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*  Regulation of metabolic networks by small molecule metabolites | BMC Bioinformatics | Full Text
These groups of compounds and the enzymes they regulate form modules that mirror the modules and pathways of the underlying ... Chemical structure also often determines how groups of similar compounds can regulate sets of enzymes. ... We present an analysis of one of the mechanisms by which metabolic regulation occurs: enzyme inhibition and activation by small ... repression or activation of enzyme gene transcription)[4], and enzyme inhibition/activation by small molecules (allosteric ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-88
*  Silencer (genetics) - Wikipedia
Repression of the lac operon[edit]. The lac operon in the prokaryote E. coli consists of genes that produce enzymes to break ... When the repressor's allosteric site is not bound to lactose, its active site will bind to the operator to prevent RNA ... RNA polymerase, a DNA-dependent enzyme, transcribes the DNA sequences, called nucleotides, in the 3' to 5' direction while the ... Repression of the TATA box[edit]. Eukaryotic genes contain an upstream promoter and a core promoter also referred to as a basal ...
  https://en.wikipedia.org/wiki/Silencer_%28DNA%29
*  Microbial Biochemistry, Book by G. N. Cohen (Hardcover) | chapters.indigo.ca
Enzyme induction in catabolic systems. 15. Transcription. RNA polymerase. 16. Negative regulation. 17. Enzyme repression in ... 5. Allosteric enzymes. 6. Glycolysis, gluconeogenesis, glycogen and cellulose biosynthesis. 7. The pentose phosphate and Entner ...
  https://www.chapters.indigo.ca/en-ca/books/microbial-biochemistry/9789401789073-item.html
*  Definition of enzyme repression - Chemistry Dictionary
... and the expression of all enzymes necessary for the synthesis of the end product enzyme is abolished. ... Definition of enzyme repression. 1) Enzyme repression is the mode by which the synthesis of an enzyme is prevented by repressor ...
  http://www.chemistry-dictionary.com/definition/enzyme+repression.php
*  Protocols and Video Articles Authored by Lijun Liu
... lipase inhibitors by directly interacting with the inhibitor ligands or by indirectly addressing allosteric effect on enzyme ... Six rice genotypes differing in grain filling rate were field grown, and PA levels and activities of the enzymes involved in PA ... EZH2-mediated Puma Gene Repression Regulates Non-small Cell Lung Cancer Cell Proliferation and Cisplatin-induced Apoptosis ... The structure showed HER3 as an allosteric activator of EGFR and revealed a conserved role of the allosteric mechanism in ...
  https://www.jove.com/author/Lijun_Liu
*  Search Results - - 76 Results - Digital Library
The cotton FAD2 enzyme has a high identity of 75% with other plant FAD2 enzymes. The enzyme has three histidine-rich motifs ... Chapter III explores how catabolite repression affects pyrimidine metabolism. The global catabolite repression control protein ... Chapter II details the enzymology of Pseudomonas aspartate transcarbamoylase (ATCase), its allosteric regulation and how it is ... It is a class A enzyme with a molecular mass of 480 to 520 kDa. It has a pH optimum of 9.5 and is stable at high temperatures. ...
  https://digital.library.unt.edu/explore/collections/UNTETD/browse/?fq=untl_institution%3AUNT&sort=added_a&fq=str_degree_discipline%3AMolecular+Biology
*  Free Science Flashcards about Micro metabolism ch5
Enzyme Structure: A number of enzymes are pure proteins (simple enzymes) however many enzymes (holoenzymes) consist of a ... The inhibitor (end product-made in side thee cell) attaches to the allosteric site of the enzyme when it is plentiful and is ... 4- Enzyme Repression (Genetic Control): End product binds with DNA and stops its production. ... 5. The unaltered enzyme reacts with other substrate molecules. Classification of Enzymes. Enzymes can be classified into six ...
  https://www.studystack.com/flashcard-650746
*  micro 520 final Flashcards - Cram.com
What is a specific example of enzyme repression? Arginine biosynthesis. ArgR (repressor) is an allosteric regulator that only ... An enzyme is made only when its substrate is present. Enzyme induction usually involves catabolic enzymes. ... An excess of the subsrate represses the synthesis of the enzyme. Enzyme repression usually involves biosynthetic/anabolic ... What happens to an allosteric enzyme when the allosteric regulator binds to it? ...
  http://www.cram.com/flashcards/micro-520-final-411808
*  Temperature desynchronizes sugar and organic acid metabolism in ripening grapevine fruits and remodels their transcriptome |...
The repression was just beyond the significance threshold in G2 for HSF B4 (VIT_06s0009g02730) and HSF B2A (VIT_10s0597g00050 ... 2). This is in agreement with previous studies on the corresponding enzyme activities in green [85] and ripening berries [23, ... Genes encoding most enzymes of primary metabolism remained noticeably stable with temperature, even those exhibiting some ... bottom-up control of plant glycolytic flux from hexose-phosphates to pyruvate owed to PEP's pronounced feedback allosteric ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-016-0850-0
*  Frontiers | Transcriptional and metabolic effects of glucose on Streptococcus pneumoniae sugar metabolism | Microbiology
GlcN6P was identified as an allosteric effector that alleviates the repression of nagA and nagB mediated by the transcriptional ... Green dashed lines indicate positive metabolic regulation of enzymes. Dark gray dashed lines represent relief of LDH activation ... Enzyme I (ptsI), were induced during growth on Man (Table 1), indicating that Man translocation is primarily mediated by a PTS ... Görke, B., and Stülke, J. (2008). Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat. ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2015.01041/full
*  Regulation of enzymes Flashcards by Giulia Di Todaro | Brainscape
Study Regulation of enzymes flashcards from Giulia Di Todaro ... Allosteric inhibitors have a much stronger effect on enzyme ... excess of a metabolite may slow synthesis by repression. -Both induction and repression involve cis elements, specific DNA ... 1.Into multi-enzyme complexes or organelles. Ex: enzymes of the TCA cycle are all located within the mitochondrion. 2.Enzymes ... occur through an increased supply of substrate to an enzyme with a high Km. -allosteric activation of a rate-limiting enzyme ...
  https://www.brainscape.com/flashcards/regulation-of-enzymes-6825069/packs/10824418
*  Enzyme | Article about enzyme by The Free Dictionary
Find out information about enzyme. biological catalyst catalyst, substance that can cause a change in the rate of a chemical ... reaction without itself being consumed in the reaction; the... Explanation of enzyme ... The activity of many enzymes is regulated according to the allosteric principle. Such enzymes have an allosteric site that is ... Other compounds may repress the synthesis of enzymes. In animals, the induction and repression of enzyme synthesis is ...
  http://encyclopedia2.thefreedictionary.com/Enzyme
*  BMS02 - Molecules and Cells :evergreen tree
BMS02 - Molecules and Cells :evergreen_tree: : A Coggle Diagram about Enzymes and Coenzymes, Electrochemical Equilibria, PH and ... Allosteric binding is when another molecule binds to the enzyme (not at the active site). This can either have a positive or ... Induction or repression of enzyme synthesis is the most long term means of regulation. This is usually controlled by hormones e ... Most enzymes follow saturation kinetics - this is shown on a Michaelis-Menten plot. The plot assumes the enzyme is saturated ...
  https://coggle.it/diagram/WGvSzqmGe9w7mAG7/t/bms02-molecules-and-cells-evergreen_tree
*  PRM15 protein (Saccharomyces cerevisiae) - STRING interaction network
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their ... Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose ... Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their ... Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their ...
  https://string-db.org/network/4932.YMR278W
*  Lecture 22
enzyme synthesis (induction and repression) [hours or days]. Note: neurotransmitter release from synaptic vesicles can be very ... allosteric. acetyl-CoA. -. 3. Pyruvate kinase. glycolysis. allosteric & covalent mod. fructose -1,6-bisphosphate. alanine, ATP ... Examples of key regulatory enzymes the list is endless and changes with expanding knowledge, but the following are plainly ... allosteric. ADP, GDP. ATP, GTP. 16. Carbamyl phosphate synthetase. nitrogen excretion. gene expression allosteric. N-acetyl ...
  http://www.bmb.leeds.ac.uk/teaching/icu3/lecture/22/index.htm
*  Targeting FBPase is an emerging novel approach for cancer therapy | Cancer Cell International | Full Text
Previous studies have mainly focused on catabolic glycolysis, but recently, FBPase, a rate-limiting enzyme in gluconeogenesis, ... insulin acts to repress the transcription of gluconeogenic enzymes. This repression of the expression of gluconeogenic enzymes ... Allosteric inhibition of rat liver fructose 1,6-diphosphatase by adenosine 5′-monophosphate. J Biol Chem. 1965;240:651-62. ... 1). FBP1 has been identified as the regulatory enzyme of gluconeogenesis, but the physiological role of FBP2 is far from clear. ...
  https://cancerci.biomedcentral.com/articles/10.1186/s12935-018-0533-z
*  Phosphofructokinase 1 - Wikipedia
PFK1 is an allosteric enzyme and has a structure similar to that of hemoglobin in so far as it is a dimer of a dimer. One half ... Phosphofructokinase-1 (PFK-1) is one of the most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric ... PFK is inhibited by glucagon through repression of synthesis. Glucagon activates protein kinase A which, in turn, shuts off the ... Allosteric activators such as AMP and ADP bind to the allosteric site as to facilitate the formation of the R state by inducing ...
  https://en.wikipedia.org/wiki/Phosphofructokinase_1
*  Amino acid synthesis - Wikipedia
Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes ... This enzyme is regulated by at least four different mechanisms: 1. Repression and depression due to nitrogen levels; 2. ... All the enzymes in this biosynthetic pathway are subject to regulation via feedback inhibition and/or repression at the genetic ... At high concentrations this enzyme will be inactive and serine will not be produced. At low concentrations of serine the enzyme ...
  https://en.wikipedia.org/wiki/Amino_acid_synthesis
*  JCI - Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
FXR target gene expression. Mice with deficiencies in bile acid biosynthetic enzymes, such as the Cyp7a1-/- and Cyp27a1-/- ... The enzyme is quite promiscuous with respect to sterol substrate and acts on several 7α-hydroxylated intermediates of the bile ... Since other FXR target genes are expressed normally in these animals, and the capacity to respond to cholate by repression of 7 ... Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen responsive ...
  https://www.jci.org/articles/view/16309
*  Sucrose phosphorylase - Wikipedia
In the reaction, sucrose binds to the enzyme, at which point fructose is released by the enzyme-substrate complex. A covalent ... There has been little research on methods of the allosteric regulation of sucrose phosphorylase, so at this point the function ... Global regulation of DNA molecules containing the gene for sucrose phosphorylase is performed by catabolite repression. First ... à Gln mutant enzymes." Biochemistry Journal 403.3 (2007): 441-449. Schwarz, A. and B. Nidetzky. "Asp-196-->Ala mutant of ...
  https://en.wikipedia.org/wiki/Sucrose_phosphorylase
*  Improvement of L-phenylalanine production from glycerol by recombinant Escherichia coli strains: The role of extra copies of...
Iuchi S, Lin ECC: arcA ( dye ), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic ... Deletions of the genes maeA (encoding NAD-dependent malic enzyme) and maeB (encoding NADP-dependent malic enzyme) have not led ... Hines JK, Fromm HJ, Honzatko RB: Novel allosteric activation site in Escherichia coli fructose-1,6-bisphosphatase. J Biol Chem ... of specific enzyme activity is defined as the amount of enzyme required to release 1 μmol phosphate per minute per milligram of ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-014-0096-1
*  Protocols and Video Articles Authored by Scott B. Rothbart
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 Cell Reports. Sep, 2015 , Pubmed ID: ... A D53 Repression Motif Induces Oligomerization of TOPLESS Corepressors and Promotes Assembly of a Corepressor-nucleosome ... We now report that the secondary target is the downstream folate-dependent enzyme in de novo purine synthesis, ... Although histone methylation has been well studied, the functions of nonhistone lysine methylation and its regulatory enzymes, ...
  https://www.jove.com/author/Scott++B._Rothbart
*  Microbial Biochemistry | Georges N. Cohen | Springer
Enzyme Repression in Anabolic Pathways. Cohen, G. N.. Pages 219-225 Preview Buy Chapter $29.95 ... Allosteric Enzymes. Cohen, G. N.. Pages 59-71 Preview Buy Chapter $29.95 ...
  http://www.springer.com/us/book/9789401789073
*  Genetics - Medical Microbiology - NCBI Bookshelf
... and biosynthetic enzymes are repressed by the product of the pathway. Enzymes that participate in a single biochemical pathway ... A), If a and b are in the same structural gene (e.g., encoding the enzyme that converts X to Y), neither the a+b nor the ab+ ... The trp operon in E. coli is controlled both by repression and attenuation. In the presence of excess tryptophan, initiation of ... Furthermore, regulatory proteins are allosteric, meaning that they can exist in different conformations which exhibit different ...
  https://www.ncbi.nlm.nih.gov/books/NBK7908/?report=reader
*  François Jacob - Wikipedia
Studies of enzyme activity control were progressing through theories of the (allosteric) action of small molecules on the ... It was known that cells ramp up their production of the enzymes that do these steps when exposed to lactose, rather than ... and the transcriptional repression is lifted. In this way, a robust feedback loop is constructed that allows the set of lactose ... In 1961 Jacob and Monod explored the idea that the control of enzyme expression levels in cells is a result of regulation of ...
  https://en.wikipedia.org/wiki/Fran%C3%A7ois_Jacob