*  Almotriptan - Wikipedia
... almotriptan has a high and specific affinity for serotonin 5-HT1B/1D receptors. Binding of the drug to the receptor leads to ... receptor agonist for the treatment of migraine". Clinical pharmacokinetics. 44 (3): 237-46. doi:10.2165/00003088-200544030- ... 2008 Apr;28(4):383-91 Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of ... McEnroe, JD; Fleishaker, JC (2005). "Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) ...
  https://en.wikipedia.org/wiki/Almotriptan
*  Articles Added on September 29, 2012
... classified as high-affinity serotonin 5-HT(1B/D) receptor agonists with lower affinity for 5-HT(1A) receptors. Both migraine ... We aimed to explore the protein expression of IMD and its receptors, calcitonin receptor-like receptor (CRLR) and receptor ... Update in TSH receptor agonists and antagonists. Gershengorn Marvin C MC Laboratory of Endocrinology and Receptor Biology, ... The physiological role of the TSH receptor (TSHR) as a major regulator of thyroid function is well understood, but TSHRs are ...
  http://www.biomedsearch.com/added/20120929-p13.html
*  Plus it
Binding affinities (pKi) for serotonin receptor agonists and antagonists at different receptors involved in gastrointestinal ... receptors but moderate to no affinity for other relevant serotonin receptors (i.e., 5-HT1B, 5-HT1D, 5-HT3, and 5-HT4; pKi , ... SF-2 showed a similar affinity for D2 receptor to that of itopride (in this study) and a 1434-fold lower affinity than that of ... but moderate to no affinity for other relevant serotonin receptors (i.e., 5-HT1B, 5-HT1D, 5-HT3, and 5-HT4; pKi , 5.00), as ...
  http://jpet.aspetjournals.org/content/338/3/917
*  Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands
... with up to 300-fold higher affinities for this subtype. Three of the ligands were agonists of the G protein pathway. Analysis ... Serotonin (5-hydroxytryptamine [5-HT]) G protein-coupled receptors are therapeutic targets for CNS disorders but are also ... Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands. Rodriguez, David Stockholm University, Faculty of ... From docking screens of 1.3 million compounds, 22 molecules were predicted to be selective for the 5-HT1B receptor over the 5- ...
  http://su.diva-portal.org/smash/record.jsf?pid=diva2:748405
*  SL-067 | N-Methylquipazine dimaleate, 98% | 28614-26-8 | Life Science Products | SynInnova
... but no affinity with central 5-HT1B serotonin receptors.. Reference : Glennon. R. A. et. al.: Eur. J. Pharmacol., 168(3), 387, ... It is a tertiary amine analogue of quipazine, agonist at 5-HT3 serotonin receptors with an affinity similar to that of ...
  http://www.syninnova.com/catalog/product/SL-067
*  Reversible Segmental Cerebral Arterial Vasospasm and Cerebral Infarction | Cerebrovascular Disease | JAMA Neurology | The JAMA...
In a recent review, Parsons11 concluded that there are contractile serotonin receptors in large pre- and post-circle of Willis ... Sumatriptan is an agonist with affinity for 5-HT1B (serotonin), 5-HT1D, and contractile 5-HT1-like receptors. It induces ... Parsons AA 5-HT receptors in human and animal cerebrovasculature. Trends Pharmacol Sci. 1991;12310- 315Google ScholarCrossref ... vessels and relaxation receptors in small resistance pial arterioles.. We cannot entirely exclude the possibility that our ...
  https://jamanetwork.com/journals/jamaneurology/fullarticle/773771
*  Asenapine (Professional Patient Advice) - Drugs.com
... moderate affinity for H2 receptors. Asenapine has no significant affinity for muscarinic receptors. The binding affinity to the ... Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake ... Serotonin Modulators: May enhance the adverse/toxic effect of Antipsychotic Agents. Specifically, serotonin modulators may ... Antipsychotic Agents may enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. ...
  https://www.drugs.com/ppa/asenapine.html
*  Meta-Chlorophenylpiperazine - Wikipedia
It behaves as an agonist at most serotonin receptors. mCPP has been shown to act not only as a serotonin reuptake inhibitor but ... mCPP possesses significant affinity for the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, and 5-HT7 receptors, as well ... Charney DS, Woods SW, Goodman WK, Heninger GR (1987). "Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP ... Hamik A, Peroutka SJ (1989). "1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human ...
  https://en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine
*  Drug Summary
... and serotonin-receptor agonists increase central serotonin effects. Cases of serotonin syndrome have been reported, primarily ... Almotriptan binds with high affinity to 5-HT1D, 5-HT1B, and 5-HT1F receptors. The pathophysiology of migraine is not completely ... and serotonin-receptor agonists increase central serotonin effects. Cases of serotonin syndrome have been reported, primarily ... such as selective serotonin-receptor agonists ('triptans'), has resulted in serotonin syndrome in some cases. Serotonin ...
  http://www.pdr.net/drug-summary/Axert-almotriptan-malate-2126
*  Carteolol - Wikipedia
It has been found to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist in addition to being a beta blocker. Langlois M, ... "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents ... for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77-87. PMID 8093601. El-Kamel A, Al-Dosari H, Al-Jenoobi F (2006 ...
  https://en.wikipedia.org/wiki/Carteolol
*  Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening ( INTRODUCTION ...
... receptor,for,functional,screening,biological,advanced biology technology,biology laboratory technology,biology device ... INTRODUCTION ...Many G-protein coupled receptors (GPCRs) trigger upon binding of an a...One of the methods of choice (reviewed ... Human serotonin 5HT2B receptor: A CHO cell line expressing the serotonin 5HT2B receptor, the Gα16 coupling protein and ... EC50 values are similar to affinity values obtain by radioligand binding and/or other functional assays. ...
  http://www.bio-medicine.org/biology-technology/Cell-lines-expressing-recombinant-aequorin-and-a-G-protein-coupled-receptor-for-functional-screening-1376-1/
*  5-(Nonyloxy)tryptamine - Wikipedia
... a novel high-affinity 5-HT1D beta serotonin receptor agonist". Journal of Medicinal Chemistry. 37 (18): 2828-30. doi:10.1021/ ... "Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors". Journal of Medicinal Chemistry. 39 (1): 314-22. ... 5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor. Increasing the O- ... 5-Benzyloxytryptamine 5-Carboxamidotryptamine 5-Ethoxy-DMT Sumatriptan Glennon RA, Hong SS, Dukat M, Teitler M, Davis K ( ...
  https://en.wikipedia.org/wiki/5-(Nonyloxy)tryptamine
*  Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between...
... on serotonin and dopamine receptors activity in rat brain. Gen Physiol Biophys 2009, 28: 41-46. Spec NoGoogle Scholar. ... and adenosine receptors).. In particular, the ELF-EMFs decrease the affinity of the G-protein-coupled 5-HT1B serotonergic ... receptor with a consequent decreased signal transduction (Massot et al., 2000; Espinosa et al., 2006), decrease the affinity of ... Rosi S, McGann K, Hauss-Wegrzyniak B, Wenk GL: The influence of brain inflammation upon neuronal adenosine A2B receptors. J ...
  https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-473
*  BRL-15,572 - Wikipedia
BRL-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-HT1D, with around 60x ... SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs ... and most older ligands for these receptors bind to both subtypes with approximately equal affinity, so development of compounds ... Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and ...
  https://en.wikipedia.org/wiki/BRL-15,572
*  Yohimbine - Wikipedia
Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5- ... Yohimbine interacts with serotonin and dopamine receptors in high concentrations. Yohimbine has been studied as a way to ... Yohimbine also, however, interacts with α1 receptors, albeit with lower affinity; therefore, at higher doses an α1 blockade can ... Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes only minor corpus ...
  https://en.wikipedia.org/wiki/Yohimbine
*  Eletriptan - Wikipedia
Eletriptan is a serotonin receptor agonist, specifically an agonist of certain 5-HT1 family receptors. Eletriptan binds with ... receptors. It has a modest affinity to the 5-HT[1A, 1E, 2B, 7] receptors, and little to no affinity at the 5-HT[2A, 2C, 3, 4, ... 5A, 6] receptors. Eletriptan has no significant affinity or pharmacological activity at adrenergic α1, α2, or β; dopaminergic ... This is due to the unusual side effect of coronary vasoconstriction due to serotonin 5HT1B antagonism, which can precipitate a ...
  https://en.wikipedia.org/wiki/Eletriptan
*  Faster-acting antidepressants may soon be a reality
Serotonin reuptake inhibitors are used to treat depression, but their exact mechanism is unknown. New research lifts the lid ... Using a technique called translating ribosome affinity purification, the team were able to identify the serotonin receptors on ... Serotonin is one such neurotransmitter. It is released from the first neuron and binds to receptors on the second neuron. ... The mixed response is because there are 14 subtypes of serotonin receptor throughout the body and any single nerve could have a ...
  https://www.medicalnewstoday.com/articles/318713.php?sr
*  Pergolide - Wikipedia
... it has high D1 receptor affinity and is one of the most potent D1 receptor agonists of the dopamine receptor agonists that are ... Among similar antiparkinsonian drugs, cabergoline but not lisuride exhibit this same type of serotonin receptor binding. In ... Pergolide acts on many of the same receptors as dopamine to increase receptor activity. In 2007 pergolide was withdrawn from ... Pergolide acts as an agonist of dopamine D2 and D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may ...
  https://en.wikipedia.org/wiki/Pergolide
*  5-Carboxamidotryptamine - Wikipedia
Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of ... It has negligible affinity for the 5-HT1E and 5-HT1F receptors. 5-CT binds strongest to the 5-HT1A receptor and it was once ... high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 ... is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, ...
  https://en.wikipedia.org/wiki/5-Carboxamidotryptamine
*  3H-spiroperidol binding in human temporal cortex (brodmann areas 41-42) occurs at multiple high affinity states with...
3H-Spiroperidol labels multiple high affinity states with serotonergic selectivity in human prefrontal cortex and with ... Titeler M, Lyon RA, Davis KH, Glennon RA (1987) Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role ... Conn PJ, Sanders-Bush E (1987) Central serotonin receptors: effector systems, physiological roles and regulation. ... data indicates that two of the3H-spiroperidol affinity states may represent the high and low affinity states of the serotonin ( ...
  https://link.springer.com/article/10.1007/BF00589902
*  Penbutolol - Wikipedia
Chapter 4 in The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. Ed. Bryan L. Roth. Springer Science & ... "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents ... Penbutolol acts on the β1 adrenergic receptors in both the heart and the kidney. When β1 receptors are activated by a ... Penbutolol is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making ...
  https://en.wikipedia.org/wiki/Penbutolol
*  Triptan - Wikipedia
Hamel, E. (1999). "The biology of serotonin receptors: focus on migraine pathophysiology and treatment". Can J Neurol Sci. 26 ... Comparison of sumatriptan and dihydroergotamine showed that dihydroergotamine has high affinity and sumatriptan has medium ... HT1B and 5‑HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent ... doi:10.1111/j.1526-4610.2010.01691.x. Gillman (2010). "Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity ...
  https://en.wikipedia.org/wiki/Triptan
*  5-HT5A receptor - Wikipedia
When selective activation of this receptor is desired in scientific research, the non-selective serotonin receptor agonist 5- ... ASP-5736 AS-2030680 AS-2674723 Latrepirdine (non-selective) Risperidone (non-selective), moderate 206nM affinity. SB-699,551 5- ... Marazziti D, Ori M, Nardini M, Rossi A, Nardi I, Cassano GB (2001). "mRNA expression of serotonin receptors of type 2C and 5A ... serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. The gene described in ...
  https://en.wikipedia.org/wiki/5-HT5A_receptor
*  Trifluoromethylphenylpiperazine - Wikipedia
Due to the serotonin agonist effects and increase in serotonin, norepinephrine, and dopamine levels produced by the BZP/TFMPP ... Robertson DW, Bloomquist W, Wong DT, Cohen ML (1992). "mCPP but not TFMPP is an antagonist at cardiac 5HT3 receptors". Life ... Unlike the related piperazine compound meta-chlorophenylpiperazine (mCPP), TFMPP has insignificant affinity for the 5-HT3 ... receptor (IC50 = 2,373 nM). TFMPP also binds to the SERT (EC50 = 121 nM) and evokes the release of serotonin. It has no effects ...
  https://en.wikipedia.org/wiki/Trifluoromethylphenylpiperazine
*  Tertatolol - Wikipedia
Soudijn, W.; Olivier, Berend; Wijngaarden, I. van (1997). Serotonin receptors and their ligands. Amsterdam: Elsevier. ISBN 0- ... "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents ... Tertatolol has also been shown to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist, similarly to propranolol and ... May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn- ...
  https://en.wikipedia.org/wiki/Tertatolol