The Interaction of Colchicine and Some Related Alkaloids with Rat Brain Tubulin | Molecular Pharmacology
The Interaction of Colchicine and Some Related Alkaloids with Rat Brain Tubulin. WILLIAM O. MCCLURE and JAMES C. PAULSON ... The Interaction of Colchicine and Some Related Alkaloids with Rat Brain Tubulin. WILLIAM O. MCCLURE and JAMES C. PAULSON ... The Interaction of Colchicine and Some Related Alkaloids with Rat Brain Tubulin. WILLIAM O. MCCLURE and JAMES C. PAULSON ... The Interaction of Colchicine and Some Related Alkaloids with Rat Brain Tubulin ...http://molpharm.aspetjournals.org/content/13/3/560
Alkaloids Introduction | Alkaloid | Chemical Compounds
... caffeine and colchicine. alkaloids. alkaloids.They are insensitive to microamounts of alkaloids. colchicine. ... Basicity: Some alkaloids are not basic e.g. Colchicine, Piperine, Quaternary alkaloids. Nitrogen: The nitrogen in some ... Phenolic Alkaloids e.g.According to basicity Alkaloids are classified into: Weak bases e. Colchicine .g. Narceine Neutral ... alkaloids.They could not be applied in case of thermolabile and volatile alkaloids.Precipitation of the total alkaloids and ...https://www.scribd.com/doc/59395798/Alkaloids-Introduction
NAVER Academic | Isolation of Colchicine from Sandersonia aurantiaca and Gloriosa superba. Variation in the Alkaloid Levels of...
... and can thus potentially be utilized as alternative sources for commercial colchicine. Colchicine levels are highest at the ... HPlC and GCMS analysis showed that both Gloriosa superba and Sandersonia aurantiaca contained colchicine. During extraction ... Gloriosa and Sandersonia corm extracts contain about 0.9% colchicine, ... Gloriosa and Sandersonia plants were analyzed to determine their endogenous colchicine levels and the seasonal variation in ...https://academic.naver.com/article.naver?doc_id=65295246
IJMS | Free Full-Text | Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth...
In clinical settings, colchicine (CLC) induces patients' hair shedding. Compared to the control, the ex vivo hair fiber ... In clinical settings, colchicine (CLC) induces patients' hair shedding. Compared to the control, the ex vivo hair fiber ... Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid ... Keywords: alopecia; colchicine; dermal papilla; interactome; Protein ANalysis THrough Evolutionary Relationships; Search Tool ...http://www.mdpi.com/1422-0067/16/2/3579
Quadraploid | Article about Quadraploid by The Free Dictionary
The chemical agent that most effectively disrupts the normal separation of chromosomes is the alkaloid colchicine, which ... The condition can be induced artificially with the drug colchicine and the production of polyploid individuals has become a ... By treating seeds and buds with a dilute solution of colchicine, experimental polyploids are easily obtained.) ...https://encyclopedia2.thefreedictionary.com/Quadraploid
Lardaceous liver | Article about lardaceous liver by The Free Dictionary
Some substances become more toxic after passing through the liver, for example, the alkaloid colchicine is converted to a more ...http://encyclopedia2.thefreedictionary.com/lardaceous+liver
Colchicum - Wikipedia
Plants in this genus contain toxic amounts of the alkaloid colchicine which is used pharmaceutically to treat gout and Familial ...https://en.wikipedia.org/wiki/Colchicum
Several natural products such as Taxol, Vinca alkaloids, colchicine and their synthetic analogues that target microtubules have ... These molecules specifically bind to the colchicine-binding site of the tubulins and prevent their polymerization required for ...http://cancerres.aacrjournals.org/content/73/8_Supplement/2475
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney...
15 Study results have also suggested that the alkaloid colchicine, which is indicated for the treatment of acute gout, may also ... Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. ... Clinical and health care use characteristics of patients newly starting allopurinol, febuxostat, and colchicine for the ... colchicine prescription (HR, 1.26; 95% CI, 1.06-1.50; P = .010), steroid prescription (HR, 1.56; 95% CI, 1.29-1.88; P ,.001), ...http://ahdbonline.com/issues/2017/november-2017-vol-10-no-8/2495-major-cardiovascular-events-in-patients-with-gout-and-associated-cardiovascular-disease-or-heart-failure-and-chronic-kidney-disease-initiating-a-xanthine-oxidase-inhibitor
Recognizing And Treating Lower Extremity Gout | Podiatry Today
Colchicine is a tricyclic alkaloid.15 The mechanism of colchicine involves microtubular polymerization, an important process in ... Other FDA-approved colchicine formulations contain probenecid (Benemid). Low doses of colchicine (0.6 mg) three times a day may ... Colchicine is highly effective when patients take it within the first 12 to 36 hours of the attack. It acts as an anti- ... Oral colchicines and/or NSAIDs are first-line agents for systemic treatment of acute gout in the absence of contraindications. ...https://www.podiatrytoday.com/recognizing-and-treating-lower-extremity-gout?page=8
James Wilfred Cook - Wikipedia
Central to his research was the clarification of the structure of Alkaloid Colchicine: a compound that has anti-cancer ... Searching for parallel but less toxic compounds, similar to colchicine, he synthesized and studied many artificially created ...https://en.wikipedia.org/wiki/James_Wilfred_Cook
Chapter 9: Tubules\Filaments - Introduction
Colchicine is an alkaloid extracted from the plant Colchicum sativum. Colcemid, a synthetic derivative, is commonly used in ... Colchicine or vincristine depolymerize microtubules, and/or prevent their polymerization from the monomer tubulin. ...http://homepages.gac.edu/~cellab/chpts/chpt9/intro9.html
10 MEADOW SAFFRON Colchicum Autumnale AUTUMN CROCUS Seeds Colchicine Flower
... the seeds and corns contain the alkaloid colchicine. Colchicine is an atypical anti-inflammatory that is one of the primary ... Colchicine was eventually isolated in 1820 by French chemists and was finally approved by the FDA in 1939. As a landscaping ...https://eastseedfarm.ecrater.co.uk/p/16808051/10-meadow-saffron-colchicum-autumnale-autumn
Toxic Plants and Their Effects
MEADOW SAFFRON (Colchicum autumnale); entire plant; gastrointestinal tract affected by colchicine and other alkaloids; plant ... gastrointestinal tract affected by the toxin colchicine and other alkaloids; plant also causes dermatitis.. Avena sativa (OATS ... gastrointestinal tract affected by the toxin colchicine and other alkaloids; plant also causes dermatitis.. Colocasia esculenta ... ERGOT); an ascomycetous fungus which grows on small grain (e.g., rye); also contains the alkaloid indole.. Clematis spp. ( ...http://poultryhelp.com/toxicplants.html
Harmful & Poisonous Plants: H-N
MEADOW SAFFRON (Colchicum autumnale); entire plant; gastrointestinal tract affected by colchicine and other alkaloids; plant ... NUX-VOMICA TREE (Strychnos nux-vomica); entire plant; nervous system affected by the alkaloid strychnine. The following ... seeds; nervous system affected by cytisine, a nicotine-like alkaloid.. Lactuca sariola (PRICKLY LETTUCE); plant may contain ... leaves and roots; cardiovascular svstem affected by alkaloid toxins.. Montia perfoliata (MINER'S LETTUCE); plant may contain ...http://www.anapsid.org/resources/plants-hn.html
Gloriosa lily, Gloriosa superba - Master Gardener Program
... containing high levels of the toxic alkaloid colchicine, but especially in the tubers, and can be fatal to humans and animals ...https://wimastergardener.org/article/gloriosa-lily-gloriosa-superba/
Demecolcine - Wikipedia
It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with ...https://en.wikipedia.org/wiki/Demecolcine
Probenecid and Colchicine
... and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[( ... DESCRIPTION Probenecid and Colchicine contains probenecid, which is a uricosuric agent, ... Colchicine is an alkaloid obtained from various species of Colchicum. The chemical name for colchicine is (S)-N-(5,6,7,9- ... Colchicine consists of pale yellow scales or powder; it darkens on exposure to light. Colchicine is soluble in water, freely ...http://www.egeneralmedical.com/rxlist00000389.html
US Patent # 9,556,198. Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof -...
... vinca alkaloids, colchicines, colcemid, cisplatin, and nocadazol. The presence of the compound of the present invention shall ... Colchicine typifies another class of antimitotic agents. Colchicine, while not used as an antitumor agent, is a microtubule ... One such class is the vinca alkaloids exemplified by vincristine, vinblastine, vindesine, and vinorelbine. The vinca alkaloids ... Ngamga, et al., "Millaurine and Aceytlmillaurine Alkaloids from Milletia laurentii", J. of Nat. Prod., vol. 56, No. 12, pp. ...http://patents.com/us-9556198.html
Baeometra - Wikipedia
... and is known to be a poisonous plant containing the alkaloid colchicine. It has been introduced to Australia, where it is ... http://www.plantzafrica.com/plantab/baemetrauni.htm Vinnersten & Larsson (2010) Colchicine is still a chemical marker for the ...https://en.wikipedia.org/wiki/Baeometra
Iphigenia (plant) - Wikipedia
As with other taxa in Colchicaceae Iphigenia contains phenethylisoquinoline alkaloids including colchicine. Iphigenia oliveri ... Larsson S & Rønsted N, Reviewing Colchicaceae alkaloids - perspectives of evolution on medicinal chemistry. Curr. Topics Med. ... Colchicine is still a chemical marker for the expanded Colchicaceae. Biochem. Syst. Ecol. 38: 1193, 2010. ...https://en.wikipedia.org/wiki/Iphigenia_(plant)
High-performance Thin-layer Chromatographic-densitometric Quantification and Recovery of Bioactive Compounds for Identification...
... is used as adjuvant therapy in gout for its potential antimitotic activity due to high colchicine(s) alkaloids. This study ... validated method for simultaneous quantification of bioactive alkaloids (colchicine and gloriosine) in G. superba L. and to ... validated method for simultaneous quantification of bioactive alkaloids (colchicine and gloriosine) in G. superba L.Five ... Quantification data reveal that content of colchicine (Rf: 0.72) and gloriosine (Rf: 0.61) varies from 0.035%-0.150% to 0.006%- ...https://www.sigmaaldrich.com/catalog/papers/29142436
IJMS | Free Full-Text | Activation of the Ubiquitin Proteasome Pathway by Silk Fibroin Modified Chitosan Nanoparticles in...
Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid ... Drug, Colchicine. Previous Article in Journal. Protection of Retina by Mini-αA in NaIO3-Induced Retinal Pigment Epithelium ...http://www.mdpi.com/1422-0067/16/1/1657
Colchicum | definition of colchicum by Medical dictionary
A perennial herb that is the primary source of colchicine, an alkaloid used for treating gout in mainstream medicine.. ... Related to colchicum: colchicine. colchicum. (kŏl′chĭ-kəm, kŏl′kĭ-). n.. 1. Any of various bulbous plants of the genus ... 2. The dried ripe seeds or corms of the autumn crocus, both of which yield colchicine. ...http://medical-dictionary.thefreedictionary.com/colchicum
Protocols and Video Articles Authored by Jennifer Smith
In addition, using examples from binding results with several important drugs including vinca alkaloids, colchicine, eribulin, ...https://www.jove.com/author/Jennifer_Smith