*  ASMscience | Complement in Infections
Complement is activated by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. The lectin ... are specific components of the alternative pathway of complement activation. The complement activation is tightly regulated by ... and depletion of complement components. A deficiency in any component of the classical pathway is associated with an increased ... This chapter highlights the various roles of the complement system in the orchestration of the immune response towards ...
  http://www.asmscience.org/content/book/10.1128/9781555816872.ch06
*  Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement | The Journal of Immunology
C5 convertases of the alternative and classical pathways of complement are complex serine proteases that are made up of two or ... The conversion of human complement component C5 into fragment C5b by the alternative pathway C5 convertase. Biochem. J. 199: ... In the classical pathway C3 convertase C4b,C2a has a structure similar to the alternative pathway C3 convertase in having C2a ... C3 convertases of the alternative pathway (monomeric C3/C5 convertase assembled with monomeric C3b (C3b,Bb)) and the classical ...
  http://www.jimmunol.org/content/166/4/2635
*  Complement C3-C5 Convertases - C3 Convertase Summary Report | CureHunter
These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. ... Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A ... C3 Convertases, Complement; C3-C5 Convertases, Complement; C5 Convertases, Complement; Complement C3 C5 Convertases; Convertase ... Convertase, C3-C5; Convertase, Complement 3; Convertases, Complement C3; Convertases, Complement C3-C5; Convertases, Complement ...
  http://www.curehunter.com/public/keywordSummaryD050577-Complement-C3-C5-Convertases-C3-Convertase.do
*  Complement membrane attack complex - Wikipedia
All three pathways of the complement system (classical, lectin and alternative pathways) initiate the formation of MAC. Another ... two regulators of complement. The membrane attack complex is initiated when the complement protein C5 convertase cleaves C5 ... Terminal complement pathway deficiency Peitsch MC, Tschopp J (1991). "Assembly of macromolecular pores by immune defense ... Deficiencies of C5 to C9 components does not lead to generic infections, but only to increased susceptibility to Neisseria spp ...
  https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
*  Alternative complement pathway - Wikipedia
After the creation of C5 convertase (either as (C3b)2BbP or C4b2a3b from the classical pathway), the complement system follows ... The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the ... This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although ... The C5-convertase of the alternative pathway consists of (C3b)2BbP (sometimes referred to as C3b2Bb). ...
  https://en.wikipedia.org/wiki/Alternative_complement_pathway
*  Recombinant Mouse Complement Component C5
... is produced by our E.coli expression system and the target gene encoding Asn679- ... that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway ( ... 关于Complement C5】:. Mouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally ... Complement C5产品说明】:. Recombinant Mouse Complement Component C5 is produced by our E.coli expression system and the target gene ...
  http://www.sinobio.net/cytokine/other_cytokine/Complement_Component_C5_C5a_Mouse.html
*  Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis
C5 convertase (C4b2a3b for the classical and lectin pathways, and C3bBbC3b for the alternative pathway). This enzyme cleaves C5 ... Early complement activation. Complement is activated through three different pathways. The alternative pathway is spontaneously ... In the classical and lectin pathways, C3 convertase is formed by a fragment of C4b and C2a (C4b2a), while, in the alternative ... and mediated by the action of thrombin on C5 convertase. Other complement activation pathways occur through proteases, such as ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042011000500009&lng=en&nrm=iso&tlng=en
*  Human complement component 5
In the classical pathway C5 convertase is composed of C4b2a3b and in the alternative pathway is C3bBbC3b. Both C5 convertases ... Distal Recognition Site for Classical Pathway Convertase Located in the C345C/Netrin Module of Complement Component C5. The ... C5 convertase cleaves C5 about 800 amino acids away from C345C. Other complement proteins such as C6 and C7 interact with C5 at ... This diagram of C5 convertase shows where C5 is cleaved (dotted arrows) to become activated and where the functional C5-C345C ...
  http://www.bio.davidson.edu/courses/Immunology/Students/spring2006/Fiser/C5.html
*  Complement B/C2 (IPR011360) | InterPro | EMBL-EBI
... complement C2 and complement factor B, which, respectively, have analogous roles in the classical and alternative pathways of ... Briefly, they are activated by cleavage and function as the serine protease components of the C3/C5 convertases, which play ... Complement B/C2 (IPR011360). Short name: Compl_C2_B Overlapping homologous superfamilies *von Willebrand factor A-like domain ... New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.. EMBO J. 19 164-73 2000 ...
  http://www.ebi.ac.uk/interpro/entry/IPR011360
*  Patent US7999081 - Anti-C5 alpha antibodies - Google Patents
... specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 ... in particular for the therapy of diseases involving tissue damage deriving from uncontrolled activation of the complement ... "Distal recognition site for classical pathway convertase located in the C345C/netrin module of complement component C5," J. ... rabbit erythrocyte lysis by inhibiting C5 conversion similarly through the classical pathway and the alternative pathway. ...
  http://www.google.com/patents/US7999081?dq=5,579,517
*  List of EC numbers (EC 3) - Wikipedia
... complement component C5 convertase. Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: complement ... factor I EC 3.4.21.46: complement factor D EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase EC 3.4.21.48: ... complement subcomponent C1s EC 3.4.21.43: classical-complement-pathway C3/C5 convertase EC 3.4.21.44: Transferred entry: ... Proprotein convertase 1 EC 3.4.21.94: Proprotein convertase 2 EC 3.4.21.95: Snake venom factor V activator EC 3.4.21.96: ...
  https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)
*  C5-convertase - Wikipedia
... or the alternative pathway (C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical ... C3 and C5 convertase activity is generated upon addition of Factors B and D. The classical pathway C5 convertase is composed of ... The complement component C5 can be also activated by fluid phase C5 convertase. C5 is activated by CVFBb in the presence of ... Target of function The target of C5 convertase is complement protein C5. C5 is a two-chain (α, β) plasma glycoprotein (Mr = ...
  https://en.wikipedia.org/wiki/C5-convertase
*  Urinary Excretion of C5b-9 in Severe PreeclampsiaNovelty and Significance | Hypertension
The complement cascade may be activated through classical (CP), lectin (LP), or alternative pathways (AP). Although each ... C5 convertases cleave C5 to generate C5a (anaphylatoxin) and C5b, which combines with complement proteins C6-9 to form C5b-9 ( ... Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. Am J Obstet Gynecol. ... propagating a systemic inflammatory response and placing strain on both classical and alternative complement signaling pathways ...
  http://hyper.ahajournals.org/content/62/6/1040
*  Classical complement pathway - Wikipedia
C3b binds to the C3 convertase (C4bC2a), to form C5 convertase (C4bC2aC3b). C5 convertase then cleaves C5 into C5a and C5b. ... Alternative complement pathway - another complement system pathway Lectin pathway - another complement system pathway Noris, ... Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade ... The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune ...
  https://en.wikipedia.org/wiki/Classical_complement_pathway
*  Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor...
... ruling out activation of the classical and lectin pathways by the strings. In contrast, C3, FB, FD, FP and C5, FH and FI ... This was verified when non-functional FB blocked the formation of AP C3 convertase complexes (C3bBb) on ULVWF strings. ... C3 and C5; complement factor (CF) B, CFD, CFP, CFH and CFI of the AP; and C4 of the classical and lectin (but not alternative) ... The alternative complement pathway (AP) is an important nonantibody- requiring host defense system. Thrombotic ...
  https://scholarship.rice.edu/handle/1911/71021
*  Complement factor b | definition of Complement factor b by Medical dictionary
What is Complement factor b? Meaning of Complement factor b medical term. What does Complement factor b mean? ... Looking for online definition of Complement factor b in the Medical Dictionary? Complement factor b explanation free. ... this is the alternative pathway C5 convertase. From C5b through C9, the classical and alternative pathways are the same. ... complement pathways. 1. the classical complement pathway (initiated usually by binding of C1 to IgG or IgM antibody to C1) is a ...
  http://medical-dictionary.thefreedictionary.com/Complement+factor+b
*  C3-convertase - Wikipedia
"Formation of classical C3 convertase during the alternative pathway of human complement activation". PubMed Article. Retrieved ... It is a membrane protein and regulates also C5 convertase of the classical and alternative pathway. DAF protects host cells ... C3 convertase can be used to refer to the form produced in the alternative pathway (C3bBb) or the classical and lectin pathways ... C3 convertase formation can occur in three different pathways: the classical, lectin, and alternative pathways. Cleavage of ...
  https://en.wikipedia.org/wiki/C3-convertase
*  C2 Gene - GeneCards | CO2 Protein | CO2 Antibody
... pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... combining with C4A and C4B to form C3/C5 convertase,classical pathway of C3 activation *C2 ... Among its related pathways are Immune response Lectin induced complement pathway and Complement Pathway. GO annotations related ... Alternative Splicing Database (ASD) splice patterns (SP) for C2 Gene. ExUns:. 1a. ·. 1b. ·. 1c. ·. 1d. ·. 1e. ^. 2a. ·. 2b. ^. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=C2
*  Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms | The Journal of Immunology
... alternative pathway [AP] initiation); additionally, it stabilizes both the AP C3 and C5 convertases. Only the AP C5 convertase ... alternative pathway. C4BP. C4b-binding protein. CPB. cardiopulmonary bypass. CP. classical pathway. CR. complement receptor. FB ... Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease. Lancet 308: 1001- ... The spectrum of complement alternative pathway-mediated diseases. Immunol. Rev. 223: 300-316. ...
  http://www.jimmunol.org/content/190/8/3831
*  Frontiers | Which pathways trigger the role of complement in ischaemia/reperfusion injury? | Immunology
... classical, lectin and alternative] as mediators of ischaemia/reperfusion injury, and in particular highlight the role of lectin ... Here we consider recent evidence for each of the three major pathways of complement activation [classical, lectin and ... Here we consider recent evidence for each of the three major pathways of complement activation [ ... Less clear however is the mechanism of complement activation that leads to the cleavage of C3 in ischaemic tissues and to what ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2012.00341/full
*  Complement system - Wikipedia
The complex of C3b(2)Bb is a protease which cleaves C5 into C5b and C5a. C5 convertase is also formed by the Classical Pathway ... Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway ... Alternative pathwayEdit. Main article: Alternative complement pathway. The alternative pathway is continuously activated at a ... Reaction Cascade of the Complement System: Classical, Alternative and Lectin Pathway, Amplification Loop, Terminal Pathway, and ...
  https://en.m.wikipedia.org/wiki/Complement_system
*  Complement C3 Plasma Level | Molecular Otolaryngology and Renal Research Laboratories
The three complement activation pathways (alternative, classical, lectin) converge at the stage of C3 cleavage to generate the ... In the presence of abundant C3b, C5 convertases are formed.. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are ... Consumption of C3 is consistent with activation of the alternative pathway of complement (see Zhang et al. Defining the ... fluid-phase dysregulation of C3 and C5 convertases that can lead to partial or complete consumption of circulating complement ...
  https://morl.lab.uiowa.edu/clinical-diagnostics/complement-assays/tests-included/complement-c3-plasma-level
*  Evolving Immunity
... innate immune systems possess all three complement activation pathways (classical, alternative, lectin), and their complement ... C3b can group with the C4b/C2b complex to form a C5 convertase complex, which cleaves C5 into C5a and C5b. C5b attracts the ... 1999). These animals do not use the classical pathway of activation, but instead rely on the lectin and alternative pathways. ... the alternative and lectin pathways do not. The classical pathway was the first of the three to be discovered, due to its ...
  http://www.talkdesign.org/faqs/Evolving_Immunity1.2.html
*  670-nm light treatment reduces complement propagation following retinal degeneration | Journal of Neuroinflammation | Full Text
Expression of complement genes was assessed by quantitative polymerase chain reaction (qPCR), and immunohistochemistry. Counts ... In conjunction, there was significant reduction in retinal expression of complement genes C1s, C2, C3, C4b, C3aR1, and C5r1 ... These findings have relevance to the cellular events of complement activation underling the pathogenesis of AMD, and highlight ... Our data indicate that 670-nm light pretreatment reduces lipid peroxidation and complement propagation in the degenerating ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-257
*  Basic concepts in immunity and inflammation
The resulting C4bC2aC3b is a C5 convertase. The generation of C5 convertase is the end of the classical pathway. It results in ... spontaneous activation of the alternative pathway of complement occurs in plasma, which leads to consumption of complement ... Lectin pathway.. Pathways of complement system:. Classical pathway:. The binding of the antibody to its antigen triggers the ... The resulting C4bC2aC3b is a C5 convertase. The generation of C5 convertase is the end of the lectin pathway. The biological ...
  http://periobasics.com/basic-concepts-in-immunity-and-inflammation.html