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*  Galactosemia - Wikipedia
Therefore, aldose reductase reduces galactose to its sugar alcohol form, galactitol. Galactitol, however, is not a suitable ... However, recent studies suggest that galactose dehydrogenase is responsible for converting galactose to galactonolactone, which ... types of sugars including galactose, to sugar alcohols.[6] Recent data suggests that aldose reductase is the enzyme responsible ... "Aldose Rudctase Inhibitors." Your Total Health. "Archived copy". Archived from the original on 2009-07-12. Retrieved 2011-01-19 ...
  https://en.wikipedia.org/wiki/Galactosemia
*  Sorbitol dehydrogenase - Wikipedia
... the sugar alcohol form of glucose, into fructose. Together with aldose reductase, it provides a way for the body to produce ... In uncontrolled diabetes, large amounts of glucose enter these tissues and is then converted to sorbitol by aldose reductase. ... The SDH proteins have a close evolutionary relationship with alcohol dehydrogenase, which also belongs to the protein ... Sorbitol dehydrogenase uses NAD+ as a cofactor; its reaction is sorbitol + NAD+ --> fructose + NADH + H+. A zinc ion is also ...
  https://en.wikipedia.org/wiki/Sorbitol_dehydrogenase
*  Galactosemic cataract - Wikipedia
... aldose reductase, will convert significant amounts of the sugar to its galactitol form. As it turns out, the lens is a ... Thus, the sugar alcohol idly begins to accumulate in the lens. As galactitol concentration increases in the lens, a hypertonic ... As is mentioned above, galactitol is not a suitable substrate for the enzyme, polyol dehydrogenase, which catalyzes the next ... Aldose reductase requires NADPH for the reduction of galactose to galactitol, while glutathione reductase utilizes NADPH to ...
  https://en.wikipedia.org/wiki/Galactosemic_cataract
*  Sorbitol - Wikipedia
It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar alcohol; ... Aldose reductase is the first enzyme in the sorbitol-aldose reductase pathway responsible for the reduction of glucose to ... Aldose reductase inhibitors, which are substances that prevent or slow the action of aldose reductase, are currently being ... Butterworth's Sugar-Free Syrup Hungry Jack Butter Sugar- Free Syrup Log Cabin Sugar-Free Syrup Jelly/Jam Smucker's Sugar- Free ...
  https://en.wikipedia.org/wiki/Sorbitol
*  Thiamine in the polyol pathway
Among possible mechanisms, increased formation of advanced glycation end products (AGE), increased aldose reductase (AR) ... catalyzes the reduction of glucose to the corresponding sugar alcohol, sorbitol, which is then converted to fructose by ... ROS can partially inhibit glyceraldehyde-phosphate dehydrogenase, resulting in the accumulation of glycolytic metabolites, ... studies suggested that polyol pathway hyperactivity is implicated in the pathogenesis of diabetic retinopathy.Aldose reductase ...
  http://flipper.diff.org/app/pathways/info/389
*  Levels of pentose phosphate pathway enzymes from Candida shehatae grown in continuous culture | SpringerLink
These studies investigated the titers of xylose reductase, xylitol dehydrogenase,... ... These studies investigated the titers of xylose reductase, xylitol dehydrogenase, glucose-6-phosphate dehydrogenase and alcohol ... Sheys GR, Arnold WJ, Watson JA, Hyashi JA, Doughty CC (1971) Aldose reductase fromRhodotorula. J Biol Chem 246:3824-3827Google ... van Dijken JP, Scheffers WA (1986) Redox balances in the metabolism of sugars by yeasts. FEMS Microbiol Rev 32:199-224Google ...
  https://link.springer.com/article/10.1007/BF00939322
*  A Role for Sorbitol in Desiccation Tolerance of Developing Maize Kernels: Inference from the Properties of Maize Sorbitol...
Characteristics of alcohol/polyol dehydrogenases. The zinccontaining long-chain alcohol dehydrogenases. Eur.J.Biochem. 167: 195 ... Cowley BD,Jr., Ferraris JD, Carper D, Burg MB (1990) In vivo osmoregulation of aldose reductase mRNA, protein, and sorbitol in ... Beck E, Hopf H (1990) Branched-chain sugars and sugar alcohols. In PM Dey, JB Harborne, eds. Methods in Plant Biochemistry, Vol ... Extensive variations and basic features in the alcohol dehydrogenase - sorbitol dehydrogenase family. Eur.J.Biochem. 140: 17-23 ...
  https://rd.springer.com/chapter/10.1007/978-3-642-79133-8_22
*  Liver Damage is a Growing Epidemic - Karma Yoga Daily
Excess Sugar Consumption Drives Rising NAFLD Rates. While alcohol-related cirrhosis is driving up mortality rates, rising ... in which glucose is metabolized to sorbitol by aldose reductase, and sorbitol is subsequently metabolized to fructose by ... sorbitol dehydrogenase (see figure below).. It is estimated when you are healthy, only about 3 percent of glucose goes through ... NAC supplementation has been effective in minimizing damage associated with alcohol consumption when taken prior to alcohol ...
  https://karmayogadaily.com/2018/08/02/liver-damage-growing-epidemic/
*  Microbial and Bioconversion Production of D-xylitol and Its Detection and Application
parapsilosis xyl1 gene encoding xylose reductase (XR) which is controlled by an alcohol dehydrogenase promoter was introduced ... LC-MS with negative ESI was employed to analyze sugars and sugar polyols in atmospheric aerosols [75]. Since sugars and sugar ... In these yeasts and fungi, D-xylose was first reduced to D-xylitol by either NADH- or NADPH-dependent xylose reductase (aldose ... Exudation of alcohol and aldehyde sugars from roots of defoliated Lolium perenne L. grown under sterile conditions. J Chem. ...
  http://www.ijbs.com/v06p0834.htm
*  Patent US6710040 - Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors - Google Patents
... alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome ... an aldose reductase inhibitor; a glycogen phosphorylase inhibitor; a sorbitol dehydrogenase inhibitor; a fatty acid oxidation ... Activation of the alcohol function to an alkyl or arylsulfonate is accomplished by reaction with the corresponding sulfonyl ... Preferred materials for this include lactose or milk sugar and high molecular weight polyethylene glycols. When aqueous ...
  http://www.google.co.uk/patents/US6710040
*  Sporobolus stapfianus: Insights into desiccation tolerance in the resurrection grasses from linking transcriptomics to...
RWC along with transcripts for alcohol dehydrogenase (contigs 9827 and 23145), cytosolic aldehyde dehydrogenase (contigs 17275 ... Mundree S, Whittaker A, Thomson J, Farrant J. An aldose reductase homolog from the resurrection plant Xerophyta viscosa Baker. ... Lipid-sugar interactions relevance to anhydrous biology. Plant Physiol. 1988;86:754-8.PubMedPubMed CentralView ArticleGoogle ... malate dehydrogenase (contigs 13020 and 23772), succinate dehydrogenase (contigs 5834 and 17169), isocitrate dehydrogenase ( ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-017-1013-7
*  KEGG SSDB Best Search Result: rde:RD1 1072
obr:102722494 aldose reductase 313 109 ( -) 31 0.301 163 -, 1 rey:O5Y_10915 hypothetical protein K03098 200 109 ( -) 31 0.347 ... ela:UCREL1_6871 putative alcohol dehydrogenase domain-c 373 107 ( -) 30 0.309 123 -, 1 fbt:D770_06545 glycosyl hydrolase family ... hdl:HALDL1_08965 sugar ABC transporter K02010 378 105 ( -) 30 0.316 79 -, 1 jag:GJA_2459 his Kinase A domain protein 1155 105 ... psim:KR76_04355 sugar ABC transporter K02010 350 103 ( 3) 29 0.346 52 -, 2 rhc:RGUI_4259 CobN component of cobalt chelatase ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=rde:RD1_1072
*  MATERIALS AND METHODS FOR MODULATING SEED SIZE, SEED NUMBER, AND SEED SUGAR CONTENT IN PLANTS - Patent application
4A), and there be metabolized by an as-yet-undefined means (low levels of SDH or a distinctive maize aldose reductase (AR)). ... 4A and 4B, these reactants include not only fructose (a sugar), sorbitol (a sugar alcohol), but also the nucleotides, NAD and ... In one embodiment, the mutant sorbitol dehydrogenase is a sorbitol dehydrogenase 1 of Zea mays. In a specific embodiment, a ... As used herein, sugar content can refer to sugars, e.g., fructose, sucrose, and glucose, and to sugar alcohols, e.g., sorbitol ...
  http://www.patentsencyclopedia.com/app/20110191909
*  KEGG BRITE: KEGG Orthology (KO) - Mus musculus (mouse)
... glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] K11146 DHRS3; short-chain dehydrogenase/reductase 3 [ ... aldose reductase) 67861 Akr1b10; aldo-keto reductase family 1, member B10 (aldose reductase) 67880 Dcxr; dicarbonyl L-xylulose ... 00520 Amino sugar and nucleotide sugar metabolism [PATH:mmu00520] 00620 Pyruvate metabolism [PATH:mmu00620] ... alcohol dehydrogenase 1/7 [EC:1.1.1.1] K13951 ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1] K13980 ADH4; alcohol dehydrogenase ...
  http://www.genome.jp/kegg-bin/get_htext?mmu00001+394435
*  Aldose reductase - Wikipedia
... but the corresponding keto sugar is not produced because sorbitol dehydrogenase is incapable of oxidizing galactitol. ... The alcohol product is formed via a transfer of the pro-R hydride of NADPH to the re face of the substrate's carbonyl carbon. ... AKR1B1 Aldo-keto reductase Petrash JM (April 2004). "All in the family: aldose reductase and closely related aldo-keto ... In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that ...
  https://en.wikipedia.org/wiki/Aldose_reductase
*  KEGG SSDB Best Search Result: rpd:RPD 3722
cid:P73_4492 putative alcohol dehydrogenase 342 108 ( -) 30 0.331 118 -, 1 cser:CCO03_09840 alpha/beta hydrolase 341 108 ( -) ... bte:BTH_II0945 nitric oxide reductase K04561 773 115 ( -) 32 0.305 118 -, 1 bthe:BTN_3925 cytochrome C and Quinol oxidase ... cum:NI26_00345 nucleoside-diphosphate sugar epimerase 277 107 ( -) 30 0.301 93 -, 1 lbz:LBRM_11_0330 stearic acid desaturase ... scw:TU94_10330 aldose epimerase K01785 323 101 ( -) 29 0.361 72 ,-, 1 sen:SACE_2079 aspartate carbamoyltransferase catalytic ...
  http://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=rpd:RPD_3722
*  KEGG BRITE: KEGG Orthology (KO) - Acinetobacter baumannii AYE
ABAYE2799 rubB; rubredoxin-NAD(+) reductase ABAYE1861 frmA; Alcohol dehydrogenase class 3 (Alcohol dehydrogenase class III) (S ... K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] K00064 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] K00128 ... 00520 Amino sugar and nucleotide sugar metabolism [PATH:aby00520] 00620 Pyruvate metabolism [PATH:aby00620] ... ABAYE1522 putative iron-containing alcohol dehydrogenase ABAYE1861 frmA; Alcohol dehydrogenase class 3 (Alcohol dehydrogenase ...
  http://www.genome.jp/kegg-bin/get_htext?aby00001+ABAYE2333
*  Quercetin: A Versatile Flavonoid
Quercetin has been found to be an inhibitor of the enzyme aldose reductase, which plays a role in converting glucose (sugar) to ... a sugar alcohol) in the body. People with diabetes develop secondary problems, such as neuropathy, retinopathy, diabetic ... Both xanthine dehydrogenase and xanthine oxidase are involved in the metabolism of xanthine to uric acid. Xanthine ... 1-Benzopyran -4-one antioxidant as aldose reductase inhibitors. Med Chem 1999;42:1881-93. 109. Cai J, Nelson KC, Wu M, et al. ...
  http://spotidoc.com/doc/18890/quercetin--a-versatile-flavonoid
*  Frontiers | Role of protein and mRNA oxidation in seed dormancy and germination | Plant Science
... or by methionine sulfoxide reductase (methionine oxidation). Seed dormancy alleviation in the dry state, referred to as after- ... or by methionine sulfoxide reductase (methionine oxidation). Seed dormancy alleviation in the dry state, referred to as after- ... For example these authors showed that alcohol dehydrogenase is carbonylated in axes of all seeds undergoing germination, which ... aldose reductase, methionine synthase, translation factors, and several molecular chaperones (Job et al., 2005). Despite such ...
  https://www.frontiersin.org/articles/10.3389/fpls.2013.00077/full
*  Methods for using dehydrogenases in baking - Patent # 6306445 - PatentGenius
The present invention also relates to compositions containing an effective amount of one or more dehydrogenases for improving ... of one or more dehydrogenases which improve one or more properties of the dough or a baked product obtained from the dough. The ... sugar alcohol (such as sorbitol), starch, rice, corngrits, or soy. The dehydrogenase(s) and/or additional enzymes may be ... proline dehydrogenase (E.C. 1.5.99.8); monodehydroascorbate reductase (E.C. 1.6.5.4); NAD(P)H:quinone dehydrogenase (E.C. 1.6. ...
  http://www.patentgenius.com/patent/6306445.html
*  Basic Concepts
... alcohol dehydrogenase inhibitor) can be used instead of ethanol infusion. ˗ Fomepizole infusion is now proffered for Tx of ... Aldose reductase) - galactokinase trap galactose in cell by phosphorylation as galactose-1-phosphate  Gal-1-Uridyltransferase ... retinopathy); Diabetic microangiopathy → ↑synthesis of type-IV collagen in basement membrane & mesangium ˗ Tight blood sugar ... Eg: Alcoholic cirrhotic patient works as a volunteer for a non profit organization that assist patient with alcoholic cirrhosis ...
  http://spotidoc.com/doc/22634/basic-concepts
*  Frontiers | Drug Repositioning for Effective Prostate Cancer Treatment | Physiology
Zhu, C. (2013). "Aldose reductase inhibitors as potential therapeutic drugs of diabetic complications," in Diabetes Mellitus - ... Disulfiram is the first FDA approved alcohol aversive drug used for the treatment of alcohol dependence for more than 60 years ... 2006b). Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J. Med. Chem. 49, 2677- ... Digoxin, as a cardiac glycoside, has basically steroid-like structure including an unsaturated lactone ring and sugar moieties ...
  https://www.frontiersin.org/articles/10.3389/fphys.2018.00500/full
*  Human Metabolome Database: Showing metabocard for Sorbitol (HMDB0000247)
1. Aldose reductase. General function:. Involved in oxidoreductase activity. Specific function:. Catalyzes the NADPH-dependent ... 5. Sorbitol dehydrogenase. General function:. Involved in zinc ion binding. Specific function:. Converts sorbitol to fructose. ... Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced ... This compound belongs to the class of chemical entities known as sugar alcohols. These are hydrogenated forms of carbohydrate ...
  http://www.hmdb.ca/metabolites/HMDB00247
*  Lactate dehydrogenase - Wikipedia
Aldose reductase. *Beta-Ketoacyl ACP reductase. *Carbohydrate dehydrogenases. *Carnitine dehydrogenase. *D-malate dehydrogenase ... Ethanol is dehydrogenated to acetaldehyde by alcohol dehydrogenase, and further into acetic acid by acetaldehyde dehydrogenase ... Both of these conditions affect how the body breaks down sugars, primarily in certain muscle cells. Lactate dehydrogenase-A ... lactate dehydrogenase A. (subunit M). Human lactate dehydrogenase M4 (the isoenzyme found in skeletal muscle). From PDB: 1I10​. ...
  https://en.wikipedia.org/wiki/Lactate_dehydrogenase
*  Improved sugar co-utilisation by encapsulation of a recombinant Saccharomyces cerevisiae strain in alginate-chitosan capsules |...
In an inhibitory dilute acid spruce hydrolysate, freely suspended yeast cells consumed the sugars in a sequential manner after ... Encapsulation of xylose-fermenting S. cerevisiae leads to improved simultaneous and efficient utilisation of several sugars, ... Simulations also showed pronounced concentration gradients of sugars, which resulted in simultaneous xylose and glucose ... more xylose compared with suspended cells over 96-hour fermentations in medium containing both sugars. The higher consumption ...
  https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/1754-6834-7-102