4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate...
... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain ...http://molpharm.aspetjournals.org/content/12/6/900
Diprophylline - Wikipedia
It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Xanthine "International Non-Proprietary Names. ... Schwabe, U; Ukena, D; Lohse, MJ (September 1985). "Xanthine Derivatives as Antagonists at A1 and A2 Adenosine Receptors". ...https://en.wikipedia.org/wiki/Diprophylline
Anaesthesia and right ventricular failure. - Free Online Library
Calcium channel blockers, adenosine, magnesium, nitroglycerine and phosphodiesterase inhibitors all reduce PVR (79,80). ... Phosphodiesterase-III inhibitors increase contractility and produce both systemic and pulmonary vasodilation. In patients with ... 152.) Lobato E, Beaver T. Treatment with phosphodiesterase inhibitors type II and V: milrinone and sildenafil is an effective ... It acts by inhibiting the breakdown of cyclic guanine monophosphate by the phosphodiesterase type V isoenzyme. In children and ...https://www.thefreelibrary.com/Anaesthesia+and+right+ventricular+failure-a0200779996
Pharmacology of Caffeine | SpringerLink
Ukena, D., Schudt, C., and Sybrecht, G. W. (1993). Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase ... Locomotor Activity Adenosine Receptor Endogenous Adenosine Adenosine Analog Caffeine Treatment These keywords were added by ... Correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life ... Sattin, A., and Ralf, T. W. (1970). The effect of adenosine and adenine nucleotides on the cyclic adenosine 3',5'-phosphate ...https://link.springer.com/chapter/10.1007/978-1-4757-2913-9_5
EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem CAS 51350-19-7 | 324630
The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and ... adenosine deaminase. Find MSDS or SDS, a COA, data sheets and more information. ... Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors ... More,, The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor ...http://www.emdmillipore.com/CA/en/product/EHNA-Hydrochloride-CAS-51350-19-7-Calbiochem,EMD_BIO-324630
Bavituximab Repeat-Dose Trial in Patients Co-Infected With Chronic Hepatitis C Virus and Human Immunodeficiency Virus - Full...
Requirement for chronic daily treatment with NSAIDs, antiplatelet drugs (e.g., phosphodiesterase inhibitors, adenosine ...https://clinicaltrials.gov/show/NCT00503347?order=339
Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment | Journal of the American Heart Association
Propentofylline is a phosphodiesterase inhibitor and adenosine reuptake inhibitor with vasodilator properties. Results have ... Cholinesterase inhibitors provide modest cognitive benefit but the effect appears to be less than that seen in AD patients with ... Additionally, the cholinesterase inhibitor donepezil was studied in a RCT in patients with cerebral autosomal dominant ... Concerns over the use of cholinesterase inhibitors for VCI have included the lower effect sizes compared to AD; the ...http://jaha.ahajournals.org/content/6/5/e005568
Piracetam and Piracetam-Like Drugs | SpringerLink
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high ... Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood: brain barrier disruption in multiple ... The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional ... Nagakura A, Niimura M, Takeo S. Effects of a phospho-diesterase IV inhibitor rolipram on microsphere embolism-induced defects ...https://link.springer.com/article/10.2165%2F11319230-000000000-00000
Caffeine Standard at Thomas Scientific
adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following ... adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following ... A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It… ...https://www.thomassci.com/scientific-supplies/Caffeine-Standard
Frontiers | Functional testing in animal models of spinal cord injury: not as straight forward as one would think | Frontiers...
... monophosphate phosphodiesterase inhibitors. Psychopharmacology (Berl) 77, 309-316. doi: 10.1007/bf00432761. Pubmed Abstract , ... Wachtel, H. (1982). Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3 ...https://www.frontiersin.org/articles/10.3389/fnint.2013.00085/full
Aminophylline - Wikipedia
Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. Intravenous Aminophylline can be ... Like other methylated xanthine derivatives, aminophylline is both a competitive nonselective phosphodiesterase inhibitor which ... Adenosine also antagonizes chronotropic and ionotropic effects of circulating catecholamines. Overall, adenosine decreases the ... Adenosine's effects are concentration-dependent. Adenosine's receptors are competitively antagonized by methylxanthines such as ...https://en.wikipedia.org/wiki/Aminophylline
When and in Whom Should Stress Myocardial Perfusion Imaging be Performed - Renal and Urology News
In case pharmacologic testing is required, medications containing caffeine, phosphodiesterase inhibitors, or adenosine receptor ... Stress testing is performed with exercise or pharmacologic stress (dipyridamole, adenosine, regadenoson, or dobutamine), with ... The preferred pharmacologic stressors for myocardial perfusion imaging are the coronary vasodilators dipyridamole, adenosine, ...https://www.renalandurologynews.com/cardiology/when-and-in-whom-should-stress-myocardial-perfusion-imaging-be-performed/article/584208/
Caffeine Can Decrease Insulin Sensitivity in Humans | Diabetes Care
... it is both an adenosine receptor antagonist and a phosphodiesterase inhibitor (30). In the periphery, interstitial adenosine ... Fredholm BB: Effect of adenosine, adenosine analogues and drugs inhibiting adenosine inactivation on lipolysis in rat fat cells ... Dipyridamole, an adenosine reuptake inhibitor, acts opposite to caffeine but is unable to cross the blood-brain barrier. In an ... In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. ...http://care.diabetesjournals.org/content/25/2/364.full
Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
Described are uses of A.sub.2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses ... 1995) The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-a (TNF-. ... In addition, selective antagonists are being developed by Adenosine Therapeutics.  Inhibitors of extracellular adenosine ... Particular examples include, but are not limited to, enzymes such as adenosine deaminase, adenosine kinase, and adenosine ...http://patents.com/us-20170143726.html
... necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and ... The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clincial score ... Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication. ... Adenosine kinase inhibitor GP515 improves experimental colitis in mice.. Journal of Pharmacological and Experimental ...http://www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de/original_papers/index.html
Aminophylline - DrugBank
... adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for ... Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, ... Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone ... G-protein coupled adenosine receptor activity. Specific Function. Receptor for adenosine. The activity of this receptor is ...https://www.drugbank.ca/drugs/DB01223
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. ...https://druginfo.nlm.nih.gov/drugportal/name/Dipyridamole
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed...
... were studied in awake mice lacking one or both of the adenosine A(1) or A(2A) receptors (A(1)R or A(2A)R, respectively) using ... indicating effects of endogenous adenosine. The A(2A)R plays an important role in the modulation of O(2)C and LA by acute and ... Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes.. *Dieter Ukena, Christian Schudt, Gerhard ... Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo. * ...https://www.semanticscholar.org/paper/Physiological-roles-of-A1-and-A2A-adenosine-in-body-Yang-Chen/462ed1bcc5b5b1847b0a4a38c0ad02de3c3ee91b
Phosphodiesterase inhibitor - Wikipedia
Ukena D, Schudt C, Sybrecht GW (February 1993). "Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ... correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors". Life ... and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a ...https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor
Dipyridamole - DrugBank
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. ... A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. ... Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor ... Kulkarni SK, Patil CS: Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects. ...https://www.drugbank.ca/drugs/DB00975
Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. |...
We evaluated the effects of cilostazol, a selective inhibitor of cyclic adenosine monophosphate phosphodiesterase, on the pial ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia.. K ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. ...http://stroke.ahajournals.org/content/20/5/668
Ph Ib/IIa Study of Cabazitaxel Plus Bavituximab in Castration-resistant Prostate Cancer - Full Text View - ClinicalTrials.gov
A history of any condition requiring anti-platelet therapy (eg, phosphodiesterase inhibitors, adenosine diphosphate receptor ...https://clinicaltrials.gov/ct2/show/NCT01335204
Pulmonary pharmacology Flashcards by Malorie Deakins | Brainscape
1. phosphodiesterase inhibitor. 2. adenosine receptor antagonist. 3. activation of histone deacetylases ... 1. Phosphodiesterase inhibitor. 2. adenosine receptor antagonist. 3. activation of histone deacetylases ...https://www.brainscape.com/flashcards/pulmonary-pharmacology-3640870/packs/5189750
Apremilast (CC-10004) | CAS 608141-41-9 | AbMole BioScience | Apremilast Price
Buy PDE inhibitor Apremilast (CC-10004) from AbMole BioScience. ... orally available small molecule inhibitor of PDE4 with IC50 of ... competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist. ... A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adults.. Samrao A, et al. Arch ... Apremilast (CC-10004) is an oral phosphodiesterase 4 inhibitor. The Ki-value (affinity constant) of apremilast for PDE4 is 68 ...http://www.abmole.com/products/apremilast.html
Vardenafil hydrochloride Trihydrate (BAY38-9456) | CAS 224785-90-4 | AbMole BioScience | Vardenafil hydrochloride Trihydrate...
Buy PDE inhibitor Vardenafil hydrochloride Trihydrate (BAY38-9456) from AbMole BioScience. ... Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. ... competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist. ... RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM. ...http://www.abmole.com/products/vardenafil-hydrochloride-trihydrate.html