Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease | Circulation
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet. 2003; 72: ... Of the 16, 9 showed an increased risk in individuals homozygous for the a allele compared with b allele carriers (b/b plus b/a ... Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994; 330: 1041-1046. ... Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease. Juan P. Casas, Leonelo E. Bautista, Steve E. Humphries ...http://circ.ahajournals.org/content/109/11/1359
DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups | Diabetes
... risk of disease in the general population. Increasing the predictive value of genetics for type 1 diabetes susceptibility ... The highest-risk HLA DR-DQ genotype (DR3/4-DQB1*0302; DR4≠DRB1*0403) was found in 2.3% (n = 713) of GPC and 10.1% (n = 90) of ... between DPB1 alleles and other susceptibility loci. One measure of whether the association of an allele with a disease reflects ... An increased risk due to allele DPB1*0202 and a decreased risk due to allele DPB1*0402 have also been reported (10,11). ...http://diabetes.diabetesjournals.org/content/53/8/2158
Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta...
When those with a specific T allele of the TCF7L2 gene (the most significant type 2 diabetes susceptibility gene) are exposed ... increase in the risk of cardiovascular disease, 90% increase in the risk of cardiovascular mortality and 49% increase in the ... there appears to be a specific genotype that is particularly susceptible to the adverse effects of immobility. ... Warren TY, Barry V, Hooker S, Sui X, Church T, Blair S (2010) Sedentary behaviors increase risk of cardiovascular disease ...https://link.springer.com/article/10.1007%2Fs00125-012-2677-z
Polymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse...
... the FcγRIIa 131R low affinity IgG2-binding allele was associated with susceptibility to disease with the 131H/H genotype being ... Minor alleles of -1031 and -863 SNPs were associated with increased susceptibility to severe malaria. The high-affinity IgG2 ... Our results indicate that the 131R allele is associated with susceptibility to disease with the 131H/H genotype being ... This allele was not in significant LD with HLA-DRB1 and HLA-B alleles indicating that association with susceptibility to ...https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-7-13
Genetics of Alzheimer's Disease: A Centennial Review
... presence of an ApoE ε4 allele in the proband increased AD susceptibility in the relatives. However, there was also increased AD ... Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on ... high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc ... the increased risk of disease in family members of AD patients with disease onset ,65 years and the autosomal dominant ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2735049/?lang=en-ca
Frontiers | Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic...
Recent advances in the genomics of CVDs have fostered huge expectations about future use of susceptibility variants for ... Recent advances in the genomics of CVDs have fostered huge expectations about future use of susceptibility variants for ... Common complex cardiovascular disorders (e.g., coronary heart disease, hypertonia, or thrombophilia) result from a combination ... Common complex cardiovascular disorders (e.g., coronary heart disease, hypertonia, or thrombophilia) result from a combination ...https://www.frontiersin.org/articles/10.3389/fpubh.2017.00358/full
The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han...
The C/C genotype and C allele appear to be risk factor for an increasing incidence in these cardiovascular disorders. ... Indeed, the susceptibility to disease and the SNP genotype distributions in the NOS3 gene were different in Chinese and ... Table 3). For rs2070744, nominal differences were found in the genotype (. , , Table 3) and allele (. , , Table 3) ... Our results revealed that the rs2070744 C allele presents a remarkable risk for increasing the susceptibility for HIE in ...https://www.hindawi.com/journals/bmri/2016/1957374/
The On-going Challenge of Latent TB | Philosophical Transactions of the Royal Society B: Biological Sciences
Although active disease is characterized by uncontrolled increases in bacillary numbers, imaging and autopsy studies show that ... with disease susceptibility in a similar bimodal fashion with both insufficient and abundant responses tied to disease ... those who are homozygotes for the T allele (T/T) have increased LTA4H expression and inflammatory cerebrospinal fluid, but ... 2012 Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148, 434-446. ( ...http://rstb.royalsocietypublishing.org/content/369/1645/20130437
Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with...
... genetic models assume a trend per copy of the minor allele to contribute to the trait or disease susceptibility on genotype ... in increasing/decreasing susceptibility to the development of complex disease is still scarce. A well-known example is 32 bp ... 1Exact sequences of detected alleles are given in Figure 2.. n = number of carriers of the genotype; indel - insertion/deletion ... Western societies face high and increasing rates of CVD (such as coronary artery disease, hypertension, arteriosclerosis, heart ...https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-11-15
ACE and TBFGR1 genes interact in influencing the susceptibility to abdominal aortic aneurysm | IRIS Università degli Studi di...
... and the contemporary presence of ACE DD genotype and TGFBR1 6A allele, increased the predisposition to the disease [OR = 5.09 ( ... and the contemporary presence of ACE DD genotype and TGFBR1 6A allele, increased the predisposition to the disease [OR = 5.09 ( ... At univariate analysis a significant association between ACE DD, but not AT1R CC and TGFBR1 6A allele, and the susceptibility ... At univariate analysis a significant association between ACE DD, but not AT1R CC and TGFBR1 6A allele, and the susceptibility ...https://flore.unifi.it/handle/2158/323460
IJERPH | Free Full-Text | Lipoprotein Lipase (LPL) Polymorphism and the Risk of Coronary Artery Disease: A Meta-Analysis
... polymorphism has been extensively investigated as a potential risk factor for coronary artery disease (CAD). However, the ... This included HindIII H+H+ genotype (OR = 1.28, 95% CI = 1.09-1.49, p = 0.002, I2 = 43%) and H+ allele genotype (OR = 1.27, 95 ... A statistically significant increase in the risk of CAD was associated with LPL HindIII polymorphism. ... was employed to assess the association of the LPL polymorphism with CAD susceptibility. Results: We performed a meta-analysis ...http://www.mdpi.com/1660-4601/14/1/84
JAK2 and STAT3 Polymorphisms in a Han Chinese Population with Behçet's Disease | IOVS | ARVO Journals
Japanese patients with Crohn's disease on the other hand showed a significant association with the C allele and the CC genotype ... Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease. ... Genotype frequencies were estimated by direct counting. Allele and genotype frequencies were compared between patients and ... Concerning the distribution of allele and genotype, the frequency of the GG genotype of STAT3 rs2293152 was significantly ...http://iovs.arvojournals.org/article.aspx?articleid=2127373
Two Polymorphisms in the Fractalkine Receptor CX3CR1 Gene Influence the Development of Atherosclerosis: A Meta-Analysis
... and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as ... Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... in the heterozygous state but increased the risk of ischemic cerebrovascular disease (ICVD) in the homozygote state. The 249I ... showed that the 280M allele carriers of the CX3CR1 T280M polymorphism decreased the risk of AS and coronary artery disease (CAD ...https://www.hindawi.com/journals/dm/2014/913678/abs/
Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient-ventilator interactions,...
42] compared 60 children with ARDS to 60 controls and found an increase in the frequency of the ACE I/D genotype in the ARDS ... Whilst some adult studies have suggested ACE gene I/D polymorphism increases susceptibility or risk of mortality in patients ... Both types of interfaces were used in patients with lung disease. The interface had to be changed in 20 patients because of ... group, although severe hypoxaemia was less frequent in patients with the D allele. Further explorative studies are awaited with ...https://link.springer.com/article/10.1007/s00134-012-2807-6
HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q | BMC Medical Genetics | Full Text
... high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc ... Prion DiseaseAPOE GenotypeMultiple Displacement AmplificationHuman Prion DiseaseInsulin Degrading Enzyme ... Our study assumes that, as for prion disease, a common variant of HECTD2 is the susceptibility allele. However, multiple rare ... In this study we test whether the HECTD2 susceptibility allele seen in prion disease is also implicated in LOAD. ...https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-10-90
The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels
In conclusion, the CD40 rs1883832 T allele acts as a risk factor for increased susceptibility to sepsis and may be involved in ... The results showed that the frequencies of the TT genotype and the CD40 rs1883832 T allele were significantly higher in sepsis ... Sepsis is a severe and progressive disease characterized by systemic inflammatory response syndrome (SIRS). CD40 serves as a ... Plasma sCD40L levels were also significantly increased in sepsis patients. In addition, TT genotype carriers among sepsis ...https://www.hindawi.com/journals/bmri/2018/7497314/abs/
Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types |...
... so too does the chance that some of these alleles will confer susceptibility to autoimmune disease (2). Furthermore, because ... a linear model incorporating the main effects of host genotype and virus genotype, and the host genotype*virus genotype ... MHC genotypes through increased resistance to infectious disease. As MHC allelic diversity increases over time in a population ... host genotype-of-passage) versus an unfamiliar (a genotype it hasn't been passaged through) MHC genotype. On average (based on ...http://www.pnas.org/content/109/9/3422
Sickle Cell Disease and Anesthesia | Anesthesiology | ASA Publications
Rare complications include increased susceptibility to heat exhaustion, splenic infarction at altitude or after exercise, and, ... genotype of SCD is the homozygous state of the mutant allele (βSβS), coding exclusively for hemoglobin S production. ... Sickle cell disease can arise from a variety of closely related genotypes. The alleles encoding the β-globin chain display ... increased baseline leukocyte count, activated coagulation pathways, increased cytokines, and increased numbers of circulating ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1942826
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The rapid increase in multiresistant serotype 19A as a cause of invasive and respiratory pneumococcal disease has been ... MBL levels were significantly lower in patients with the A/0 and 0/0 genotype compared to homozygotes for the wild-type alleles ... We also performed a meta-analysis of studies on MBL2 polymorphisms and susceptibility to invasive pneumococcal disease. The ... The rs1799889 5G/5G genotype was associated with an increased risk of unfavourable outcome [odds ratio (OR) 1.69, 95 % ...https://www.jove.com/visualize?author=Arie%20van%20der%20Ende%20
Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a...
... that possession of the less common Dra I allele is associated with an increased risk of developing alcoholic liver disease; (3 ... Human cytochrome p4502E1 (CYP2E1): from genotype to phenotype. Pharmacogenetics 1996;6:203-11. ... Although earlier in vitro work suggested that the c2 allele was associated with increased inducibility of the enzyme,23 several ... However, the findings of this first reported study of Taq I polymorphism and liver disease suggest possession of the A1 allele ...http://mp.bmj.com/content/53/2/88
HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren's Syndrome
T allele and C/T genotype as well as AKNA −1372C,A (rs10817595) A/A genotype as susceptibility genetic factors of pSS, ... allele and 59% for the allele) .. In addition as pSS is a disease that primary affects women between ages 30 and 50 and our ... A polymorphism A/A genotype was associated with an increased risk of pSS (OR = 2.60; 95% CI = 1.11-6.12; ). Conclusions. We ... Allele and Genotype Frequencies. Allele and genotype frequencies of polymorphic sites in patients with pSS and controls are ...https://www.hindawi.com/journals/bmri/2017/5845849/
Protocols and Video Articles Authored by Wen-Chi Chen (Translated to Danish)
With respect to the allelic analysis, we observed significantly increased C-allele (65.9%) and decreased T-allele (34.1%) ... We suggest that the IL-1-beta gene promoter polymorphism can be used as a genetic marker for susceptibility to Graves' disease ... We found significantly increased frequencies of the C/C homozygous genotype (chi(2) test, P=0.038; odds ratio (OR)=2.558, 95% ... Using multivariable logistic regression, older age, increased body mass index, menopausal status, and PGR rs484389 genotype CT ...https://www.jove.com/author/Wen-Chi_Chen?language=Danish
Proteomic and Genomic Biomarkers for Age-Related Macular Degeneration | SpringerLink
Toward early detection of susceptibility to age-related macular degeneration (AMD), we quantified plasma carboxyethylpyrrole ( ... Yang Z, Camp NJ, Sun H (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science ... to 3-fold greater than the risk based on genotype alone. AMD donors carrying the ARMS2 and HTRA1 risk alleles were the most ... offer a potential early warning system for predicting susceptibility to this blinding disease. ...https://link.springer.com/chapter/10.1007/978-1-4419-1399-9_47
HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q | BMC Medical Genetics | Full Text
Groups were further analysed following stratification by APOE genotype. The rs12249854 minor allele (A) frequency was higher ( ... In this study we test whether the HECTD2 susceptibility allele seen in prion disease is also implicated in LOAD. DNA from 320 ... No significant difference was seen in minor allele frequency in the presence or absence of the APOE ε4 allele. The common ... HECTD2 maps to 10q and has been implicated in susceptibility to human prion diseases which are also neurodegenerative ...https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2350-10-90
Association of IL10 and TGFB single nucleotide polymorphisms with intervertebral disc degeneration in Iranian population: a...
... allele of IL-10 -592A/C were more prevalent among patients, whereas the 'C' and 'A' alleles of respective SNPs were ... In addition, the IL-10 haplotypes including 'ACC', 'ATA', and 'ACA' were significantly associated with disease. Meanwhile, the ... genotype of both IL-10 -819C/T and IL-10 -592A/C SNPs were more frequent in controls. ... The 'T' allele of IL-10 -819C/T and the 'C' ... patients and therefore increased the disease susceptibility. ...https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12881-018-0572-2