*  Antidiabetic Biguanides Sales Market Analysis, Recent Trends and Regional Growth Forecast by Types and Applications 2017 |...
Before It's News). Antidiabetic Biguanides Sales Market is a professional and in-depth study on the current state of Antidiabetic Biguanides Sales market. Various definitions and classification of the industry, applications of the Antidiabetic Biguanides Sales Market industry and chain structure are given. Present day status of the Antidiabetic Biguanides Sales Market industry policies and news are analysed.. The Antidiabetic Biguanides Sales Market analysis of an industry is a crucial thing for various stakeholders like investors, CEOs, traders, suppliers and others. The Antidiabetic Biguanides Sales Market industry research report is a resource, which provides current as well as upcoming technical and financial details of the industry.. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Antidiabetic Biguanides Sales Market @ http://www.360marketupdates.com/10444174. ...
  http://beforeitsnews.com/healthcare/2017/03/antidiabetic-biguanides-sales-market-analysis-recent-trends-and-regional-growth-forecast-by-types-and-applications-2017-2507577.html
*  PHMB - Setting the record straight - ByotrolByotrol
One of the chemicals used in Byotrol technology is Polyhexamethylene biguanide hydrochloride (PHMB), a biocide that has been used widely for decades providing valuable disinfection, cleaning and hygiene functions in a wide selection of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments and wound care products. PHMB is an effective public health biocide supported under the Biocidal Products Directive in Europe and REACh*.. ECHA has reviewed all available data for PHMB including 30 year old rat feeding studies, where rats ingested 5 times their body weight of PHMB, and recommended that PHMB be classified and labelled on products where PHMB is included at ,1% as H351 - suspected of causing cancer. This classification is for biocidal (not cosmetic where it is permitted at certain levels for certain uses, or medical device) products in Europe and will not apply across other parts of the world.. One manufacturer of PHMB has stated they believe this ...
  http://www.byotrol.co.uk/revised-classification-phmb/
*  News - ECHA
ECHA/PR/13/24. ECHA invites the parties concerned to comment on new proposals for harmonised classification and labelling (CLH) of tributyltin compounds and PHMB. The public consultation will be open for 45 days and will end on 22 July 2013.. Helsinki, 06 June 2013 - Tributyltin compounds already have a harmonised group entry in Annex VI of the CLP Regulation, covering acute toxicity, specific target organ toxicity - repeated exposure, eye irritation, skin irritation and environmental hazards. The dossier submitter, Germany, proposes classification for reproductive toxicity and to update the entry for acute toxicity.. The other substance launched for public consultation is polyhexamethylene biguanide hydrochloride (PHMB). In its opinion of 9 September 2011, RAC agreed PHMB to be classified for acute toxicity by inhalation. However, in 2012, new data on acute toxicity was made available and the dossier submitter (France) is now proposing to change the classification from acute tox. 1 to acute ...
  https://echa.europa.eu/it/view-article/-/journal_content/title/new-clh-public-consultations-launched-on-tributyltin-compounds-and-phmb
*  Enzymatic detergent Aniosyme DD1, decontaminating, 1 liter with dispenser - pserviceweb.com
Aniosyme DD1 guarantees a high performance cleaning and optimum safety, fits perfectly in a perspective of the properties' detergents standardization. Bottle 1 liter, concentrated Efficacy proven product that optimizes cleaning- Pre-disinfection / decontamination broad-spectrum detergent *- Neutral pH *- Detergent pre-disinfectant / decontaminant high performance *- Broad spectrum of efficacy INDICATIONS: Deep cleaning and pre-disinfection / decontamination of medical and surgical instruments, medical devices and endoscopic equipment.Cleaning in ultrasonic tanks.Collection of contaminated instruments.STATEMENT: quaternary ammonium propionate, of polyhexamethylene biguanide hydrochloride, enzymatic complex (protease, lipase and amylase), surfactants, stabilizers, sequestering agent, perfume, dye.PROPERTY 'MICROBIOLOGICAL: Bactericidal: EN 1040, EN 13727, NF T 72-170, SARM (EN 13727), Active on Mycobacterium tuberculosis (B.K.). Lieviticida: EN 1275 (C. albicans).Active on HIV-1, BVDV (HCV) virus model,
  http://www.pserviceweb.com/home/en/disinfection-decontamination-and-conservation/14776-enzymatic-detergent-aniosyme-dd1-decontaminating-1-liter-with-dispenser.html
*  Patent US6936640 - Biguanide/quaternary ammonium containing copolymeric biocides and use ... - Google Patents
Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
  http://www.google.co.uk/patents/US6936640
*  Alogliptin Tablets Special Drug Use Surveillance Type 2 Diabetes Mellitus: Combination Therapy With Biguanides - Full Text View...
This is a special drug use surveillance on long-term use of alogliptin with a 1-year (12-month) observational period, designed to investigate the safety and efficacy of long-term combination therapy with alogliptin and biguanides in participants with type 2 diabetes mellitus in the routine clinical setting.. Participants diagnosed with type 2 diabetes mellitus who responded inadequately to treatment with biguanides in addition to diet therapy and exercise therapy will be enrolled. The planned sample size is 1,000.. The usual adult dosage for oral use is 1 alogliptin tablet (25 mg) once daily. ...
  https://clinicaltrials.gov/ct2/show/NCT01964976?term=121-014&rank=1
*  Biguanide
... Biguanides (ATC A10 BA) form a class of oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment.
  http://www.chemeurope.com/en/encyclopedia/Biguanide.html
*  Biguanides - Low Carb RN (CDE)
If you have not already done so, please read my introduction page (HERE). . How do biguanides work? Biguanides work by decreasing the output of glucose from the liver. They also activate an enzyme which help cells to become more sensitive (less resistant) to insulin. This is particularly helpful in Type 2 diabetes, although those…
  https://lowcarbrn.wordpress.com/diabetes/drugs-to-treat-diabetes/biguanides/
*  Swimming Pool Biguanide ChemicalsSwimming Pool Bio Sanitizer
Swimming Pool Biguanide Chemicals is a 3 part manual process, it is very, very expensive. Sometimes costing several times more than chlorine. Biguanide needs to be purchased in bulky containers and needs to be manually added to the pool water regularly.
  http://gochemless.com/learning-center/swimming-pool-biguanide-chemicals/
*  Polyhexanide - Wikipedia
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection. PHMB eye drops have been used as a treatment for eyes ...
  https://en.wikipedia.org/wiki/Polyhexanide
*  POLYHEXAMETHYLENE BIGUANIDE HCL || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
  http://www.ewg.org/skindeep/ingredient/705058/POLYHEXAMETHYLENE_BIGUANIDE_HCL/
*  16018-83-0 - 1-(4-Fluorophenyl)biguanide hydrochloride, 98% - L07330 - Alfa Aesar
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
  https://www.alfa.com/en/catalog/L07330/
*  Polyhexamethylene guanidine - Wikipedia
Polyhexamethylene guanidine (PHMG) is a guanidine derivative that is used as a biocidal disinfectant, often in the form of its salt polyhexamethylene guanidine phosphate (PHMG-P). Studies have shown that PHMG in solution has fungicidal as well as bactericidal activity against both Gram-positive and Gram-negative bacteria. The substance also has detergent, anti-corrosive, and flocculant properties and prevents biofouling. PHMG-P is a white powdered solid, and as all polyguanidine salts, readily soluble in water. Unlike the related polymer polyhexanide (PHMB), PHMG has been described as a relatively new compound with properties, potency, and effects being not yet fully recognized. Preliminary findings indicate that PHMG and its derivatives primarily rely on damaging the cell membrane by inhibiting the activity of cellular dehydrogenases. When PHMG is aerosolized and inhaled, it harms the lungs, causing death of the cells lining the bronchioles and widespread damage to alveoli, along with ...
  https://en.wikipedia.org/wiki/Polyhexamethylene_guanidine
*  Plus it
There are two broad types of insulin sensitizers: the biguanides and the thiazolidinediones, also called peroxisome proliferator-activated receptor-γ agonists.. The biguanides enhance insulin action, stimulating glucose uptake in the liver and in the periphery and also suppressing hepatic glucose output. They only work when insulin is present, do not stimulate insulin secretion or release, and do not cause hypoglycemia. They are used for patients with type 2 diabetes who have residual β-cell function, typically when diet and exercise are insufficient for diabetic control. They are also useful in the insulin resistance syndrome and constitute an increasingly popular treatment for polycystic ovarian syndrome, often inducing ovulation and resulting in pregnancy. Phenformin was the original biguanide but was removed from the market in the 1960s because of reports of fatal lactic acidosis. Metformin (Glucophage) is the only biguanide currently available in the U.S.. Metformin is ...
  http://care.diabetesjournals.org/content/30/Supplement_2/S206
*  EP 1049763 A1 20001108 - CLEANING AND DISINFECTING CONTACT LENSES WITH A BIGUANIDE AND A PHOSPHATE-BORATE BUFFER
295417364 - EP 1049763 A1 2000-11-08 - CLEANING AND DISINFECTING CONTACT LENSES WITH A BIGUANIDE AND A PHOSPHATE-BORATE BUFFER - [origin: WO9924541A1] The present invention is directed to aqueous biguanide-containing disinfecting solutions containing an improved buffer system comprising both a phosphate and borate buffer. Preferred embodiments of the invention include methods and compositions for simultaneously cleaning and disinfecting contact lenses.[origin: WO9924541A1] The present invention is directed to aqueous biguanide-containing disinfecting solutions containing an improved buffer system comprising both a phosphate and borate buffer. Preferred embodiments of the invention include methods and compositions for simultaneously cleaning and disinfecting contact lenses.
  https://data.epo.org/gpi/EP1049763A1-CLEANING-AND-DISINFECTING-CONTACT-LENSES-WITH-A-BIGUANIDE-AND-A-PHOSPHATE-BORATE-BUFFER
*  Patent WO2000035500A1 - Contact lens cleaner comprising biguanide and poloxamine - Google Patents
The present invention is directed to a biguanide-containing disinfecting solution containing a particular type of poloxamine for stabilizing a polymeric biguanide. The poloxamine surfactant comprises at least about 90 weight percent of poly(oxyethylene) and poly(oxypropylene) segments, in one or more copolymer chains, wherein the weight average molecular weight of said surfactant is from about 10,000 to about 30,000 and wherein at least about 70 weight percent of said poly(oxyethylene) and poly(oxypropylene) segments are poly(oxyethylene) segments, and wherein the HLB value is at least 27. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution. Products according to the present invention provide enhanced cleaning while maintaining biocidal efficacy.
  http://www.google.co.uk/patents/WO2000035500A1?cl=en
*  Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria | Biochemical Journal
Complex I catalyses electron transfer from NADH to hydrophilic electron acceptors by two distinct mechanisms, both localized uniquely at the flavin site. The NADH:FeCN and NADH:O2 reactions proceed via two sequential steps in which NADH reduces the flavin and dissociates, and then the electron acceptor reacts directly (see Figure 2E, left-hand reaction) [26]; for the NADH:HAR and NADH:paraquat reactions NADH reduces the flavin, but the electron acceptor reacts only if a nucleotide is bound in the reduced flavin site (see Figure 2E, right-hand reaction) [27]. Note that although NADH:O2 oxidoreduction produces superoxide, we detect the H2O2 formed following superoxide dismutation, and thus refer to 'H2O2 production'. Data showing the effects of biguanides on these different reactions are shown in Figure 2. Figure 2(A) shows that metformin stimulates the rates of the two reactions (the NADH:FeCN and NADH:O2 reactions) that rely on oxidation of the nucleotide-free reduced flavin [15,26], but, ...
  http://www.biochemj.org/content/462/3/475
*  Biguanides | Type 2 Diabetes Medications
Biguanides are a class of medications used to treat type 2 diabetes. Metformin is the most common type of drug in this class. Learn more today.
  http://www.diabetesmonitor.com/education-center/medications/biguanides.htm
*  Type 2 Diabetes: Biguanides
Another name for Type 2 Diabetes is Type 2 Diabetes. Actions of biguanide medication include: * Reduce the amount of glucose produced by the liver * Reduce ...
  http://www.freemd.com/type-2-diabetes/treatment-drugs-biguanides.htm
*  Does your micellar solution contain polyaminopropyl biguanide? | Parokeets
Polyaminopropyl biguanide will soon land on the unsafe lists. Here are some of the micellar solutions with and some without mentioned preservative.
  https://www.parokeets.com/en/2015/06/does-your-micellar-solution-contain-polyaminopropyl-biguanide/
*  The Toxoplasma Blog: Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors...
Twenty-one biguanide and dihydrotriazine derivatives were synthesized and evaluated as inhibitors of dihydrofolate reductase (DHFR) from opportunistic microorganisms: Pneumocystis carinii (pc), Toxoplasma gondii (tg), Mycobacterium avium (ma), and rat liver (rl). The most potent compound in the series was B2-07 with 12 nM activity against tgDHFR. The most striking observation was that B2-07 showed similar potency to trimetrexate, approximately 233-fold improved potency over trimethoprim and approximately 7-fold increased selectivity as compared to trimetrexate against tgDHFR. Molecular docking studies in the developed homology model of tgDHFR rationalized the observed potency of B2-07. This molecule can act as a good lead for further design of molecules with better selectivity and improved potency ...
  http://toxoplasmaparasite.blogspot.com/2009/11/synthesis-and-biological-evaluation-of.html
*  1-(2,6-diethyl-phenyl)-biguanide | C12H19N5 - PubChem
1-(2,6-diethyl-phenyl)-biguanide | C12H19N5 | CID 548295 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
  https://pubchem.ncbi.nlm.nih.gov/compound/548295
*  Arcaine sulfate,N,N'-1,4-Butanediylbisguanidinesulfate 14923-17-2 Route Of Synthesis Synthetic Routes
Arcaine sulfate,N,N'-1,4-Butanediylbisguanidinesulfate 14923-17-2 route of synthesis, Arcaine sulfate,N,N'-1,4-Butanediylbisguanidinesulfate chemical synthesis methods, Arcaine sulfate,N,N'-1,4-Butanediylbisguanidinesulfate synthetic routes ect.
  http://www.molbase.com/en/synthesis_14923-17-2-moldata-88259.html
*  7089 Excilon™ AMD Antimicrobial I.V. Sponge 2 x 2 1400/case [7089] - $261.81 : Balego & Associates Inc. - BalegoOnline.org,...
Balego & Associates Inc. - BalegoOnline.org 7089 Excilon™ AMD Antimicrobial I.V. Sponge 2 x 2 1400/case [7089] - Excilon™ AMD drain sponges are impregnated with PHMB (Polyhexamethylene Biguanide), a powerful yet safe antiseptic that has a broad range effectiveness against gram positive and gram negative microorganisms including some multi-drug resistant strains such as MRSA. This exciting new product provides healthcare facilities a low cost, prophylactic method of treatment
  http://www.balegoonline.org/index.php?main_page=product_info&cPath=13_342_347&products_id=1811&zenid=a3nekulg8bjbq2s6lje4ca3561