*  Regulation of metabolic networks by small molecule metabolites | BMC Bioinformatics | Full Text
These groups of compounds and the enzymes they regulate form modules that mirror the modules and pathways of the underlying ... Chemical structure also often determines how groups of similar compounds can regulate sets of enzymes. ... We present an analysis of one of the mechanisms by which metabolic regulation occurs: enzyme inhibition and activation by small ... repression or activation of enzyme gene transcription)[4], and enzyme inhibition/activation by small molecules (allosteric ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-88
*  Search Results - - 76 Results - Digital Library
The cotton FAD2 enzyme has a high identity of 75% with other plant FAD2 enzymes. The enzyme has three histidine-rich motifs ... Chapter III explores how catabolite repression affects pyrimidine metabolism. The global catabolite repression control protein ... Chapter II details the enzymology of Pseudomonas aspartate transcarbamoylase (ATCase), its allosteric regulation and how it is ... It is a class A enzyme with a molecular mass of 480 to 520 kDa. It has a pH optimum of 9.5 and is stable at high temperatures. ...
  https://digital.library.unt.edu/explore/collections/UNTETD/browse/?fq=untl_institution%3AUNT&sort=added_a&fq=str_degree_discipline%3AMolecular+Biology
*  Definition of enzyme repression - Chemistry Dictionary
... and the expression of all enzymes necessary for the synthesis of the end product enzyme is abolished. ... Definition of enzyme repression. 1) Enzyme repression is the mode by which the synthesis of an enzyme is prevented by repressor ...
  http://www.chemistry-dictionary.com/definition/enzyme+repression.php
*  micro 520 final Flashcards - Cram.com
What is a specific example of enzyme repression? Arginine biosynthesis. ArgR (repressor) is an allosteric regulator that only ... An enzyme is made only when its substrate is present. Enzyme induction usually involves catabolic enzymes. ... An excess of the subsrate represses the synthesis of the enzyme. Enzyme repression usually involves biosynthetic/anabolic ... What happens to an allosteric enzyme when the allosteric regulator binds to it? ...
  http://www.cram.com/flashcards/micro-520-final-411808
*  Temperature desynchronizes sugar and organic acid metabolism in ripening grapevine fruits and remodels their transcriptome |...
The repression was just beyond the significance threshold in G2 for HSF B4 (VIT_06s0009g02730) and HSF B2A (VIT_10s0597g00050 ... 2). This is in agreement with previous studies on the corresponding enzyme activities in green [85] and ripening berries [23, ... Genes encoding most enzymes of primary metabolism remained noticeably stable with temperature, even those exhibiting some ... bottom-up control of plant glycolytic flux from hexose-phosphates to pyruvate owed to PEP's pronounced feedback allosteric ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-016-0850-0
*  Protocols and Video Articles Authored by Lijun Liu
... lipase inhibitors by directly interacting with the inhibitor ligands or by indirectly addressing allosteric effect on enzyme ... Six rice genotypes differing in grain filling rate were field grown, and PA levels and activities of the enzymes involved in PA ... EZH2-mediated Puma Gene Repression Regulates Non-small Cell Lung Cancer Cell Proliferation and Cisplatin-induced Apoptosis ... The structure showed HER3 as an allosteric activator of EGFR and revealed a conserved role of the allosteric mechanism in ...
  https://www.jove.com/author/Lijun_Liu
*  Phosphofructokinase 1 - Wikipedia
PFK1 is an allosteric enzyme and has a structure similar to that of hemoglobin in so far as it is a dimer of a dimer. One half ... Phosphofructokinase-1 (PFK-1) is one of the most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric ... PFK is inhibited by glucagon through repression of synthesis. Glucagon activates protein kinase A which, in turn, shuts off the ... Allosteric activators such as AMP and ADP bind to the allosteric site as to facilitate the formation of the R state by inducing ...
  https://en.wikipedia.org/wiki/Phosphofructokinase_1
*  Free Science Flashcards about Micro metabolism ch5
Enzyme Structure: A number of enzymes are pure proteins (simple enzymes) however many enzymes (holoenzymes) consist of a ... The inhibitor (end product-made in side thee cell) attaches to the allosteric site of the enzyme when it is plentiful and is ... 4- Enzyme Repression (Genetic Control): End product binds with DNA and stops its production. ... 5. The unaltered enzyme reacts with other substrate molecules. Classification of Enzymes. Enzymes can be classified into six ...
  https://www.studystack.com/flashcard-650746
*  Amino acid synthesis - Wikipedia
Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes ... This enzyme is regulated by at least four different mechanisms: 1. Repression and depression due to nitrogen levels; 2. ... All the enzymes in this biosynthetic pathway are subject to regulation via feedback inhibition and/or repression at the genetic ... At high concentrations this enzyme will be inactive and serine will not be produced. At low concentrations of serine the enzyme ...
  https://en.wikipedia.org/wiki/Amino_acid_synthesis
*  Sucrose phosphorylase - Wikipedia
In the reaction, sucrose binds to the enzyme, at which point fructose is released by the enzyme-substrate complex. A covalent ... There has been little research on methods of the allosteric regulation of sucrose phosphorylase, so at this point the function ... Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression. First ... à Gln mutant enzymes." Biochemistry Journal 403.3 (2007): 441-449. Schwarz, A. and B. Nidetzky. "Asp-196-->Ala mutant of ...
  https://en.wikipedia.org/wiki/Sucrose_phosphorylase
*  Regulation of enzymes Flashcards by Giulia Di Todaro | Brainscape
Study Regulation of enzymes flashcards from Giulia Di Todaro ... Allosteric inhibitors have a much stronger effect on enzyme ... excess of a metabolite may slow synthesis by repression. -Both induction and repression involve cis elements, specific DNA ... 1.Into multi-enzyme complexes or organelles. Ex: enzymes of the TCA cycle are all located within the mitochondrion. 2.Enzymes ... occur through an increased supply of substrate to an enzyme with a high Km. -allosteric activation of a rate-limiting enzyme ...
  https://www.brainscape.com/flashcards/regulation-of-enzymes-6825069/packs/10824418
*  BMS02 - Molecules and Cells :evergreen tree
BMS02 - Molecules and Cells :evergreen_tree: : A Coggle Diagram about Enzymes and Coenzymes, Electrochemical Equilibria, PH and ... Allosteric binding is when another molecule binds to the enzyme (not at the active site). This can either have a positive or ... Induction or repression of enzyme synthesis is the most long term means of regulation. This is usually controlled by hormones e ... Most enzymes follow saturation kinetics - this is shown on a Michaelis-Menten plot. The plot assumes the enzyme is saturated ...
  https://coggle.it/diagram/WGvSzqmGe9w7mAG7/t/bms02-molecules-and-cells-evergreen_tree
*  Enzyme | Article about enzyme by The Free Dictionary
Find out information about enzyme. biological catalyst catalyst, substance that can cause a change in the rate of a chemical ... reaction without itself being consumed in the reaction; the... Explanation of enzyme ... The activity of many enzymes is regulated according to the allosteric principle. Such enzymes have an allosteric site that is ... Other compounds may repress the synthesis of enzymes. In animals, the induction and repression of enzyme synthesis is ...
  http://encyclopedia2.thefreedictionary.com/Enzyme
*  François Jacob - Wikipedia
Studies of enzyme activity control were progressing through theories of the (allosteric) action of small molecules on the ... It was known that cells ramp up their production of the enzymes that do these steps when exposed to lactose, rather than ... and the transcriptional repression is lifted. In this way, a robust feedback loop is constructed that allows the set of lactose ... In 1961 Jacob and Monod explored the idea that the control of enzyme expression levels in cells is a result of regulation of ...
  https://en.wikipedia.org/wiki/Fran%C3%A7ois_Jacob
*  Protocols and Video Articles Authored by Scott B. Rothbart
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 Cell Reports. Sep, 2015 , Pubmed ID: ... A D53 Repression Motif Induces Oligomerization of TOPLESS Corepressors and Promotes Assembly of a Corepressor-nucleosome ... We now report that the secondary target is the downstream folate-dependent enzyme in de novo purine synthesis, ... Although histone methylation has been well studied, the functions of nonhistone lysine methylation and its regulatory enzymes, ...
  https://www.jove.com/author/Scott++B._Rothbart
*  Glucokinase - Wikipedia
"Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase". Structure. 12 (3): 429-38. ... This class of transactivators bind to the "E box" sequence of genes for a number of regulatory enzymes. The liver promoter in ... "Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system ... The BGPR for wild type glucokinase is about 28% at a glucose concentration of 5 mmol/l, indicating that the enzyme is running ...
  https://en.wikipedia.org/wiki/Glucokinase
*  Genetics - Medical Microbiology - NCBI Bookshelf
... and biosynthetic enzymes are repressed by the product of the pathway. Enzymes that participate in a single biochemical pathway ... A), If a and b are in the same structural gene (e.g., encoding the enzyme that converts X to Y), neither the a+b nor the ab+ ... The trp operon in E. coli is controlled both by repression and attenuation. In the presence of excess tryptophan, initiation of ... Furthermore, regulatory proteins are allosteric, meaning that they can exist in different conformations which exhibit different ...
  https://www.ncbi.nlm.nih.gov/books/NBK7908/?report=reader
*  Transcriptional regulation - Wikipedia
Some examples of this include producing the mRNA that encode enzymes to adapt to a change in a food source, producing the gene ... Englesberg, E.; Lee, N. (1965). "Positive Control of Enzyme Synthesis by Gene C in the L-Arabinose System". Journal of ... It may also happen that a repressor may function by allosteric competition against a determined activator to repress gene ... In breast cancer, transcriptional repression of BRCA1 may occur more frequently by over-expressed microRNA-182 than by ...
  https://en.wikipedia.org/wiki/Transcriptional_regulation
*  Silencer (genetics) - Wikipedia
When the repressor's allosteric site is not bound to lactose, its active site will bind to the operator to prevent RNA ... This abnormal repression occurs when the RE1/NRSE region within the BDNF promoter region is activated by the binding of REST/ ... The lac operon in the prokaryote E. coli consists of genes that produce enzymes to break down lactose. Its operon is an example ... RNA polymerase, a DNA-dependent enzyme, transcribes the DNA sequences, called nucleotides, in the 3' to 5' direction while the ...
  https://en.wikipedia.org/wiki/Silencer_(genetics)
*  Microbial Biochemistry | Georges N. Cohen | Springer
Enzyme Repression in Anabolic Pathways. Cohen, G. N.. Pages 219-225 Preview Buy Chapter $29.95 ... Allosteric Enzymes. Cohen, G. N.. Pages 59-71 Preview Buy Chapter $29.95 ...
  http://www.springer.com/us/book/9789401789073
*  The AMP-activated protein kinase pathway - new players upstream and downstream | Journal of Cell Science
... it is quantitatively much more important than the allosteric activation. Like the allosteric effect, activation by the upstream ... As yet, repression of AMPK activation by glycogen has not been reproduced in a cell-free system; so the molecular mechanism ... Chock, P. B. and Stadtman, E. R. (1977). Superiority of interconvertible enzyme cascades in metabolite regulation: analysis of ... 1). It achieves this not only through direct phosphorylation of metabolic enzymes, but also through effects on gene expression ...
  http://jcs.biologists.org/content/117/23/5479
*  Learn: Biochem 2 (by najudexi) - Memorize.com - Remember and Understand
Chapter 8 Enzymes as Catalysts. • Enzyme-cataylzed reaction (E+SES, ES EP, EPE+P) enzymes binds substrate bringing into correct ... Allosteric enzymes bind allosteric site causing a conformation change, usually have multiple (2+) interacting subunits active/ ... Regulation of enzyme synthesis by induction/repression gene transcription, stabilization of mRNA (overall slow in humans), ... Functional groups in catalysis - proximity and orientation (in all enzymes), all enzymes stabilize TS by electrostatic ...
  http://memorize.com/biochem-2/najudexi
*  Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages.
However, p38 MAPK inhibition in PPARγ-K365 expressing cells fully ablated repression of Egr-1 luciferase activity (Fig. 3B). ... Carbon monoxide (CO) arises physiologically in cells during the oxidative catabolism of heme by heme oxygenase (HO) enzymes [1] ... 1 µg total RNA was reverse transcribed into cDNA by MMLV enzyme (Promega, Mannheim, Germany) with random hexamers (1 µg/µg ... Likely candidates include availability of Coenzyme Q, nucleotides, fatty acids in addition to allosteric regulation or ...
  http://www.biomedsearch.com/nih/Carbon-Monoxide-Induced-PPAR-SUMOylation/22046279.html
*  ASMscience | Nucleotide Metabolism an
Bacterial DNA replication enzymes as targets for antibacterial drug discovery. Expert Opin Drug Discov 7: 327- 339.[PubMed][ ... The dUTPase enzyme is essential in Mycobacterium smegmatis. PLoS One 7:e37461. [PubMed][CrossRef]. ... Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J Bacteriol 189: 6236 ... UMP kinase from Mycobacterium tuberculosis: mode of action and allosteric interactions, and their likely role in pyrimidine ...
  http://www.asmscience.org/content/book/10.1128/9781555818845.chap30
*  IJMS | Free Full-Text | Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players | HTML
Yan, H.L.; Xue, G.; Mei, Q.; Wang, Y.Z.; Ding, F.X.; Liu, M.F.; Lu, M.H.; Tang, Y.; Yu, H.Y.; Sun, S.H. Repression of the miR- ... BACE-AS regulates the expression of β-secretase-1 (BACE1), a crucial enzyme in Alzheimer's disease pathophysiology [174]. Linc- ... protein at the chromatin of the cyclin D1 promoter region and cause an allosteric effect on this protein. This TLS ... circRNAs are predicted to be resistant to degradation by cellular enzymes such as ribonucleases and thus more stable than ...
  http://mdpi.com/1422-0067/14/9/18319/htm