*  Phospholipase C gamma Summary Report | CureHunter
It is structurally related to PHOSPHOLIPASE C DELTA with the addition of SRC HOMOLOGY DOMAINS and pleckstrin homology domains ... A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. ... 04/15/1994 - "Likewise, activity of PLC-gamma 1 was considerably higher in adenomas and carcinomas than in normal mucosa. ". 04 ... PLC-gamma 2; PLC-gamma D; PLCgamma2; Phospholipase C gamma 1; Phospholipase C gamma 2; Phospholipase C gamma D; Phospholipase C ...
  http://www.curehunter.com/public/keywordSummaryD051966-Phospholipase-C-gamma.do
*  Emerging Anticancer Therapeutic Targets and the Cardiovascular System | Circulation Research
An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-gamma 1. FEBS Lett. 1995; 358: 287-292. ... On/off-regulation of phospholipase C-gamma 1-mediated signal transduction. Adv Enzyme Regul. 2007; 47: 104-116. ... suggesting impaired UP-S activity.144 Loss of the activity of the 20S and/or 26S proteasome in parallel with increased levels ... Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation. Cancer Res. 1997; 57: ...
  http://circres.ahajournals.org/content/106/6/1022
*  Gene Report for G00001754 - Genes2Cognition Neuroscience Research Programme
Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. ... Co-incubation of recombinant LRRK2 and EF1A significantly reduces the kinase activity of LRRK2, whereas its GTPase activity ... Phospholipase C (PLC)-gamma1 has two putative PH domains, an NH(2)-terminal and a split PH domain. Here we report studies on ... The activity of EF-1 alpha is enhanced in polyphenylalanine synthesis by a complementary component, EF-1 beta delta. It is also ...
  http://www.genes2cognition.org/db/Gene/G00001754
*  Protocols and Video Articles Authored by Solomon H. Snyder
... this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. Here, we demonstrate ... Jan, 2002 , Pubmed ID: 11823862 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the ... K activity. This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1. ... Phospholipase C-gamma is Required for Agonist-induced Ca2+ Entry Cell. Nov, 2002 , Pubmed ID: 12437926 We report here that PLC- ...
  https://www.jove.com/author/Solomon+H._Snyder
*  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (P19174) | InterPro | EMBL-EBI
GO:0004435 phosphatidylinositol phospholipase C activity GO:0004871 signal transducer activity GO:0005509 calcium ion binding ... Phosphoinositide phospholipase C family (IPR001192)*Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma (IPR016279)* ...
  http://www.ebi.ac.uk/interpro/protein/P19174
*  BAG3 - Wikipedia
"Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity ... "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J ... Cunningham SA, Arrate MP, Brock TA, Waxham MN (November 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: ... "Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas". Proc. Natl. Acad ...
  https://en.wikipedia.org/wiki/BAG3
*  Eukaryotic translation elongation factor 1 alpha 1 - Wikipedia
"Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity ... Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. ... eEF1A has also been found to bind to several kinases, phospholipases, and synaptic proteins. For instance, while associated ... "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta ...
  https://en.wikipedia.org/wiki/Eukaryotic_translation_elongation_factor_1_alpha_1
*  PLCG1 - Wikipedia
"Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity ... "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". ... Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. The protein encoded by ... "Entrez Gene: PLCG1 phospholipase C, gamma 1". Singh SM, Murray D (September 2003). "Molecular modeling of the membrane ...
  https://en.wikipedia.org/wiki/PLCG1
*  Plus it
Induction of the P2z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-gamma in ... Ethidium influx as assay of hemichannel activity.. Effects of PAR1 activation on hemichannel activity was assayed using ... Rho-GTPase activity is correlated with LPA- but not carbachol-induced ATP release. A and B: 1321N1 cells were treated with 300 ... After luciferase activity reached steady state, 1321N1 monolayers were treated for up to 15 min with 2 U/ml of thrombin, 3 μM ...
  http://ajpcell.physiology.org/content/295/1/C231
*  Effect of Circulating Epinephrine on Platelet Function and Hematocrit | Hypertension
Jelsema CL, Axelrod J. Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of ... Phospholipase A2, which releases arachidonic acid from platelet lipids to form thromboxane A2 (TXA2), plays an important role ... Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIa and dual role of ... Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. J Biol Chem. 1986;261 ...
  http://hyper.ahajournals.org/content/25/5/1096.full
*  神戸大学 医学研究科 中村研究室
Reconstitution of GTP-gamma-S-dependent phospholipase D activity with ARF, RhoA, and a soluble 36-kDa protein. ... PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity. ... Potential role of protein phosphorylation in GTP-gamma-S-dependent activation of phospholipase D. ... Mammalian phospholipase D. Activation by ammonium sulfate and nucleotides. Nakamura, SI., Shimooku, K., Akisue, T., Jinnai, H ...
  http://www.med.kobe-u.ac.jp/biochemistry/publication.html
*  Molecular Mechanisms of Mammalian Sperm-Zona Pellucida Interaction: Crosstalk Between Sperm and Egg | SpringerLink
Jelsema, C.L. and Axelrod, J. (1987) Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma ... Dissociation of sperm receptor activity from acrosome reaction-inducing activity of the mouse zona pellucida protein, ZP3. Dev ... Florman, H.M. and Wassarman, P.M. (1985) O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity. ... Shur, B.D. and Hall, N.G. (1982a) Sperm surface galactosyltransferase activities during in vitro capacitation. J. Cell Biol 95 ...
  https://link.springer.com/chapter/10.1007/978-1-4613-0645-0_47
*  Navigieren Sie durch unsere Phospholipase C gamma 1 ELISA Kits
Phospholipase C gamma 1 ELISA Kits vergleichen und bestellen. ... Phospholipase C gamma 1 ELISA Kits für viele Reaktivitäten. ... The products of PLC (zeige HSPG2 ELISA Kits)-gamma activity mediate the innate immune response by regulating respiratory burst ... phospholipase C-I , phospholipase C-beta-1 , PLC gamma 1 , phospholipase C-gamma-1b , phospholipase C, gamma 1 , 1-phosphatidyl ... phospholipase C, gamma 1 (formerly subtype 148) , phospholipase C-148 , phospholipase C-II , phospholipase C-gamma-1 , ...
  http://www.antikoerper-online.de/rtk-signalweg-pathway-8/phospholipase-c-gamma-1-elisa-kit-7736/
*  G protein βγ subunits: Central mediators of G protein-coupled receptor signaling
Jelsema CL, Axelrod J. Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta-gamma subunits of ... Direct Modulation of Phospholipase D Activity by Gβγ Mol Pharmacol. 2006;70:311-318. [PubMed] ... Regulation of Eukaryotic Phosphatidylinositol-Specific Phospholipase C and Phospholipase D. Ann Rev Biochem. 1997;66:475-509. [ ... G-protein-coupled Receptor Agonists Activate Endogenous Phospholipase Cε and Phospholipase Cβ3 in a Temporally Distinct Manner ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2688713/?lang=en-ca
*  Regulation of phospholipase D activity in neuroblastoma cells
In permeabilized SH-SY5Y cells, both the carbachol- and GTP gamma S-induced Peth formation was inhibited by GDP beta S, ... Regulation of phospholipase D activity in neuroblastoma cells. Gustavsson, Lena; Boyano-Adanez, Maria del Carmen; Larsson, ... Carbachol induced phospholipase D activity in SH-SY5Y cells. Muscarinic antagonists inhibited the response with potencies ... Carbachol induced phospholipase D activity in SH-SY5Y cells. Muscarinic antagonists inhibited the response with potencies ...
  https://lup.lub.lu.se/search/publication/1109867
*  Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin...
"Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin- ... Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in ... Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in ... If no firing activity was observed during the wash out period, ACSF with 20 mM K+ was applied to induce firing to verify cell ...
  https://www.deepdyve.com/lp/ou_press/estradiol-dependent-stimulation-and-suppression-of-gonadotropin-2HYCLej8zg
*  High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma | Cancer...
... phospholipase C, gamma 1 (PLCG1), and growth factor receptor-bound protein 7 (GRB7; refs. 28-31). Aberrant upregulation of FAK ... Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A 1999;96:9021-6. ... but rather they inhibit kinase activity. Therefore, it was important to determine whether the inactivation of FAK activity was ... Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res 2008;68:1935-44. ...
  http://cancerres.aacrjournals.org/content/73/9/2873.long
*  PLD2 - Wikipedia
... phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and ... "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J ... Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene. Phosphatidylcholine (PC)-specific phospholipases D ( ... "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. 276 (30): 28252-60. doi:10.1074/jbc. ...
  https://en.wikipedia.org/wiki/PLD2
*  Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma...
Phospholipase C-gamma 1 and phosphatidylinositol 3-kinase were identified as substrates phosphorylated on tyrosine, as down- ... Ligand-induced clustering of the Fc mu R also induced activity of src family kinases, Lck, Fyn, Lyn, and Src, as well as their ... which phosphorylate and thereby activate regulatory enzymes such as phospholipase C-gamma 1 and phosphatidylinositol 3-kinase. ... Triggering via Fc mu R also induced the activity of Syk and Zap-70, tyrosine kinases demonstrated to associate with zeta and ...
  http://www.uniprot.org/citations/8759729
*  Tissue expression of ABL1 - Summary - The Human Protein Atlas
GO:1900275 [negative regulation of phospholipase C activity]. GO:1903351 [cellular response to dopamine]. GO:1904528 [positive ... GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]. GO:0042127 [regulation of cell proliferation]. GO: ... GO:1900275 [negative regulation of phospholipase C activity]. GO:1901216 [positive regulation of neuron death]. GO:1902715 [ ... GO:0016301 [kinase activity]. GO:0016310 [phosphorylation]. GO:0016604 [nuclear body]. GO:0016740 [transferase activity]. GO: ...
  http://www.proteinatlas.org/ENSG00000097007-ABL1/tissue/vulva%252Fanal+skin
*  Synuclein-alpha Antibody (Phospho-Tyr136) (OAAF07792) | Rabbit Polyclonal Antibody
regulation of phospholipase activity. 4. response to interferon-gamma. 22. response to interleukin-1. 57. ... negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. 66. ...
  https://www.avivasysbio.com/en/synuclein-alpha-antibody-phospho-tyr136-oaaf07792.html
*  Pathway Central: Chemokine Signaling
In leukocytes, the signalling is mediated by Gi subunits, and the beta gamma subunits activate the PLC-Beta2 (Phospholipase-C- ... This induction of calcium mobilization is one of the activities very often used to determine chemokine activity. There is ... Activated beta gamma subunits of G-Proteins trigger a series of reactions, commencing with the hydrolysis of PIP2 ( ... G-proteins dissociate into G-alpha and G-beta gamma subunits, which are able to activate signaling molecules that mediate ...
  http://sabiosciences.com/pathway.php?sn=Chemokine_Signaling
*  KAKEN - Research Projects | Trials for development of novel inhibitors for intracellular signaling. (KAKENHI-PROJECT-06558095)
PLC-gamma possesses a phospholipase C inhibitor (PCI) region adjacent to its SH2 and SH3 motifs that strongly suppresses the ... Publications] Homma,Y.,&Emori,Y.: 'A dual signal mediator showing RhoGAP and phospholipase C‐δ stimulating activities.' EMBO J. ... Publications] Y.Homma et.al.: 'A dual functional signal mediator showing RhoGAP and phospholipase C-δ stimulating activities.' ... Publications] Y.Homma et.al.: 'A dual functional signal mediator showing RhoGAP and phospholipase C-delta simulating activities ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06558095/
*  PEDF - Wikipedia
PEDF-R has phospholipase A2 activity which liberates fatty acids from glycerolipids. PEDF enhances gamma-secretase activity, ... PEDF induces PPAR-gamma expression which in turn induces p53, a tumor suppressor gene involved in cell cycle regulation and ... Neurotrophic activity does not require the serpin reactive loop". The Journal of Biological Chemistry. 270 (43): 25992-9. doi: ... Ho TC, Chen SL, Yang YC, Liao CL, Cheng HC, Tsao YP (Nov 2007). "PEDF induces p53-mediated apoptosis through PPAR gamma ...
  https://en.wikipedia.org/wiki/PEDF
*  RANDOX 25I-NBOMe (2C-I-NBOMe, Cimbi-5) ELISA [R-NBOMe] Equl offers Enzyme Assay Kits, Reagent Mixtures, Enzymes, Glycobiology,...
Glucose-6-Phosphate Dehydrogenase, High-Activity, Suspension. * Ribonuclease* Deoxyribonuclease I. * Ribonuclease. * ... alpha,beta,gamma,x ray detector. * pump* Vacuum pump* * Portable PM10/PM2.5 sampler ...
  http://www.equl.com/index.php?main_page=product_info&cPath=70_1541_1709&products_id=322614