*  EMA Authorized Product Information Research Net Regulatory Science Institute, Inc.
Allogeneic T cells genetically modified with a retroviral vector encoding for a truncated form of the human low affinity nerve growth factor receptor ( LNGFR) and the herpes simplex I virus thymidine kinase (HSV-TK Mut2 ...
*  Lirias: Expression of the low-affinity p75 nerve growth factor receptor in the developing rat pituitary gland
We investigated, by means of in situ hybridization with a digoxigenin-labelled RNA probe, the expression of the low-affinity p75 nerve growth factor receptor (NGFR) in the developing pituitary primordium of the rat. In 13-day pc embryos, intense staining of p75 NGFR mRNA was present in the cytoplasm of all cells of Rathke's pouch. In day-17 pc embryos p75 NGFR expression was present primarily in the cells of the intermediate lobe. In the newborn rat pituitary only very weak staining was observed, predominantly in the intermediate lobe. In neural structures the staining at day 13 pc was comparable to that of day 17 pc. Since p75 expression is seen very early during pituitary development and declines during the time the expression of pituitary hormonal phenotypes are steadily increasing, we suggest that the p75 NGFR expression in Rathke's pouch may play a temporally defined role in the ...
*  ActoFactor™ Recombinant Human Nerve growth factor (beta polypeptide) (CHO) | Creative Bioarray
Recombinant Human Nerve growth factor-beta (rHu beta-NGF) is a potent neurotrophic factor, which supports the growth and survivability of nerve and/or glial cells. The active form of rHu beta-NGF is a dimer, formed by two identical subunits, which is held together by strong hydrophobic interactions. Recombinant human Nerve Growth Factor beta produced in CHO is a homodimer, glycosylated, polypeptide chain of 2 identical 119 amino acids and a molecular mass of 16,950 Dalton ...
*  Changes in the expression of the nerve growth factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased...
The nerve growth factor (NGF) receptors p75LNGR and TrkA are expressed by thymic epithelial cells. Presumably, the NGF-TrkA system is involved in the paracrine communication between thymic epithelial cells and thymocytes, whereas the functional role
*  Estrogen alters trkA and p75 neurotrophin receptor expression within sympathetic neurons - Hasan - 2005 - Developmental...
Survival and growth of sympathetic neurons is regulated by nerve growth factor acting through trkA and p75NTR receptors. Sympathetic neurons are also affected by gonadal steroid hormones, particularly estrogen. To determine if estrogen may influence sympathetic neurons via altered neurotrophin receptor expression, we investigated effects of acute or chronic estrogen administration on levels of trkA and p75NTR proteins, numbers of immunoreactive neurons, and numbers of neurons expressing trkA, p75NTR, and estrogen receptor-α transcripts. Superior cervical ganglia from ovariectomized or estradiol-treated rats were processed for in situ hybridization or immunohistochemistry, and percentages of stained neurons quantitated or processed for Western blot analysis. In ovariectomized rats, approximately 50% of sympathetic neurons expressed trkA mRNA and protein. ...
*  Human nerve growth factor improves spatial memory in aged but not in young rats | Journal of Neuroscience
The behavioral effects of human nerve growth factor (NGF) were assessed in Fischer-344 rats of two ages: 4 months old (4MO) and 23 months old (23MO). Recent memory was tested in delayed alteration (T maze), reference memory in a place discrimination (water maze), and sensorimotor skills in a battery of sensorimotor tasks. Each rat was preoperatively trained in each task, given either a control procedure (CON), or continuous infusion of human NGF via an osmotic minipump, and retested again 3 weeks later. Two doses of NGF were delivered: 40 micrograms and 160 micrograms (total amount infused over a period of 4 weeks). In 23MO-NGF rats, both doses improved performance in the recent memory task, and in some measures of the place learning task, but had no effect on sensorimotor skills. In 4MO-NGF rats, the low dose impaired performance in the recent memory task, but not in the place discrimination or in the ...
*  HKU Scholars Hub: Blockade of Glucocorticoid-Induced Tumor Necrosis Factor-Receptor-Related Protein Signaling Ameliorates...
Article: Blockade of Glucocorticoid-Induced Tumor Necrosis Factor-Receptor-Related Protein Signaling Ameliorates Murine Collagen-Induced Arthritis by Modulating Follicular Helper T ...
*  Ectopic trkA expression mediates a NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons....
We have investigated the role of trkA, the tyrosine kinase NGF receptor, in mediating the survival response of embryonic neurons to NGF. Embryonic trigeminal mesencephalic (TMN) neurons, which normally survive in the presence of brain-derived neurotrophic factor (BDNF) but not NGF, become NGF-responsive when microinjected with an expression vector containing trkA cDNA. In contrast, microinjection of ciliary neurotrophic factor (CNTF)-dependent embryonic ciliary neurons with the same construct does not result in the acquisition of NGF responsiveness by these neurons despite de novo expression of trkA mRNA and protein. The failure of trkA to result in an NGF-promoted survival response in ciliary neurons is not due to absence of the low-affinity NGF receptor, p75, in these neurons. Quantitative RT/PCR and immunocytochemistry showed that TMN and ciliary neurons both express p75 mRNA and protein. These findings not only provide ...
*  "TrkA expression decreases the in vivo aggressiveness of C6 glioma cell" by Mahesh B. Lachyankar, Alonzo H. Ross et al.
We stably expressed the nerve growth factor receptor trkA or a truncated trkA lacking the kinase domain (trkA delta) in a highly tumorigenic rat glioma cell line, C6. Survival of rats with large intrastriatal inocula of C6trkA cells was significantly longer than for rats bearing C6 or C6trkA delta cells. Histological studies revealed that C6trkA cells were much less invasive than C6 or C6trkA delta cells and had a greater rate of apoptosis. There was no apparent induction of differentiation of C6 cells by trkA. Therefore, unlike what is observed in neuroblastomas, trkA decreases tumorigenicity by modulating invasiveness and tumor cell death independent of inducing differentiation. This novel mechanism suggests a new therapeutic strategy for malignant gliomas.
*  A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by...
Neuroblastoma is the most common extracranial solid tumor of childhood. One important factor that predicts a favorable prognosis is the robust expression of the TRKA and p75NTR neurotrophin receptor genes. Interestingly, TRKA and p75NTR expression is often attenuated in aggressive MYCN-amplified tumors, suggesting a causal link between elevated MYCN activity and the transcriptional repression of TRKA and p75NTR, but the precise mechanisms involved are unclear. Here, we show that MYCN acts directly to repress TRKA and p75NTR gene transcription. Specifically, we found that MYCN levels were critical for repression and that MYCN targeted proximal/core promoter regions by forming a repression complex with transcription factors SP1 and MIZ1. When bound to the TRKA and p75NTR promoters, MYCN recruited the histone deacetylase HDAC1 to induce a repressed chromatin state. Forced re-expression of endogenous TRKA and p75NTR with exposure to the HDAC ...
*  Neurons regulate Schwann cell genes by diffusible molecules. | JCB
Successful peripheral nerve regeneration and functional recovery require the reestablishment of the neuron-Schwann cell relationship in the regenerating rat sciatic nerve, neurons differentially regulate Schwann cell genes. The message for the low-affinity NGF receptor, p75NGFR, is induced in Schwann cells distal to the injury and is repressed as regenerating axons make contact with these cells. The inverse is true for mRNA of the myelin gene P0; expression decreases distal to injury and increases as new axons contact Schwann cells and a program of myelination is initiated. Using an in vitro co-culture paradigm in which primary neurons and adult Schwann cells are separated by a microporous membrane, we show that axon contact is not an absolute requirement for neuronal regulation of Schwann cell genes. In this system neurons but not other cell types, repress the expression of Schwann cell p75NGFR while inducing the expression ...
*  Rho regulates p75NTR expression after injury. (A) Trans | Open-i
Rho regulates p75NTR expression after injury. (A) Transverse sections throughout rat lesion sites show cells double labeled with p75NTR-specific antibody (red)
*  Receptor, nerve growth factor | Article about Receptor, nerve growth ...
Looking for Receptor, nerve growth factor? Find out information about Receptor, nerve growth factor. A multimeric protein that promotes nerve cell growth and may protect some types of nerve cells from damage, including nerve cells in the cholinergic system Explanation of Receptor, nerve growth factor
*  Structural basis for ligand-mediated mouse GITR activation. - Oxford Neuroscience
Glucocorticoid-induced TNF receptor ligand (GITRL) is a member of the TNF super family (TNFSF). GITRL plays an important role in controlling regulatory T cells. The crystal structure of the mouse GITRL (mGITRL) was determined to 1.8-A resolution. Contrary to the current paradigm that all ligands in the TNFSF are trimeric, mGITRL associates as dimer through a unique C terminus tethering arm. Analytical ultracentrifuge studies revealed that in solution, the recombinant mGITRL exists as monomers at low concentrations and as dimers at high concentrations. Biochemical studies confirmed that the mGITRL dimer is biologically active. Removal of the three terminal residues in the C terminus resulted in enhanced receptor-mediated NF-kappaB activation than by the wild-type receptor complex. However, deletion of the tethering C-terminus arm led to reduced activity. Our studies suggest that the mGITRL may undergo a dynamic population shift among different oligomeric forms via C terminus-mediated conformational
*  KAKEN - Research Projects | Role of Nerve Growth Factor Receptor in Differentiation, Maturation and Spontaneous Regression of...
Principal Investigator:SUGIMOTO Tohru, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (B), Research Field:Pediatrics
*  postdoctoral position
A postdoctoral position is available in my laboratory in the areas of neurotrophic factor receptors, signal transduction and terminal differentiation of neural cells lines. Our studies include the structure of receptors, the roles of individual signal transduction pathways and the connection between neuronal differentiation and cell proliferation. My laboratory is located at the Worcester Foundation which offers a pleasant, relaxed atmosphere in a pretty suburban town near Boston. We are particularly eager to recruit a recent Ph.D. who would be eligible for a Neuroscience Training Grant recently awarded to the Worcester Foundation (American citizenship or Permanent Resident). The starting time is flexible. Some recent publications from our laboratory include: Timm et al. 1994. Circular dichroism studies of the interaction between four neurotrophins and the extracellular domain of the low affinity neurotrophin receptor. ...
*  Plus it
ProBDNF as a Death Signal Henry K. Teng, Kenneth K. Teng, Ramee Lee, Saundrene Wright, Seema Tevar, Ramiro D. Almeida, Pouneh Kermani, Risa Torkin, Zhe-Yu Chen, Francis S. Lee, Rosemary T. Kraemer, Anders Nykjaer, and Barbara L. Hempstead. (see pages 5455-5463). Neurotrophins are synthesized as precursors that undergo intracellular cleavage before they are secreted. Many of the actions of the mature forms result from activation of Trk receptor tyrosine kinases. However, precursors such as proNGF can also be secreted. In the case of proNGF, recent studies indicate that it can bind to the p75NTR receptor and a coreceptor, sortilin, and thus mediate apoptosis. This week, Teng et al. report that proBDNF also is secreted from neurons but did not bind to TrkB receptor tyrosine kinase. Rather, proBDNF acted as a proapoptotic signal as examined in sympathetic neurons. ProBDNF-induced cell death required expression of both p75NTR and sortilin. Preformed complexes of proBDNF and the soluble extracellular ...
*  Nerve growth factor, molecular model - Stock Image C001/1623 - Science Photo Library
Nerve growth factor. Molecular model showing the secondary structure of nerve growth factor (NGF). NGF is a small protein, which is involved in the growth, differentiation (specialisation of cells) and survival of particular target neurones (nerve cells). It is hoped it will be able to serve as a therapeutic agent in neurodegenerative conditions such as Alzheimer's disease. - Stock Image C001/1623
*  GITR Ligand/TNFSF18 Research Products: Novus Biologicals
GITR Ligand/TNFSF18 products available through Novus Biologicals. Browse our GITR Ligand/TNFSF18 product catalog backed by our Guarantee+.
*  Dompé initiates enrollment in rhNGF phase I/II REPARO study for neurotrophic keratitis - LinkOPH
The first patient has been enrolled in the phase I/II REPARO study, the first international clinical trial evaluating the ophthalmological use of a topical solution of recombinant human Nerve Growth Factor (rhNGF) for the treatment of moderate to severe neurotrophic keratitis (NK). Full Story →. ...
*  NGF (Nerve Growth Factor)
Nerve growth factor (NGF), is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). It is critical for the survival and maintenance of sympathetic and sensory neurons.
*  Nerve Growth Factor
In article ,39bn5p$gik at news.uni-c.dk,, emil2345 at inet.uni-c.dk (Soren Vestergaard) says: , ,As I am re-reading the literature on neurotrophic factors I have come to ,understand that NGF also has action on the mast cells. It is widely known ,that NGF is resposable for the differentiation and growing of the sensory ,and symphatic nervous system, but perhaps this trophic molecule also has ,a more generel inpact on the immunological system. , ,If anyone has any input on this I would be very pleased to se some ideas ,put forwards. Thanks. , ,Soren ,e-mail: emil2345 at inet.uni-c.dk ,DK - Denmark You might want to look at Thorpe et al. Mechanisms of lymphocyte activation by nerve growth factor. Ann NY Acad Sci 594:78-83 (1990 ...
*  Natural Protein Could Help Spot, Treat Li... ( Nerve growth factor found at higher l...)
Health,...Nerve growth factor found at higher levels in these tumors scientists...WEDNESDAY Sept. 19 (HealthDay News) -- A natural protein called nerve...NGF is an essential component in the growth and differentiation of neu...This study found that NGF also appears to be a factor in liver cancer...,Natural,Protein,Could,Help,Spot,,Treat,Liver,Cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
*  ActoFactor™ Recombinant Mouse Nerve growth factor - Creative Bioarray
Creative Bioarray produces the world's most comprehensive list of research-use cells, including tumor cells, primary cells, stem cells AND transformed cells. Creative Bioarray offers ActoFactor™ Recombinant Mouse Nerve growth factor for your research.