alpha 1-Antitrypsin Deficiencyalpha 1-AntitrypsinPulmonary EmphysemaEmphysemaPhenotypeLiver DiseasesPulmonary Disease, Chronic ObstructiveForced Expiratory VolumeTrypsin Inhibitorsalpha 1-AntichymotrypsinLung DiseasesAirway ObstructionLungPancreatic ElastaseAirway RemodelingHeterozygoteHomozygoteProteostasis DeficienciesBronchiectasisAirway ResistanceLiverAllelesHepatitisLiver CirrhosisSmokingRespiratory Function TestsMutationSpirometrySerpinsGenotypeBronchitisVital Capacity