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*  "Structure of germ line immunoglobulin alpha heavy-chain RNA and its lo" by G. Radcliffe, Y. C. Lin et al.
This germ line alpha RNA has a small open reading frame that does not include the C alpha domain, and this RNA appears to be ... a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. ... We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha heavy-chain genes in ... immunoglobulin M-expressing cells of the I.29 mu B-cell lymphoma, ...
  https://escholarship.umassmed.edu/wfc_pp/222/
*  IGHA1 - Immunoglobulin heavy constant alpha 1 - Homo sapiens (Human) - IGHA1 gene & protein
... together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable ... Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). ... Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the ... Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens ( ...
  http://www.uniprot.org/uniprot/P01876
*  A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale in silico analysis | BMC...
immunoglobulin alpha-1 heavy chain constant region (GI:184749). 35. IT-18 ... Growth regulated protein alpha (GRO-α), beta (GRO-β), and ENA-78 have been reported to be co-induced with IL-8 in A549 cells ... and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-3-29
*  Frontiers | Mast Cells as Cellular Sensors in Inflammation and Immunity | Immunology
Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell 75, 969- ... They include for example mice lacking high affinity IgE receptor alpha or beta chains as well as mice deficient in various ... Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28 ... Busse, W. W. (2001). Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. Am. J. Respir. Crit. Care Med. 164, S12-S17 ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2011.00037/full
*  Antibodies | Free Full-Text | Role and Redirection of IgE against Cancer | HTML
... up a series of convincing results indicating that cancer might be tackled by the effector functions of this immunoglobulin ... Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell 1993, 75 ... Vangelista, L.; Cesco-Gaspere, M.; Lamba, D.; Burrone, O. Efficient folding of the FcepsilonRI alpha-chain membrane-proximal ... The two extracellular immunoglobulin domains of the α chain contain the IgE binding region (the membrane-proximal domain) and ...
  http://mdpi.com/2073-4468/2/2/371/htm
*  The IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesis
Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell ... Class switching in B cells lacking 3' immunoglobulin. heavy chain enhancers. J Exp Med. 1998;188:1421-1431. [PMC free article] ... The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. Leukemia. 2011 ... The immunoglobulin heavy chain (IgH) locus undergoes numerous changes during B-cell differentiation, affecting transcription, V ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5351691/
*  Mu Heavy Chain Disease: Background, Pathophysiology, Epidemiology
... are rare B-cell proliferative disorders characterized by the synthesis and secretion of incomplete immunoglobulin heavy chains ... are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains: alpha, gamma, or mu. ... a mutated immunoglobulin heavy chain that is incapable of either partnering with light chains to form a complete immunoglobulin ... Normal immunoglobulin molecules are symmetrical and consist of 2 pairs of polypeptide chains, designated the light and heavy ...
  https://emedicine.medscape.com/article/200758-overview
*  OriGene - CD8A (NM 001768) Human ORF cDNA Clone
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one ... Lenti ORF clone of Cd8a (Myc-DDK-tagged) - Mouse CD8 antigen, alpha chain (cDNA clone MGC:41580 IMAGE:1247019). $500. 4 weeks. ... Lenti ORF clone of Cd8a (mGFP-tagged) - Mouse CD8 antigen, alpha chain (cDNA clone MGC:41580 IMAGE:1247019). $550. 3 weeks. ...
  http://www.origene.com/orf_clone/trueclone/NM_001768/RC206608/CD8A.aspx
*  CD8 biotin Antibody | ProSpec
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 identifies cytotoxic/ ... The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta ... CD8 alpha chains binds to class-I MHC molecules alpha-3 domains. ...
  https://www.prospecbio.com/cd8-biotin_antibody
*  Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end | SpringerLink
A common mechanism for the synthesis of membrane and secreted immunoglobulin alpha, gamma and mu chains. Nature 298:77-79PubMed ... Phillips C, Pachikara N, Gunderson SI (2004) U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site ... ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell 20:303-312PubMedCrossRefGoogle Scholar ... Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3-prime ends ...
  https://link.springer.com/article/10.1007%2Fs00424-016-1828-3
*  Lenti-CD8 CAR (scFv-b2c-CD3ζ, CA-8) Viral Particle vector - Creative Biolabs
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one ... chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] ...
  https://www.creative-biolabs.com/car-t/lenti-cd8-car-scfv-b2c%CE%B6-ca-8-vp-2869.htm
*  anti-CD8 antibody [SP16] | GeneTex
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ... Synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 ...
  http://www.genetex.com/CD8-antibody-SP16-GTX16696.html
*  Immune physiologic D/C Flashcards by Lorne Runge | Brainscape
IgJ is an immunoglobulin, 15 kDa, with typical immunoglobulin beta pleated sheets that binds the alpha chains of IgA and mu ... zeta chain dimer).CD3 chains belong to the immunoglobulin superfamily. The transmembrane portion is negatively charged but ... IL-35 is a dimer containing p35 (IL-12 alpha) and EBI3 (Ebstain Bar virus Induced 3) chain that binds to gp130 .. IL-27 is a ... TCR alpha and beta chains ( 95%) or epsilon and gamma (5%). 3 additional dimeric signaling molecules are associated, 2 types of ...
  https://www.brainscape.com/flashcards/immune-physiologic-d-c-2484247/packs/4392200
*  Plus it
... alpha immunoglobulin heavy chain enhancer. Toxicology 200: 235-246. ... Zheng Y, Ouaaz F, Bruzzo P, Singh V, Gerondakis S, and Beg AA (2001) NF-kappa B RelA (p65) is essential for TNF-alpha-induced ... at the DRE and κB motif to influence transcriptional activity of the hs4 enhancer fragment of immunoglobulin heavy chain gene ( ... Denis MG (1998) Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily. Int J ...
  http://molpharm.aspetjournals.org/content/71/1/145
*  CD8A Antibody (C-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, E - Buy Now! |Abgent
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. ... The functional co-receptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ... CD8 alpha chains binds to class I MHC molecules alpha-3 domains. ... IgM µ chain IgG (H&L) IgM (H&L). IgG (gamma chain) IgG + IgM (H ... T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL. ...
  http://www.abgent.com/products/AP1414b-CD8A-Antibody-C-term
*  Produktübersicht anti-CD8B Antikörper
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta ... CD8 antigen beta-chain , CD8 antigen, beta chain , CD8 antigen, beta-chain , OX-8 membrane antigen , CD8 beta chain , CD8 ... anti-CD79b Molecule, Immunoglobulin-Associated beta Antikörper * anti-CD79a Molecule, Immunoglobulin-Associated alpha ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ...
  http://www.antikoerper-online.de/t-zell-rezeptor-signalweg-pathway-12/cd8b-antibody-7854/
*  List of MeSH codes (D12.776.124) - Wikipedia
... immunoglobulin heavy chains MeSH D12.776.124.486.485.705.500.350 -- immunoglobulin alpha-chains MeSH D12.776.124.486.485.705. ... immunoglobulin heavy chains MeSH D12.776.124.790.651.705.500.350 -- immunoglobulin alpha-chains MeSH D12.776.124.790.651.705. ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 -- immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 ... immunoglobulin alpha-chains MeSH D12.776.124.790.651.114.619.251 -- immunoglobulin d MeSH D12.776.124.790.651.114.619.251.500 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
*  CD8 - SM2134F | acris-antibodies.com
Both alpha and beta chains share significant homology to immunoglobulin variable light chains.. ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ... T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-lymphocyte differentiation antigen ... Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody. Not available. ...
  https://www.acris-antibodies.com/antibodies/primary-antibodies/cd8-sm2134f.htm
*  The Immunoglobulin a System | SpringerLink
The International Symposium on the Immunoglobulin A System was organized in observance of the twenty-fifth anni- versary of the ... Mouse IgA Myeloma Proteins with Alpha Chain Deletions: A Comparison with Human Alpha Chains with Deletions ... Immunoglobulin A was chosen as the sub- ject of the Symposium because of its broad scope in relation to all biologic sciences, ... antibody antigen bacteria dentistry genetics immune system immunity immunization immunoglobulin infection planning prevention ...
  https://link.springer.com/book/10.1007/978-1-4613-4550-3
*  CD8A - Wikipedia
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ... Nakayama K, Tokito S, Okumura K, Nakauchi H (1989). "Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8 ... Norment AM, Lonberg N, Lacy E, Littman DR (1989). "Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. ...
  https://en.wikipedia.org/wiki/CD8A
*  anti-CD8a antibody | Mouse anti-Chicken CD8a Monoclonal Antibody (Clone CT-8)-AAH25715.1
Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by ... The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one ... T-cell surface glycoprotein CD8 alpha chain UniProt Synonym Protein Names T-lymphocyte differentiation antigen T8/Leu-2; CD_ ...
  https://www.mybiosource.com/prods/Antibody/Monoclonal/CD8a/datasheet.php?products_id=532686
*  anti-Osteopontin Primary Antibodies
... osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein , secreted phosphoprotein 1 (osteopontin, bone ...
  https://www.antikoerper-online.de/regulation-of-cell-size-pathway-78/osteopontin-antibody-17497/
*  IL4R | Cancer Genetics Web
... which encodes the alpha chain of the high affinity immunoglobulin E receptor, and glioma risk (nominal trend p values 0.01 and ... This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and ... Two other chains of IL-4 receptor complex, IL-2RγC and IL-13Rα1, were absent or weakly expressed. IL-4 modestly inhibited the ... We and others have reported that IL-4 and IL-13 bind to IL-4Rα and IL-13Rα1 chains, forming functional receptors in cancer ...
  http://www.cancerindex.org/geneweb/IL4R.htm
*  Immunogenetic factors in inflammatory eye disease. influence of hlab27 and alpha1-antitrypsin phenotypes on disease...
Cox DW, Markovic VD, Teshina IE: Genes for immunoglobulin heavy chains and for alpha 1 antitrypsin are localised to specific ... Immunoglobulin heavy chain constant-region gene polymorphism in systemic lupus erythematosus. pdf383 Кб ... Lancet 2: 1358-1359, 1977 7. Breit SN, Clark P, Penny R: Alpha 1 protease inhibitor (alpha 1 antitrypsin) phenotypes in ... Alpha,-antitrypsin deficiency and/or HLA-B27+ t WAKEFIELD ET AL 1434 disease but also as important prognostic indicators in ...
  https://www.docme.ru/doc/2166144/immunogenetic-factors-in-inflammatory-eye-disease.-influe..