CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens | eLife
... cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells. ... Protective adaptive immunity relies on cellular and humoral immune responses. Through presenting processed antigens on their ... Immune cells called T follicular helper cells activate the cells that produce antibodies, the B cells. The T follicular helper ... Skin dendritic cells induce follicular helper T cells and protective humoral immune responses * C Yao ...https://elifesciences.org/articles/17979
Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection ...
... cells are professional antigen presenting cells that play a pivotal role in orchestrating both the innate and adaptive immune ... follicular dendritic cells (FDCs), and interdigitating dendritic cells (IDCs). IDCs are primarily located in the T cell areas ... Follicular dendritic cell tumour of the liver; evidence for an Epstein-Barr virus-related clonal proliferation of follicular ... 1 Dendritic cells are a heterogeneous group of cells that includes Langerhans' cells, dermal dendrocytes, ...http://jcp.bmj.com/content/57/1/87
T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells | The Journal of...
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells. Madelene W. Dahlgren, ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells ... T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells ...http://www.jimmunol.org/content/early/2015/04/25/jimmunol.1401938
Laboratory for Mucosal Immunity | RIKEN
"Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis.". Annu. Rev. Immunol. 28:243-273 ... "The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.". Immunity ... "Preferential generation of follicular B helper T (TFH) cells from Foxp3+ T cells in gut Peyer's patches.". Science, 323:1488- ... "Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune ...http://www.riken.jp/en/research/labs/ims/mucos_immun/
Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-κB p50-deficient mice | BMC...
... an important component of secreted IgM's ability to enhance adaptive immune responses. To further define the requirement for MZ ... they transport them into B cell follicles for deposition onto follicular dendritic cells (FDCs), ... These cells bound high levels of IgM-IC both in vivo and in vitro. Subsequent to the binding of IgM-IC by the MZ B cells in p50 ... Once MZ B cells bind IgM-containing immune complexes (IgM-IC), ... had small numbers of MZ B cells, as determined by cell surface ...https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-6-8
Vaccines | Free Full-Text | Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene...
Immunological staining revealed a significant migration of lymphocytic cells to the EP site, congregating around cells ... device as well as the effect that this treatment would have on the resident immune cells in that tissue was investigated. ... However, histological analysis by fluorescent microscopy revealed GFP positive cells as early as 1 h after plasmid delivery and ... Using an antibody specific for a keratinocyte cell surface marker, reporter gene positive keratinocytes in the epidermis were ...http://mdpi.com/2076-393X/1/3/384/htm
List of all Brief Reviews Articles | The Journal of Immunology
Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity. Marco Rossi and James ... The Importance of Dendritic Cells in Maintaining Immune Tolerance. Cindy Audiger, M. Jubayer Rahman, Tae Jin Yun, Kristin V. ... Signaling Pathways in T Follicular Helper Cells. Julia Rolf, Kirsten Fairfax, and Martin Turner. J Immunol 2010 184: 6563-6568 ... Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors. Bali Pulendran. J Immunol 2005 174 ...http://www.jimmunol.org/briefreviews
Autoimmune regulator - Wikipedia
2013). "AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment". ... List of human clusters of differentiation for a list of CD molecules Immune system Immune tolerance GRCh38: Ensembl release 89 ... AIRE gene is also expressed in the 33D1+ subset of dendritic cells in mouse and in human dendritic cells. The AIRE gene is ... This recognition is accomplished by the T cell receptors expressed on the cell surface. T cells receptors are generated by ...https://en.wikipedia.org/wiki/Autoimmune_regulator
CY5 Goat Anti-Mouse IgM, Human Adsorbed | SouthernBiotech
CD8α- dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses. Cell Rep ... miR-182 is largely dispensable for adaptive immunity: lack of correlation between expression and function. J Immunol. 2015;194: ... Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med. ... Expansion of CD22lo B cells in the spleen of autoimmune-prone flaky skin mice. Cell Immunol. 2005;234:124-32. (IHC-FS). ...https://www.southernbiotech.com/?catno=1020-15&type=Polyclonal
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... we are able to observe the dynamics of immune complex deposits on secondary follicular dendritic cells - on the level of a few ... The lack of mechanistic data presumably reflects the complexity involved with this adaptive response, suggesting that nonbiased ... Phagocytic cells play a major role in the innate immune system by removing and eliminating invading microorganisms in their ... Transfer bacterial cells from one plate to another using the replica-plating procedure. ● Given an experimental task, select ...https://www.jove.com/visualize/abstract/23555721/multiple-symbiont-acquisition-strategies-as-an-adaptive-mechanism
Dendritic cell-mediated immune humanization of mice: implications for allogeneic and xenogeneic stem cell transplantation -...
... cells. After immunization, draining lymph nodes became replenished with terminally differentiated human follicular Th cells, ... transplanted with human stem cells is currently limited because of incomplete maturation of lymphocytes and scarce adaptive ... Dendritic cell-mediated immune humanization of mice: implications for allogeneic and xenogeneic stem cell transplantation ... Dendritic cell-mediated immune humanization of mice: implications for allogeneic and xenogeneic stem cell transplantation. ...https://www.zora.uzh.ch/id/eprint/101940/
Mouse Aorta Smooth Muscle Cells Differentiate Into Lymphoid Tissue Organizer-Like Cells on Combined Tumor Necrosis Factor...
T cells, and smooth muscle cells (SMC). Plaque leukocytes1,2 interacting with SMC3-6 are thought to initiate adaptive immune ... However, evidence that macrophage/foam cells/dendritic-like cells (DC)7 and T cells may mediate antigen-dependent T-cell ... 8 T-cell and B-cell responses typically require antigen-presenting DC in T-cell areas, follicular DC in activated germinal ... Supernatants of TNFR-1/LTβR-activated SMC markedly supported migration of splenic T cells, B cells, and macrophages/dendritic ...http://atvb.ahajournals.org/content/30/3/395
Marginal zone B-cell - Wikipedia
Similar to B1 B cells, MZ B cells can be rapidly recruited into the early adaptive immune responses in a T cell independent ... "Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses". Immunity. 2002; ... and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. In humans the splenic ... marginal zone B-cells will fail to develop while B-1 cells will still be present. MZ B-cells are the only B-cells dependent on ...https://en.wikipedia.org/wiki/Marginal_zone_B-cell
The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease | The Journal of Immunology
... likely secondary to increased lymph node T follicular helper cells and IL-23-expressing dendritic cells (5), all changes that ... The relationship between resident microbiota and this flagship innate response and the subsequent adaptive immune response in ... Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 163: 367-380. ... Gut microbiota regulates K/BxN autoimmune arthritis through follicular helper T but not Th17 cells. J. Immunol. 196: 1550-1557. ...http://www.jimmunol.org/content/196/12/4839
Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus |...
TLRs bridge innate and adaptive immune responses and may play an important role in the pathogenesis of systemic lupus ... rather than by non-DNA specific follicular B cells. Both classes of INH-ODNs can block animal lupus. Hence, therapeutic ... CpG-DNA ligands or to immune complexed self-RNA triggers activation of autoreactive B cells and plasmacytoid dendritic cells. ... and are preferentially recognized by autoreactive B cells and plasmacytoid dendritic cells, ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar1888
Capitalizing on the Immunogenicity of Dying Tumor Cells | Clinical Cancer Research
The principal immune components charged with this task are macrophages and dendritic cells, the key mononuclear phagocytes. ... Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 2004 ... adaptive immune recognition is likely accomplished through an indirect mechanism that exploits the capture of dying tumor cells ... The uptake of dying tumor cells by macrophages and dendritic cells may evoke either tolerance or protective immunity (top). The ...http://clincancerres.aacrjournals.org/content/14/6/1603
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and...
Non-hypermutated tumors are enriched with immunosuppressive cells, and the expression of immunoinhibitors and MHC molecules is ... Hypermutated tumors are depleted of immunosuppressive cells and show upregulation of immunoinhibitory molecules. ... so far little attention has been devoted to either define the antigenicity of these mutations or to characterize the immune ... Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14:1014-22.View ArticlePubMedPubMed Central ...https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0620-6
The Birth of a Cell Type | The Journal of Immunology
... anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J. Cell Biol. 79: 184-199. ... The strange looking and rare spleen DC now are well known to be a major player in both innate resistance and adaptive immunity ... Anatomy of germinal centers in mouse spleen, with special reference to ′follicular dendritic cells'. J. Cell Biol. 77: 148-164 ... It had been shown that Ag-Ab complexes were retained on the surface of dendritic follicular reticular cells (6, 7). Also, skin ...http://www.jimmunol.org/content/178/1/3
The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity | JEM
... where B cells, interacting with T follicular helper (Tfh) and follicular dendritic cells, undergo somatic hypermutation and ... no role for Zbtb20 in the adaptive immune system has been described. ... B1 cells, follicular B cells (B220+/CD23+) from spleen, BM Blimp-GFP+/syndecan-1+ ASC and splenic PNA+/FAS+/B220+ GC B cells as ... follicular B cells; MZ, marginal zone B cells; T1/2, transitional 1/2 B cells. (C) Flow cytometry to identify B1 and ASC in ...http://jem.rupress.org/content/early/2014/04/01/jem.20131831
CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses | The Journal of Immunology
plasmacytoid dendritic cell. TCM. central memory T cell. TEM. effector memory T cell. TFH. follicular B helper T cell. TSST. ... memory T cells to mediate a faster and more effective response to secondary pathogen challenge is a central feature of adaptive ... B cell lymphoma 6. cDC. conventional dendritic cell. DC. dendritic cell. GC. germinal center. ICOS-L. ICOS ligand. PD1. ... naive cells, and CD20+CD27+ memory B cells. Circulating conventional dendritic cells (cDCs) and plasmacytoid dendritic cells ( ...http://www.jimmunol.org/content/186/10/5556?ijkey=94a887d97ecd0aacd9ba1d31d23d70d459d13202&keytype2=tf_ipsecsha
B Cells - Denzin 4/5/16 Flashcards by Tom Kuriakose | Brainscape
Study B Cells - Denzin 4/5/16 flashcards from Tom Kuriakose ... run into follicular dendritic cells, which serve as antigen ... follicular B cells : usually T-dependent responses [most adaptive immune responses!). * marginal zone B-2 B cells : usually T- ... recognition phase] : B cell + antigen → crosslinking (signal1). helper T cells or innate immune system come through with ... signal 2 : interaction with helper T cell. T-dep : mediated mainly through CD40 (on B cell) + CD40L (CD40 ligand on T cell) + ...https://www.brainscape.com/flashcards/b-cells-denzin-4-5-16-5030472/packs/7410947
Putting J Chain Back on the Map: How Might Its Expression Define Plasma Cell Development? | The Journal of Immunology
Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat. Rev. Genet. 11: 47-59. ... Mammalian B cells are subdivided into three main lineages: B2 (follicular B cells), B1, and marginal zone B cells, based on ... dendritic cell. J chain. joining chain. KO. knockout. LP. lamina propria. pIgR. poly-Ig receptor.. ... B1 cells, composed of B1a or B1b cells, are considered "innate-like" B cells (79), which differentiate early in development ...http://www.jimmunol.org/content/193/7/3248
PGI2 as a Regulator of Inflammatory Diseases
... biological response modifiers and the family of cell adhesion-promoting molecules. ... Dendritic cells are an important bridge between the innate and the adaptive immune system. PGI2 analogues decreased mouse bone ... follicular dendritic cells, endothelial cells, smooth muscle cells, and thymic nurse cells. Production of PGI2 is decreased by ... dendritic cells, eosinophils, T regulatory cells, and activated T cells [4, 17]. IP receptors are also found on many cell types ...https://www.hindawi.com/journals/mi/2012/926968/
SLE - Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus |...
It has numerous possible effects on T lymphocytes and dendritic cells, and it influences apoptosis. These differential effects ... is a proinflammatory cytokine and a B-cell growth factor. ... on a variety of cells of the innate and adaptive immune system ... Deficiency of TNF results in the absence of germinal centers and in the absence of follicular dendritic cells. In particular, ... TNF has differential effects on B cells, on T cells and on dendritic cells as well as on the process of programmed cell death. ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar770
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Control of Immune Tolerance by Aire-Expressing Cells. Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA T Follicular ... Short Talk: Toll-Like Receptor 10 Is a B-Cell Intrinsic Suppressor of Adaptive Humoral Immune Responses ... HIV-1 Alters the Threshold for Type I Interferon Signaling in Dendritic Cells. ... Short Talk: Innate Immune Mechanisms and Early NK Cell Activation as a Result of MPL and QS-21 Combination Controls the ...http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1334