Mechanism of Doxorubicin-Induced Inhibition of Sarcoplasmic Reticulum Ca2+-ATPase Gene Transcription | Circulation Research
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A, Hayami M, Fujii Kuriyama Y. Two regulatory proteins that ... We also found that p300, which was recently cloned and characterized as a transcriptional adapter protein,10 and which has been ... Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A. Human p300 protein is a coactivator for the transcription factor MyoD. J ...http://circres.ahajournals.org/content/86/1/8
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins | The EMBO...
1/δEF1 might synergize with Smad proteins by promoting the recruitment of P/CAF-p300 to the complex. The adenovirus E1a protein ... Madison DL, Yaciuk P, Kwok RP and Lundblad JR (2002) Acetylation of the adenovirus‐transforming protein E1A determines nuclear ... p300 complex. We confirmed this result using a p300- VP16 fusion protein in a two‐hybrid approach. As shown in Figure 3B, ... Zhang Q, Yao H, Vo N and Goodman RH (2000) Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor ...http://emboj.embopress.org/content/22/10/2453
EP300 - Wikipedia
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) ... Condorelli G, Giordano A (1998). "Synergistic role of E1A-binding proteins and tissue-specific transcription factors in ... "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes Dev. 9 (10): 1188 ... "Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ...https://en.wikipedia.org/wiki/EP300
A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression |...
To assess the role of CBP/p300 proteins in TNF-α gene regulation, we performed cotransfection studies with the adenovirus E1A ... The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene ... we used a mutant form of the protein (E1A 12S Δ2-36), which lacks the CBP/p300 interaction domain and fails to inhibit CBP/p300 ... E1A 12S) or mutant E1A 12S (E1AΔ2-36) protein or the expression vector alone (vector) into 68-41 T cells (A) or HeLa cells (B ...http://www.pnas.org/content/97/8/3925
YY1 - Wikipedia
"Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 ... YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein ... "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 ... and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377-88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. Zhu ...https://en.wikipedia.org/wiki/YY1
Balancing Histone/Protein Acetylation: Gene Regulation and Cancer Therapy | China-Mainland | Sigma-Aldrich
The adenovirus E1A oncoprotein competes with PCAF for p300 and CBP. The HIV Tat protein is an RNA binding protein critical for ... there is no evidence that p300 or CBP forms a stable complex with other proteins. SAGA, PCAF, and p300/CBP HATs are recruited ... Non-Histone Proteins Controlled by Acetylation. In addition to histones, a growing number of non-histone proteins have been ... In fact, it is now well recognized that protein acetylation may be as important as protein phosphorylation in regulating a wide ...https://www.sigmaaldrich.com/china-mainland/zh/technical-documents/articles/life-science-innovations/mission-shrna-library.html
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... and myelodysplastic syndrome suggest that these chimeric proteins play a causative role in the dysregulation of differentiation ... Ida K., Kitabayashi I., Taki T., Taniwaki M., Noro K., Yamamoto M., Ohki M., Hayashi Y. Adenoviral E1A-associated protein p300 ... The MLL gene is fused with the cAMP-responsive element binding protein-binding protein (CBP) gene in t(11;16)(q23;p13), which ...http://cancerres.aacrjournals.org/content/60/4/1139
Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... Fig.2F,2F, top). These 35S-labeled p300 proteins were subjected to GST pulled down with GST-tagged Nrf2 WT proteins, followed ... p300 was cloned based on its interaction with the adenovirus-transforming protein E1A, while CBP was identified by its ... Equal amounts of GST-Nrf2 proteins were used for GST pull-down analysis with p300 proteins that were radiolabeled with [35S] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2682049/
Cardiomyocyte Cell Cycle Regulation | Circulation Research
Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative ... pocket protein- and p300-binding domains. J Biol Chem. 1995; 270: 7791-7794. ... Identification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice. Am J Physiol. 1993; 264: ... E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Circ Res. 1999; 85: 319-328. ...http://circres.ahajournals.org/content/90/10/1044
KEGG ORTHOLOGY: K04498
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... Histone modification proteins. HATs (histone acetyltransferases). K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein. ... K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein. 05164 Influenza A. K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein. ... K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein. 04916 Melanogenesis. K04498 EP300, CREBBP, KAT3; E1A/CREB-binding protein ...http://www.genome.jp/dbget-bin/www_bget?ko:K04498
Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication...
TRRAP/p400 multi-protein complex and the retinoblastoma (pRb) family proteins through distinct domains in the E1A N-terminal ... oncogenic transformation and promotes viral replication through interaction with p300/CBP, ... Highlights: • Adenovirus E1A C-terminal region suppresses E1A/Ras co-transformation. • This E1A region binds with FOXK, DYRK1/ ... Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus ...https://www.osti.gov/scitech/biblio/22436638-interaction-ctbp-adenovirus-e1a-suppresses-immortalization-primary-epithelial-cells-enhances-virus-replication-during-productive-infection
HMG-I/Y Is a c-Jun/Activator Protein-1 Target Gene and Is Necessary for c-Jun-Induced Anchorage-Independent Growth in Rat1a...
Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. Mol Cell Biol 1996;16: ... B. Western blot analysis of c-Jun and HMG-I/Y proteins in control Rat1a-GFP and Rat1a-J4 cells after 3 days of incubation with ... and protein concentrations were determined using the Bio-Rad Protein Assay (Bio-Rad, Hercules, CA). Equal amounts of protein ... Scala S, Portella G, Fedele M, Chiappetta G, Fusco A. Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential ...http://mcr.aacrjournals.org/content/2/5/305
Histone acetyltransferase - Wikipedia
E1A adenovirus protein, and S-HDAg (hepatitis delta virus small delta antigen). p300/CBP have also been observed to ... p300/CBP. p300/CBP have many non-histone substrates, including the non-histone chromatin proteins HMG1, HMG-N1/HMG14, and ... and E1A adenovirus protein. It can also autoacetylate, which facilitates intramolecular interactions with its bromodomain ... structural proteins, polyamines, and proteins involved in nuclear import. Acetylation of these proteins can alter their ...https://en.wikipedia.org/wiki/Histone_acetyltransferase
A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-θ-Mediated Up...
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... such as adenovirus E1A (18), SV40 T large Ag (19), E6 and E7 proteins from human papillomavirus (20, 21), or Tax protein from ... p300 full length (GAL4-p300 FL); B, mutant p300 construct encoding aa from 1 to 1301 (GAL4-p300 1-1301); C, mutant p300 ... or E6 and E7 proteins from human papillomavirus (20, 21). In fact, p300 was first described as an E1A-interacting protein (3). ...http://www.jimmunol.org/content/180/4/2429
Growth factors can activate ATF2 via a two‐step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of...
Duyndam MC, van Dam H, van der Eb AJ and Zantema A (1996) The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can ... activator/acetyltransferase p300 (Kawasaki et al., 1998; Duyndam et al., 1999), the pX protein of hepatitis B virus, bZIP ... A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein. ... jun by the 243 amino acid adenovirus E1A protein. EMBO J, 12, 479-487. ...http://emboj.embopress.org/content/21/14/3782
Biological | Department of Chemistry
... and Adenovirus (Ad) E1A. We have most recently characterized the binding properties of pRb to HPV-E7 and Ad-E1a and are now ... Protein-DNA recognition- As a model to understand sequence-specific DNA recognition by transcriptional regulatory proteins, we ... p53 and p300/CBP, both alone and in complex with their relevant protein targets. We are also interested in the mode of ... Protein motion underlies both proper function and disease in biological systems. Many signaling and transport proteins require ...http://www.chem.upenn.edu/category/area-focus/biological?page=12
Items where Year is 1993 - CSHL Scientific Digital Repository
... and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene, 8 (6). pp. 1639-47. ISSN 0950- ... Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control ... Wang, H. G., Yaciuk, P., Ricciardi, R. P., Green, M., Yokoyama, K., Moran, E. (1993) The E1A products of oncogenic adenovirus ... Kannabiran, C., Morris, G. F., Labrie, C., Mathews, M. B. (1993) The Adenovirus-E1a 12s Product Displays Functional Redundancy ...http://repository.cshl.edu/view/year/1993.html
Histone acetyltransferase elisa and antibody
Recombinant Protein and Histone acetyltransferase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Histone acetyltransferase p300 Antibody. Also known as Histone acetyltransferase p300 (p300 HAT) (E1A-associated protein p300). ... adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the ... ELISA , Antibodies , Secondary Antibodies , Antigens , Biochemicals , cDNA Clones , Kits , Peptides , Rec Proteins , Protein ...https://www.mybiosource.com/protein_family.php?root=histone-acetyltransferase
Cd44 | healthweblognews.info
7 41 and the adenovirus E1A protein (10 28 Finally some viral proteins such as the VP35 protein of Ebola disease (2) and the ... and the NSP1 protein of rotavirus (21). In addition additional viruses create proteins that can interact with CBP/p300 and ... the histone acetyltransferases p300/CREB-binding protein (CBP) and additional cellular transcriptional cofactors such as AP-1 ... In response to DNA damage tissue homoeostasis is ensured by protein * Association studies suggest that the thyroid hormone ...http://healthweblognews.info/tag/cd44/
Endothelin-1-Dependent Nuclear Factor of Activated T Lymphocyte Signaling Associates With Transcriptional Coactivator p300 in...
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with ... by activation of protein kinase C or mitogen-activated protein kinases.28 These signaling proteins may be involved in promoting ... Protein extracts from these cells were subjected to Western blotting for p300, NFATc1, E1A, and β-actin (A), and then ... In contrast to a proapoptotic role of p300 in fibroblasts,20 analysis of adenovirus early region 1A (E1A) mutants suggests that ...http://circres.ahajournals.org/content/94/11/1492
METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION - Patent application
Viral proteins such as human adenovirus-5 E1A protein and bovine herpesvirus-1 VP8 protein contain basic KRPR and RRPR patches ... immunodeficiency virus recruits the histone acetyltransferases p300/CBP (CREB binding protein) and PCAF (p300/CBP associated ... adenovirus E1A protein interacts with the retinoblastoma protein p130 to disrupt a network of protein interactions required for ... "DNA binding protein." Such DNA binding proteins include transcription factors, enhancer proteins, suppressor proteins, and the ...http://www.patentsencyclopedia.com/app/20160137989
CiNii 論文 - Advances in Genomic Research on Hepatitis C Virus with a Useful Tool, Replicon...
Association between an oncogene and an anti-oncogene : the adenovirus E1A proteins bind to the retinoblastoma gene product ... The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300 PATEL D ... A family of transcriptional adaptor proteins targeted by the E1A oncoprotein ARANY Z. ... Polymorphism of NS5B protein relates to early clearance of hepatitis C virus by interferon plus ribavirin : a pilot study ...http://ci.nii.ac.jp/naid/10021988439
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. - Radcliffe Department of Medicine
Here we show that p300 and/or CBP (CREB-binding protein), which are transcription adaptors targeted by E1A, interact ... and supports the view that E1A binding to p300/CBP has functional significance for adenovirus replication in its natural host. ... Adenovirus E1A blocks the IFN-alpha response, allowing unhindered viral replication. ISGF3 consists of Stat1, Stat2 and p48. ... Moreover, E1A represses Stat2 transactivation and IFN-alpha-activated transcription by inhibiting p300/CBP function. This ...https://www.rdm.ox.ac.uk/publications/165123
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.
... of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated ... Balasubramanyam K,Varier RA,Altaf M,Swaminathan V,Siddappa NB,Ranga U,Kundu TK,Curcumin, a novel p300/CREB-binding protein- ... Horwitz GA,Zhang K,McBrian MA,Grunstein M,Kurdistani SK,Berk AJ,Adenovirus small e1a alters global patterns of histone ... C) Western blots showing the levels of hMOF, TIP60 and SIRT1 proteins in whole cell extracts of MCF7 cells following curcumin ...http://www.biomedsearch.com/nih/Differential-effects-garcinol-curcumin-histone/23356739.html
nej - CREB-binding protein homolog - Drosophila ...
histone acetyltransferase complex, histone methyltransferase complex, nucleoplasm, nucleus, polytene chromosome, protein complex, ...http://www.uniprot.org/uniprot/O01368
OriGene - CREBBP (NM 004380) Human ORF cDNA ...
CREBBP - CREBBP (Myc-DDK-tagged)-Human CREB binding protein (CREBBP), transcript variant 1 available for purchase from OriGene - Your Gene Company.http://www.origene.com/orf_clone/trueclone/NM_004380/RC219036/CREBBP.aspx
1m1e - Proteopedia, life in 3D
In the canonical Wnt signaling pathway, beta-catenin activates target genes through its interactions with Tcf/Lef-family transcription factors and ...http://proteopedia.org/wiki/index.php/1m1e
Creb-Binding Protein (Cbp/P300) and RNA ...
The transcriptional coactivators CBP/p300 are believed to connect DNA-bound transcription factors to the transcription machinery (Kwok et al. 1994; Kee et ...http://jcb.rupress.org/content/150/1/265
CREBBP - Wikipedia
La proteína de unión a CREB, también conocido como CREBBP o CBP es una proteína codificada en humanos por el gen CREBBP. Este gen ...https://es.wikipedia.org/wiki/CREBBP
574 Several transcription factors, including microphthalmia transcription factor (Mitf) and the transcriptional coactivator p300, have been identified as ...http://cancerres.aacrjournals.org/content/64/7_Supplement/132.5
What does p/ CIP mean? - Definition of ...
Hop on to get the meaning of p/ CIP acronym / slang / Abbreviation. The Medical & Science Acronym / Slang p/ CIP means... AcronymsAndSlang. The p/ CIP ...http://acronymsandslang.com/definition/3337905/p%2F-CIP-meaning.html
Kif3a interacts with Dynactin subunit p150Glued to ...
We have found that Kif3a is a component of the mother centriole that regulates the organization and function of the subdistal ...http://emboj.embopress.org/content/32/4/597
TCDB » SEARCH
3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are degraded in ...http://www.tcdb.org/search/result.php?tc=3.A.16
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center ...http://cancerdiscovery.aacrjournals.org/content/early/2016/12/15/2159-8290.CD-16-0975
BET bromodomain inhibition suppresses ...
Given the known roles of BET proteins as transcriptional co-activators, we next investigated whether BET inhibition led to changes in gene ...http://jem.rupress.org/content/210/11/2181
Absorption spectra of BChl ...
Absorption spectra of BChl a-associated proteins from various C. tepidum strains recovered by Ni2+-affinity purification.Absorption spectra (traces 1-6) of BChlhttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3842273_pone.0082345.g004&req=4
PCAF - Wikipedia
El factor asociado a P300/CBP (PCAF), también conocido como K acetiltransferasa 2B (KAT2B), es un coactivador transcripcional asociado con p53 y codificado ...https://es.wikipedia.org/wiki/PCAF
Structure and Function of Protein ...
The overall goal of this project is to elucidate the molecular basis for how protein acetyltransferases (PATs) recognize and ...http://grantome.com/grant/NIH/R01-GM060293-15
RCSB PDB - 1DCO: DCOH, A BIFUNCTIONAL PROTEIN-BINDING ...
1DCO: High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1DCO
Structure Cluster - 1DCP: DCOH, A BIFUNCTIONAL ...
1DCP: High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1DCP
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Help on bio
The enzyme histone acetyltransferases (HATs) are injected in high amount into a yeast cell. Explain how this might impact DNA ...http://www.clubsnap.com/forums/showthread.php?t=368690
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