Referred Muscle Pain: Basic and Clinical Findings : The Clinical Journal of Pain
Convergence of visceral and cutaneous afferent pathways in the lumbar spinal cord. Brain Res 1969;14:331-48.. *PubMed , ... neck and muscle afferents onto nociceptive and non-nociceptive neurones in trigeminal subnucleus caudalis (medullary dorsal ... Weiss S, Davis D. The significance of the afferent impulses from the skin in the mechanism of visceral pain. Skin infiltration ... Apkarian AV, Brüggemann J, Shi T, et al A thalamic model for true and referred visceral pain. In: Gebhart GF, ed. Visceral pain ...https://journals.lww.com/clinicalpain/pages/articleviewer.aspx?year=2001&issue=03000&article=00003&type=fulltext
Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages: Role of Liver X...
P. Holzer, "Acid sensing by visceral afferent neurones," Acta Physiologica, vol. 201, no. 1, pp. 63-75, 2011. View at Publisher ... and oxidative substances by somatic and visceral afferents [14, 15]. However, increasing evidence suggests that TRPV1 is ...https://www.hindawi.com/journals/mi/2013/925171/
The neurobiology of stress and gastrointestinal disease | Gut
These structures receive input from visceral and somatic afferents and from cortical structures. Cortical inputs include the ... Evidence for reciprocal positive feedback regulation of hypothalamic CRF neurones and noradrenergic locus coeruleus neurones ... with sensitising effect on visceral afferent terminals.112 The role of pathological stress on the relative activation of this ... located in certain effector neurones of the PVN, the amygdala, and locus coeruleus complex.52 CRH secretion by PVN neurones is ...http://gut.bmj.com/content/47/6/861.full
Kv1.1 Deletion Augments the Afferent Hypoxic Chemosensory Pathway and Respiration | Journal of Neuroscience
... containing chemosensory as well as other visceral afferents (Andresen and Kunze, 1994) and stimulating (0.1 ms duration) at ... 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating ... A characteristic feature of sensory afferent processing in the NTS is that, as the frequency of afferent input increases, there ... Kv1.1 Deletion Augments the Afferent Hypoxic Chemosensory Pathway and Respiration. David D. Kline, Maria C. F. Buniel, Patricia ...http://www.jneurosci.org/content/25/13/3389
Inhibition by Spinal μ- and δ-Opioid Agonists of Afferent-Evoked Substance P Release | Journal of Neuroscience
Soldo BL, Moises HC (1998) μ-Opioid receptor activation inhibits N- and P-type Ca2+ channel currents in magnocellular neurones ... Opioid μ- and δ-receptors are present on the central terminals of primary afferents, where they are thought to inhibit ... Pharmacological profiles suggesting a differential association of μ, δ and κ receptors with visceral chemical and cutaneous ... Low-frequency stimulation of afferent A δ-fibers induces long-term depression at primary afferent synapses with substantia ...http://www.jneurosci.org/content/25/14/3651
The Brain-Gut Axis in Health and Disease | SpringerLink
Clerc N, Furness JB (2004) Intrinsic primary afferent neurones of the digestive tract. Neurogastroenterol Motil 16(Suppl 1):24- ... Raybould HE (2010) Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 153(1-2): ... Craig AD (1996) An ascending general homeostatic afferent pathway originating in lamina I. Prog Brain Res 107:225-242PubMed ... Sikandar S, Dickenson AH (2012) Visceral pain: the ins and outs, the ups and downs. Curr Opin Support Palliat Care 6(1):17-26 ...https://link.springer.com/chapter/10.1007/978-1-4939-0897-4_6
Central Mechanisms Regulating Coordinated Cardiovascular and Respiratory Function - Oxford Research Encyclopedia of Neuroscience
McDougall, S. J., Peters, J. H., & Andresen, M. C. (2009). Convergence of cranial visceral afferents within the solitary tract ... The chemoreceptor primary afferent fibers arising from the carotid and aortic bodies, which run in cranial nerves IX and X ... Mandel, D. A., & Schreihofer, A. M. (2006). Central respiratory modulation of barosensitive neurones in rat caudal ... Afferent fibers conveying signals from warm receptors terminate in the dorsal column of the spinal cord, from which an ...http://neuroscience.oxfordre.com/abstract/10.1093/acrefore/9780190264086.001.0001/acrefore-9780190264086-e-64?rskey=d3DwpL&result=10
Serotonergic modulating drugs for functional gastrointestinal diseases - Spiller - 2002 - British Journal of Clinical...
Primary afferent enteric neurones Enterocytes Extrinsic mesenteric afferents. Stimulates peristalsis Stimulates chloride ... Visceral hypersensitivity in IBS. 5HT4 agonists Prucalopride. Cholinergic colonic motor nerves (enhances acetylcholine release) ... Vagal afferents Enteric interneurones & secreto-motor neurones Mesenteric afferents. Inhibit nausea due to 5HT release Inhibit ... Abbreviations: IPAN=intrinsic primary afferent neurone, VIP=Vasoactive intestinal peptide, SP=substance P, NO=nitric oxide. ...http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2002.01612.x/full
Frontiers | Modulation of gastrointestinal vagal neurocircuits by hyperglycemia | Neuroscience
Raybould, H. E. (2002). Visceral perception: sensory transduction in visceral afferents and nutrients. Gut 51(Suppl. 1), I11- ... Bailey, T. W., Hermes, S. M., Andresen, M. C., and Aicher, S. A. (2006). Cranial visceral afferent pathways through the nucleus ... Trapp, S., Ballanyi, K., and Richter, D. W. (1994). Spontaneous activation of KATP current in rat dorsal vagal neurones. ... the response to glucose appears to be related to the visceral organ that the vagal sensory neurons innervate; afferent neurons ...https://www.frontiersin.org/articles/10.3389/fnins.2013.00217/full
Frontiers | Metabotropic Glutamate Receptors as Novel Therapeutic Targets on Visceral Sensory Pathways | Neuroscience
There are many unanswered questions about mGluR along visceral afferent pathways, the answers to which may reveal many more ... Many inhibitory mGluR are also expressed in visceral afferents, many of which markedly reduce excitability. Their role in ... Many inhibitory mGluR are also expressed in visceral afferents, many of which markedly reduce excitability. Their role in ... This is promising promising for reducing activation of nociceptive afferents and pain using mGluR5 negative allosteric ...https://www.frontiersin.org/articles/10.3389/fnins.2011.00040/full
A Comparison of Visceral and Somatic Pain Processing in the Human Brainstem Using Functional Magnetic Resonance Imaging |...
Generally, we do not feel peristalsis (passage of stool or gas), yet in rodents visceral afferents are excited by non-noxious, ... Randich A, Gebhart GF (1992) Vagal afferent modulation of nociception. Brain Res Rev 17: 77-99. ... Andrew LK, Blackshaw LA (2001) Colonic mechanoreceptor inputs to rat lumbo-sacral dorsal horn neurones: distribution, ... The NTS receives a predominantly visceral input (nociceptive and non-nociceptive) from the vagal nerve and spinal afferents. ...http://www.jneurosci.org/content/25/32/7333.full
Clifford Saper | Harvard Catalyst Profiles | Harvard Catalyst
Organization of visceral and limbic connections in the insular cortex of the rat. J Comp Neurol. 1991 Sep 01; 311(1):1-16. PMID ... Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 01; 22(3):977-90. PMID: 11826126. ... Saper CB, Levisohn D. Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular ... Synaptic and morphological characteristics of temperature-sensitive and -insensitive rat hypothalamic neurones. J Physiol. 2001 ...https://connects.catalyst.harvard.edu/Profiles/display/Person/17796
Brain imaging and functional gastrointestinal disorders: has it helped our understanding? | Gut
Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain. Eur J ... are consistent with both the sparse nociceptive afferent input to S1 and the response characteristics of nociceptive neurones ... 69 The mechanism by which this occurs is thought to be related to sensitisation of visceral afferents within the spinal cord ( ... psychophysical studies have shown that despite matching a visceral and cutaneous stimulus for perceived intensity, the visceral ...http://gut.bmj.com/content/53/8/1198
Ketamine, an N -methyl-d-aspartate Receptor Antagonist, Inhibits the Spinal Neuronal Responses to Distension of the Rat...
Honda CN: Visceral and somatic afferent convergence onto neurons near the central canal in the sacral spinal cord of the cat. J ... Olivar T, Cervero F, Laird JMA: Responses of rat spinal neurones to natural and electrical stimulation of colonic afferents: ... Similar to previous studies of neurons excited by visceral stimuli, 12 these neurons encoded for the relevant visceral stimulus ... Ness TJ, Gebhart GF: Interactions between visceral and cutaneous nociception: I. Noxious cutaneous stimuli inhibit visceral ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1944110
Ampullar nerve, inferior | definition of ampullar nerve, inferior by Medical dictionary
Visceral sensory (visceral afferent) axons can run in autonomic or somatic nerves. ... visceral motor efferents via the otic ganglion for the parotid gland; special visceral afferents from the taste buds in the ... motor fibres of lower motor neurone), and a dorsal (posterior) root (sensory fibres of the first sensory neurone [whose dorsal ... A visceral motor (visceral efferent) nerve, innervating smooth muscle, cardiac muscle, or glands. Visceral motor nerves can ...https://medical-dictionary.thefreedictionary.com/ampullar+nerve%2C+inferior
Role of neurogenic inflammation in local communication in the visceral mucosa | SpringerLink
Yoshimura N, de Groat WC (1997) Plasticity of Na+ channels in afferent neurones innervating rat urinary bladder following ... evidence for a new population of chemosensitive primary sensory afferents. Neurosci Lett 72(3):352-356PubMedCrossRefGoogle ... Gabella G, Davis C (1998) Distribution of afferent axons in the bladder of rats. J Neurocytol 27(3):141-155PubMedCrossRefGoogle ... de Groat WC, Yoshimura N (2010) Changes in afferent activity after spinal cord injury. Neurourol Urodyn 29(1):63-76PubMed ...https://link.springer.com/article/10.1007/s00281-018-0674-0
sympathectomy - controversy: 10/28/12 - 11/4/12
In conclusion, our results suggest that cross-inhibitory control by various afferents in the spinal cord may exist in the feet ... Cannon's law of denervation tells us that if a post-ganglionic neurone has it's pre-ganglionic input removed, then it will ... cross-inhibitory control of various afferent in the spinal cord. ... adrenergic substances during the process of regulating visceral ... the reduction in the contralateral skin temperature may be explained by cross-inhibitory control of various afferent in the ...http://sympathectomy-controversy.blogspot.com/2012_10_28_archive.html
Is sympathectomy safe and effective?
In conclusion, our results suggest that cross-inhibitory control by various afferents in the spinal cord may exist in the feet ... Cannon's law of denervation tells us that if a post-ganglionic neurone has it's pre-ganglionic input removed, then it will ... cross-inhibitory control of various afferent in the spinal cord. ... adrenergic substances during the process of regulating visceral ... the reduction in the contralateral skin temperature may be explained by cross-inhibitory control of various afferent in the ...http://sympathectomy-controversy.blogspot.com/2013_11_03_archive.html
Amygdala Plasticity and Pain
Peripheral nociceptive afferent fibers (red lines) form synapses in the dorsal horn of the spinal cord. Axons of spinal dorsal ... J. S. Han and V. Neugebauer, "Synaptic plasticity in the amygdala in a visceral pain model in rats," Neuroscience Letters, vol ... A. Nakao, Y. Takahashi, M. Nagase, R. Ikeda, and F. Kato, "Role of capsaicin-sensitive C-fiber afferents in neuropathic pain- ... L. Goncalves and A. H. Dickenson, "Asymmetric time-dependent activation of right central amygdala neurones in rats with ...https://www.hindawi.com/journals/prm/2017/8296501/
1979) The afferent and efferent connections of the ventromedial thalamic nucleus in the rat. J Comp Neurol 183:487-518. ... The main afferents to the medial aspect of VM originate from deep cerebellar nuclei and the substantia nigra pars reticulata ( ... 1994) Effects of heterotopic noxious stimuli on activity of neurones in subnucleus reticularis dorsalis in the rat medulla. J ... and C-fibers from any part of the body and encode the intensity of noxious cutaneous and visceral stimuli (Villanueva et al., ...http://www.jneurosci.org/content/19/20/9063