Exposure of βL-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity | Biochemical...
Exposure of βL-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity. M Seccia, O ... 2. beta L-Crystallin was exposed to defined radical species that were generated radiolytically, and transglutaminase activity, ... Exposure of βL-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity ... Exposure of βL-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity ...http://www.biochemj.org/content/274/3/869
Epidermal Transglutaminase (TGase 3) Is the Autoantigen of Dermatitis Herpetiformis | JEM
Transglutaminase Activity Assay.. TGe and TGc activity was measured by incorporation of [1,4-3H]putrescine as described ... the activity of the recombinant human TGe was 2.5 times higher than the background activity of transglutaminases present in ... but not tissue transglutaminase or keratinocyte transglutaminase. These findings demonstrate that epidermal transglutaminase, ... transglutaminase; TGc, tissue (cellular, type 2) transglutaminase; TGe, epidermal (type 3) transglutaminase; TGk, keratinocyte ...http://jem.rupress.org/content/195/6/747
Plants | Free Full-Text | Regulation of Pollen Tube Growth by Transglutaminase | HTML
In such processes, the activity of transglutaminases is enhanced, leading to the formation of cross-linked products (including ... These activities are based on the dynamics of the cytoskeleton. Changes to both actin filaments and microtubules are triggered ... Transglutaminases are also secreted in the extracellular matrix, where they may take part in the assembly and/or strengthening ... Transglutaminases are suggested to have a general role in the interaction between pollen tubes and the extracellular matrix ...http://mdpi.com/2223-7747/2/1/87/htm
Transglutaminase 2-Mediated Activation of β-Catenin Signaling Has a Critical Role in Warfarin-Induced Vascular Calcification |...
Warfarin upregulates transglutaminase 2 (TG2) expression (A) and activity (B) in A10 vascular smooth muscle cells (VSMCs). TG2 ... Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. J Med Chem. ... TG2 Activity. TG2 activity in total cell lysates was assayed in an ELISA-like assay as previously described29 by incorporation ... Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures. ...http://atvb.ahajournals.org/content/32/1/123
Anti-Transglutaminase 2 antibody (ab421) References | Abcam
Anti-Transglutaminase 2 antibody (ab421) has been cited in 16 publications. References for Human, Mouse, Rat, Cat in ICC/IF, ... Petersen-Jones HG et al. Transglutaminase activity is decreased in large arteries from hypertensive rats compared with ... Deasey S et al. Transglutaminase 2 as a novel activator of LRP6/ß-catenin signaling. Cell Signal 25:2646-51 (2013). IP . PubMed ... Dafik L et al. Activation and inhibition of transglutaminase 2 in mice. PLoS One 7:e30642 (2012). IHC-FoFr ; Mouse . PubMed: ...http://www.abcam.com/transglutaminase-2-antibody-ab421-references.html
Displaying items by tag: malaria
Increase of a Calcium Independent Transglutaminase Activity in the Erythrocyte during the Infection with Plasmodium falciparum ... Man-biting Activity of Anopheles (Nyssorhynchus) albimanus and An. (Kerteszia) neivai (Diptera: Culicidae) in the Pacific ... Biting Indices, Host-seeking Activity and Natural Infection Rates of Anopheline Species in Boa Vista, Roraima, Brazil from 1996 ... Studies on the Bacillus sphaericus Larvicidal Activity against Malarial Vector Species in Amazonia ...http://memorias.ioc.fiocruz.br/issues/current-issue/itemlist/tag/malaria
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance : Interdisciplinary Toxicology
Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut ... 1985). Retinoid suppression of transglutaminase activity and envelope competence in cultured human epidermal carcinoma cells: ... 2001). Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. Biochemistry 40(16): 4904- ... 1984). Biochemical activity of intestinal microfl ora in adult coeliac disease. Nahrung 28(6-7): 711-5.CrossrefGoogle Scholar ...https://www.degruyter.com/view/j/intox.2013.6.issue-4/intox-2013-0026/intox-2013-0026.xml
Development of Celiac Disease; Pathogenesis and Strategies to Control: A Molecular Approach | OMICS International
2002) Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ ... 2003) Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity. Gut 52: 1562- ... Inhibiting the tTG activity may hamper the development of CD pathogenesis by preventing the activation of gluten reactive T ... In in vitro assessment of enteric capsules, no change in the activity of PEP compared to dry powder before encapsulation . ...https://www.omicsonline.org/open-access/development-of-celiac-disease-pathogenesis-and-strategies-to-control-a-molecular-approach-2155-9600.1000310.php?aid=32498
Coagulation in Invertebrates - Abstract - Journal of Innate Immunity 2011, Vol. 3, No. 1 - Karger Publishers
Lin X, Söderhäll K, Söderhäll I: Transglutaminase activity in the hematopoietic tissue of a crustacean, Pacifastacus ... Lindgren M, Riazi R, Lesch C, Wilhelmsson C, Theopold U, Dushay MS: Fondue and transglutaminase in the Drosophila larval clot. ... Maningas MB, Kondo H, Hirono I, Saito-Taki T, Aoki T: Essential function of transglutaminase and clotting protein in shrimp ... Wang R, Liang Z, Hall M, Söderhäll K: A transglutaminase involved in the coagulation system of the freshwater crayfish ...https://www.karger.com/Article/Abstract/322066
NCI-H596 [H596] ATCC ® HTB-178™ Homo sapiens lung adenosquam
... transglutaminase activity and production of involucrin. ...https://www.atcc.org/en/Global/Products/2/E/9/5/HTB-178.aspx?p=1&rel=%7B0%7D
TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier | Journal of Cell...
2005). Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model. J. ... Results are shown as fold change over the LCE1C −92 to +27 or LCE3E −59 to +12 activity in each cell type. For keratinocytes, ... TALE factor binding is necessary for LCE1C promoter activity in vitro and differentially affects LCE1C and LCE3E promoter ... TALE factor binding is necessary for activity of the external promoter in keratinocytes. We find that the strong TALE-binding ...http://jcs.biologists.org/content/124/10/1681
Frontiers | Steroidal Alkaloids as an Emerging Therapeutic Alternative for Investigation of Their Immunosuppressive and...
The decrease in the activity of hepatic antioxidant enzyme (SOD) was significantly prevented by holaphylline, likewise ... The decrease in the activity of hepatic antioxidant enzyme (SOD) was significantly prevented by holaphylline, likewise ... alkaloid-C and holaphylline isolated from Sarcococca saligna were found to possess immunosuppressive activities. These ... alkaloid-C and holaphylline isolated from Sarcococca saligna were found to possess immunosuppressive activities. These ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00114/full
Cigarette Smoking‐Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets | Journal of the American Heart...
... platelets also had correspondingly higher resting concentrations of intracellular calcium and transglutaminase activity. These ... TGase activity in platelet lysates showed a 40% increase in smokers'. Similar elevation was noted in 5‐HT/catecholamine‐treated ... Tissue TGase enzymatic activity was assayed by measuring the incorporation of [1.4(n)‐3H]putrescine dihydrocloride (14.4 Ci/ ... Ca2+ Level and the TGase Activity of the 5‐HT/Catecholamine‐Treated Platelets. Stimulation of cells with high levels of 5‐HT is ...http://jaha.ahajournals.org/content/6/5/e005465
Transglutaminase Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation ...
2004) Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia. Neurosci Lett 363:173-177. ... 1999) Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in ... Intracellular transglutaminase transamidating activity is increased following oxidative stress and structurally diverse TG ... To understand the relationship between TG activity and sustained ERK activation, we examined TG activity in the presence of a ...http://www.jneurosci.org/content/32/19/6561.full
Bonelli RM, Aschoff A, Niederwieser G, Heuberger C, Gruber A, Jirikowski G. Tissue transglutaminase activity in cerebrospinale ... Bonelli RM, Aschoff A, Jirikowski G. Tissue transglutaminase activity in vascular dementia. Journal of the Neurological ... s disease Tissue transglutaminase activity in vascular dementia. Neurobiology of Disease 2002 Oct;11(1):106-10.. Bonelli RM, ... Tissue transglutaminase in Alzheimer's disease and neuroleptic medication. European Journal of Neuroscience 2002.. Bonelli CM, ...http://bonelli.info/publications.html
Tissue transgluaminase 2 expression in meningiomas | Springer for Research & Development
Nakaoka H, Perez DM, Baek KJ et al (1994) Gh: a GTP-binding protein with transglutaminase activity and receptor signaling ... Impaired mitochondrial function results in increased tissue transglutaminase activity in situ. J Neurochem 75:1951-1961PubMed ... Brain tumor Cell death Tissue transglutaminase inhibitor Radiation This is a preview of subscription content, log in to check ... Griffin M, Casadio R, Bergamini CM (2002) Transglutaminases: nature's biological glues. Biochem J 368:377-396PubMedCrossRef ...https://rd.springer.com/article/10.1007/s11060-008-9642-1
Faculty Collaboration Database - Ann K. Rosenthal MD
Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. (Rosenthal AK, Derfus BA, Henry LA ... Thyroxine stimulates transglutaminase activity in articular chondrocytes. (Rosenthal AK, Heinkel D, Gohr CM) Osteoarthritis ... Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis. ( ... Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. (Rosenthal AK, Gohr CM, Mitton ...https://fcd.mcw.edu/?module=faculty&func=view&name=Ann_K._Rosenthal_MD&id=3086
DPLM Faculty Profiles - Dr. Wolberg - Department of Pathology and Laboratory Medicine - UNC School of Medicine
Recently, we identified a novel role for transglutaminase activity in venous thrombosis and speculate this enzyme is a novel ... By integrating these methodologies, we can precisely correlate enzyme activity (thrombin) and functional effect (clot formation ...http://www.med.unc.edu/olioli/faculty/biosketch-of-dr-alisa-wolberg
Activation of Extracellular Transglutaminase 2 by Thioredoxin
6A). Comparable TG2 activity could also be observed upon exposure to recombinant human Trx (Fig. 6B). No TG2 activity was ... TG2 Activity Assay TG2 activity was assayed using the glutamate dehydrogenase-coupled assay described previously (8). In brief ... Transglutaminase 2 (TG2), a ubiquitous member of the mammalian transglutaminase family, can be found in the intracellular and ... No transglutaminase activity was detectable in our preparations of recombinant Trx, TrxR, or Trx + TrxR (data not shown). We ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3199528/
Transglutaminase - Wikipedia
Transglutaminases were first described in 1959. The exact biochemical activity of transglutaminases was discovered in blood ... Eight transglutaminases have been characterised. Transglutaminases form extensively cross-linked, generally insoluble protein ... tissue transglutaminase. It is hypothesized that tissue transglutaminase may be involved in the formation of the protein ... A transglutaminase is an enzyme that catalyzes the formation of an isopeptide bond between a free amine group (e.g., protein- ...https://en.wikipedia.org/wiki/Transglutaminase
Transglutaminase for inhibiting angiogenesis - Patent # 7704943 - PatentGenius
Preferably, the transglutaminase is a human tissue transglutaminase. Advantageously, the medicament is for treating cancer, ... Additionally, the invention relates to compositions comprising a transglutaminase in an amount sufficient to inhibit ... The present invention relates to use of a transglutaminase in the preparation of a medicament for inhibiting angiogenesis. ... Lesort et al., "Distinct Nuclear Localization and Activity of Tissue Transglutaminase" J. of Biol. Chem. 273(20):11991-11994, ...http://www.patentgenius.com/patent/7704943.html
The Respiratory Burst in Activated Macrophages: Studies of Its Molecular Basis and Evidence for Downregulation in Chronic...
Harris, L.K., Pabst, M.J., and Johnston, R.B., Jr., 1984, Inreased transglutaminase activity in elicited and activated ... Nathan, C.F., 1983, Mechanisms of macrophage antimicrobial activity, Trans. R. Soc. Trop. Med. Hyg. 77:620.Google Scholar ... Sasada, M., and Johnston, R.B., Jr, 1980, Macrophage microbicidal activity: correlation between phagocytosis-assoicated ... but is accompanied by alterations in the activity and kinetic parameters of NADPH oxidase, Immunology 54: 371.Google Scholar ...https://link.springer.com/chapter/10.1007/978-1-4757-5421-6_7
High-level expression of a recombinant active microbial transglutaminase in Escherichia coli | BMC Biotechnology | Full Text
Transglutaminase activity was measured by a described colorimetric method based on hydroxamate formation . Briefly, 0.2 mL ... 4). The enzyme purity was confirmed by TGase activity assay which gave a specific activity of 24U/mg.. ... including Ca2+ independent activity, high reaction and broad specificity for acyl donors, microbial transglutaminases are ... Roles of transglutaminases in cardiac and vascular diseases. Front Biosci. 2009;12:2530-45.View ArticleGoogle Scholar. ...https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-015-0202-4
Molecular Imaging of Human ACE-1 Expression in Transgenic Rats | JACC: Cardiovascular Imaging
2008) Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for ... Enzyme activity assays (left) indicates a ,30-fold higher level of angiotensin-converting enzyme (ACE)-1 activity in the ... 1, left panel, yellow arrow), suggesting normal ACE activity in the lungs and a lack of appreciable ACE activity in normal ... Biochemical and molecular characterization of ACE-1 expression and activity. Enzyme activity assays indicated a ,30-fold higher ...http://imaging.onlinejacc.org/content/5/4/409
Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis | JCB
... that is one of the three residues critical for transglutaminase activity (Makarova et al., 1999; Pollard et al., 2012) and so ... global Rho1 activity decreased substantially before furrow ingression, suggesting that the activity Rho1 might decrease even ... causing a loss of GTPase activity and thus constitutive activity of the protein. Interestingly, the TGc domain in Cyk3 lacks a ... In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J. Biol. Chem. 271:14604-14609. doi: ...http://jcb.rupress.org/content/202/2/311
Download our free solidary book to support research on VHL disease