*  The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients - Full Text...
Sei Won Lee, Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway ... Alpha-1 antitrypsin deficiency. *History of thoracotomy. *Excessive sputum production (throughout the week) ... Airflow limitation of COPD is caused by a mixture of small airway disease (obstructive bronchiolitis) and parenchyma ... Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan ...
  https://clinicaltrials.gov/ct2/show/NCT01869205?cond=%22Pulmonary+Emphysema%22&rank=14
*  Alpha1-Antitrypsin Deficiency - Lung and Airway Disorders - Merck Manuals Consumer Version
Alpha-1 Antitrypsin Deficiency By Robert A. Wise, MD, Professor of Medicine, Division of Pulmonary and Critical Care Medicine, ... The deficiency is often confirmed by genetic testing, which also can determine the specific form of the deficiency. Doctors ... Alpha-1 antitrypsin may be given by vein to replace the deficient enzyme. It is collected from a group of donors and screened ... Alpha-1 antitrypsin deficiency is a hereditary disorder in which a lack or low level of the enzyme alpha-1 antitrypsin damages ...
  https://www.merckmanuals.com/home/lung-and-airway-disorders/chronic-obstructive-pulmonary-disease-copd/alpha-1-antitrypsin-deficiency
*  Chronic Obstructive Pulmonary Disease (COPD) and Acute Exacerbations
Common causes of COPD include cigarette smoking, air pollution, airway hyperresponsiveness, and alpha 1 antitrypsin deficiency. ... Airway inflammation causes airway edema, bronchospasm, and increased sputum production, which can lead to worsening airflow ... Evaluation of the airway and breathing should be the primary goal to determine whether noninvasive or invasive ventilation is ... The role of bacteria in COPD exacerbations is confounded by the fact that airway bacterial colonization in the stable state is ...
  http://www.psychiatryadvisor.com/infectious-diseases/chronic-obstructive-pulmonary-disease-copd-and-acute-exacerbations/article/608872/
*  Karina A. Serban, MD
chronic obstructive airway diseases (e.g. emphysema, alpha-1 antitrypsin deficiency, combined pulmonary fibrosis and emphysema ... Alpha-1 Antitrypsin Deficiency Program *COPD Program *Department of Medicine *Division of Pulmonary, Critical Care and Sleep ... Alpha-1 Antitrypsin Deficiency Overview *Chronic Bronchitis *Chronic Cough *Chronic Obstructive Pulmonary Disease (COPD) * ... I specifically look at the anti-inflammatory and immuno-modulatory role of alpha-1 antitrypsin on macrophages functions and ...
  https://www.nationaljewish.org/doctors-departments/providers/physicians/karina-a-serban
*  Alpha-1 Antitrypsin Deficiency - Penn Medicine
Complications of A1AT deficiency include:. *Bronchiectasis (damage of the large airways). *Chronic obstructive pulmonary ... a1-Antitrypsin deficiency and emphysema. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics ... a1-antitrypsin deficiency. Clin Chest Med. 2016;37(3):487-504. PMID: 27514595 www.ncbi.nlm.nih.gov/pubmed/27514595. ... AAT deficiency; Alpha-1 protease deficiency; COPD - alpha-1 antitrypsin deficiency; Cirrhosis - alpha-1 antitrypsin deficiency ...
  https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/alpha-1-antitrypsin-deficiency
*  Michael A. Campos, M.D. - Filtering by 'perfil' - Busque un Médico - University of Miami Health System
Campos MA, Lascano J. Alpha1 Antitrypsin deficiency: current best practice in testing and augmentation therapy. Ther Adv Respir ... Mendes ES, Horvath G, Campos M, Wanner A. Rapid corticosteroid effect on beta(2)-adrenergic airway and airway vascular ... The prevalence of alpha-1 antitrypsin deficiency among patients found to have airflow obstruction. COPD. 2012 Aug;9(4):352-8. ... Mendes ES, Campos MA, Wanner A. Airway Blood Flow Reactivity in Healthy Smokers and in Ex-Smokers With or Without COPD. Chest ...
  http://es.uhealthsystem.com/medicos/perfil/1303
*  Disease of the airways in chronic obstructive pulmonary disease | European Respiratory Society
... antitrypsin deficiency, and CLE for the others. They tested this hypothesis in 34 patients undergoing lung resection who had ... Comparison with alpha1antitrypsin deficiency. Am Rev Respir Dis 1989;139:1452-1458. ... The relationship between small airway diameters, a function of the proportion of airways of ,400 µm in diameter in the lung, ... Understanding of the role of the airways in COPD might be helped by considering the different aspects of airway abnormalities ...
  http://erj.ersjournals.com/content/18/34_suppl/41s
*  Intravenous alpha-1 antitrypsin augmentation therapy for treating patients with alpha-1 antitrypsin deficiency and lung disease...
Alpha-1 antitrypsin deficiency is an inherited disorder that can cause lung disease (chronic obstructive pulmonary disease or ... Alpha-1 antitrypsin deficiency is an inherited disorder that can cause chronic obstructive pulmonary disease (COPD). People who ... To review the benefits and harms of augmentation therapy with intravenous alpha-1 antitrypsin in patients with alpha-1 ... We reviewed the benefits and harms of treating patients who have the form of the disease that affects the lungs with alpha-1 ...
  http://www.cochrane.org/CD007851/AIRWAYS_intravenous-alpha-1-antitrypsin-augmentation-therapy-treating-patients-alpha-1-antitrypsin
*  What Is Alpha-1 Antitrypsin Deficiency Disorder? - Scientific American
... medicines to open up the airways, broncodilators; preventive strategies like influenza vaccine, pneumonia vaccine; occasionally ... What is alpha-1 antitrypsin deficiency?. It is a genetic defect in the production of a protective protein called alpha-1 ... If Jackson has alpha-1 antitrypsin deficiency, it means he cannot protect his lungs from his body's own defenses against ... What Is Alpha-1 Antitrypsin Deficiency Disorder?. An unauthorized biographer claims that pop star Michael Jackson is suffering ...
  https://www.scientificamerican.com/article/michael-jackson-alpha-1-antitryps/
*  COPD and Alpha-1 Antitrypsin (AAT) Deficiency | NorthShore
Read our COPD and Alpha-1 Antitrypsin (AAT) Deficiency encyclopedia resources online. ... Asthma with airflow blockage that is not completely resolved after treatment with medicine that opens the lung airways ( ... Deficiency. Skip to the navigation Topic Overview. Alpha-1 antitrypsin (AAT) is a protein normally found in the lungs and the ... Standards for the diagnosis and management of individuals with alpha1-antitrypsin deficiency. American Journal of Respiratory ...
  https://www.northshore.org/healthresources/encyclopedia/encyclopedia.aspx?documenthwid=hw164553
*  Professor Paul McLoughlin | UCD Conway
Foley, S. C.,Hopkins, N. O.,Fitzgerald, M. X.,Donnelly, S. C.,McLoughlin, P. (2007) 'Airway nitric oxide output is reduced in ... MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P. McLoughlin, NG McElvaney, (2007) Never smoking patients with Alpha-1 ... antitrypsin deficiency have morphometrically normal large airway epithelium American Thoracic Society International Conference ... MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P McLoughlin, NG McElvaney, MD (2007) Large airway morphological changes ...
  http://www.ucd.ie/conway/research/researchers/conwayfellowsa-z/professorpaulmcloughlin/publications/
*  Alpha 1-antitrypsin deficiency overview --Doctors Lounge
Apart from increasing the inflammatory reaction in the airways, cigarette smoke also directly inactivates alpha 1-antitrypsin ... Normally, alpha 1-antitrypsin is produced in the liver and exists in levels of 1.5-3.5 gram/litre. When the levels are reduced ... Alpha 1-antitrypsin deficiency (A1AD) is a genetic disorder caused by reduced levels of alpha 1-antitrypsin in blood. It leads ... Please refer to the alpha 1-antitrypsin for the various protease inhibitor (Pi) genotypes and phenotypes. ...
  https://www.doctorslounge.com/index.php/reference/diseases/121
*  Non-Chemotherapy-Related Drug-Induced Lung Injury
... tablets has been associated with lower lobe emphysema and airways obstruction similar to that seen in alpha-1 antitrypsin ... deficiency. The disease is thought to be related to acute destruction of lung parenchyma from the talc used to stabilize the ... Drug-induced Airways Disease. Major findings of drug-induced airways disease include cough and bronchospasm. ... The mechanism of ACE-I induced cough is unclear, but may involve direct airways irritation and increased airway reactivity. ACE ...
  https://www.clinicalpainadvisor.com/pulmonary-medicine/non-chemotherapy-related-drug-induced-lung-injury/article/625583/
*  Pulmonary Flashcards by Alyssa Shapiro | Brainscape
Accumulation of alpha-antitrypsin in the RER of the liver. *Predisposition of juvenile hepatitis, cirrhosis, and hepatocellular ... Airway responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing ... Variants of alpha-1antitrypsin deficiency and the way their effects?. *S varient *60% of normal levels with no pulmonary ... Browse over 1 million classes created by top students, professors, publishers, and experts, spanning the world's body of " ...
  https://www.brainscape.com/flashcards/pulmonary-3228592/packs/4732134
*  Pulmonary Flashcards - Cram.com
terminal airway destruction that may be due to smoking or to alpha-1 antitrypsin deficiency ... a1 antitrypsin deficiency dyspnea, pursed lips, minimal cough, decreased breath sounds emphysema (pink puffer) ... reversible airway obstruction secondary to bronchial hyperreactivity, airway inflammation, mucous plugging, and smooth muscle ... CT showing dilated airways and ballooned cysts at the end of the broncus (mostly lower lobes) ...
  http://www.cram.com/flashcards/pulmonary-484631
*  Alpha 1-antitrypsin deficiency - Wikipedia
In addition to increasing the inflammatory reaction in the airways, cigarette smoke directly inactivates alpha-1 antitrypsin by ... α1-antitrypsin deficiency has been associated with a number of diseases: Cirrhosis COPD Pneumothorax Asthma Granulomatosis with ... Silverman, Edwin K.; Sandhaus, Robert A. (2009-06-25). "Alpha1-Antitrypsin Deficiency". New England Journal of Medicine. 360 ( ... Silverman EK, Sandhaus RA (2009). "Alpha1-Antitrypsin Deficiency". New England Journal of Medicine. 360 (26): 2749-2757. doi: ...
  https://en.wikipedia.org/wiki/Alpha_1-antitrypsin_deficiency
*  PPT - Alpha1 Antitrypsin Deficiency: An Underrecognized Cause of Chronic Obstructive Pulmonary Disease PowerPoint presentation ...
Alpha1 Antitrypsin Deficiency: An Underrecognized Cause of Chronic Obstructive Pulmonary Disease - A free PowerPoint PPT ... Airway hyperresponsiveness *Stunted lung development *Alpha-1 antitrypsin (AAT) deficiency. Pauwels RA. Lancet. 2004364613. 7. ... Deficiency 35. Risk Factors of Lung Disease Associated with AAT Deficiency*AAT deficiency has a highly variable clinical course ... Treatment of AAT Deficiency. 11. AAT Deficiency*AAT deficiency is an autosomal, codominant, hereditary disorder characterized ...
  http://www.powershow.com/view/6a744-ZGU0O/Alpha1_Antitrypsin_Deficiency_An_Underrecognized_Cause_of_Chronic_Obstructive_Pulmonary_Disease_powerpoint_ppt_presentation
*  COPD | National Heart, Lung, and Blood Institute (NHLBI)
In COPD, less air flows in and out of the airways because of one or more of the following:. *The airways and air sacs lose ... This may occur, for example, if a person has a predisposing health issue, such as the genetic condition known as alpha-1 ... deficiency can also cause the disease. ... The airways and air sacs are elastic or stretchy. When you ... Bronchodilators relax the muscles around your airways. This helps open your airways and makes breathing easier. ...
  https://www.nhlbi.nih.gov/health-topics/copd
*  D. Shane S. O'Mahony, MD | Edmonds, WA
Airway Obstruction. *Airway Scarring. *Allergic Aspergillosis. *Allergic Pneumonitis. *Allergic Wheezing. *Alpha 1 Antitrypsin ... For help finding the right doctor, call 1-800-SWEDISH (793-3474). LEARN MORE ...
  https://www.swedish.org/swedish-physicians/profile.aspx?name=d+shane+s+omahony&id=160223
*  Lung Transplantation (include selection, evaluation, process of organ acquisition, etc.) - ONA
The most common airway complication is bronchial stenosis that is due to fibrous stricture, excessive granulation tissue, or ... and alpha-1 antitrypsin deficiency-associated emphysema (2%) are the other major indications, while a variety of other ... Airway complications. Dehiscence of the bronchial anastomosis is an uncommon early complication. Mild forms are often ... Selection of patients with CF has always raised unique concerns about the risk that chronic airways infection poses on post- ...
  https://www.oncologynurseadvisor.com/pulmonary-medicine/lung-transplantation-include-selection-evaluation-process-of-organ-acquisition-etc/article/625612/
*  Prevalence of Alpha-1 Antitrypsin (A1AT) Deficiency among Patients with COPD in Kerman, Iran
... relative deficiency of this enzyme was associated with severe and very severe airway obstruction. Conclusion: Based on the ... None of the patients had absolute deficiency of A1AT, and only13 patients (4.4%) had a relative deficiency of A1AT. There was a ... is deficiency of Alpha-1 Antitrypsin (A1AT). There is no exact statistics about the prevalence of this disease in different ... The present study aimed to determine the prevalence of alpha-1 antitrypsin (A1AT) deficiency in COPD patients in Kerman, Iran. ...
  http://jkmu.kmu.ac.ir/article_46770.html
*  Chronic Care Focus: Diagnosis and Treatment of COPD in Health Systems
Along with an extensive history of smoking, emphysema also can be caused by a rare deficiency in alpha-1- antitrypsin, which ... With the enlargement of alveoli and destruction of elastic fibers, lung tissue starts to compress the airway upon expiration, ... The chronic bronchitis patient likely has a significant smoking history, which leads to increased size and number of airway ... COPD is usually caused by cigarette smoking, which leads to progressive airway obstruction and inflammation. Unlike asthma, the ...
  http://www.pharmacytimes.com/publications/issue/2009/2009-04/2009-04-10206
*  Lungs and Airways County of San Diego, California
COPD and Alpha-1 Antitrypsin (AAT) Deficiency. *COPD and Sex. *COPD Flare-Ups ... Our topics can help you learn more about lung and airway conditions and treatments. To start, explore these lung and airway ... Learn about your lungs and airways. Healthy lungs allow you to breathe easily, without discomfort or pain. They supply oxygen ... Lungs and Airways. Skip to the navigation. ... Cystic Fibrosis: Ways to Clear the Airways. *Difference Between ...
  http://sandiego.networkofcare.org/aging/library/article.aspx?hwid=center1026
*  Seth D. Hartung, MD, MPH | Everett,WA
airway obstruction. *airway scarring. *allergic aspergillosis. *allergic pneumonitis. *allergic wheezing. *alpha 1 antitrypsin ...
  http://www.providence.org/doctors/profile.aspx?region=wa&reset=true&name=hartung+seth+david&id=159255
*  Sridar Chalaka, MD | Everett,WA
airway obstruction. *airway scarring. *allergic aspergillosis. *allergic pneumonitis. *allergic wheezing. *alpha 1 antitrypsin ...
  http://www.providence.org/doctors/profile.aspx?region=wa&reset=true&name=chalaka+sridar&id=159017