Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3 -...
These data indicate that the Delta-Notch pathway, which controls embryonic development of the mouse endocrine pancreas, can ... Expression of ngn3 in adult human duct cells induced Notch ligands Dll1 and Dll4 and neuroendocrine- and beta-cell-specific ... The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ... which is a critical factor in embryogenesis of the mouse endocrine pancreas. Infection with adenovirus ngn3 (Adngn3) induced ...https://www.semanticscholar.org/paper/Recapitulation-of-embryonic-neuroendocrine-differe-Heremans-Casteele/7fd981ff6aea0abaadf1cd07526f887e8673bf00
Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study | BMC Gastroenterology |...
The aim of the present study was to evaluate the incidence of endocrine and exocrine pancreatic insufficiency after AP and the ... The integrated morbidity of DM and IGT after AP was 59.25%, which was higher than exocrine pancreatic insufficiency. 6.2% and ... Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients with AP episodes. Oral ... were diagnosed with severe exocrine pancreatic insufficiency with FE-1<100μg/g. The morbidity of DM and IGT in patients with ...https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0663-0
Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3...
SSEA-4+ and CA19-9+ cells were isolated from adult human pancreas exocrine cells using magnetic-activated cell sorting, and ... SSEA-4-expressing cells were detected in isolated pancreas exocrine cells from adult humans. These SSEA-4+ cells exhibited ... SSEA-4-expressing cells in the adult human pancreas may have the potential for regeneration of the pancreas and may be used as ... is expressed in cells derived from adult human pancreas exocrine tissue. Here, we examined the characteristics and lineage- ...https://stemcellres.biomedcentral.com/articles/10.1186/s13287-016-0422-0
Making β Cells from Adult Cells Within the Pancreas | SpringerLink
Islet and whole pancreas transplantations provided the proof-of-concept of glucose... ... Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011; ... Diabetes Pancreas Replication Progenitors Transdifferentiation β cells Adult cells This is a preview of subscription content, ... In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008;455:627-32.PubMedCrossRefGoogle Scholar ...https://link.springer.com/article/10.1007%2Fs11892-013-0400-1
Staff Profile - Faculty of Medical Sciences - Newcastle University
Adult human exocrine pancreas differentiation to hepatocytes - potential source of a human hepatocyte progenitor for use in ... Expanding the indications for pancreas resection and autologous islet cell transplantation (IAT) in both adults and children. ... Diversifying the Indications for Pancreas Resection and Autologous Islet Cell Transplantation (IAT) in both Adults and Children ... Amer A, Mafeld S, Saeed D, Al-Jundi W, Haugk B, Charnley R, White S. Reactive lymphoid hyperplasia of the liver and pancreas. A ...http://www.ncl.ac.uk/medicalsciences/research/groups/profile/stevewhite.html
Staff Profile - Faculty of Medical Sciences - Newcastle University
Adult human exocrine pancreas differentiation to hepatocytes - potential source of a human hepatocyte progenitor for use in ... Expanding the indications for pancreas resection and autologous islet cell transplantation (IAT) in both adults and children. ... Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas. In: Journal of Hepatology: ... Diversifying the Indications for Pancreas Resection and Autologous Islet Cell Transplantation (IAT) in both Adults and Children ...http://www.ncl.ac.uk/medicalsciences/research/groups/profile/jimshaw.html
Transplantation Models to Characterize the Mechanisms of Stem Cell-Induced Islet Regeneration - Current Protocols
A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development ... Carbonic anhydrase II‐positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. ... Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132:197‐207. ... Adult pancreatic beta‐cells are formed by self‐duplication rather than stem‐cell differentiation. Nature 429:41‐46. ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-sc02b04.html
Frontiers | Commentary: "Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis" | Oncology
... pancreas) and retina (2). Yet, the amino acid sequence of Prom1 didn't reveal any motif or potential enzymatic activity that ... PROM1 is expressed in ductal cells of the exocrine component of adult pancreas (36-38). ... Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas (2008) 36(1):e1-6. doi: ... Pancreas (2009) 38(8):e207-14. doi:10.1097/MPA.0b013e3181bb5037. Pubmed Abstract , Pubmed Full Text , CrossRef Full Text , ...https://www.frontiersin.org/articles/10.3389/fonc.2015.00091/full
Exogenous CCK stimulates growth of the exocrine pancreas in adult (41, 42, 51) and neonatal rodents (46, 48,51). Prolonged ... Because the CCK-A-type receptor mediates CCK regulation of the exocrine pancreas in the mouse, we measured CCK-A receptor mRNA ... 1990) Adaptation of the exocrine pancreas to diet. Annu. Rev. Nutr. 10:85-105. ... 1988) Effects of cholecystokinin and hydrocortisone on DNA and protein synthesis in immature rat pancreas. Pancreas 3:274-278. ...http://ajpgi.physiology.org/content/276/5/G1302
2011) Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet ... Adult fish were raised in a recirculating water system (28°C ± 1°C) with a 14-hour:10-hour light-dark schedule. Spawning and ... 2016) Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. eLife 5:5. ... 2017) Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. ...http://molpharm.aspetjournals.org/content/91/6/609
研究発表 | 薬理学講座
Continuous cell supply from the Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat. Genet. 43 ...http://www.shiga-med.ac.jp/pharm/happyou.html
Intermediate cells in the adult human pancreas | Springer for Research & Development
Brown RE, Still WJS (1970) Acinar-islet cells in the exocrine pancreas of the adult cat. Am J Dig Dis 15:327-335PubMedCrossRef ... 1983). These observations show that exocrine acinar cells of the pancreas may, even beyond the neonatal period, become ... Intermediate cells in the adult human pancreas. Contribution to the transformation of differentiated cells in vertebrates ... in the pancreas of human adults with chronic insulin-dependent diabetes mellitus. In this context, reference is made to ...https://rd.springer.com/article/10.1007/BF02890214
Scientists Reprogram Adult Cells - Redorbit
Image 2: In this immunofluorescent image of an adult mouse pancreas, exocrine cells into which three transcription factors have ... Researchers were able to transform ordinary pancreas cells into a rare type that creates insulin, which may provide future help ...http://www.redorbit.com/news/health/1536033/scientists_reprogram_adult_cells/
Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical...
A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development ... Ming CS, Chen ZH (2007) Progress in pancreas transplantation and combined pancreas-kidney transplantation. Hepatobiliary& ... Around 1,300 T1DM patients receive pancreas or β-pancreatic islet transplants from cadaveric donors each year in the USA as an ... 2008) Kidney and pancreas transplantation in the United States, 1997-2006: the HRSA Breakthrough Collaboratives and the 58 DSA ...https://www.omicsonline.org/open-access/mesenchymal-stem-cell-therapy-in-type-diabetes-mellitus-and-its-main-complications-from-experimental-findings-to-clinical-practice-2157-7633.1000227.php?aid=30007
Mesenchymal Stem Cells Derived from Human Exocrine Pancreas Spontaneously Express Pancreas Progenitor-Cell Markers in a Cell...
In the present study, we isolated MSCs from the adult human exocrine pancreas to determine whether isolated MSCs have the ... MSCs have also been detected in human pancreatic tissue, including endocrine and exocrine cells. These adult human pancreas- ... Mesenchymal Stem Cells Derived from Human Exocrine Pancreas Spontaneously Express Pancreas Progenitor-Cell Markers in a Cell- ... Crude exocrine cells were methodically cultured in suspension and then in adherent culture. We expanded the human pancreatic ...https://www.hindawi.com/journals/sci/2016/2142646/abs/
Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic...
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011; ... Thus, it is difficult to use them to represent the condition of adult stem cells. IESCs are bona fide stem cells that are fast ... 5b). Previous studies also demonstrated this sequence characteristic of Sox9 binding in adult hair follicle stem cells  and ... After obtaining the global DNA methylation of promoter regions in crypts, we investigated three DNA methyltransferases in adult ...https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0507-4
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar...
In the adult pancreas, NR5A2 collaborates with PTF1A to control exocrine genes (Holmstrom et al., 2011). PTF1A is a class B ... 6D,E. (D) Consensus NR5A2-binding sequences from E17.5 (this study), adult pancreas (Holmstrom et al., 2011), adult liver ( ... lobes of the dorsal pancreas, ventral pancreas (v), stomach (s) and duodenum (d) in normal and NR5A2-depleted pancreas. All ... 2007). Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev. Biol. 7, 4. doi:10.1186/1471- ...http://dev.biologists.org/content/141/16/3123
Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE: A second pathway for regeneration of adult exocrine and endocrine pancreas: a ... Wang RN, Kloppel G, Bouwens L: Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats ... 5E-G). Kir6.2G132S transgenic pancreas at 25 weeks of age was histologically indistinguishable from wild-type pancreas (Figs. 5 ... which gives rise to endocrine and exocrine cells of developing pancreas (29). It is thus not unlikely that these DBA-labeled ...http://diabetes.diabetesjournals.org/content/55/7/1930
Pathology of exocrine neoplasms of the pancreas
Epithelial neoplasms of the exocrine pancreas in adults can be divided into solid neoplasms (ductal adenocarcinoma, acinar cell ... Secondary involvement of the pancreas can occur; the commonest metastatic tumours are renal cell carcinoma and malignant ...https://insights.ovid.com/suox/200702000/01817248-200702000-00004
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice.. Martinelli P, ...http://krebsforschung.meduniwien.ac.at/forschung-research/research-focuses/tumor-progression-and-metastasis/paola-martinelli/
Cell Transplantation 23(2) Abstracts
Our aim was to explore this potential in adult human pancreases and in both islet and exocrine tissue transplanted into mice. ... The absence of β-cell replication in many adult cadaver or autopsy pancreases could, in part, be an artifact of the postmortem ... Islets and exocrine tissue were transplanted into normoglycemic ICR-SCID mice and studied 4 and 14 weeks later. β-Cell ... Thus, it appears that adult human β-cells maintain a low level of turnover through replication and neogenesis.. Key words: ...https://www.cognizantcommunication.com/component/content/article/706
ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar...
2012). Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev. Biol. 362, 57-64. doi:10.1016 ... As pancreas-specific transcription factor 1a (Ptf1a) is essential for differentiation of exocrine pancreas (Dong et al., 2008; ... Here, we used the zebrafish as an alternative model for studying exocrine pancreas regeneration. Importantly, the pancreata in ... 2006). Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA ...http://dmm.biologists.org/content/10/3/307
Cystic Fibrosis in Adults | SpringerLink
Durie P, Forstner G: Pathophysiology of the exocrine pancreas in cystic fibrosis. JR Soc Med. 1989;82(Suppl 16):2-10.PubMed ... Penketh ARL, Wise A, Mearns MB, et al: Cystic fibrosis in adolescents and adults. Thorax. 1987;42:526-532.PubMedCrossRefGoogle ... Penketh A, Knight RK, Hodson M, et al: Management of pneumothorax in adults with cystic fibrosis. Thorax. 1982;37:850-853. ... Brissette S, Zinman R, Reidy M: Disclosure of psychosocial concerns of young adults with a dvanced cystic fibrosis (CF) by a ...https://link.springer.com/chapter/10.1007/978-1-4757-9823-4_2
Akt (Protein Kinase B)
Among two major types of epithelial (acinar and ductal) cells in the adult exocrine pancreas, ductal cells had been believed to ... constant with the epithelial beginning of the exocrine pancreas (Supplementary Fig. 1c). Ulex europaeus agglutinin 1 (UEA-1) ... The most recently published attempts to model PDAC by culturing human pancreas organoids yielded only ductal cells, not acinar ... Outcomes Portrayal of acinar and ductal populations in principal individual exocrine pancreatic tissue A few research have got ...http://www.arcillaresearch.com/index.php/category/akt-protein-kinase-b/
HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro.
In vitro expansion of beta-cells from adult human islets could solve the tissue shortage for cell replacement therapy of ... Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 169: ... its application on a large scale is limited by the availability of pancreas donors. In a normal adult pancreas, a slow rate of ... The NOTCH pathway is not normally expressed in the adult pancreas; however, it is activated in conditions associated with cell ...http://www.biomedsearch.com/nih/HES-1-involved-in-adaptation/18599525.html