*  Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E... ... 38 Pages Report] Check for Discount on Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix ... In addition, myc has a direct role in the control of DNA replication. Myc is a proto-oncogene and it often upregulates in many ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Myc (c-Myc) protein ...
  http://www.reportsnreports.com/reports/1222401-myc-proto-oncogene-protein-transcription-factor-p64-or-class-e-basic-helix-loop-helix-protein-39-or-myc-pipeline-review-h2-2017.html
*  Cellular reprogramming: recent advances in modeling neurological diseases
The basic helix loop helix transcription factor Ascl1 alone was sufficient to induce neuronal features but the addition of Brn2 ... In a further systematic screen, another basic helix loop helix transcription factor, Neurod1, was identified that enabled the ... Although some of these concerns may be independent of the transcription factor delivery strategy, episomal vectors do allow for ... Induction of human neuronal cells by defined transcription factors. Nature. 2011;476:220-223. [PMC free article] [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3236609/?lang=en-ca
*  HAND2 - Wikipedia
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... In addition, this transcription factor plays an important role in limb and branchial arch development.[6] In one study, it was ... "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex ... Dai YS, Cserjesi P (April 2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding ...
  https://en.wikipedia.org/wiki/HAND2
*  Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. - Tufts Digital...
... basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous ... In addition to well-characterised regulation of their expression, increasing evidence is emerging for additional post- ... Of particular interest is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestrates progression from neural progenitor ...
  https://dl.tufts.edu/catalog/tufts:17305
*  SPEECHLESS integrates brassinosteroid and stomata signalling pathways.
In Arabidopsis thaliana, the basic helix-loop-helix transcription factor SPEECHLESS (SPCH) regulates the entry, amplifying and ... Here, we show that in addition to MAPKs, SPCH activity is also modulated by brassinosteroid (BR) signalling. The GSK3/SHAGGY- ... asymmetric cell-division - arabidopsis-thaliana - receptor kinases - phosphorylation sites - transcription factors - secretory ...
  http://library.wur.nl/WebQuery/wurpubs/427649
*  The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
... an effect augmented by coexpression of the basic-helix-loop helix transcription factor E47. The ability to interact directly ... In addition to this, ectopic expression of EBF induces the activity... (More). The development of mature B lymphoid cells ... an effect augmented by coexpression of the basic-helix-loop helix transcription factor E47. The ability to interact directly ... Transcription Factors : physiology, Cell Line, Cell Differentiation : immunology, Cell Differentiation : genetics, Base ...
  https://lup.lub.lu.se/search/publication/108016
*  Biomolecules | Free Full-Text | Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter...
In addition to these transcription factors, activator protein-1 may also be activated in hepatocytes due to its association ... An increase in ROS activates nuclear factor erythroid-2-related factor-2 (Nrf2) and hypoxia inducible factor (HIF) to provide ... Increased ROS, IL-1β, acetaldehyde, and increased hepatic iron, all activate nuclear factor-kappa B (NF-κB) transcription ... These transcription factors are central to alcohol-mediated hepatotoxicity. ...
  http://www.mdpi.com/2218-273X/6/3/29/htm
*  OriGene - HAND2 (NM 021973) Human ORF cDNA Clone
Gene Summary: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene ... In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul ...
  http://www.origene.com/orf_clone/trueclone/NM_021973/RC224436/HAND2.aspx
*  Heart and Neural Crest Derivatives Expressed 2 (HAND2) ELISA Kits
basic helix-loop-helix transcription factor HAND2 , class A basic helix-loop-helix protein 26 , deciduum, heart, autonomic ... In addition, this transcription factor plays an important role in limb and branchial arch development. ... helix-loop-helix transcription factor expressed in embryo and deciduum , thing-2 , han , hands off , dHAND basic helix-loop- ... The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ...
  http://www.antibodies-online.com/tube-formation-pathway-81/hand2-elisa-kit-1411/
*  Protocols and Video Articles Authored by Monica L. Vetter (Translated to Danish)
Proneural basic helix-loop-helix (bHLH) transcription factors play a central role in regulating neurogenesis, and thus the ... In addition, our data reveal that other retinal factors are required for accurate regulation of Math5 by Pax6. ... Basic helix-loop-helix (bHLH) transcription factors are required for the development of specific subpopulations of neurons, but ... Sep, 2005 , Pubmed ID: 16112102 Proneural basic helix-loop-helix (bHLH) transcription factors are critical positive regulators ...
  https://www.jove.com/author/Monica+L._Vetter?language=Danish
*  Myogenesis - Wikipedia
... basic helix-loop-helix) proteins transcription factor family. Cells that make myogenic bHLH transcription factors (including ... In addition, satellite cells have the capability to also differentiate into bone or fat. In this way, satellite cells have an ... Basic helix-loop-helix (bHLH) transcription factors, MyoD, Myf5, myogenin, and MRF4 are critical to its formation. MyoD and ... Sim2, a BHLH-Pas transcription factor, inhibits transcription by active repression and displays enhanced expression in ventral ...
  https://en.wikipedia.org/wiki/Myogenesis
*  Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells | Circulation...
HIF-2α is a basic helix-loop-helix/PAS domain transcription factor that is similar in composition to HIF-1α but has distinct ... Following the addition of 250 μmol/L H2O2 to the sample of interest, 100 μL was removed at specific time points and added to ... a transcription factor required for pluripotency of embryonic stem cells. This latter regulatory role for HIF-2α provides a ... Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells. Cindy M. Martin ...
  http://circres.ahajournals.org/content/102/9/1075.long
*  Myc - Wikipedia
Myc family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motifs. Through ... This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ...
  https://en.wikipedia.org/wiki/Myc
*  An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling. ...
... with the basic helix-loop-helix transcription factor MYC2. PYL6 and MYC2 interact in yeast two hybrid assays and the ... Finally, pyl6 T-DNA mutant plants show an increased sensitivity to the addition of JA along with ABA in cotyledon expansion ... An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling. ... An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling ...
  https://www.ncbi.nlm.nih.gov/pubmed?term=27357749
*  Plus it
... which belong to the basic helix-loop-helix leucine zipper transcription factors (5). SREBP-1a and -1c are encoded by a single ... rendering the 1a isoform much more active in stimulating transcription (14). In addition to their roles in transcription, ... Tontonoz P, Kim JB, Graves RA, Spiegelman BM: ADD1, a novel helix-loop helix transcription factor associated with adipocyte ... Free fatty acids are thought to represent an important factor linking excess fat mass to type 2 diabetes. In addition, free ...
  http://diabetes.diabetesjournals.org/content/51/suppl_3/S414
*  OriGene - TCF4 (NM 001083962) Human ORF cDNA Clone
Human transcription factor 4 (TCF4), transcript variant 1 available for purchase from OriGene - Your Gene Company. ... Gene Summary: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein ... In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs ... Mouse transcription factor 4 (Tcf4). $920. 3 weeks. MR222956L1. Lenti ORF clone of Tcf4 (Myc-DDK-tagged) - Mouse transcription ...
  http://www.origene.com/orf_clone/trueclone/NM_001083962/RC224345/TCF4.aspx
*  Identification of a Survival-Promoting Peptide in Medium Conditioned by Oxidatively Stressed Cell Lines of Nervous System...
... a member of the family of basic helix-loop-helix transcription factors (McCormick et al., 1996) that may function to promote ... In addition, this area can be defined readily because it forms a sharp boundary with area 4 medially (where the granular layer ... In addition, it was observed that initial batches of the peptide contained Ser instead of Ala at position 20, a substitution ... In addition, there were no signs of bacterial or fungal growth in the cultures that were treated with appropriate antibiotic ...
  http://www.jneurosci.org/content/18/18/7047.long
*  Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons |...
Myf5 is a key basic Helix-Loop-Helix transcription factor capable of converting many non-muscle cells into muscle. Together ... This phenomenon may be widespread and it remains to be seen how many other potentially potent regulatory genes, in addition to ... Furthermore, the gene encoding the basic Helix-Loop-Helix transcription factor mSim1 is expressed in adjacent cells in both the ... Myf5 is transcribed in differentiated neurons after the expression of neural basic Helix-Loop-Helix transcription factors. The ...
  http://dev.biologists.org/content/127/2/319
*  Myc - Wikipedia
Myc family of transcription factors contain a bHLH (basic helix-loop-helix) structural and LZ (leucine zipper) motives. Through ... This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding ...
  https://en.wikipedia.org/wiki/C-myc
*  ARNT2 - Wikipedia
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The ... suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis ... 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role ... Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex ...
  https://en.wikipedia.org/wiki/ARNT2
*  Plus it
The basic helix-loop-helix transcription factors Twist1 and Twist2 have been found to abrogate oncogene-induced apoptosis and ... In addition, like Twist1, Twist2 has an altered expression in a set of primary tumours and tumour cell lines, indicating that ...
  http://cancerres.aacrjournals.org/content/67/9_Supplement/5291
*  Mehrdad Shamloo | Stanford Medicine Profiles
Basic helix-loop-helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the ... In addition to our proof of concept studies showing the cognitive deficits of β1-ADR knockout mice, we have also shown that ... Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia EUROPEAN JOURNAL OF ... The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) ...
  https://med.stanford.edu/profiles/mehrdad-shamloo
*  Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice | JCB
Merkel cells originate from epidermal progenitors and require expression of the basic helix-loop-helix transcription factor ... In addition to its role as a barrier, skin also houses multiple somatosensory receptors, each tuned to detect different forms ... A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive ... Recent work suggests that the transcription factor Sox2 is a direct, positive regulator of Atoh1, whereas the Polycomb ...
  http://jcb.rupress.org/content/208/3/367
*  SMART: Secondary literature for PAC domain
Basic-helix-loop-helix (bHLH) transcription factors are involved in the control of many developmental processes in vertebrates ... The addition of p-coumaric acid to the apoPYP sample did not result in the recovery of PYP. In contrast, yellow products were ... cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs ... Many basic helix-loop-helix (bHLH) transcription factors are known as key regulators of embryonic development or ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=PAC
*  JAIRO | Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal...
Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cellsBasic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells ...
  http://jairo.nii.ac.jp/0012/00004633/en
*  The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Hand2 has no effect on the initial stages of sympathetic neuron development, including the expression of the proneural gene ascl1 and the pan-autonomic regulatory genes phox2b and phox2a, nor on generic neuronal differentiation as assessed by the expression of elavl3. Therefore, hand2 seems to be required selectively for initial noradrenergic but not pan-neuronal differentiation.. Hand2 has been considered an important member of the transcriptional network controlling sympathetic neuron development due to its ability to induce the generation of noradrenergic/catecholaminergic neurons in gain-of-function experiments (Howard et al., 1999; Howard et al., 2000). Overexpression is an important tool to identify candidate target genes, but in the sympathetic lineage different effects were observed upon transcription factor overexpression compared with in vivo loss-of-function approaches. Gata2/3, for instance, is essential for Th expression during normal development of sympathetic ...
  http://dev.biologists.org/content/133/20/4015
*  Genes | Free Full-Text | A Genome-Wide Identification and Analysis of the Basic Helix-Loop-Helix Transcription Factors ...
The basic helix-loop-helix (bHLH) transcription factors in insects play essential roles in multiple developmental processes including neurogenesis, sterol metabolism, circadian rhythms, organogenesis and formation of olfactory sensory neurons. The identification and function analysis of bHLH family members of the most destructive insect pest of rice, Nilaparvata lugens, may provide novel tools for pest management. Here, a genome-wide survey for bHLH sequences identified 60 bHLH sequences (NlbHLHs) encoded in the draft genome of N. lugens. Phylogenetic analysis of the bHLH domains successfully classified these genes into 40 bHLH families in group A (25), B (14), C (10), D (1), E (8) and F (2). The number of NlbHLHs with introns is higher than many other insect species, and the average intron length is shorter than those of Acyrthosiphon pisum. High number of ortholog families ...
  http://www.mdpi.com/2073-4425/7/11/100
*  Neurogenin-3 - Wikipedia
Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[5]. Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[6] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[7]. Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro.[8] Human[9] and rodent[10][11][12][13][14][15][16][17][18] exocrine cells have been reprogrammed into ...
  https://en.wikipedia.org/wiki/NEUROG3
*  HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/A0JND0
*  Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
Basic helix-loop-helix (bHLH) transcription factors are required for proper formation of the vertebrate and invertebrate nervous systems (Bertrand et al., 2002). The vertebrate neural bHLH transcription factors have been classified into subgroups based on their temporal pattern of expression (Lee, 1997) and on their homology to Drosophila proneural genes (Bertrand et al., 2002). The factors Mash1, a homolog of the Drosophila Achaete-scute genes (Johnson et al., 1990), and Math1, a homolog of the Drosophila atonal gene (Akazawa et al., 1995), both belong to the early expressed sub-group of bHLH factors because of their expression in progenitor cells of the developing neural tube, but they reside in distinct sub-classes based on sequence homology (Bertrand et al., 2002). Gene knockout studies have demonstrated ...
  http://dev.biologists.org/content/131/6/1319
*  Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance...
Transcription factors undergo very dynamic binding cycles on promoters (Hager et al., 2009; Michel, 2009). 'Slow' promoters are thought to require more extensive chromatin modification for activation than 'fast' promoters and hence require greater promoter residence time for activation. Consistent with this, increased dwell time on promoters is associated with more active transcription (Stavreva et al., 2004; Hager et al., 2009; Voss et al., 2011). Could differential requirements for transcription factor occupancy be used to differentially control distinct targets of a master regulatory transcription factor in response to a changing cellular environment? We have explored whether such a mechanism might coordinate cell cycle length and differentiation during nervous system development.. The proneural basic helix-loop-helix ...
  http://dev.biologists.org/content/139/10/1718
*  Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in...
This study uncovered a function of the dual specificity ERK MAP kinase phosphatase, MKP3, for the specification of mesenchymal progenitors in the somite sclerotome. We showed that Mkp3 was expressed in a twin-striped pattern, which closely matched the emergence of scleraxis transcripts along the anteroposterior somite edges (Fig. 1). This pattern suggested a link between the modulation of FGF signalling by MKP3 and scleraxis expression. We demonstrated that somitic expression of Mkp3 in the dorsal sclerotome was itself dependent on active ERK MAP kinase. This implied that FGF signalling in dorsal sclerotome cells is modulated by a negative feedback loop, which involves MKP3 and ERK MAP kinase. Indeed, we found that the levels of Mkp3 transcripts detected in response to FGF beads can cycle between extensive overexpression after a short exposure to complete loss of endogenous Mkp3 message after 24 hours (Fig. 3A-C; data not shown). We showed by western blot analysis that this dynamic response ...
  http://dev.biologists.org/content/132/6/1305
*  Abstract 14: The Helix-Loop-Helix Transcription Factor nPAS4 Induces Sprouting Angiogenesis and Regulates Tip Cell Formation |...
Introduction: Neuronal PAS4 (nPAS4) -formerly known as LE-PAS- is a helix-loop-helix-PAS (HLH-PAS) transcription factor that has recently been cloned as the vertebrate homologue of the drosophila protein dysfusion (dys). In drosophila, the lack of dys is characterized by impaired midline fusion of tracheal tubes. Forced expression of dys results in aberrant sprouting of tracheal tubes in drosophila. In neurons, nPAS4 plays a role in the formation of GABA-releasing synapses. Based on the morphological similarity between tracheal tube formation and angiogenesis, we aimed to investigate the role of nPAS4 in angiogenesis in vertebrates.. Methods and Results: RT-PCR and Western blotting analyses showed that nPAS4 is expressed at low levels in various endothelial cell lines. The expression of nPAS4 is not upregulated by angiogenic growth factors but is induced by hypoxia. Moreover, membrane ...
  http://atvb.ahajournals.org/content/32/Suppl_1/A14
*  Genetic risk expressed in early regulator of gene expression | Genes 2 Brains 2 Mind 2 Me
Image via Wikipedia The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and neurite outgrowth. As such, it makes for a particularly interesting point to begin to understand mental illness and its complex developmental origins. The recent paper by Ho et al., 'Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness…
  https://genes2brains2mind2me.com/2009/06/29/genetic-risk-expressed-in-early-regulator-of-gene-expression/
*  Proneural genes - Wikipedia
Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor cells. Proneural genes have multiple functions in neural development. They integrate positional information and contribute to the specification of progenitor-cell identity. From the same ectodermal cell types, neural or epidermal cells can develop based on interactions between proneural and neurogenic genes. Neurogenic genes are so called because loss of function mutants show an increase number of developed neural precursors. On the other hand, proneural genes mutants fail to develop neural precursor cells. The proneural genes are expressed in groups of cells (proneural clusters) from which one progenitor cell - typically the one in the middle - will be singled out, leading to the formation of many different types of ...
  https://en.wikipedia.org/wiki/Proneural_genes
*  HEA798Hu | 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型) | Homo sapiens (Human,人) USCN(武汉优尔生商贸有限公司)
HEA798Hu, High Sensitive ELISA Kit for Hypoxia Inducible Factor 1 Alpha (HIF1a), 低氧诱导因子1α(HIF1a)检测试剂盒(酶联免疫吸附试验法,高敏型), HIF1-A; MOP1; PASD8; Basic Helix-Loop-Helix Transcription Factor; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
  http://www.uscnk.cn/uscn/High-Sensitive-ELISA-Kit-for-Hypoxia-Inducible-Factor-1-Alpha-
*  Cell cycle switch to endocycle: the nucleolus lends a hand. - Physiology, Anatomy and Genetics
The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis but how its developmental activity is regulated is largely unknown. We recently showed that Hand1 is sequestered in the nucleoli of rodent trophoblast stem (TS) cells by the I-mfa domain-containing protein HICp40 and that this is associated with their proliferation and continuing self-renewal. However when these cells commit to differentiate into trophoblast giant (TG) cells, Hand1 is phosphorylated by the polo-like kinase Plk4 (Sak) and released into the nucleus to activate downstream target genes. This event underlies the release of Hand1 from the nucleolus and represents the 'molecular switch' that promotes mitotic cell cycle exit and the onset of endoreduplication. In this brief discussion we examine the wider implications of these findings and address some of the unanswered questions that remain.
  https://www.dpag.ox.ac.uk/publications/251937
*  "Serotonin-Expressing Cells in the Corpus of the Stomach Originate from" by Brian T. Johnston
Neurogenin 3 and its downstream target NeuroD are basic helix-loop-helix transcription factors which promote endocrine differentiation in the gastrointestinal tract. However, mice lacking Ngn3 still produce several hormones in the stomach. Lineage tracing mouse models demonstrated that a majority of hormone cells in the corpus region of the stomach did not express Ngn3 or NeuroD during differentiation. Serotonin and histamine cells were entirely NeuroD-independently derived, and serotonin cells were additionally entirely Ngn3-independently derived. In this study, we isolated serotonin and histamine cells from the gastric corpus of transgenic mice expressing the fluorescent marker CFP. Serotonin cells expressed multiple mast cell markers by RT-PCR, and were found to be nearly absent in a mast cell-deficient mouse model. Labeled bone marrow transplant mice ...
  http://escholarship.umassmed.edu/gsbs_diss/639/
*  Gene Expression Literature Detail
J:89474 Morikawa Y, Cserjesi P, Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204 ...
  http://www.informatics.jax.org/gxdlit/key/37408
*  Neurogenic differentiation capacity of subacromial bursal tissue-derived stem cells. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Adem Aydın, Gökhan Duruksu, Gülay Erman, Cansu Subaşı, Ayça Aksoy, Zehra Seda Unal, Erdal Karaöz].
  http://www.sigmaaldrich.com/catalog/papers/24115219
*  anti-HIF1 alpha antibody | GeneTex
HIF1 alpha antibody (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)) for ICC/IF, IHC-Fr, IHC-P, IP, WB, ChIP assay. Anti-HIF1 alpha pAb (GTX127309) is tested in Human, Mouse, Rat, Bovine samples. 100% Ab-Assurance.
  http://www.genetex.com/HIF1-alpha-antibody-GTX127309.html
*  Gene Expression Literature Detail
J:55991 Brown D, Wagner D, Li X, Richardson JA, Olson EN, Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29 ...
  http://www.informatics.jax.org/gxdlit/key/15085
*  Gene Expression Literature Detail
J:165754 Watanabe T, Koibuchi N, Chin MT, Transcription factor CHF1/Hey2 regulates coronary vascular maturation. Mech Dev. 2010 Sep-Dec;127(9-12):418-27 ...
  http://www.informatics.jax.org/gxdlit/key/114737
*  Anti-cancer gene discovered: Perspective for therapy
With mice, and in collaboration with colleagues from the United States, they showed that loss of one of those genes, Atonal homolog 1 or ATOH1, causes colon cancer. The gene regulates the last step in the specialization to epithelial cell of the colon. Humans with colon cancer frequently have an inactivated ATOH1 gene, the researchers observed.. Treatment. The researchers could - in a test tube - reactivate the gene in human colon cancer cells. The tumor cells stopped growing and committed suicide. Since they were able to switch the gene on with a reasonably simple chemical, this opens possibilities to one day perhaps switch the gene back on in living patients. It will be very important in the future to study in detail how exactly ATOH1 does performs its anti-cancer job. ...
  http://www.innovations-report.com/html/reports/life-sciences/anti-cancer-gene-discovered-perspective-therapy-128067.html
*  HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP] (NB100-132H): Novus Biologicals
Mouse Monoclonal Anti-HIF-2 alpha/EPAS1 Antibody (ep190b) [HRP]. Validated: WB, ELISA, IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
  https://www.novusbio.com/products/hif-2-alpha-epas1-antibody-ep190b_nb100-132h
*  anti-MATH1 antibody [C2C3], C-term | GeneTex
MATH1 antibody [C2C3], C-term (atonal homolog 1 (Drosophila)) for IHC-P. Anti-MATH1 pAb (GTX111898) is tested in Mouse samples. 100% Ab-Assurance.
  http://www.genetex.com/MATH1-antibody-C2C3-C-term-GTX111898.html
*  Gene Expression Literature Detail
J:143526 Storm R, Cholewa-Waclaw J, Reuter K, Brohl D, Sieber M, Treier M, Muller T, Birchmeier C, The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development. 2009 Jan;136(2):295-305 ...
  http://www.informatics.jax.org/gxdlit/key/87286