*  4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate...
... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain. ... a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain ...
  http://molpharm.aspetjournals.org/content/12/6/900
*  Diprophylline - Wikipedia
It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Xanthine "International Non-Proprietary Names. ... Schwabe, U; Ukena, D; Lohse, MJ (September 1985). "Xanthine Derivatives as Antagonists at A1 and A2 Adenosine Receptors". ...
  https://en.wikipedia.org/wiki/Diprophylline
*  Anaesthesia and right ventricular failure. - Free Online Library
Calcium channel blockers, adenosine, magnesium, nitroglycerine and phosphodiesterase inhibitors all reduce PVR (79,80). ... Phosphodiesterase-III inhibitors increase contractility and produce both systemic and pulmonary vasodilation. In patients with ... 152.) Lobato E, Beaver T. Treatment with phosphodiesterase inhibitors type II and V: milrinone and sildenafil is an effective ... It acts by inhibiting the breakdown of cyclic guanine monophosphate by the phosphodiesterase type V isoenzyme. In children and ...
  https://www.thefreelibrary.com/Anaesthesia+and+right+ventricular+failure-a0200779996
*  Pharmacology of Caffeine | SpringerLink
Ukena, D., Schudt, C., and Sybrecht, G. W. (1993). Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase ... Locomotor Activity Adenosine Receptor Endogenous Adenosine Adenosine Analog Caffeine Treatment These keywords were added by ... Correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life ... Sattin, A., and Ralf, T. W. (1970). The effect of adenosine and adenine nucleotides on the cyclic adenosine 3',5'-phosphate ...
  https://link.springer.com/chapter/10.1007/978-1-4757-2913-9_5
*  EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem CAS 51350-19-7 | 324630
The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and ... adenosine deaminase. Find MSDS or SDS, a COA, data sheets and more information. ... Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors ... More,, The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor ...
  http://www.emdmillipore.com/CA/en/product/EHNA-Hydrochloride-CAS-51350-19-7-Calbiochem,EMD_BIO-324630
*  Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment | Journal of the American Heart Association
Propentofylline is a phosphodiesterase inhibitor and adenosine reuptake inhibitor with vasodilator properties. Results have ... Cholinesterase inhibitors provide modest cognitive benefit but the effect appears to be less than that seen in AD patients with ... Additionally, the cholinesterase inhibitor donepezil was studied in a RCT in patients with cerebral autosomal dominant ... Concerns over the use of cholinesterase inhibitors for VCI have included the lower effect sizes compared to AD; the ...
  http://jaha.ahajournals.org/content/6/5/e005568
*  Piracetam and Piracetam-Like Drugs | SpringerLink
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high ... Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood: brain barrier disruption in multiple ... The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional ... Nagakura A, Niimura M, Takeo S. Effects of a phospho-diesterase IV inhibitor rolipram on microsphere embolism-induced defects ...
  https://link.springer.com/article/10.2165%2F11319230-000000000-00000
*  Caffeine Standard at Thomas Scientific
adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following ... adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following ... A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It… ...
  https://www.thomassci.com/scientific-supplies/Caffeine-Standard
*  Frontiers | Functional testing in animal models of spinal cord injury: not as straight forward as one would think | Frontiers...
... monophosphate phosphodiesterase inhibitors. Psychopharmacology (Berl) 77, 309-316. doi: 10.1007/bf00432761. Pubmed Abstract , ... Wachtel, H. (1982). Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3 ...
  https://www.frontiersin.org/articles/10.3389/fnint.2013.00085/full
*  Aminophylline - Wikipedia
Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. Intravenous Aminophylline can be ... Like other methylated xanthine derivatives, aminophylline is both a competitive nonselective phosphodiesterase inhibitor which ... Adenosine also antagonizes chronotropic and ionotropic effects of circulating catecholamines. Overall, adenosine decreases the ... Adenosine's effects are concentration-dependent. Adenosine's receptors are competitively antagonized by methylxanthines such as ...
  https://en.wikipedia.org/wiki/Aminophylline
*  Original Papers
... necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and ... The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clincial score ... Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication. ... Adenosine kinase inhibitor GP515 improves experimental colitis in mice.. Journal of Pharmacological and Experimental ...
  http://www.klinikum.uni-muenchen.de/Abteilung-fuer-Klinische-Pharmakologie/de/original_papers/index.html
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
Described are uses of A.sub.2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses ... 1995) The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-a (TNF-. ... In addition, selective antagonists are being developed by Adenosine Therapeutics. [0112] Inhibitors of extracellular adenosine ... Particular examples include, but are not limited to, enzymes such as adenosine deaminase, adenosine kinase, and adenosine ...
  http://patents.com/us-20170143726.html
*  Aminophylline - DrugBank
... adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for ... Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, ... Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone ... G-protein coupled adenosine receptor activity. Specific Function. Receptor for adenosine. The activity of this receptor is ...
  https://www.drugbank.ca/drugs/DB01223
*  Phosphodiesterase inhibitor - Wikipedia
Ukena D, Schudt C, Sybrecht GW (February 1993). "Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ... correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors". Life ... and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a ...
  https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor
*  Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. |...
We evaluated the effects of cilostazol, a selective inhibitor of cyclic adenosine monophosphate phosphodiesterase, on the pial ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia.. K ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. ... Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. ...
  http://stroke.ahajournals.org/content/20/5/668
*  Ph Ib/IIa Study of Cabazitaxel Plus Bavituximab in Castration-resistant Prostate Cancer - Full Text View - ClinicalTrials.gov
A history of any condition requiring anti-platelet therapy (eg, phosphodiesterase inhibitors, adenosine diphosphate receptor ...
  https://clinicaltrials.gov/ct2/show/NCT01335204
*  Pulmonary pharmacology Flashcards by Malorie Deakins | Brainscape
1. phosphodiesterase inhibitor. 2. adenosine receptor antagonist. 3. activation of histone deacetylases ... 1. Phosphodiesterase inhibitor. 2. adenosine receptor antagonist. 3. activation of histone deacetylases ...
  https://www.brainscape.com/flashcards/pulmonary-pharmacology-3640870/packs/5189750
*  Apremilast (CC-10004) | CAS 608141-41-9 | AbMole BioScience | Apremilast Price
Buy PDE inhibitor Apremilast (CC-10004) from AbMole BioScience. ... orally available small molecule inhibitor of PDE4 with IC50 of ... competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist. ... A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adults.. Samrao A, et al. Arch ... Apremilast (CC-10004) is an oral phosphodiesterase 4 inhibitor. The Ki-value (affinity constant) of apremilast for PDE4 is 68 ...
  http://www.abmole.com/products/apremilast.html
*  Patent US5667793 - Skin care compositions for treating cellulite - Google Patents
... based adenosine antagonists such as caffeine or theophylline are also known to be effective phosphodiesterase inhibitors. ... These agents block the antilipolytic action of adenosine, a potent endogenous inhibitor of lipolysis. ... Other known methods in lipolysis stimulation are achieved by inhibiting phosphodiesterase in order to prevent or at least limit ...
  http://www.google.com/patents/US5667793?dq=5920316
*  Patent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patents
... phosphodiesterase inhibitors (such as, for example, papaverine, zaprinast, sildenafil, IC 351 and the like); adenosine, ergot ... a phosphodiesterase inhibitor, adenosine, an ergot alkaloid, a vasoactive intestinal peptide, a prostaglandin, a dopamine ... a phosphodiesterase inhibitor, adenosine, an ergot alkaloid, a vasoactive intestinal peptide, a prostaglandin, a dopamine ... thromboxane synthase inhibitors, and dual acting thromboxane synthase inhibitors and thromboxane receptor antagonists. ...
  http://www.google.com/patents/US6693122?dq=6978253
*  Circulating Adenosine Levels Before and After Intravenous (IV) Persantine - Full Text View - ClinicalTrials.gov
Phosphodiesterase Inhibitors. Enzyme Inhibitors. Platelet Aggregation Inhibitors. To Top. *For Patients and Families ... Adenosine is normally removed from the bloodstream by an adenosine transporter, which is a protein that takes up adenosine from ... Adenosine levels: Adenosine levels will be measured at baseline, and 2 minutes after the persantine dose. We have recently ... Persantine causes an increase in the adenosine level in the blood. Adenosine is a naturally occurring substance in the body ...
  https://clinicaltrials.gov/ct2/show/study/NCT00760708?show_desc=Y
*  Patent US6037346 - Local administration of phosphodiesterase inhibitors for the treatment of ... - Google Patents
The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, ... Pharmaceutical compositions comprising a multifunctional phosphodiesterase inhibitor and an adenosine uptake inhibitor. ... Suitable phosphodiesterase inhibitors include, but are not limited to, inhibitors of the type III phosphodiesterases (cAMP- ... Pharmaceutical Compositions Comprising A Multifunctional Phosphodiesterase Inhibitor and An Adenosine Uptake Inhibitor. ...
  http://www.google.com.au/patents/US6037346
*  Cilostazol - Wikipedia
Cilostazol is a phosphodiesterase inhibitor with therapeutic focus on cyclic adenosine monophosphate (cAMP). It inhibits ... Cilostazol is a selective inhibitor of phosphodiesterase type 3 (PDE3) with therapeutic focus on increasing cAMP. An increase ... The proton pump inhibitor omeprazole, a potent inhibitor of CYP2C19, increases exposure to the active metabolite of cilostazol ... The FDA-approved labeling of cilostazol notes that grapefruit juice (which is a CYP3A4 inhibitor) increases the drug's maximum ...
  https://en.wikipedia.org/wiki/Cilostazol
*  Patente US20020143188 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patentes
... phosphodiesterase inhibitors (such as, for example, papaverine, zaprinast, sildenafil, IC 351 and the like); adenosine, ergot ... a phosphodiesterase inhibitor, adenosine, an ergot alkaloid, a vasoactive intestinal peptide, a prostaglandin, a dopamine ... a phosphodiesterase inhibitor, adenosine, an ergot alkaloid, a vasoactive intestinal peptide, a prostaglandin, a dopamine ... a phosphodiesterase inhibitor, adenosine, an ergot alkaloid, a vasoactive intestinal peptide, a prostaglandin, a dopamine ...
  http://www.google.es/patents/US20020143188