100689442 Gnb1; G protein subunit beta 1 100756281 Gnb2; G protein subunit beta 2 100756790 Gnb3; G protein subunit beta 3 ...
  http://www.genome.jp/kegg-bin/get_htext?cge00001+100774486