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Alpha-Adrenergic Antagonist (Alpha-Blockers). *Beta-Blocker Actions (Beta-Adrenergic Antagonists). *Beta-Adrenergic Antagonist ...https://www.chapters.indigo.ca/en-ca/books/mosbys-pharmacology-memory-notecards-visual/9780323171878-item.html
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Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds. US20050238620 *. Jun 22, 2005. Oct 27, 2005. ... Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use. ... Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses. ... Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use ...http://www.google.com/patents/US5698589?dq=5998925
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Antagonists L-765,314 Risperidone Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of ... "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. ... 1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also ...https://en.wikipedia.org/wiki/Alpha-1B_adrenergic_receptor
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... relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists". Journal ... It acts as a centrally-acting α1 and α2 adrenergic receptor antagonist (with IC50 4.85 μM and 0.0091 μM, respectively). In ... "Electrophysiologic and Hemodynamic Effects of Chronic Oral Therapy With the Alpha 2-agonists Clonidine and Tiamenidine in ...https://en.wikipedia.org/wiki/Tiamenidine
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... related to ketanserin such as ritanserin are more selective 5-HT2A receptor antagonists with low affinity for alpha-adrenergic ... Trazodone is a potent 5-HT2A antagonist, as well as an antagonist on other serotonin receptors. Mirtazapine is a 5-HT2A, 5-HT2C ... Other antagonists are MDL-100,907 (prototype of another new series of 5-HT2A antagonists) and cyproheptadine. Pizotifen is a ... These cells need to express both the alpha 2-6-linked sialic acid component of the 5-HT2A receptor in order to endocytose JCV. ...https://en.wikipedia.org/wiki/5-HT2A_receptor
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One study showed that benzoctamine, a serotonin and alpha-adrenergic antagonist, does not reduce blood pressure through a ... "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously ... A possible treatment for hypertension is blocking peripheral vascular seretonergic neurons or alpha-adrenergic neurons on ... Other animal studies also point to the drug as a possible mechanism by which to reduce blood pressure through the adrenergic ...https://en.wikipedia.org/wiki/Benzoctamine
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1959b) reported that pre-treatment with scopolamine (an acetylcholine antagonist), phenoxybenzamine (an adrenergic alpha ... Clinical Aspects of Opiate Antagonists and Partial Agonists. pp 118-124 in Martin and Isbell(1978). Isbell H, Vogel VH (1949 ... and correlated these effects with their potency as a serotonin antagonist in smooth muscle. With the exception of "ALD-52", all ... the clinical use of opiate antagonists (e.g., nalorphine and naloxone(Narcan)) as treatment for opiate overdoses, the ability ...https://en.wikipedia.org/wiki/Harris_Isbell
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Phencyclidine-Induced Deficits in Prepulse Inhibition of Startle are Blocked by Prazosin, an Alpha-1 Noradrenergic Antagonist |...
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Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system. Using alpha blockers, scientists began characterizing arterial blood pressure and central vasomotor control in the autonomic nervous system. Today, they can be used as clinical treatments for a limited number of diseases. Although alpha blockers can only treat a small range of diseases, some of them have clinical uses, such as having the ability to treat hypertension, Raynaud's disease, Congestive Heart Failure, erectile dysfunction, etc. Generally speaking, all of these treatments ...https://en.wikipedia.org/wiki/Alpha_blocker
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Ioannides, C, Okine, L and Parke, DV (1979) Effects of β-adrenoceptor antagonists on the hepatic mixed-function oxygenases in the rat ...http://epubs.surrey.ac.uk/823555/
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The maturation of femoral circulatory responses to efferent lumbar nerve stimulation was tested in 51 developing swine (1 day-3 mo old) under pentobarbital sodium anesthesia (10-30 mg/kg). Aortic pressure, heart rate, and femoral and carotid arterial flows (measured by electromagnetic flow transducers) were recorded simultaneously. Femoral vascular resistance was calculated as mean aortic pressure/mean flow. Transection of the lumbar nerve fibers below the last ganglion in the sympathetic chain did not after femoral resistance in day-old animals but decreased femoral resistance in swine 1 wk of age and older. Efferent lumbar nerve stimulation at various combinations of frequencies and intensities revealed an atropine-blockable vasodilator component in the femoral circulatory response in swine 1 mo of age and older. After alpha-adrenergic receptor blockade with phentolamine (0.25 or 0.5 mg/kg), femoral vasodilation occurred during ...http://ajpheart.physiology.org/content/240/4/H505
NIOSHTIC-2 Publications Search - 20036435 - Acute dilation to alpha(2)-adrenoceptor antagonists uncovers dual constriction and...
BACKGROUND AND PURPOSE: In mouse tail arteries, selective alpha(2)-adrenoceptor antagonism with rauwolscine caused powerful dilation during constriction to the alpha(1)-adrenoceptor agonist phenylephrine. This study therefore assessed phenylephrine's selectivity at vascular alpha-adrenoceptors and the mechanism(s) underlying dilation to rauwolscine. EXPERIMENTAL APPROACH: Mouse isolated tail arterhttps://www.cdc.gov/niosh/nioshtic-2/20036435.html
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