*  The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium | Science
It has been debated whether the potassium channel of the atrium is activated by the alpha subunit or by the beta gamma subunits ... The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium ... The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium ... The alpha subunit of the GTP binding protein activates muscarinic potassium channels of the atrium ...
  http://science.sciencemag.org/content/240/4860/1782
*  gq g11 gtp binding protein alpha subunits
Research Grants about gq g11 gtp binding protein alpha subunits ... heterotrimeric GTP-binding protein alpha subunits that activate ... Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Y ... heterotrimeric gtp binding proteins , gtp binding protein alpha subunits , gq g11 gtp binding protein alpha subunits ... gtp binding protein alpha subunits*cyclic amp*knockout mice*g12 g13 gtp binding protein alpha subunits*patch clamp techniques* ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/heterotrimeric/gtp/gq-g11-gtp-binding-protein-alpha-subunits-12352.html
*  G-protein, beta subunit (IPR001632) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... The activated receptor promotes the exchange of bound GDP for GTP on the G protein alpha subunit. GTP binding changes the ... Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: ...
  http://www.ebi.ac.uk/interpro/entry/IPR001632
*  Fungal G-protein, alpha subunit (IPR002975) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... The activated receptor promotes the exchange of bound GDP for GTP on the G protein alpha subunit. GTP binding changes the ... This family consists of the fungal class of G-protein alpha subunits. In Saccharomyces cerevisiae, two GTP-binding alpha ...
  http://www.ebi.ac.uk/interpro/entry/IPR002975
*  G alpha subunit - Wikipedia
The activated receptor promotes the exchange of bound GDP for GTP on the G protein alpha subunit. GTP binding changes the ... alpha; there are also fungal and plant classes of alpha subunits. The alpha subunit consists of two domains: a GTP-binding ... and to dissociate into active alpha subunit (GTP-bound) and beta/gamma dimer. The alpha subunit and the beta/gamma dimer go on ... The length of the G protein signal is controlled by the duration of the GTP-bound alpha subunit, which can be regulated by RGS ...
  https://en.wikipedia.org/wiki/G_alpha_subunit
*  GNA13 Gene - GeneCards | GNA13 Protein | GNA13 Antibody
Protein Coding), G Protein Subunit Alpha 13, including: function, proteins, disorders, pathways, orthologs, and expression. ... Expression of GTP-binding protein alpha subunits in human thymocytes. (PMID: 7791744) Kabouridis PS … Tsoukas CD (Molecular and ... in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell ... Protein Symbol:. Q14344-GNA13_HUMAN. Recommended name:. Guanine nucleotide-binding protein subunit alpha-13 Protein Accession: ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=GNA13&ortholog_desc=all
*  GNAQ - Wikipedia
G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C- ... Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (1995). "Expression of GTP-binding protein alpha subunits in human ... TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 ... Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a ...
  https://en.wikipedia.org/wiki/GNAQ
*  RGS1 - Wikipedia
The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... "RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors". J. ... 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J. Biol. Chem. ...
  https://en.wikipedia.org/wiki/RGS1
*  RGS18 - Wikipedia
The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene. This gene encodes a member of the ... GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. ...
  https://en.wikipedia.org/wiki/RGS18
*  RGS17 - Wikipedia
The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... Fischer T, De Vries L, Meerloo T, Farquhar MG (Jul 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative ... Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene. This gene encodes a member of the ...
  https://en.wikipedia.org/wiki/RGS17
*  OriGene - RGS18 (NM 130782) cDNA Clone
Human regulator of G-protein signaling 18 (RGS18) available for purchase from OriGene - Your Gene Company. ... The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. ...
  http://www.origene.com/human_cdna/NM_130782/SC321112.aspx
*  G protein - Wikipedia
... are activated by G protein-coupled receptors and are made up of alpha (α), beta (β), and gamma (γ) subunits. "Small" G proteins ... that exchanges GDP for GTP - thus turning the GPCR "on". The GTP (or GDP) is bound to the Gα subunit in the traditional view of ... "Regulator of G protein signalling"). Receptors stimulate GTP binding (turning the G protein on). RGS proteins stimulate GTP ... act as GTPase-activating proteins (GAPs), are specific for Gα subunits. These proteins accelerate the hydrolysis of GTP to GDP ...
  https://en.wikipedia.org/wiki/G-proteins
*  RGS14 - Wikipedia
... to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the ... Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene. RGS14 is a member of the ...
  https://en.wikipedia.org/wiki/RGS14
*  Immunohistochemical Distribution of RGS7 Protein and Cellular Selectivity in Colocalizing with Gαq Proteins in the Adult Rat...
"Immunohistochemical Distribution of RGS7 Protein and Cellular Selectivity in Colocalizing with Gαq Proteins in the Adult Rat ... GAIP is membrane‐anchored by palmitoylation and interacts with the activated (GTPbound) form of G alpha i subunits. ... Selective uncoupling of RGS action by a single point mutation in the G protein α‐subunit. ... GAIP and RGS4 are GTPase‐activating proteins for the Gi subfamily of G protein alpha subunits. ...
  https://www.deepdyve.com/lp/wiley/immunohistochemical-distribution-of-rgs7-protein-and-cellular-1Om00K70sR
*  Rod cell - Wikipedia
Upon binding to rhodopsin, the alpha subunit of the G protein replaces a molecule of GDP with a molecule of GTP and becomes ... activated. This replacement causes the alpha subunit of the G protein to dissociate from the beta and gamma subunits of the G ... As a result, the alpha subunit is now free to bind to the cGMP phosphodiesterase (an effector protein). The alpha subunit ... First, it prevents the interaction between the G protein and the activated receptor. Second, it serves as an adaptor protein to ...
  https://en.wikipedia.org/wiki/Rod_cell
*  Principles of Biochemistry/Gluconeogenesis and Glycogenesis - Wikibooks, open books for an open world
When insulin binds on the G protein-coupled receptor, the alpha subunit of GDP in the G protein changes to GTP and dissociates ... Protein kinase A itself is activated by the hormone adrenaline. Epinephrine binds to a receptor protein that activates ... from the inhibitory beta and gamma subunits. The alpha subunit binds on adenylyl cyclase to inhibit its activity. As a result, ... two molecules of cyclic AMP bind to the regulatory subunit of protein kinase A, which activates it allowing the catalytic ...
  https://en.wikibooks.org/wiki/Principles_of_Biochemistry/Gluconeogenesis_and_Glycogenesis
*  anti-RGS14 antibody [N1N3] | GeneTex
... regulator of G-protein signaling 14) for IHC-P, WB. Anti-RGS14 pAb (GTX115457) is tested in Human, Mouse samples. 100% Ab- ... to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ... This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates ...
  http://www.genetex.com/RGS14-antibody-N1N3-GTX115457.html
*  Visual phototransduction - Wikipedia
... with the GTP still bound to the alpha subunit. The alpha subunit-GTP complex activates phosphodiesterase or PDE. PDE breaks ... The opsin activates the regulatory protein transducin. This causes transducin to dissociate from its bound GDP, and bind GTP, ... then the alpha subunit of transducin dissociates from the beta and gamma subunits, ... GTPase Accelerating Protein (GAP) interacts with the alpha subunit of transducin, and causes it to hydrolyse its bound GTP to ...
  https://en.wikipedia.org/wiki/Visual_phototransduction
*  GNA13 - Wikipedia
"Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry. 144 (1): 45-51. doi ... Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene. GNA13 has been ... "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the ... "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13". Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW ...
  https://en.wikipedia.org/wiki/GNA13
*  Second messenger system - Wikipedia
... the alpha subunit of the G-protein transducer breaks free from the beta and gamma subunits, all parts remaining membrane-bound ... the conformation change exposes a binding site for a G-protein. The G-protein (named for the GDP and GTP molecules that bind to ... These small molecules bind and activate protein kinases, ion channels, and other proteins, thus continuing the signaling ... The alpha subunit, now free to move along the inner membrane, eventually contacts another membrane-bound protein - the "primary ...
  https://en.wikipedia.org/wiki/Second_messenger_system
*  Opioid receptor - Wikipedia
G proteins activate and dissociate into their constituent Gα and Gβγ sub-units. The Gβγ sub-unit binds to the intracellular ... GTP) bind to. They are classified as heterotrimeric, meaning they contain three different sub-units, which include an alpha (α ... subunit, and a gamma (γ) sub-unit. The gamma and beta sub-units are permanently bound together, producing a single Gβγ sub-unit ... a GTP molecule binds to the free nucleotide-binding pocket, and the G protein becomes active. A Gα(GTP) complex is formed, ...
  https://en.wikipedia.org/wiki/Opioid_receptor
*  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The ... alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate ... and for G protein-effector interaction. G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate ... Compartment GO Terms for Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5. ...
  https://pharos.nih.gov/idg/targets/P63218
*  List of MeSH codes (D12.776.476) - Wikipedia
... gtp-binding protein alpha subunit, gi2 MeSH D12.776.476.375.100.300 -- gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... gtp-binding protein alpha subunits, gs MeSH D12.776.476.387.500.124 -- guanylate cyclase-activating proteins MeSH D12.776. ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.476.375.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ... rac gtp-binding proteins MeSH D12.776.476.525.700.100.100 -- rac1 gtp-binding protein MeSH D12.776.476.525.700.200 -- rhoa gtp- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
*  Pathway Central: Chemokine Signaling
G-proteins are inactive when GDP is bound to the G-protein subunit, but they become active when GDP is exchanged for GTP. ... G-proteins dissociate into G-alpha and G-beta gamma subunits, which are able to activate signaling molecules that mediate ... Activated beta gamma subunits of G-Proteins trigger a series of reactions, commencing with the hydrolysis of PIP2 ( ... In leukocytes, the signalling is mediated by Gi subunits, and the beta gamma subunits activate the PLC-Beta2 (Phospholipase-C- ...
  http://sabiosciences.com/pathway.php?sn=Chemokine_Signaling
*  GoLoco motif - Wikipedia
When the ligand is associated to the receptor, GDP is displaced from G-alpha and GTP is bound. The GTP/G-alpha complex ... Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which ... The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. ... "Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 97 ...
  https://en.wikipedia.org/wiki/GoLoco_motif