1,2-alpha-mannosidase - Wikipedia
RCSB PDB - 2WYI: Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase complexed with swainsonine
Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase complexed with swainsonine ... which has been shown to be a retaining alpha-mannosidase that targets both alpha-1,3 and alpha-1,6 mannosyl linkages, an ... The enzymatic hydrolysis of alpha-mannosides is catalyzed by glycoside hydrolases (GH), termed alpha-mannosidases. These ... Structure and Kinetic Investigation of Streptococcus Pyogenes Family Gh38 Alpha-Mannosidase. Suits, M.D.L., Zhu, Y., Taylor, E. ...
Lysosomal alpha-mannosidase and alpha-mannosidosis - PubMed
Mutations in the gene encoding for alpha-mannosidase cause alpha- mannosidosis, an autosomal recessive dise … ... Lysosomal alpha-mannosidase with acidic pH optimum is ubiquitous in human tissues where is expressed in two major forms, A and ... Lysosomal alpha-mannosidase and alpha-mannosidosis Silvia Paciotti 1 , Michela Codini 2 , Anna Tasegian 1 , Maria Rachele ... Lysosomal alpha-mannosidase and alpha-mannosidosis Silvia Paciotti et al. Front Biosci (Landmark Ed). 2017. . ...
NIH 3D - GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE ...
![CLASS I ALPHA-MANNOSIDASES [FBgg0000834] | Virtual Fly Brain](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAYAAAAf8/9hAAAA5UlEQVQ4je3Rvy6EQRQF8J8haL9CoxAN7UapnHgCz+AZxJ+CaHRbqNWeQKIR+xUksoloSDSKVYpiotLIUOxsrC/fPgGnmZs75545dw7/mGo2qjp3cIQFnGEJEQ/YSzG8tQpUdQ6lvMH6hAe72MVnikN6KMPLeMIJLicMZ1yhj4uqzvMwUy5PsYqPcrYh4BBrxfk+DkKxHgupg2e8tgjcY8XP2hsQUgwZd2PEOWzifaz3iO2GYH9kC7bwUupuiuEWx2XnHnZSDD2cF861YVK/UpjFIgajH26iqvO0YayDFMNXK+kP4hsvgTh2f9LaWwAAAABJRU5ErkJggg==)
CLASS I ALPHA-MANNOSIDASES [FBgg0000834] | Virtual Fly Brain
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... form: FBgg0000834, label: CLASS I ALPHA-MANNOSIDASES }, description: [ . ], comment: [] }, query: Get JSON for ... form: FBgg0000859, label: ALPHA-MANNOSIDASES } ], relationships: [], xrefs: [], anatomy_channel_image: [], pub_ ... Open CLASS I ALPHA-MANNOSIDASES in VFB. VFB Term Json. { term: { core: { iri: http://flybase.org/reports/FBgg0000834, ...
DISCOVERY OF A SELECTIVE LYSOSOMAL ALPHA-MANNOSIDASE INHIBITOR FROM AN IMINO-SUGAR LIBRARY - Immunology
Alpha-mannosidosis: MedlinePlus Genetics
Alpha-mannosidosis is a rare inherited disorder that causes problems in many organs and tissues of the body. Explore symptoms, ... Mutations in the MAN2B1 gene cause alpha-mannosidosis. This gene provides instructions for making the enzyme alpha-mannosidase ... Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants. Biochem J. 2004 Jul 15;381 ... Mutations in the MAN2B1 gene interfere with the ability of the alpha-mannosidase enzyme to perform its role in breaking down ...
Phenotypic Anchoring of Gene Expression Changes during Estrogen-Induced Uterine Growth | Environmental Health Perspectives |...
mannosidase 2, alpha B1. CLDN4. 101410_at. claudin 4. CLDN7. 99561_f_at. claudin 7. ... Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. ... Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat. Toxicol ... complement component 1, q subcomponent, alpha polypeptide. C1QB. 96020_at. complement component 1, q subcomponent, beta ...
Lysosomal Storage Disease: Overview, Classification of Lysosomal Storage Diseases, Glycogen Storage Disease Type II
Alpha-mannosidase catalyzes the degradation of accumulated mannose-containing oligosaccharides. Deficiency of alpha-mannosidase ... Alpha-Mannosidosis and Beta-Mannosidosis. Lysosomal alpha-mannosidase is a major exoglycosidase in the glycoprotein degradation ... A deficiency of this enzyme causes the lysosomal storage disease alpha-mannosidosis. Lysosomal alpha-D-mannosidase is involved ... Recent progress in lysosomal alpha-mannosidase and its deficiency. Exp Mol Med. 2001 Mar 31. 33(1):1-7. [QxMD MEDLINE Link]. ...
REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies
MMRRC:042966-MUMedlinePlus: Genetic Conditions: D
Deficiency of alpha-mannosidase, see Alpha-mannosidosis. *Deficiency of aromatic-L-amino-acid decarboxylase, see Aromatic l- ... Deficiency of steroid 17-alpha-monooxygenase, see 17 alpha-hydroxylase/17,20-lyase deficiency ... Deficiency of alpha-glucosidase, see Pompe disease. * ... Deficient alpha granule syndrome, see Gray platelet syndrome. * ...
DailyMed - LAMZEDE- velmanase alfa-tycv injection, powder, lyophilized, for solution
... caused by gene variants in Mannosidase Alpha Class 2B Member 1. Alpha-mannosidase catalyzes the degradation of accumulated ... Alpha-mannosidosis is a lysosomal storage disease that results from reduced activity of the enzyme alpha-mannosidase, ... All patients had alpha-mannosidase activity below 11% of normal and in the range of 8 to 29 µmol/h/mg at baseline. All patients ... The deficiency of alpha-mannosidase causes an intra-lysosomal accumulation of mannose-rich oligosaccharides in various tissues ...
Publication Detail
... alpha-Mannosidase/genetics; snRNP Core Proteins/genetics ... Among African Americans, a locus near a third α-mannosidase- ... Among Hispanics, we identified a genetic locus for upper-lower lobe ratio near the α-mannosidase-related gene MAN2B1 ( ... Mannosidases/genetics; Middle Aged; N-Acetylglucosaminyltransferases/genetics; Nerve Tissue Proteins/genetics; Polymorphism, ... and that genes related to α-mannosidase may influence risk of emphysema. ...
Browse ORF cDNA clones by species Oryctolagus cuniculus, letter m, page 1
Humant kromosom 1 - Wikipedia
MAN1A2 mannosidase alpha class 1A member 2 [ Homo sapiens (human) ]». Gene. NCBI. 6. juni 2017. Henta 26. juni 2017.. ... EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 [ Homo sapiens (human) ]». Gene. NCBI. 25. juni 2017. Henta 26 ... IFI6 interferon alpha inducible protein 6 [ Homo sapiens (human) ]». Gene. NCBI. 4. juni 2017. Henta 26. juni 2017.. ... COL11A1 collagen type XI alpha 1 chain [ Homo sapiens (human) ]». Gene. NCBI. 6. juni 2017. Henta 26. juni 2017.. ...
Langerhans Cell Histiocytosis Workup: Laboratory Studies, Imaging Studies, Other Tests
Ultrastructural methods and enzyme histochemical studies (alpha-D-mannosidase and adenosine triphosphatase [ATPase]) have ... Markus D Boos, MD, PhD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics. ... Christopher R Shea, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, ...
Biomarkers Search
Site-specific glycosylation analysis of the bovine lysosomal alpha-mannosidase.. Faid V; Evjen G; Tollersrud OK; Michalski JC; ... Global and site-specific detection of human integrin alpha 5 beta 1 glycosylation using tandem mass spectrometry and the ...
McCutchen C[au] - Search Results - PubMed
Lamzede (velmanase alfa) dosing, indications, interactions, adverse effects, and more
Alpha-mannosidosis dosing for Lamzede (velmanase alfa), frequency-based adverse effects, comprehensive interactions, ... Alpha-mannosidase catalyzes the degradation of accumulated mannose-containing oligosaccharides. Deficiency of alpha-mannosidase ... Velmanase alfa provides an exogenous source of alpha-mannosidase; it eventually internalizes via binding to the mannose-6- ... Alpha-Mannosidosis Indicated for treatment of noncentral nervous system manifestations of alpha-mannosidosis in adult and ...
Swainsonine | Harvard Catalyst Profiles | Harvard Catalyst
... kifunensine-resistant alpha-mannosidase is enzymatically and immunologically related to the cytosolic alpha-mannosidase. Arch ... Swainsonine, (8 alpha,8a alpha)-Isomer*Swainsonine, (8 alpha,8a alpha)-Isomer ... An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also ... Swainsonine, (1R-(2 beta,8a alpha))-Isomer*Swainsonine, (1R-(2 beta,8a alpha))-Isomer ...
Ligand view of Manalpha(1-2)Manalpha(1-2)Manalpha(1-6)Manalpha(1-4)-anhydromannitol (102996 - YPIHRVUWOHGTNJ-WFOMTQOISA-N) -...
Profile | Biosciences | University of Exeter
... alpha 1 step exhibited either full or partial resistance to ricin. Therefore, we conclusively identified mannosidase 2, alpha 1 ... alpha 1 step exhibited either full or partial resistance to ricin. Therefore, we conclusively identified mannosidase 2, alpha 1 ... Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. ... Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. ...
BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
... an alpha-mannosidase (EC 3.2.1.114) removes one alpha 1,3- linked and one alpha 1,6- linked mannose residue. In this study, we ... a putative lysosomal alpha-mannosidase and a Co(II)-activated alpha-mannosidase. The analysis of the N-glycan structures of an ... 2006): A deletion in the golgi alpha-mannosidase II gene of Caenorhabditis elegans results in unexpected non-wild-type N-glycan ... The processing of N-linked oligosaccharides by alpha-mannosidases in the endoplasmic reticulum and Golgi is a process conserved ...
Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis | Nature Communications
... for endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1) and 5′-CGATGCCCTGAGGCTCTTTT-3′ and 5′- ... governed by the neuron-specific22 calcium/calmodulin-dependent protein kinase II alpha (CaMKIIa) promoter (CaMKIIaCre-mCATLoxP ... An internal control was used to detect false negatives using the endogenous the alpha-synuclein (SCNA) gene. Its forward and ...
Cardona Francesca | Scheda personale | Università degli Studi di Firenze | UniFI
Hybrid Multivalent Jack Bean alpha-Mannosidase Inhibitors: The First Example of Gold Nanoparticles Decorated with ... Matteo Chioccioli (April 2007, Laurea in Chemistry): "Search for novel inhibitors of glucoamylase and golgi alpha mannosidasi: ... Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases. CHEMICAL ... targeting Golgi α-mannosidase from Drosophila melanogaster. ORGANIC CHEMISTRY FRONTIERS, vol. 2021, pp. 6648-6656, ISSN:2052- ...
Mucopolysaccharidosis Type I - GeneReviews® - NCBI Bookshelf
Alpha-mannosidosis AR. Mild dysostosis. Deficiency of alpha mannosidase. NEU1 Mucolipidosis I (sialidosis type II) (OMIM 256550 ... IDUA encodes alpha-L-iduronidase, a glycosidase that removes nonreducing terminal α-L-iduronide residues during the lysosomal ... Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency. Am J Hum Genet. 1996;58:75-85. [PMC free article: ... Carbohydrate structures of recombinant human alpha-L-iduronidase secreted by Chinese hamster ovary cells. J Biol Chem. 1997;272 ...