Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep. |...
Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep.. E H Blaine ... Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep. ... Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep. ... Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep. ...http://circres.ahajournals.org/content/43/1/36
Acute Effects of Intravenous Ouabain in Healthy Volunteers | Clinical Science
Both plasma atrial and brain natriuretic peptide levels were increased after ouabain administration. ... Acute Effects of Intravenous Ouabain in Healthy Volunteers. G. B. Pidgeon, A. M. Richards, M. G. Nicholls, L. K. Lewis, T. G. ... Acute Effects of Intravenous Ouabain in Healthy Volunteers. G. B. Pidgeon, A. M. Richards, M. G. Nicholls, L. K. Lewis, T. G. ... 4. Ouabain injection was associated with a fall in plasma angiotensin II levels and a rise in plasma adrenaline levels, but ...http://www.clinsci.org/content/86/4/391
Pharmacological Reports Page 6
Low-dose ouabain administration increases Na(+),K(+)-ATPase activity and reduces cardiac force development in rats.. CONCLUSION ... Concomitant administration of small doses of CB1 and/or CB2 receptor agonists and COX-2 or NOS inhibitors can be effective in ... Co-administration of diosmin with fexofenadine can reduce the dosage and results in reduced side effects of fexofenadine. The ... CONCLUSIONS: These data suggest that in vivo induction of CYP in mice by multiple administration of CBZ is independent of PXR. ...https://medworm.com/journal/pharmacological-reports/6/
The hyperthyroid heart. An analysis of systolic and diastolic properties in single rat ventricular myocytes. | Circulation...
The effect of pacing rate and ouabain administration on systolic and diastolic function was examined. Single myocytes isolated ... such as low pacing rates or digitalis glycoside administration. It can account for the hypoperformance of the hyperthyroid ...http://circres.ahajournals.org/content/66/3/773
Developmental programming of hypertension and kidney disease.
Administration of ouabain, a Na-K-ATPase ligand, to these rats abolished apoptosis and increased cell proliferation in the ... Ouabain protects against adverse developmental programming of the kidneyNature CommunicationsYear: 201014172-s2.0-78650095332. ... Khodus GR,Kruusmägi M,Li J,Liu XL,Aperia A. Calcium signaling triggered by ouabain protects the embryonic kidney from adverse ... Administration of COX-2 inhibitor to rats with altered renal development induces a greater renal vasoconstriction [84, 85]. Use ...http://www.biomedsearch.com/nih/Developmental-programming-hypertension-kidney-disease/23251800.html
JoVE Author Search: Quevedo J
Administration, Behavior, Wistar Rats, Superoxide, Rat, Animal, Bdnf, Amygdala, Depression, Animal Model, Animals, Memory, ... Intracerebroventricular ouabain administration induces oxidative stress in the rat brain.. Abstract. 01/21/2010. 2.4. Muscle & ... Interesting enough, acute administration, but not chronic administration of memantine at higher dose (20 mg/kg) increased BDNF ... Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus.. Abstract. ...http://labindex.jove.com/author/Quevedo-J
Protocols and Video Articles Authored by Lijun Liu
... of the non-pumping pool is associated with a loss of receptor function as evidenced by the failure of ouabain administration to ... but higher doses of ouabain inhibited activity. ANP attenuated ouabain-induced Na⁺-K⁺-ATPase activity. Furthermore, ouabain (50 ... The effect of ouabain on Na⁺-K⁺-ATPase activity was shown in a biphasic manner. Ouabain (0.01-1 nmol/L) had a small but ... Ouabain-induced activation of Akt was not prevented by the Src inhibitor PP2. In contrast, ERK1/2 were not activated by ouabain ...https://www.jove.com/author/Lijun_Liu
Studies on the Cornea :IV. Some Effects of Ouabain on Pinocytosis and Stromal Thickness in the Rabbit Cornea | IOVS | ARVO...
Administration of ouabain in vivo or in vitro leads to corneal swelling and a marked reduction in the number of pinocytotic ... Some Effects of Ouabain on Pinocytosis and Stromal Thickness in the Rabbit Cornea. Invest. Ophthalmol. Vis. Sci. 1965;4(5):844- ... Ouabain and Aqueous Humor Dynamics in the Rabbit Eye. Transcorneal Electrical Stimulation Promotes Survival of Photoreceptors ... A comparison of ouabain-treated, cold-inhibited, and neonatal corneas, as well as consideration of electron histochemical ...http://iovs.arvojournals.org/article.aspx?articleid=2125183
Effects of Ouabain on the Left Ventricular Response to Exercise in Patients with Angina Pectoris | Circulation
Before administration of ouabain, exercise was associated with depressed pumping performance of the left ventricle in four ... Effects of Ouabain on the Left Ventricular Response to Exercise in Patients with Angina Pectoris. D. LUKE GLANCY, LAWRENCE M. ... Ouabain improved LV performance at rest in only a minority of patients, but during the stress of exercise, LV hemodynamics were ... The response of the left ventricle to a level of supine bicycle exercise that induced angina, and the effects of ouabain (0.01 ...http://circ.ahajournals.org/content/43/1/45
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor | Respiratory Research |...
Intra-tracheal administration of GLP, ouabain or Gram(-) LPS. Each mouse was anesthetized with isoflurane, and an incision was ... ouabain (F) or GLP plus ouabain (GLP + ouabain) (G). Plethysmographic analysis of lung function (H), where the enhanced pause ( ... Ouabain induced a less-intense hemorrhage, and animals injected with GLP plus ouabain presented high mortality rates ... Ouabain is known to affect the immune system by modulating cytokine production, and its administration has been shown to induce ...https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-014-0093-2
... we blocked Na+/K+-ATPase with 250 μm ouabain. Figure 4B demonstrates that selective administration of ouabain to neurites ... 0.05 compared with equivalent day for ouabain only, n.s. = not significant; n = 15 and 19 compartments for ouabain and ouabain ... To determine the contribution of sodium channels to ouabain-induced neurite degeneration, we coadministered TTX and ouabain to ... 2F) (ouabain + TTX: day 3, 87.9 ± 2.0; day 6, 80.4 ± 3.0 versus TTX: day 3, 117.9 ± 10.5; day 6, 122.8 ± 11.1; Student's ...http://www.jneurosci.org/content/33/49/19250
Cardiac Glycosides to Treat Cystic Fibrosis and Other IL-8 Dependent Disorders - Patent application
... administration for ouabain is in the vicinity of the calculated IC50. Therefore, neither ouabain nor digoxin is suitable ... 31 Ouabain (g-strophanthin) 0.02 ± 0.00 -0.73 0.14 2.28 ± 0.10 32 Dihydro-ouabain 0.20 ± 0.00 -0.71 0.15 45.50 ± 3.90 The ... administration. The parenteral preparations may be solutions, dispersions or emulsions suitable for such administration. The ... 50nM of ouabain, and ca.70-100 nM for digitoxin. IC50 doses for these drugs are ca. 100 nM for oleandrin and ca. 200 nM for ...http://www.patentsencyclopedia.com/app/20140187505
Ouabain protects against adverse developmental programming of the kidney
Long-term ouabain administration produces hypertension in rats. Hypertension 22, 178-187 (1993). [PubMed] ... The ouabain effects on Wt1 and Pax2 mRNA were abolished in kidneys simultaneously exposed to ouabain and helenalin (Fig. 4c,d). ... Exposure to ouabain increases calcium activity. Exposure of embryonic kidneys to ouabain caused a significant increase in the ... This daily dose of ouabain has previously been shown to result in plasma levels of ouabain around 1 nM43 and to have little ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2963829/
Protocols and Video Articles Authored by Max Gassmann
Administration of the Na, K-ATPase blocker ouabain caused rapid increase in the right ventricular Na(+) and elimination of the ... Administration of the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) led to vasoconstriction of peripheral ... Moreover, continuous EPO administration in mice, resulted in an increased number of KCs, up-regulation of liver EPO-R ... We found that prolonged administration of high doses of Epo in mice leads to great inhibition of liver hepcidin mRNA levels, ...https://www.jove.com/author/Max_Gassmann
Effect of Ouabain on Active Transport of Sodium in the Cornea | JAMA Ophthalmology | The JAMA Network
Administration of ouabain resulted in a decrease in aqueous flow and a drop in intraocular pressure, presumably due to an ... Effect of Ouabain on Active Transport of Sodium in the Cornea. Arch Ophthalmol. 1964;72(4):525-528. doi:10.1001/archopht. ... Introduction Ouabain (G-Strophanthin) inhibits the activity of Na-K activated adenosinetriphosphatase (ATPase) in in vitro and ... It was the purpose of this investigation to study the effect of ouabain on the active transport of sodium across the corneal ...https://jamanetwork.com/journals/jamaophthalmology/article-abstract/627744?redirect=true
Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model
M. Y. Lee, S.-H. Bae, S.-Y. Chang et al., "Photobiomodulation by laser therapy rescued auditory neuropathy induced by ouabain ... at four weeks after drug administration and these increased thresholds remained until 12 weeks after drug administration. KG ... Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model. Jae-Hun Lee,1,2 Min ... After twelve weeks of drug administration, the KG and KI groups showed a total loss of HCs and a partial loss of nerve fibers ...https://www.hindawi.com/journals/bmri/2018/9158187/
Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo...
Chronic Δ9-THC administration has been shown to reduce the impact of an ischemic insult evoked by a reduced blood pressure and ... A 1 μl syringe was lowered into the left striatum to a depth of 4.0 mm (Dijkhuizen et al., 1996). Ouabain (0.5 μl 1 mm; n= 30; ... Three adjacent coronal T2 maps of neonatal rat brain 7 d after ouabain injection. a,No treatment; b, THC treatment; c, THC + ... Three adjacent coronal ADC maps of neonatal rat brain 15 min after ouabain injection. a, No treatment;b, THC treatment; c, THC ...http://www.jneurosci.org/content/21/17/6475
Ouabain - Wikipedia
Intravenous administration results in greater available concentrations and has been shown to decrease the LD50 to 2.2 mg/kg, ... a precursor to ouabain. The glycosylation of ouabagenin with rhamnose produced ouabain. Strophanthidin "ouabain" in the World ... Ouabain is a highly toxic compound with a LD50 of 5 mg/kg when administered orally to rodents. However, ouabain has a low ... Although ouabain is no longer approved for use in the USA, in France and Germany, intravenous ouabain has a long history in the ...https://en.wikipedia.org/wiki/Ouabain
Digoxin - ONA
Ouabain (g-strophanthin) is structurally similar to digoxin but not from the foxglove purpurea plant. Rather, it is found in ... After oral administration of digoxin, there is a 6- to 8-hour tissue distribution phase and then a gradual excretion, with the ... Intravenous administration provides about 20% more of the drug then when the same dose is given orally. The pediatric elixir ... Ouabain has been largely relegated to the experimental laboratory where it is used to specifically block the sodium-potassium- ...https://www.oncologynurseadvisor.com/cardiology/digoxin/article/583032/
Tresorie - OUR SUPPLEMENT [Supplement]
Ouabain caused a violent rigor, with hyperpyrexia, vomiting, and headache, and was discontinued, the patients general condition ... Only slight improvement followed the administration of Nativelles digitaline and theosalvose with bleeding and purgation. ... In 1924 an attack of cardiac failure was relieved by digitalis, ouabain, and diuretics, and subsequent slight attacks were ...http://homeoint.org/hompath/articles/4179.html
Brain 'Ouabain' Mediates Sympathetic Hyperactivity in Congestive Heart Failure | Circulation Research
Administration of Fab fragments or γ-globulins ICV did not result in changes in MAP or HR. In control rats, RSNA showed a ... Is the circulating ouabain-like compound ouabain? Am J Hypertens.. 1994;7:647-650. ... More recently, Doris et al29 did find ouabain immunoreactive material but no authentic ouabain in the plasma of patients with ... OLA is expressed as nanograms of ouabain equivalents per milliliter plasma and micrograms of ouabain equivalents per gram ...http://circres.ahajournals.org/content/77/5/993
"ATP-mediated Vasodilatation Occurs via Activation of Inwardly-Rectifyi" by Anne R. Crecelius, Brett S. Kirby et al.
... which was not different than that observed for combined ouabain plus BaCl2 administration. Our novel results indicate that the ... following combined ouabain plus BaCl2 infusion. In follow-up studies, BaCl2alone inhibited the vasodilator responses to ATP on ... Combined infusion of ouabain (to inhibit Na+/K+-ATPase) and barium chloride (BaCl2; to inhibit KIR channels) abolished KCl- ... which was not different than that observed for combined ouabain plus BaCl2 administration. Our novel results indicate that the ...http://ecommons.udayton.edu/hss_fac_pub/17/
Ouabain and BDNF Crosstalk on Ganglion Cell Survival in Mixed Retinal Cell Cultures | Springer for Research & Development
Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element ... Schoner W, Bauer N, Mülle-Ehmsen J et al (2003) Ouabain as a mammalian hormone. Ann N Y Acad Sci 986:678-684PubMedCrossRef ... Scheiner-Bobis G, Schoner W (2001) A fresh facet for ouabain action. Nat Med 7:1288-1289PubMedCrossRefGoogle Scholar ... Ouabain BDNF Retina Neuronal survival Synergistic effect Aline Araujo dos Santos and Elizabeth Giestal-de-Araujo have ...https://rd.springer.com/article/10.1007/s10571-015-0160-3
Adaptations in the Lygaeinae | Proceedings of the Royal Society of London B: Biological Sciences
b) Ouabain resistance of Na+/K+-ATPase in vitro. Na+/K+-ATPases of all seven Lygaeinae tested here showed a highly similar ... 3H-cardenolide-sequestration in nine Lygaeinae and three outgroup species 10 days after oral administration. Bars indicate the ... is highly sensitive to ouabain, starting to show inhibition at ouabain concentrations as low as 10−7 M. Our data thus support ... IC50 values of ouabain for hemipteran Na+/K+-ATPase tested in vitro. (IC50 values are calculated based on the fitted curves as ...http://rspb.royalsocietypublishing.org/content/282/1805/20142346
Cardiac Glycosides and Cardiomyopathy | Hypertension
In particular the administration of 10 μg/kg per day of MBG for 4 weeks caused increased blood pressure, cardiac fibrosis, and ... Similarly, longer term infusion of plant-derived ouabain (15 μg/kg per day for 18 weeks), at doses that just double the plasma ... The presence of endogenous cardiac glycosides, including marinobufagenin (MBG)3 and endogenous ouabain (EO)4 in the human ... Pierdomenico SD, Bucci A, Manunta P, Rivera R, Ferrandi M, Hamlyn JM, Lapenna D, Cuccurullo F, Mezzetti A. Endogenous ouabain ...http://hyper.ahajournals.org/content/47/3/343