*  The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis | BMC Evolutionary Biology | Full Text
... constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in ... of the Ciona GPCR repertoire wherein the LGR-like subfamily exhibits a lineage specific gene expansion of a group of receptors ... A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal ... A typical cysteine-rich LDL-A domain found in human LDL receptor and human LDL Receptor related Protein (LRP) consists of ~40 ...
  https://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-8-129
*  Wnt3a induces exosome secretion from primary cultured rat microglia | BMC Neuroscience | Full Text
Dihydropyrimidinase-related protein. 62157. 1. CRMP (schizophrenia risk gene) development. ATP synthase subunit alpha, ... Primary cultures of microglia were prepared from the brains of P6 Sprague Dawley rats using percoll density gradients as ... Hendrickx M, Leyns L: Non-conventional frizzled ligands and wnt receptors. Dev Growth Differ. 2008, 50: 229-243. 10.1111/j.1440 ... with different affinities for Wnt ligands or through the association of Frizzled with different combinations of co-receptor [8- ...
  https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-13-144
*  OCT4 Remodels the Phenotype and Promotes Angiogenesis of HUVECs by Changing the Gene Expression Profile
The lower the p-value, the more significant the GO term is. FDR stands for the false discovery rate of the GO item. The lower ... S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog). NM_002961. ... kinase insert domain receptor (a type III receptor tyrosine kinase). NM_002253. ... Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell ...
  http://www.medsci.org/v13p0386.htm
*  Elevated Polymorphism and Divergence in the Class C Scavenger Receptors of Drosophila melanogaster and D. simulans | Genetics
1994 Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related ... shares with mammalian class A scavenger receptors (SR-As) the ability to bind compounds such as acetylated low-density ... polymorphism in a gram negative binding protein and an alpha-2-macroglobulin. J. Mol. Evol. 59: 498-506. ... Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including ...
  http://www.genetics.org/content/169/4/2023?ijkey=2e575054260eb138a383193891c628d094777c69&keytype2=tf_ipsecsha
*  Department of Regenerative Medicine and Cell Biology
The a2-macroglobulin receptor/low density lipoprotein receptor-related protein and the receptor associated protein: an overview ... Taha, T.A., Argraves, K.M., and Obeid, L.M. (2004) Sphingosine-1-phosphate receptors: receptor specificity versus functional ... A Stromal Cell-derived Factor 1 alpha Analogue Improves Endothelial Cell Function in Lipopolysaccharide-induced Acute ... Glycoprotein 330/low density lipoprotein receptor-related protein-2 endocytosis of low density lipoproteins via interaction ...
  http://cba.musc.edu/Faculty/ArgravesK.htm
*  Biological targeting compositions and methods of using the same - Patent application
... receptor; polyamide; peptide; carbohydrate; oligosaccharide; polysaccharide; low density lipoprotein (LDL) or an apoprotein of ... glycoconjugate receptors (enteric bacteria), Lewis(b) blood group antigen receptor (Heliobacter pylori), CR3 receptor, protein ... CROSS-REFERENCE TO RELATED APPLICATIONS Related Applications [0001]The present application constitutes is related to U.S. ... in Alpha-minimum essential medium (MEM) supplemented with 25 mM HEPES, 20 mg/dL glucose, 5% fetal bovine serum, 100 U/ml ...
  http://www.patentsencyclopedia.com/app/20100041133
*  The Hemopexin Domain of Matrix Metalloproteinase-9 Activates Cell Signaling and Promotes Migration of Schwann Cells by Binding...
Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix ... 1998) Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide ... 2000) The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl ... receptor and low density lipoprotein receptor related protein suggests that this receptor is a multifunctional receptor. J Biol ...
  http://www.jneurosci.org/content/28/45/11571
*  Similar articles for PubMed (Select 8645243) - PubMed - NCBI
... receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein ... The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor. ... The roles of alpha 2-antiplasmin and plasminogen activator inhibitor 1 (PAI-1) in the inhibition of clot lysis. ... Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to ...
  https://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed&from_uid=8645243
*  BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells | PNAS
... receptor, low-density lipoprotein receptor-related protein 1 (LRP1) [reviewed in Rehman et al. (27)]. Binding of α2M* to LRP1 ... 2000) The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl ... and its receptor low-density lipoprotein receptor-related protein 1 in human uterine muscle cells isolated from pregnant women ... 2004) Localization of low density lipoprotein receptor-related protein 1 to caveolae in 3T3-L1 adipocytes in response to ...
  http://www.pnas.org/content/113/16/E2335
*  Allen Cooper, MD | Stanford Medicine Profiles
A COMPARISON OF THE ROLES OF THE LOW-DENSITY-LIPOPROTEIN (LDL) RECEPTOR AND THE LDL RECEPTOR-RELATED PROTEIN-ALPHA-2- ... both acute and chronic barrier disruption increase the number of low density lipoprotein (LDL) receptors and LDL receptor mRNA ... Uptake is mediated in part by the LDL receptor, the LRP (alpha a-macroglobulin receptor), and perhaps by a sieving mechanism ... is a ligand for the low density lipoprotein receptor (LDLR) and the low density lipoprotein receptor-related protein (LRP). The ...
  https://med.stanford.edu/profiles/allen-cooper
*  Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient...
The low density lipoprotein receptor-related protein/alpha 2- macroglobulin receptor is a receptor for connective tissue growth ... 34 who demonstrated that the multiligand receptor, LDL receptor-related protein/α2-macroglobulin receptor, is the major cell ... Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ... Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective ...
  http://circ.ahajournals.org/content/106/2/246
*  Patente US5486599 - Construction and use of synthetic constructs encoding syndecan - Google Patentes
To make this fusion protein, an entire protein, such as an HBGF or an HBGF-receptor, can be cloned and expressed as part of the ... This invention relates to the field of proteoglycans and of cell surface receptors for biological effector molecules, more ... This can be lysine epsilon amines or a primary alpha amine found at the N-terminus of most proteins. The protein should not ... to create a soluble chimeric receptor with greater affinity for bFGF then either the receptor or the low affinity receptor ...
  http://www.google.es/patents/US5486599?dq=flatulence
*  METHODS AND MATERIALS FOR ASSESSING A MAMMAL'S SUSCEPTIBILITY FOR VENOUS THROMBOEMBOLISM - Patent application
LRP1 4035 low density lipoprotein-related protein 1 12 12q13-q14 55808549 55893409 14 13 13 (alpha-2-macroglobulin receptor) ... ESRRA 2101 estrogen-related receptor alpha 11 11q13 63829620 63840786 5 4 4 ESRRB 2103 estrogen-related receptor beta 14 ... including leukotrienes and receptors); estrogen, progesterone and androgen receptors, co-regulators and enzymes related to ... OLR1 4973 oxidized low density lipoprotein (lectin- 12 12p13.2-p12.3 10202166 10216057 12 10 10 like) receptor 1 OSMR 9180 ...
  http://www.patentsencyclopedia.com/app/20120058484
*  Tumors: Too sweet to remember? | Molecular Cancer | Full Text
... of pattern recognition receptors which show homology with the Drosophila Toll protein and the human interleukin-1 receptor ... Misra UK, Gonzalez-Gronow M, Gawdi G, Pizzo SV: The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha ... In contrast, dendrites do not bind CEA expressed on normal colon epithelium containing low levels of Lewis antigens. This ... glycoproteins such as the mucin-related epitopes Tn (GalNAcα-O-Ser/Thr), TF (Thomsen-Friedenreich, Galβ1→3GalNAcα-O-Ser/Thr) ...
  https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-6-78
*  anti-LRP1 antibody | Mouse anti-Human LRP1 / CD91 Monoclonal Antibody-NP 002323.2
Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 ... UniProt Protein Name Prolow-density lipoprotein receptor-related protein 1 UniProt Synonym Protein Names Alpha-2-macroglobulin ... Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies. Binding And Uptake Of Ligands By Scavenger Receptors ... prolow-density lipoprotein receptor-related protein 1 NCBI Official Synonym Full Names low density lipoprotein receptor-related ...
  https://www.mybiosource.com/prods/Antibody/Monoclonal/LRP1-CD91/LRP1/datasheet.php?products_id=245241
*  US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...
... macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes ... The present invention relates to the use of alpha (2) ... receptor/Low density lipoprotein receptor-related protein. J. ... CD36 and the recently identified phosphatidyl serine-binding protein act as sensors of apoptotic cell death and receptors for ... alpha.2MR" or "the .alpha.2M receptor"), also known as LDL (low-density lipoprotein) receptor-Related Protein ("LRP") or CD91, ...
  http://patents.com/us-9566348.html
*  Toxins | Free Full-Text | Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function | HTML
... a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the ... high density lipoprotein, low density lipoprotein, very low density lipoprotein, trypsin, transferrin, lactoferrin, pepsinogen ... However, no receptor for Hbp on the bacterial outer membrane has been identified so far. The Hbp beta-barrel, which would be ... Kostakioti, M.; Stathopoulos, C. Role of the alpha-helical linker of the C-terminal translocator in the biogenesis of the ...
  http://www.mdpi.com/2072-6651/2/6/1179/htm
*  Risk factors for dementia | BJPsych Advances
Another ApoE receptor, the low-density lipoprotein receptor-related protein (LRP), was shown to increase risk for Alzheimer's ... Alpha-2 macroglobulin (A2M), a ligand for LRP and a serum pan-protease inhibitor, has also been shown in some studies to ... Other research groups have concentrated on receptors for ApoE, reasoning that if ApoE conferred increased risk then ... polymorphisms in ApoE receptors may modify that risk. A polymorphism in very low-density lipoprotein receptor (VLDL-R) was ...
  http://apt.rcpsych.org/content/7/1/24.full
*  Patent US6936298 - Antithrombogenic membrane mimetic compositions and methods - Google Patents
The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable ... endogenous protein C, an endothelial protein C receptor, and an endogenous protein C activator protein. ... Protein C activation by a TM containing membrane-mimetic system is an efficient process, as evidenced by low concentrations of ... protein C (0.1 μM), and thrombin (10 nM). APC production is determined as a function of TM surface density at venous and ...
  http://www.google.com/patents/US6936298?dq=5166694
*  Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family | Molecular...
In this review, we summarize the current understanding of the function of these apoE receptors with a focus on their role in ... Recent studies have shown that members of the low-density lipoprotein receptor family, including LRP, LRP1B, SorLA/LR11, and ... Knowledge of the interactions between these distinct low-density lipoprotein receptor family members and APP may ultimately ... Aβ is produced by proteolytic processing of a transmembrane protein, β-amyloid precursor protein (APP), by β- and γ-secretases ...
  https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-1-8
*  Publications - Mayo Clinic
Insulin's effect on synthesis rates of liver proteins. A swine model comparing various precursors of protein synthesis. ... Overland CJ, Low PA, Litchy WJ, Davies JL, Dyck PJ, Dyck PJ, O'Brien PC, Albers JW, Andersen H, Bolton CF, England JD, Klein CJ ... Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc. 1990 Nov; 65 (11):1408-14 View ... Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. ...
  http://www.mayo.edu/research/SearchPublications/Publications?authid=10101519
*  Thiol Oxidative Stress Induced by Metabolic Disorders Amplifies Macrophage Chemotactic Responses and Accelerates Atherogenesis...
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol ... Presence of LDL receptor-related protein/alpha 2-macroglobulin receptors in macrophages of atherosclerotic lesions from ... Deficiency in the RANTES receptors CCR5 in ApoE−/− mice showed similar effects,21 but other studies suggest that CCR5 ... Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor ...
  http://atvb.ahajournals.org/content/29/11/1779
*  HEAL-N-SOOTHE Proteolytic Systemic Enzyme - OFFICIAL SITE
Consistent with this hypothesis, we have recently shown that impaired EVF is related to low density lipoprotein (LDL) vitamin E ... alpha2-macroglobulin purified from plasma mimicked the inhibitory effect of whole plasma on bromelain activity. If proteolysis ... We also examined their effects on the catalytic activities and protein levels of related enzymes: cytosolic phospholipase A(2 ... including CD128a/CXCR1 and CD128b/CXCR2 that serve as receptors for the neutrophil chemoattractant IL-8 and its murine ...
  https://securessl.losethebackpain.com/products/123/sp-heal-n-soothe-lbp397c?utm_type=aff&utm_source=6211&tid=f9dd33f60bd32c13498326a8b0db1fc7
*  Tethering and tickling | JCB
These receptors interact with their ligands on the AC either directly or via bridging proteins. The dominance, cooperation, and ... CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity. 14:303-313. ... The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and ... The tethering step makes it feasible for signaling to proceed through low avidity PS-PSR interactions. Specificity and ...
  http://jcb.rupress.org/content/155/4/501
*  WikiGenes - CCRIS 5161 - azane; platinum(+2) cation; dichloride
... alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. ... involves poor dissociation from the receptor in endosomes and a decrease in available surface receptors over the time of ... Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially ... at 37 degrees C with human plasma proteins and with bovine serum albumin. Does aquation precede protein binding? LeRoy, A.F., ...
  https://www.wikigenes.org/e/chem/e/84691.html