*  Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel ...
Expression of the α-subunit of the amiloride-sensitive sodium channel (αENaC) is regulated by a number of factors in the lung, ... Abbreviations used: ENaC, amiloride-sensitive sodium channel; αENaC, α-subunit of ENaC; EMSA, electrophoretic mobility-shift ... Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel ( ... Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel ( ...
  http://www.biochemj.org/content/364/2/537
*  Epithelial sodium channel - Wikipedia
The epithelial sodium channel (short: ENaC, also: amiloride-sensitive sodium channel) is a membrane-bound ion channel that is ... and are also thought to form sodium channels. The epithelial sodium(Na+) channel (ENac) family belongs to the ENaC/P2X ... Amiloride and triamterene are potassium-sparing diuretics that act as epithelial sodium channel blockers. Jasti J, Furukawa H, ... Snyder PM, McDonald FJ, Stokes JB, Welsh MJ (Sep 1994). "Membrane topology of the amiloride-sensitive epithelial sodium channel ...
  https://en.wikipedia.org/wiki/Epithelial_sodium_channel
*  Photosensitive version of amiloride allows regulating the function of sodium-specific ion channels with light
... which allows regulating the function of sodium-specific ... ... The diuretic agent amiloride is used for the treatment of high ... Select sodium channel blockers have anti-diabetic effects. May 15, 2014 (HealthDay)-Blockade of voltage-gated sodium channels ( ... Structure of sodium channels different than previously believed. April 17, 2014 Sodium channels are implicated in many serious ... Photosensitive version of amiloride allows regulating the function of sodium-specific ion channels with light. July 22, 2014, ...
  https://phys.org/news/2014-07-photosensitive-version-amiloride-function-sodium-specific.html
*  Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.
Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility ... Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.. ... Further amiloride or benzamil administration prevented this lithium-induced downregulation of AQP2. Amiloride reduced ... Blocking lithium entry with amiloride attenuates lithium-induced diabetes insipidus, thus providing a rationale for its use in ...
  http://repository.ubn.ru.nl/handle/2066/79977
*  The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes | Journal of Cell Science
The epithelial sodium channel, ENaC, is a non-voltage-gated, amiloride-sensitive sodium channel highly expressed in kidney, ... 2000). Structure and regulation of amiloride-sensitive sodium channels. Annu. Rev. Physiol. 62, 573-594. doi:10.1146/annurev. ... 2006). The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. J. ... The epithelial sodium channel (ENaC), in addition to its function of regulating sodium transport in kidney, has recently been ...
  http://jcs.biologists.org/content/126/9/1942
*  Frontiers | Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines | Immunology
Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium channels (ENaC) which play a crucial role in ... Reabsorption is a two-step process: first, sodium enters via sodium-permeable channels in the apical membranes of alveolar type ... via sodium-permeable channels in the apical membranes of alveolar type 1 and 2 cells followed by active extrusion of sodium ... Cytokines and chemokines affect alveolar amiloride-sensitive epithelial sodium chan... ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00766/full
*  Angiotensin II Stimulates Renin in Inner Medullary Collecting Duct Cells via Protein Kinase C and Independent of Epithelial...
In vivo studies examined the effects of epithelial sodium channel blockade (amiloride; 5 mg/kg per day) on CD renin expression ... Ang II stimulates the epithelial sodium channel via the Ang II type 1 receptor and increases mineralocorticoid receptor ... Amiloride cotreatment did not alter these responses despite a reduction in the rate of progression of systolic blood pressure. ... Aldosterone (10−10 to 10−7 mol/L) with or without amiloride did not modify the upregulation of renin mRNA in Ang II-treated ...
  http://hyper.ahajournals.org/content/early/2011/01/31/HYPERTENSIONAHA.110.165902
*  Localization and characterization of phenamil-sensitive Na+ influx in isolated rainbow trout gill epithelial cells | Journal of...
Alvarez de Canessa, C. M., Fyfe, G. K. and Zhang, P. (2000). Structure and regulation of amiloride-sensitive sodium channels. ... We were unable to use effective concentrations of amiloride or any of the amiloride derivatives to specifically block the NHE ... Amiloride and other amiloride analogues could not be used to block the NHE due to their efficacy at also blocking eNaC family ... channel. These data do not support the existence of acid-sensing ion channels (ASICs) in gill epithelium. ASICs have been found ...
  http://jeb.biologists.org/content/206/3/551
*  Plus it
An intact amiloride‐sensitive sodium channel is required for the renal effects of the compound. The data further suggest that ... in the presence of an unblocked sodium channel, XAG could act also through inhibition of the epithelial sodium channel in the ... Pretreatment with the sodium channel blocker, amiloride, completely abolished the natriuretic and kaluretic actions of the ... Effects of blockade of the amiloride‐sensitive sodium channel on renal actions of XAG. Normal rats were prepared for clearance ...
  http://physreports.physiology.org/content/1/6/e00155
*  Scnn1b - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad
Amiloride-sensitive sodium channel subunit beta Aliases:. Not Available. RefSeq:. NM_012648. ... acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006] ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/assay/drnocpe5175567-primepcr-ddpcr-expression-probe-assay-scnn1b-rat
*  Anti-SCNN1B antibody (ab28668) | Abcam
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the ... Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. ... Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells.. Physiol Rep 2:N/A (2014). WB ... Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. ...
  http://www.abcam.com/scnn1b-antibody-ab28668.html
*  Prolactin increases open-channel density of epithelial Na+ channel in adult frog skin | Journal of Experimental Biology
Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia. Am. J. Physiol. 263 (Cell ... The single-channel current (i) and the Na+-channel density (M: sum of open and blocked channels) were calculated from: 3 and 4 ... increased the open-channel density (M) of the epithelial Na+ channel 6.1±1.2-fold but decreased the single-channel current i to ... Lindemann, B. and Van Driessche, W. (1977). Sodium-specific membrane channels of frog skin are pores: current fluctuations ...
  http://jeb.biologists.org/content/206/8/1319
*  Influence of Early Salt Diet on Taste and Blood Pressure in Rats | Springer for Research & Development
Sodium deficient rats are unmotivated by sodium chloride solutions mixed with the sodium channel blocker amiloride. Behav. ... Amiloride-sensitive sodium channels and expression of sodium appetite in rats. Am. J. Physiol. 253 (Regulatory Integrative Comp ... Sodium intake linked to amiloride-sensitive gustatory transduction in C57BL/6J and 129/J mice. Physiol. Behav., 57:231-239, ... Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat. Behav. Neurosci., 104:734-741 ...
  https://rd.springer.com/chapter/10.1007/978-0-585-29598-5_4
*  Frontiers | Carotid baroreflex responsiveness in normotensive African Americans is attenuated at rest and during dynamic leg...
... via altered amiloride-sensitive epithelial sodium channel (ENaC) function (Ambrosius et al., 1999; Pratt et al., 2002), and ... Racial difference in the activity of the amiloride-sensitive epithelial sodium channel. Hypertension 40, 903-908. ... 1999). Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00029/full
*  acd-2 - Uncharacterized protein - Caenorhabditis elegans - acd-2 gene & protein
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]UniRule annotation. ,p>Information ... Ion channel, Sodium channelUniRule annotation. ,p>Information which has been generated by the UniProtKB automatic annotation ...
  http://www.uniprot.org/uniprot/P91100
*  Plus it
1990) Regulation of the amiloride-blockable sodium channel from epithelial tissue. Mol. Cell. Biochem. 99:141-150. ... 1991) Effects of vasopressin and cAMP on single amiloride- blockable Na channels. Am. J. Physiol. 260(Cell Physiol. 29):C1071- ... 1982) The role of sodium-channel density in the natriferic response of the toad urinary bladder to an antidiuretic hormone. J. ... Post-cAMP cellular events involve a complex mechanism in which water channels (referred to as aquaporins) and Na+ channels are ...
  http://jpet.aspetjournals.org/content/281/1/62
*  Plus it
Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations. Am J Physiol Lung ... delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol 303: L1013-L1026, 2012. ... Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 82: 735- ... The second family of amiloride-sensitive Na+ channels in the lung is nonselective cation (NSC) channels that have Na+-K+ ...
  http://ajplung.physiology.org/content/305/9/L595
*  The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 378: 730-733 [PubMed] ... Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport. ... Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. 82: ... amiloride-sensitive sodium channels. The DEG/ENaC family is exceptionally large in genomes of Drosophila species relative to ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3583452/?lang=en-ca
*  SCNN1B - Wikipedia
As ENaC is strongly inhibited by amiloride, it is also referred to as an "amiloride-sensitive sodium channel". The first cDNA ... Alvarez de la Rosa D, Canessa CM, Fyfe GK, Zhang P (2000). "Structure and regulation of amiloride-sensitive sodium channels". ... Rossier BC, Pradervand S, Schild L, Hummler E (2002). "Epithelial sodium channel and the control of sodium balance: interaction ... "Structural organisation of the gene encoding the alpha-subunit of the human amiloride-sensitive epithelial sodium channel". ...
  https://en.wikipedia.org/wiki/SCNN1B
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Proteolytic activation is a characteristic feature of the amiloride-sensitive epithelial sodium channel (ENaC). The final ... epithelial sodium channel, ENaC, proteases, proteolytic channel activation, ion channel, cleavage sites, cleavage fragments ... Demonstration of Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by Combining Current Measurements with ... These results suggest a causal link between channel cleavage and channel activation. Moreover, they confirm the concept that a ...
  https://www.jove.com/visualize/abstract/21779388/a-conformation-sensitive-monoclonal-antibody-against-a2-domain-von
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Proteolytic activation is a characteristic feature of the amiloride-sensitive epithelial sodium channel (ENaC). The final ... epithelial sodium channel, ENaC, proteases, proteolytic channel activation, ion channel, cleavage sites, cleavage fragments ... Here, we employ the human cardiac sodium channel (hNaV1.5), expressed in Xenopus oocytes, to demonstrate the cut-open setup and ... Developmental Biology, Issue 85, Voltage clamp, Cut-open, Oocyte, Voltage Clamp Fluorometry, Sodium Channels, Ionic Currents, ...
  https://www.jove.com/visualize/abstract/19238202/localisation-function-endocannabinoid-system-human
*  Diuretic - Wikipedia
Epithelial sodium channel blockers: amiloride and triamterene. The term "calcium-sparing diuretic" is sometimes used to ... Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. ... This is large in comparison to normal renal sodium reabsorption which leaves only about 0.4% of filtered sodium in the urine. ... Loop diuretics, such as furosemide, inhibit the body's ability to reabsorb sodium at the ascending loop in the nephron, which ...
  https://en.wikipedia.org/wiki/Diuretic
*  G protein-gated ion channel - Wikipedia
"Regulation of the amiloride-blockable sodium channel from epithelial tissue". Mol. Cell. Biochem. 99 (2): 141-50. doi:10.1007/ ... Schubert B, VanDongen AM, Kirsch GE, Brown AM (August 1989). "Beta-adrenergic inhibition of cardiac sodium channels by dual G ... Blocking IK,ACh channel activity could be a therapeutic target in atrial fibrillation and is an area under study. GIRK channels ... These ion channels are transmembrane ion channels with selectivity filters and a G protein binding site. The GPCRs associated ...
  https://en.wikipedia.org/wiki/G_protein-gated_ion_channel
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Proteolytic activation is a characteristic feature of the amiloride-sensitive epithelial sodium channel (ENaC). The final ... epithelial sodium channel, ENaC, proteases, proteolytic channel activation, ion channel, cleavage sites, cleavage fragments ... Demonstration of Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by Combining Current Measurements with ... These results suggest a causal link between channel cleavage and channel activation. Moreover, they confirm the concept that a ...
  https://www.jove.com/visualize/abstract/22615919/clinical-severity-thalassaemiahb-e-disease-is-associated-with
*  NPD Prescription Drugs Canadian Pharmacy - Buy Lopressor Metoprolol Tartrate online
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