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*  Molecular Vision: Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B...
... for formation of the alternative pathway convertase, several complement proteins, including complement factor H (CFH), act as ... alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J Clin ... Interestingly, CFH is expressed at a high level in RPE layers [9,10]. In contrast, other complement components, such as C3, C5 ... Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus ...
  http://www.molvis.org/molvis/v23/561/
*  Complement C3-C5 Convertases - C3 Convertase Summary Report | CureHunter
These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. ... Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A ... C3 Convertases, Complement; C3-C5 Convertases, Complement; C5 Convertases, Complement; Complement C3 C5 Convertases; Convertase ... Convertase, C3-C5; Convertase, Complement 3; Convertases, Complement C3; Convertases, Complement C3-C5; Convertases, Complement ...
  http://www.curehunter.com/public/keywordSummaryD050577-Complement-C3-C5-Convertases-C3-Convertase.do
*  Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement | The Journal of Immunology
C5 convertases of the alternative and classical pathways of complement are complex serine proteases that are made up of two or ... The conversion of human complement component C5 into fragment C5b by the alternative pathway C5 convertase. Biochem. J. 199: ... In the classical pathway C3 convertase C4b,C2a has a structure similar to the alternative pathway C3 convertase in having C2a ... C3 convertases of the alternative pathway (monomeric C3/C5 convertase assembled with monomeric C3b (C3b,Bb)) and the classical ...
  http://www.jimmunol.org/content/166/4/2635
*  Complement membrane attack complex - Wikipedia
All three pathways of the complement system (classical, lectin and alternative pathways) initiate the formation of MAC. Another ... two regulators of complement. The membrane attack complex is initiated when the complement protein C5 convertase cleaves C5 ... Terminal complement pathway deficiency Peitsch MC, Tschopp J (1991). "Assembly of macromolecular pores by immune defense ... Deficiencies of C5 to C9 components does not lead to generic infections, but only to increased susceptibility to Neisseria spp ...
  https://en.wikipedia.org/wiki/Complement_membrane_attack_complex
*  Alternative complement pathway - Wikipedia
After the creation of C5 convertase (either as (C3b)2BbP or C4b2a3b from the classical pathway), the complement system follows ... The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the ... This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although ... The C5-convertase of the alternative pathway consists of (C3b)2BbP (sometimes referred to as C3b2Bb). ...
  https://en.wikipedia.org/wiki/Alternative_complement_pathway
*  Recombinant Mouse Complement Component C5
... is produced by our E.coli expression system and the target gene encoding Asn679- ... that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway ( ... 关于Complement C5】:. Mouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally ... Complement C5产品说明】:. Recombinant Mouse Complement Component C5 is produced by our E.coli expression system and the target gene ...
  http://www.sinobio.net/cytokine/other_cytokine/Complement_Component_C5_C5a_Mouse.html
*  Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction: potential use in transfusion therapy |...
C3 and C5 convertases of the 3 complement pathways, namely the classical, alternative, and lectin.5 Specifically, CR1 binds to ... The specificity of alternative complement pathway-mediated lysis of erythrocytes: a survey of complement and target cells from ... to block all complement activation pathways or 10 mM EGTA in the presence of 2 mM MgCl2 (lane 3) to block the classical pathway ... but possesses decay-accelerating activity for C3 convertases of the alternative and classical pathways.35 In our studies, ...
  http://www.bloodjournal.org/content/101/12/5046?sso-checked=true
*  Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis
C5 convertase (C4b2a3b for the classical and lectin pathways, and C3bBbC3b for the alternative pathway). This enzyme cleaves C5 ... Early complement activation. Complement is activated through three different pathways. The alternative pathway is spontaneously ... In the classical and lectin pathways, C3 convertase is formed by a fragment of C4b and C2a (C4b2a), while, in the alternative ... and mediated by the action of thrombin on C5 convertase. Other complement activation pathways occur through proteases, such as ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042011000500009&lng=en&nrm=iso&tlng=en
*  The complement system and innate immunity - Immunobiology - NCBI Bookshelf
Indeed, it now seems clear that complement first evolved as part of the innate immune system, where it still plays an important ... Although first discovered as an effector arm of the antibody response, complement can also be activated early in infection in ... This activity was said to 'complement' the antibacterial activity of antibody, hence the name. ... Complement was discovered many years ago as a heat-labile component of normal plasma that augments the opsonization of bacteria ...
  https://www.ncbi.nlm.nih.gov/books/NBK27100/
*  Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes | BMC Biology | Full Text
Alternative pathway (AP) C5 convertases were generated on small streptavidin beads that were coated with purified C3b molecules ... The C5 convertase is a multi-molecular protease complex that catalyses the cleavage of native C5 into its biologically ... Finally, we define two interfaces on C5 important for its recognition by surface-bound C5 convertases. We establish a highly ... Through development of a highly purified model system for C5 convertases, we here aim to provide insights into the surface- ...
  https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-015-0203-8
*  Human complement component 5
In the classical pathway C5 convertase is composed of C4b2a3b and in the alternative pathway is C3bBbC3b. Both C5 convertases ... Distal Recognition Site for Classical Pathway Convertase Located in the C345C/Netrin Module of Complement Component C5. The ... C5 convertase cleaves C5 about 800 amino acids away from C345C. Other complement proteins such as C6 and C7 interact with C5 at ... This diagram of C5 convertase shows where C5 is cleaved (dotted arrows) to become activated and where the functional C5-C345C ...
  http://www.bio.davidson.edu/courses/Immunology/Students/spring2006/Fiser/C5.html
*  List of EC numbers (EC 3) - Wikipedia
... complement component C5 convertase. Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: complement ... factor I EC 3.4.21.46: complement factor D EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase EC 3.4.21.48: ... complement subcomponent C1s EC 3.4.21.43: classical-complement-pathway C3/C5 convertase EC 3.4.21.44: Transferred entry: ... Proprotein convertase 1 EC 3.4.21.94: Proprotein convertase 2 EC 3.4.21.95: Snake venom factor V activator EC 3.4.21.96: ...
  https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)
*  Complement B/C2 (IPR011360) | InterPro | EMBL-EBI
... complement C2 and complement factor B, which, respectively, have analogous roles in the classical and alternative pathways of ... Briefly, they are activated by cleavage and function as the serine protease components of the C3/C5 convertases, which play ... Complement B/C2 (IPR011360). Short name: Compl_C2_B Overlapping homologous superfamilies *von Willebrand factor A-like domain ... New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.. EMBO J. 19 164-73 2000 ...
  http://www.ebi.ac.uk/interpro/entry/IPR011360
*  C5-convertase - Wikipedia
... or the alternative pathway (C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical ... C3 and C5 convertase activity is generated upon addition of Factors B and D. The classical pathway C5 convertase is composed of ... The complement component C5 can be also activated by fluid phase C5 convertase. C5 is activated by CVFBb in the presence of ... Target of function The target of C5 convertase is complement protein C5. C5 is a two-chain (α, β) plasma glycoprotein (Mr = ...
  https://en.wikipedia.org/wiki/C5-convertase
*  Patent US7999081 - Anti-C5 alpha antibodies - Google Patents
... specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 ... in particular for the therapy of diseases involving tissue damage deriving from uncontrolled activation of the complement ... "Distal recognition site for classical pathway convertase located in the C345C/netrin module of complement component C5," J. ... rabbit erythrocyte lysis by inhibiting C5 conversion similarly through the classical pathway and the alternative pathway. ...
  http://www.google.com/patents/US7999081?dq=5,579,517
*  ENZYME: 3.4.21.
Complement factor I 3.4.21.46 Complement factor D 3.4.21.47 Alternative-complement-pathway C3/C5 convertase 3.4.21.48 Cerevisin ... Complement subcomponent C1r 3.4.21.42 Complement subcomponent C1s 3.4.21.43 Classical-complement-pathway C3/C5 convertase 3.4. ... Proprotein convertase 1 3.4.21.94 Proprotein convertase 2 3.4.21.95 Snake venom factor V activator 3.4.21.96 Lactocepin 3.4. ...
  https://enzyme.expasy.org/EC/3.4.21.-
*  Urinary Excretion of C5b-9 in Severe PreeclampsiaNovelty and Significance | Hypertension
The complement cascade may be activated through classical (CP), lectin (LP), or alternative pathways (AP). Although each ... C5 convertases cleave C5 to generate C5a (anaphylatoxin) and C5b, which combines with complement proteins C6-9 to form C5b-9 ( ... Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia. Am J Obstet Gynecol. ... propagating a systemic inflammatory response and placing strain on both classical and alternative complement signaling pathways ...
  http://hyper.ahajournals.org/content/62/6/1040
*  Classical complement pathway - Wikipedia
C3b binds to the C3 convertase (C4bC2a), to form C5 convertase (C4bC2aC3b). C5 convertase then cleaves C5 into C5a and C5b. ... Alternative complement pathway - another complement system pathway Lectin pathway - another complement system pathway Noris, ... Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade ... The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune ...
  https://en.wikipedia.org/wiki/Classical_complement_pathway
*  Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor...
... ruling out activation of the classical and lectin pathways by the strings. In contrast, C3, FB, FD, FP and C5, FH and FI ... This was verified when non-functional FB blocked the formation of AP C3 convertase complexes (C3bBb) on ULVWF strings. ... C3 and C5; complement factor (CF) B, CFD, CFP, CFH and CFI of the AP; and C4 of the classical and lectin (but not alternative) ... The alternative complement pathway (AP) is an important nonantibody- requiring host defense system. Thrombotic ...
  https://scholarship.rice.edu/handle/1911/71021
*  C3-convertase - Wikipedia
"Formation of classical C3 convertase during the alternative pathway of human complement activation". PubMed Article. Retrieved ... It is a membrane protein and regulates also C5 convertase of the classical and alternative pathway. DAF protects host cells ... C3 convertase can be used to refer to the form produced in the alternative pathway (C3bBb) or the classical and lectin pathways ... C3 convertase formation can occur in three different pathways: the classical, lectin, and alternative pathways. Cleavage of ...
  https://en.wikipedia.org/wiki/C3-convertase
*  Complement factor b | definition of Complement factor b by Medical dictionary
What is Complement factor b? Meaning of Complement factor b medical term. What does Complement factor b mean? ... Looking for online definition of Complement factor b in the Medical Dictionary? Complement factor b explanation free. ... this is the alternative pathway C5 convertase. From C5b through C9, the classical and alternative pathways are the same. ... complement pathways. 1. the classical complement pathway (initiated usually by binding of C1 to IgG or IgM antibody to C1) is a ...
  http://medical-dictionary.thefreedictionary.com/Complement+factor+b
*  C2 Gene - GeneCards | CO2 Protein | CO2 Antibody
... pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... combining with C4A and C4B to form C3/C5 convertase,classical pathway of C3 activation *C2 ... Among its related pathways are Immune response Lectin induced complement pathway and Complement Pathway. GO annotations related ... Alternative Splicing Database (ASD) splice patterns (SP) for C2 Gene. ExUns:. 1a. ·. 1b. ·. 1c. ·. 1d. ·. 1e. ^. 2a. ·. 2b. ^. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=C2
*  Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms | The Journal of Immunology
... alternative pathway [AP] initiation); additionally, it stabilizes both the AP C3 and C5 convertases. Only the AP C5 convertase ... alternative pathway. C4BP. C4b-binding protein. CPB. cardiopulmonary bypass. CP. classical pathway. CR. complement receptor. FB ... Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease. Lancet 308: 1001- ... The spectrum of complement alternative pathway-mediated diseases. Immunol. Rev. 223: 300-316. ...
  http://www.jimmunol.org/content/190/8/3831
*  670-nm light treatment reduces complement propagation following retinal degeneration | Journal of Neuroinflammation | Full Text
Expression of complement genes was assessed by quantitative polymerase chain reaction (qPCR), and immunohistochemistry. Counts ... In conjunction, there was significant reduction in retinal expression of complement genes C1s, C2, C3, C4b, C3aR1, and C5r1 ... These findings have relevance to the cellular events of complement activation underling the pathogenesis of AMD, and highlight ... Our data indicate that 670-nm light pretreatment reduces lipid peroxidation and complement propagation in the degenerating ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-257
*  Basic concepts in immunity and inflammation
The resulting C4bC2aC3b is a C5 convertase. The generation of C5 convertase is the end of the classical pathway. It results in ... spontaneous activation of the alternative pathway of complement occurs in plasma, which leads to consumption of complement ... Lectin pathway.. Pathways of complement system:. Classical pathway:. The binding of the antibody to its antigen triggers the ... The resulting C4bC2aC3b is a C5 convertase. The generation of C5 convertase is the end of the lectin pathway. The biological ...
  http://periobasics.com/basic-concepts-in-immunity-and-inflammation.html