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*  Down syndrome cell adhesion molecule
Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). ... Neutrophil count 13 Estradiol plasma levels (breast cancer) 5 Anxiety in major depressive disorder 4 ... Down syndrome cell adhesion molecule interacts with PRKAG1 subunit and plays an important role in netrin-1 induced neurite ... Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of ...
  https://pharos.nih.gov/idg/targets/DSCAM
*  Induction of NAD(P)H Oxidase by Oxidized Low-Density Lipoprotein in Human Endothelial Cells | Circulation
Kinetics of activation of the respiratory burst oxidase in a fully soluble system from human neutrophils. J Biol Chem. 1988; ... Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive ... Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src. Science. 1990; 248: 727-730. ... Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. Proc Natl Acad Sci U ...
  http://circ.ahajournals.org/content/104/15/1767
*  anti-L-Selectin antibody (FITC) | Product No. ABIN114234
Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node ... L-selectin is expressed on most T and B lymphocytes, neutrophils, monocytes, eosinophils.1 Pre-incubation of lymphocytes with ... Activation (Act). 2 Affinity Purification. (AP). 2 Apoptosis Blocking (AB). 2 Apoptosis Induction (AI). ... evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes." in: Journal of immunology ( ...
  http://www.antibodies-online.com/antibody/114234/anti-Selectin+L+SELL+antibody+FITC/
*  L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated...
... to enhance β2 integrin activation in vitro, and to increase ICAM-1-dependent neutrophil recruitment in vivo. From these studies ... Migration from the bloodstream into LNs is regulated by a multistep adhesion cascade, which involves different adhesion ... L-Selectin Shedding after Antigen Activation Regulates T Lymphocyte Entry into PLNs.. After activation by antigen, T cells show ... After activation by antigen and shedding of transgenic L-selectin, the number of immigrant CD8 T cells from F5/WT mice in PLNs ...
  http://jem.rupress.org/content/198/9/1323
*  Inflammation and Immune System Contribution to the Etiology... : Nursing Research
Immune system activation and inflammation are intricately involved in the development a ... Zarbock A.,, & Ley K. ( 2009). Neutrophil adhesion and activation under flow. Microcirculation, 16, 31-42. doi:10.1080/ ... adhesion, activation, and a subsequent increase in infiltration of monocytes,T lymphocytes, and neutrophils (Brevetti, Schiano ... Upon neutrophil "capturing" (loose" binding to the endothelium), the selectins, primarily P-selectin, mediate the neutrophil ...
  http://journals.lww.com/nursingresearchonline/Fulltext/2014/09000/Inflammation_and_Immune_System_Contribution_to_the.8.aspx?WT.mc_id=HPxADx20100319xMP
*  In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury | Thorax
A) Circulating and (B) alveolar neutrophil adhesion molecule (CD11b, CD18 and CD49) and activation maker (CD64) expression in ... In vivo, salbutamol increased circulating neutrophils, but had no effect on alveolar neutrophils or on neutrophil activation. ... 18 Reduced neutrophil-endothelial adhesion, through the down regulation of neutrophil integrin adhesion molecule expression ( ... Patients with ALI/ARDS showed increased neutrophil activation and adhesion molecule expression compared with at risk-patients ...
  http://thorax.bmj.com/content/62/1/36
*  Neutrophil Methods and Protocols | Springer for Research & Development
Neutrophil Methods and Protocols, Second Edition provides a concise set of protocols writ ... Neutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. ... Detection of Bidirectional Signaling During Integrin Activation and Neutrophil Adhesion Stuart M. Altman, Neha Dixit, Scott I. ... NADPH oxidase bactericidal activity gene expression human neutrophil neutrophil neutrophil apoptosis neutrophil phagocytosis ...
  https://rd.springer.com/book/10.1007/978-1-62703-845-4
*  Compositions and methods useful for treating circulatory and hypovolemic shock - University of Kentucky Research Foundation
Human neutrophil activation and increased adhesion by various resuscitation fluids. Crit Care Medicine 28:74-75, 2000 ... 1991) demonstrated that activation of the δ-opioid receptor via K+ channels produced a cardioprotective effect and the subtypes ... Fryer, R. M., Wang, Y., Hsu, A. K., Gross, G. J. Essential activation of PKC-8 in opioid-initiated cardioprotection. Am J ... Schultz, J., Hzu, A., Nasase, H., Gross, G.J. TAN-67, a 81-opioid receptor agonist reduces infarct size via activation of G i/o ...
  http://www.freepatentsonline.com/7705119.html
*  Albuterol - Medical Countermeasures Database - CHEMM
Patients with ALI/ARDS showed increased neutrophil activation and adhesion molecule expression compared with at risk-patients ... In vivo, salbutamol increased circulating neutrophils, but had no effect on alveolar neutrophils or on neutrophil activation. ... Neutrophil activation, adhesion molecule expression and inflammatory cytokines were measured. Results: In vitro, physiological ... there is increased neutrophil recruitment and activation. Physiological concentrations of salbutamol did not alter neutrophil ...
  https://chemm.nlm.nih.gov/countermeasure_albuterol.htm
*  Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury
... κB Activation and Neutrophil Adhesion Induced by I/R. As an oxidant-sensitive transcription factor, NF-κB activation plays a ... e) and (f) The expression of adhesion molecules CD18 and CD11b on rat neutrophils, respectively. The expression of adhesion ... To examine the activation of NADPH oxidase, expression of on the membrane and translocations of organizer subunits , , and from ... Figure 10: CP pretreatment inhibits NADPH oxidase activation induced by I/R. (a) Representative Western blot bands of , , and ...
  https://www.hindawi.com/journals/ecam/2013/728020/
*  S100A9 Gene - GeneCards | S10A9 Protein | S10A9 Antibody
Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.. ... It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis ... It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis ... via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A9
*  Mouse Galectin 3 ELISA Kit (ab113343) | Abcam
Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages ... opsonization of apoptotic neutrophils, and activation of mast cells. Probably forms homo- or heterodimers. Interacts with DMBT1 ...
  http://www.abcam.com/mouse-galectin-3-elisa-kit-ab113343.html
*  Neutrophil inhibitors - Patent # 5708141 - PatentGenius
... neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a ... Compositions enriched for Neutrophil Inhibitory Factor which inhibit ... The isolated factor appears to inhibit neutrophil adhesion to endothelial cell monolayers by inhibiting neutrophil activation. ... This invention relates to factors which inhibit neutrophil activity, including inhibition of neutrophil activation and adhesion ...
  http://www.patentgenius.com/patent/5708141.html
*  Lgals3 - Galectin-3 - Rattus norvegicus (Rat) - Lgals3 gene & protein
... opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal ... Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages ... Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages ... opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal ...
  http://www.uniprot.org/uniprot/P08699
*  Hypersensitivity Vasculitis: Background, Pathophysiology, Etiology
These autoantibodies then bind neutrophils, subsequently leading to neutrophil adhesion to vessel walls and cellular activation ... Inflammatory mediators, adhesion molecules, and local factors may affect the endothelial cells and play a role in the ... Roles of leukocyte/endothelial cell adhesion molecules in the pathogenesis of vasculitis. Am J Med. 1999 Jun. 106(6):677-87. [ ... In ANCA-mediated vasculitis, intracellular proteins from neutrophils become expressed on the cell surface, leading to formation ...
  https://emedicine.medscape.com/article/1083719-overview
*  New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia | SpringerLink
Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow. J ... CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. ... Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation. Blood. 2007;109:661-9.CrossRefPubMedGoogle Scholar ... Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion ...
  https://link.springer.com/article/10.1007%2Fs12026-013-8449-0
*  ChemoCentryx Announces Presentations of Positive Results from Phase II ANCA-Associated Vasculitis Trials ('CLEAR' and 'CLASSIC'...
By blocking the C5aR, avacopan is thought to reduce vasculitis by reducing neutrophil activation, accumulation, and adhesion, ... In AAV, neutrophils are attracted to sites of vascular destruction as well as activated at those sites by the activity of the ... Anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis, or AAV, is a type of rare autoimmune inflammation ... This damage is caused by the destructive activity of inflammatory leukocytes in the body, with neutrophils considered to be the ...
  https://www.cnbc.com/2016/11/07/globe-newswire-chemocentryx-announces-presentations-of-positive-results-from-phase-ii-anca-associated-vasculitis-trials-acleara-and.html
*  Most recent papers with the keyword Hemolytic uremic | Read by QxMD
Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells. ... www.readbyqxmd.com/read/29142942/complement-activation-induces-neutrophil-adhesion-and-neutrophil-platelet-aggregate-formation- ... It is well known that the oxidative imbalance generated by Stx induces platelet activation, contributing to thrombus formation ...
  https://www.readbyqxmd.com/keyword/6970
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
E-selectin mediates capture and rolling of neutrophils and IL-8 mediates activation and firm adhesion of neutrophils. After ... In co-culture, MSC suppressed neutrophil adhesion to TNFα-stimulated endothelium. Our flow based-adhesion models mimic the ... adhesion and transmigration of the neutrophil across the endothelium; and fourth accumulation of neutrophils at the site of ... endothelial cells are activated resulting in the upregulation of adhesion and activation molecules. For example, activation of ...
  https://www.jove.com/visualize/abstract/25816133/tumor-necrosis-factor-disrupts-claudin-5-endothelial-tight-junction
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
E-selectin mediates capture and rolling of neutrophils and IL-8 mediates activation and firm adhesion of neutrophils. After ... adhesion and transmigration of the neutrophil across the endothelium; and fourth accumulation of neutrophils at the site of ... endothelial cells are activated resulting in the upregulation of adhesion and activation molecules. For example, activation of ... In these conditions leucocytes undergo a brief tethering step followed by activation and firm adhesion, followed by a crawling ...
  https://www.jove.com/visualize/abstract/22509281/unique-cell-type-specific-junctional-complexes-vascular-endothelium
*  Inflammation Flashcards by Alejandro Piris Niño | Brainscape
1. Activation of endothelium - need to be activated to allow adhesions of neutrophils. 2. Activation of neutrophils - activate ... The adhesion of neutrophils to endothelium causes them to aggregate along the vessel walls in a process termed margination. ... process where cells (like neutrophils and macrophages) ingest solid particles. After adhesion the phagocyte then ingests the ... CELLS: Neutrophils (mainly). Synthesized from arachidonic acid, especially in neutrophils, and appear to have vasoactive ...
  https://www.brainscape.com/flashcards/inflammation-6640237/packs/10519702
*  Protocols and Video Articles Authored by Noo Li Jeon (Translated to Turkish)
This microfluidic technique allows detailed kinetic studies of cell adhesion and reveals neutrophil activation within seconds ... Neutrophil recruitment to the substrate proved to be highly sensitive to disturbances in flow streamlines, which enhanced the ... Neutrophils migrate more efficiently toward single IL-8 gradients than single LTB4 gradients as measured by the effective ... Neutrophil Chemotaxis in Linear and Complex Gradients of Interleukin-8 Formed in a Microfabricated Device Nature Biotechnology ...
  https://www.jove.com/author/Noo+Li_Jeon?language=Turkish
*  Leukocyte Interactions Mediated by P-Selection | Springer for Research & Development
Many of these responses require cellular activation as well as cell-cell... ... a juxtacrine system for adhesion and activation of neutrophils. J. Cell Biol. 115:223.PubMedCrossRefGoogle Scholar ... Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140. Science 249:414.PubMedCrossRef ... Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated ...
  https://rd.springer.com/chapter/10.1007/978-1-4613-9266-8_11
*  Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis
22 CD59 seems to be involved in T cell adhesion and activation,23 neutrophil activation through tyrosine kinase,24 and cell ... Deckert M, Kubar J, Bernard A. CD58 and CD59 molecules exhibit potentializing effects in T cell adhesion and activation. J ... The SF neutrophils expressed significantly more CD55 and CD35 compared with the PB neutrophils, and the expression of CD46 was ... The complement cascade (CC) can be divided into four major phases: early complement activation; C3-convertase activation and ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042011000500009&lng=en&nrm=iso&tlng=en
*  Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2)...
We will measure neutrophil activation, proinflammatory cytokines and adhesion molecule expression and nuclear factor kappa B ( ... NFkB) activation. Furthermore, we will measure cell-specific indices of activation and injury to the alveolar epithelium and ...
  https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-13-170