*  Diminished Adenosine A1 Receptor Expression in Pancreatic α-Cells May Contribute to the Pathology of Type 1 Diabetes | Diabetes
Protein concentrations were determined by Bradford assay (Bio-Rad), and cAMP levels were measured using the Cyclic Nucleotide ... Experiments shown in panel E and F were performed in the presence of the phosphodiesterase inhibitor R0-20-1724 (25 μmol/L). ... Adenosine receptor activation ameliorates type 1 diabetes. FASEB J 2007;21:2379-2388pmid:17405852. ... Inhibition of N-,P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor. Eur J ...
  http://diabetes.diabetesjournals.org/content/62/12/4208
*  CGMP-specific phosphodiesterase type 5 - Wikipedia
"Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Adv Cyclic Nucleotide Res ... "Separation of multiple molecular forms of cyclic adenosine-3',5'-monophosphate phosphodiesterase in rat cerebellum by ... Fertel R, Weiss B (1976). "Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" (abstract). ... cGMP-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various ...
  https://en.wikipedia.org/wiki/CGMP-specific_phosphodiesterase_type_5
*  Cyclic nucleotide - Wikipedia
... and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic UMP (cUMP) are less understood. cAMP is 3'5'-cyclic adenosine ... Cyclic nucleotides can be found in many different types of eukaryotic cells, including photo-receptor rods and cones, smooth ... cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate ...
  https://en.wikipedia.org/wiki/Cyclic_nucleotide
*  Frontiers | PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis | Pharmacology
More recently, we analyzed the bronchoalveolar lavage of CF and wild-type mice for cell infiltrates and expression of pro- ... More recently, we analyzed the bronchoalveolar lavage of CF and wild-type mice for cell infiltrates and expression of pro- ... Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and ... Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and ...
  https://www.frontiersin.org/articles/10.3389/fphar.2012.00167/full
*  Pentoxifylline - Wikipedia
Essayan DM (2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi ... Pentoxifylline is also an antagonist at adenosine 2 receptors. In a study, the effect of pentoxifylline as a phosphodiestrase ... inhibitor was study on the pentylenetetrazol-induced seziure in the wild-type mice. Pentoxifylline in that study reduced the ... Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which ...
  https://en.wikipedia.org/wiki/Pentoxifylline
*  Metallo-dependent phosphatase-like (IPR029052) | InterPro | EMBL-EBI
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (IPR006294). *NAD pyrophosphatase/5-nucleotidase NadN (IPR006420) ... 3,5-cyclic adenosine monophosphate phosphodiesterase CpdA (IPR026575). *Vacuolar protein sorting-associated protein 29 ( ... Predicted phosphoesterase, YhaO type (IPR014576). *Uncharacterised conserved protein UCP033093, metallophosphoesterase-type ( ... cyclic nucleotide phosphodiesterase activity.. J. Biol. Chem. 283 30942-9 2008. Matange N, Podobnik M, Visweswariah SS. ...
  http://www.ebi.ac.uk/interpro/entry/IPR029052
*  Caffeine-induced anxiety disorder - Wikipedia
Methylxanthines such as caffeine inhibit the action of cyclic nucleotide phosphodiesterase, which normally acts to break down ... Adenosine acts on A1 receptors to decrease opening of N-type Ca2+ channels in some hippocampal neurons, and therefore decrease ... Caffeine acts as an antagonist of adenosine A1 and A2A receptors. Adenosine is a normal neuromodulator that activates adenosine ... and adenosine monophosphate (AMP) and signal transduction in the form of cyclic adenosine monophosphate (cAMP). A2B and A3 ...
  https://en.wikipedia.org/wiki/Caffeine-induced_anxiety_disorder
*  ASMscience | Introduction to Second M
... and a variety of cyclic nucleotide-gated ion channels. The parallels between the mammalian cAMP network and the bacterial ... Today, the mammalian cyclic AMP (cAMP) signal transduction network is known to include a dizzying array of G-protein-coupled ... also known as cyclic di-GMP [c-di-GMP]) to proteins that contained either the GGDEF domain, the EAL domain, or both and showed ... receptors, a plethora of G-protein subunits, 10 adenylyl cyclases (9 membrane bound and 1 cytosolic), 11 PDE families, and ...
  http://www.asmscience.org/content/book/10.1128/9781555816667.ch01
*  Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
... and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, ... and the catalytic actions of cyclic nucleotide phosphodiesterase (PDE). Energy stress conditions like diet restriction, hypoxia ... The divergent mechanism of actions of resveratrol in vitro and in animals coupled with the reported health benefits in type 2 ... adenosine monophosphate activated kinase; Glu, glucose; AGEs, advanced glucose end-products; , superoxide anion; , Hydroxide ...
  https://www.hindawi.com/journals/jdr/2016/9737483/
*  Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients - Full Text View - ClinicalTrials.gov
... by adenylyl cyclase and metabolized by cyclic nucleotide phosphodiesterases (PDEs). Type 4 PDE (PDE4) is selective to cAMP in ... 5-cyclic adenosine monophosphate (cAMP) system induced by different types of chronic but not acute antidepressant treatment ... Andersen PH, Klysner R, Geisler A. Cyclic AMP phosphodiesterase activity in rat brain following chronic treatment with lithium ... Phosphodiesterase 4 Inhibitors. Phosphodiesterase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action ...
  https://clinicaltrials.gov/ct2/show/NCT00369798
*  Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes | BMC Bioinformatics | Full Text
Until recently, the roles of cyclic nucleotides in plant cells have proven difficult to uncover. With an understanding of the ... Our analysis found that several ion channels and a class of thioesterases constitute the possible cyclic nucleotide binding ... Contrary to some reports, we found no biochemical or bioinformatic evidence for a plant cyclic nucleotide regulated protein ... This paper provides a molecular framework for the discussion of cyclic nucleotide function in plants, and resolves a ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-6-6
*  EHNA - Wikipedia
"Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine ... which also acts as a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type 2 (PDE2). "Sigma Aldrich". ... EHNA (erythro-9-(2-hydroxy-3-nonyl)adenine) is a potent adenosine deaminase inhibitor, ... adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes". Mol Pharmacol. 48 (1): 121-130. PMID ...
  https://en.wikipedia.org/wiki/EHNA
*  Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). - PubMed - NCBI
2013 May 1;85(9):1297-305. doi: 10.1016/j.bcp.2013.02.026. Epub 2013 Mar 5. Research Support, N.I.H., Extramural; Research ... Cyclic AMP/metabolism*. *Cyclic Nucleotide Phosphodiesterases, Type 4/chemistry*. *Cyclic Nucleotide Phosphodiesterases, Type 4 ... cyclic 3'5' adenosine monophosphate (cAMP). PDE4 inhibitors are known to have anti-inflammatory properties, but their use in ... PDE4 is one of eleven known cyclic nucleotide phosphodiesterase families and plays a pivotal role in mediating hydrolytic ...
  https://www.ncbi.nlm.nih.gov/pubmed/23473803
*  PDE4 | Springer for Research & Development
Type IV cAMP phosphodiesterase Cyclic 3'5' adenosine monophosphate (cAMP) is a key second messenger that is responsible for ... Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu ... Keravis T, Lugnier C. Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs. Curr Pharm Des. 2010;16:1114-25.PubMed ... Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic ...
  https://rd.springer.com/referenceworkentry/10.1007/978-1-4419-0461-4_336
*  dnc - cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I - Drosophila melanogaster (Fruit fly) - dnc gene & protein
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.Curated. Phylogenomic databases. evolutionary ... Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.1 Publication. ,p>Manually curated information for which there ... These various submissions may originate from different sequencing projects, different types of experiments, or different ... cyclic phosphodiesterase 8 (Pde8), cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G (dnc), cAMP-specific 3',5'-cyclic ...
  http://www.uniprot.org/uniprot/Q9W4T4
*  Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide ... type. Contribution to journal publication status. published. subject. *Endocrinology and Diabetes. keywords. phosphodiesterase ... By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide ... By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide ...
  https://lup.lub.lu.se/search/publication/5085262
*  Myelin basic protein - Wikipedia
Cyclic-nucleotide 3'-phosphodiesterase and multiple molecules of the Immune system. GRCh38: Ensembl release 89: ENSG00000197971 ... In general, the major form of MBP is a protein of about 18.5 Kd (170 residues). In melanocytic cell types, MBP gene expression ... 1985). "Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent ... 28 (1): 1-17. doi:10.1002/jnr.490280102. PMID 1710279. Eylar EH, Brostoff S, Hashim G, Caccam J, Burnett P (September 1971). " ...
  https://en.wikipedia.org/wiki/Myelin_basic_protein
*  Phosphodiesterase inhibitor - Wikipedia
2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... "Separation of multiple molecular forms of cyclic adenosine 3',5'-monophosphate phosphodiesterase in rat cerebellum by ... Jan 2012). "Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental ... Fertel, R. and Weiss, B.: Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" Mol. ...
  https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor
*  Phosphodiesterase - Wikipedia
Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are ... "Separation of multiple molecular forms of cyclic adenosine-3′,5′-monophosphate phosphodiesterase in rat cerebellum by ... Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ...
  https://en.wikipedia.org/wiki/Phosphodiesterase
*  Adenylyl cyclase - Proteopedia, life in 3D
... cyclic adenosine monophosphate phosphodiesterase[9]. Pyrophosphate Cleavage of the by-product of this reaction, PPi, by ... Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels on neurons close to allow electrochemical signals to flow ... Type II Structure A monomer of C2 domain of has an internal, hydrophobic, anti-parallel surrounded by several, amphipathic , ... Cyclic Adenosine Monophosphate In mammals, cAMP acts as a secondary messenger, one of its functions is to control the activity ...
  http://proteopedia.org/wiki/index.php/Adenylyl_cyclase
*  Understanding of chest pain in microvascular disease proved by cardiac magnetic resonance image (UMPIRE): study protocol for a...
Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exerciseCirculationYear ... Adenosine-stress CMR protocol. Following image localizers, ventricular long cine images will be acquired. Adenosine (140 mcg/kg ... Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function ... Adenosine infusion protocol Adenosine (Adenoscan™, Sanofi-Synthelabo, Berlin, Germany) will be infused at 140 μg/kg/min [13], ...
  http://www.biomedsearch.com/nih/Understanding-chest-pain-in-microvascular/25154607.html
*  Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination...
Lugnier C: Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic ... Mouse delayed-type hypersensitivity model. CD-1 mice (n = 5/group) were sensitized with 2,4-dinitrofluorobenzene (DNFB) ... Inhibition of human monocyte TNF production by adenosine receptor agonists. Life Sci. 1993, 52: 1917-1924. 10.1016/0024-3205(93 ... Bender AT, Beavo JA: Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006, 58: 488- ...
  https://rd.springer.com/article/10.1186/ar2602
*  Plus it
Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B ... Houslay MD, Sullivan M, Bolger GB: The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: ... Of the many animal models used in the study of non-insulin-dependent (type 2) diabetes, the JCR:LA-cp rat is unique in that it ... Beavo JA: Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev75 :725 -748,1995. ...
  http://diabetes.diabetesjournals.org/content/51/4/1194
*  Control of ATP Release by Red Blood Cells and Therapeutic Applications Thereof - Patent application
Liu, Y., et al., Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake. ... Lugnier, C., Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic ... Haslam, R. J., N. T. Dickinson, and E. K. Jang, Cyclic nucleotides and phosphodiesterases in platelets. Thromb Haemost, 1999. ... Shakur, Y., et al., Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid ...
  http://www.patentsencyclopedia.com/app/20120083443
*  A New Site and Mechanism of Action for the Widely Used Adenylate Cyclase Inhibitor SQ22,536 | Molecular Pharmacology
1969) Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3′,5′-monophosphate-dependent protein ... 1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim ... 1991) Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent ... 8-bromoadenosine 3′,5′-cyclic monophosphate. 8-CPT-cAMP. 8-(4-chlorophenylthio)adenosine 3′,5′-cyclic monophosphate. 8-CPT-2′-O ...
  http://molpharm.aspetjournals.org/content/83/1/95.long