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*  Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2 - Roy Zent
Integrins are transmembrane receptors formed by non-covalently bound alpha and beta subunits. The beta-1 subunit binds 12 alpha ... Aim 3) Develop models for the roles of the TM/CD domains in integrin alpha-1-beta-1 and alpha-2-beta-1 function and specificity ... This is seen in the two major collagen binding receptors, integrins alpha-1-beta-1 and alpha-2-beta-1, which not only have ... Aim 1) Determine the structures of the individual integral alpha-1, alpha-2, and beta-1 TM/CT domains and of the alpha-1-beta-1 ...
  http://grantome.com/grant/NIH/R01-DK083187-04
*  Interactions between extracellular matrix and growth factors in wound healing - Schultz - 2009 - Wound Repair and Regeneration ...
... regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci USA 1997; 94: 13612-7. ... Atkins S, Smith KG, Loescher AR, Boissonade FM, Ferguson MW, Robinson PP. The effect of antibodies to TGF-beta1 and TGF-beta2 ... Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-71. ... Boudreau NJ, Jones PL. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 1999; 339 (Part 3) ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00466.x/references
*  Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells.
In MCs plated on monomer type I collagen, alpha1, alpha2, and beta1 integrin chains were recruited into focal contacts. However ... Integrin alpha1beta1. Integrins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Mitogen-Activated Protein ... 0/Blood Proteins; 0/Cdkn1b protein, rat; 0/Cell Cycle Proteins; 0/Cyclin E; 0/Integrin alpha1beta1; 0/Integrins; 0/Microtubule- ... on polymerized type I collagen, alpha2 and beta1, but not alpha1, integrin chains were condensed into focal contacts. ...
  http://www.biomedsearch.com/nih/Distinct-structural-forms-type-collagen/10972675.html
*  A short note on adhesion molecules
e.g. alpha1-beta1 integrin binds type IV collagen e.g. cadherin-E acts as a universal intercellular epithelial 'glue'. e.g. ... alpha5beta1 integrin = VLA-5 = CD49e/CD29 FN(RGD). alpha6beta1 integrin = VLA-6 = CD49f/CD29 LM alphaLbeta2 integrin = LFA-1 = ... The integrins (e.g. alpha L beta 2 integrin) must first be activated, for example by platelet-activating factor! The integrin ... Integrins on cell surfaces often need to be activated before they will bind their ligand. The alpha IIb beta 3 integrin on ...
  http://anaesthetist.com/icu/organs/immune/adhere.htm
*  Immune Semaphorins: Novel Features of Neural Guidance Molecules | SpringerLink
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 2007;446:680-4. doi: ... Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. J Invest Dermatol. 2008;128:151- ... Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 2003;424:398-405. doi: 10.1038/nature01790.PubMed ... C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin- ...
  https://link.springer.com/article/10.1007%2Fs10875-008-9263-7
*  Review. The lens as a model for fibrotic disease | Philosophical Transactions of the Royal Society B: Biological Sciences
2004 TGFbeta2 influences alpha5-beta1 integrin distribution in human lens cells. Exp. Eye Res. 79, 437-442. doi:10.1016/j.exer. ... 2004 Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am. J. Pathol. 165, 617-630. ... β1 integrin is the most diverse integrin subunit as it can associate with 12 different α integrin chains [131], thus is the ... 2005 Upregulation of alphavbeta6 integrin, a potent TGF-beta1 activator, and posterior capsule opacification. J. Cataract ...
  http://rstb.royalsocietypublishing.org/content/366/1568/1301
*  COL16A1 Gene - GeneCards | COGA1 Protein | COGA1 Antibody
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. (PMID: 16754661) Eble JA … Grässel S ... Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within ... GO annotations related to this gene include integrin binding. An important paralog of this gene is COL22A1. ... Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=COL16A1&keywords=GH01H031707&prefilter=genomic_location
*  Reactome | GlcGalHyl-COL1A2 [extracellular region]
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens) * Collagen type I fibril [ ... Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens) * Collagen, laminin, ... Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens) * Collagen type I fibril [ ... Integrin cell surface interactions (Homo sapiens) * Collagen type I binds integrin alpha11beta1 (Homo sapiens) * Collagen type ...
  https://reactome.org/content/detail/R-HSA-2089984
*  Reactome | GlcGalHyl-COL2A1(182-1241) [extracellular region]
Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens) * Collagen, laminin, ... Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens) * Collagen type II fibril [extracellular ... Integrin cell surface interactions (Homo sapiens) * Collagen type II binds integrin alpha10beta1 (Homo sapiens) * Collagen type ... Collagen type II fibril:Integrins alpha2beta1, alpha1beta1, alpha11beta1 [plasma membrane] (Homo sapiens) * Collagen type II ...
  http://www.reactome.org/content/detail/R-HSA-2127330
*  Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
The Alpha1 Beta1 Integrin VLA-1 and TNF-Alpha Protect Influenza Specific CD8+ Effector T Cells from Apoptosis during Acute ...
  https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=854
*  Laminin assembles into separate basement membrane and fibrillar matrices in Schwann cells | Journal of Cell Science
Stewart, H. J., Turner, D., Jessen, K. R. and Mirsky, R. ( 1997). Expression and regulation of alpha1beta1 integrin in Schwann ... Lohikangas, L., Gullberg, D. and Johansson, S. ( 2001). Assembly of laminin polymers is dependent on beta1-integrins. Exp. Cell ... a) β1-integrin was distributed in fibrillar arrays prior to treatment with laminin. Panels b and c reveal integrin and laminin ... Flow cytometry of β1-integrin (e) and α-dystroglycan (f) reveal that β1-integrin levels are about threefold higher in HPC, ...
  http://jcs.biologists.org/content/115/5/1005
*  Collagen, type XVI, alpha 1 - Wikipedia
Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 ... Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of ...
  https://en.wikipedia.org/wiki/Collagen,_type_XVI,_alpha_1
*  ITGA7 - Wikipedia
... alpha1-beta1-gamma1), laminin-2 (alpha2-beta1-gamma1) and laminin-4 (alpha2-beta2-gamma1). Alpha-7/beta-1 is the major integrin ... The alpha-7/beta-1 integrin complex clearly plays a role in the development of striated muscle and smooth muscle. Alpha-7/beta- ... alpha-7 integrin (complexed to beta-1 integrin) is localized to Z-discs and costamere structures, bound to the four and one ... Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell- ...
  https://en.wikipedia.org/wiki/ITGA7
*  Outline of immunology - Wikipedia
Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1 VLA-4 - Heterodimer: CD49d / CD29 Alpha-5 beta-1 Integrin ... Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1 Leukocyte-adhesion receptor: LFA-1 - Heterodimer: CD11a / CD18 ... Cell adhesion molecules Integrins - Obligate heterodimers of one alpha and one beta subunits Alpha subunits A1 A2 A3 A4 A5 A6 ... Dimers Cytoadhesin receptor Integrin alpha6beta4 Glycoprotein IIb/IIIa - Heterodimer: ITGA2B / ITGB3 Fibrinogen receptor ...
  https://en.wikipedia.org/wiki/Outline_of_immunology
*  List of MeSH codes (D12.776.543) - Wikipedia
... integrin alpha1 MeSH D12.776.543.750.705.408.100.350 -- integrin alpha2 MeSH D12.776.543.750.705.408.100.400 -- integrin alpha3 ... beta-1 MeSH D12.776.543.750.070.300.300.340.725 -- receptors, adrenergic, beta-2 MeSH D12.776.543.750.070.300.300.340.900 -- ... integrin alpha1beta1 MeSH D12.776.543.750.072.200 -- integrin alpha2beta1 MeSH D12.776.543.750.072.300 -- integrin alpha3beta1 ... integrin alpha1beta1 MeSH D12.776.543.750.705.876.280 -- integrin alpha2beta1 MeSH D12.776.543.750.705.876.311 -- integrin ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
*  MGAT5B - Wikipedia
"Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B". Land A, Braakman ... 2006). "N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and ... Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B ... Abbott KL, Troupe K, Lee I, Pierce M (2006). "Integrin-dependent neuroblastoma cell adhesion and migration on laminin is ...
  https://en.wikipedia.org/wiki/MGAT5B
*  Laminin - Wikipedia
In muscle, it binds to alpha dystroglycan and integrin alpha7-beta1 via the G domain, and via the other end binds to the ... Laminins are trimeric molecules; laminin-1 is an alpha1 beta1 gamma1 trimer. It has been suggested that the domains I and II ... Kühn, Klaus (1997). "Extracellular matrix constituents as integrin ligands". In Elbe, Johannes A. Integrin-ligand interaction. ... For example, the laminin alpha1 and alpha2 chains each have five C-terminal laminin G domains, where only domains LG4 and LG5 ...
  https://en.wikipedia.org/wiki/Laminin
*  Collagen, type V, alpha 1 - Wikipedia
... is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins ... Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one ... 1998). "cDNA sequence and expression of the mouse alpha1(V) collagen gene (Col5a1)". Biochim. Biophys. Acta. 1397 (3): 275-84. ...
  https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_1
*  MGAT5 - Wikipedia
2007). "Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in ... "Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase". Dennis JW, Granovsky M, ... This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved ... Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 ...
  https://en.wikipedia.org/wiki/MGAT5
*  Collagen, type VI, alpha 1 - Wikipedia
... is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins ... Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of ... The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ... The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that ...
  https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1
*  Laminin, beta 1 - Wikipedia
Laminin subunit beta-1 is a protein that in humans is encoded by the LAMB1 gene. Laminins, a family of extracellular matrix ... 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: ... Lohi J, Leivo I, Franssila K, Virtanen I (1997). "Changes in the distribution of integrins and their basement membrane ligands ...
  https://en.wikipedia.org/wiki/Laminin,_beta_1