*  Prevention of oxidant-induced cell death by intralysosomal iron binding
The lung is particularly prone to oxidative stress by its exposure to ambient oxygen and inhaled environmental oxidants. Abnormal assimilation and accumulation of iron are found in many lung disorders, which in redox-active form will exacerbate oxidative tissue damage. It may be that the most important cellular pool of redox -active iron exists within lysosomes. As a result, these organelles are very vulnerable to oxidative stress and may burst due to peroxidative membrane destabilization. Support for the importance of intralysosomal iron in cellular oxidant damage includes the observation that the iron chelator, desferrioxamine, which almost exclusively localizes within the lysosomal compartment, will protect cells against oxidati ve challenge. Iron chelators targeted to the lysosomes may therefore be a particularly efficient therapeutic strategy for cells under conditions of substantial oxidative stress.. The present study, employing cultures of human respiratory epithelial cells and ...
*  NIOSHTIC-2 Publications Search - 00211599 - Role of surface complexed iron in oxidant generation and lung inflammation induced...
The pathogenesis of the pulmonary damage caused by the inhalation of silicates was studied by examining the effects of iron (7439896) complexation on oxidant generation in-vitro and in-vivo. The mineral dusts studied included silica (14808607), crocidolite (12001284), kaolinite (1318747), and talc (14807966). Significant concentrations of surface iron were seen in all of the mineral oxide dusts an
*  Plus it
3405 Extracellular oxidants such as those generated during inflammation or tissue ischemia-reperfusion can induce apoptosis, but the mechanism through which they do this is not well-defined. We investigated the role of specific protein oxidation in oxidant-induced apoptosis. Using redox-proteomics, we found that the actin-binding protein cofilin is a key target of oxidation that mediates induction of apoptosis by taurine chloramine, a physiological oxidant produced by activated neutrophils. In treated cells, cofilin loses its affinity with actin and translocates from the cytosol to the mitochondria. Only oxidized cofilin interacts with the organelles and it induces mitochondrial swelling and cytochrome c release. Cells become resistant to oxidant-induced apoptosis when Cys to Ala cofilin mutants are over-expressed. Moreover, over-expression of wild-type cofilin causes a 2-fold increase in the sensitivity of cells to oxidant-induced apoptosis. Exposure of cofilin to taurine chloramine results ...
*  Does the creamy hydrogen peroxide treatment work? | Debate.org
I tried to use the creamy hydrogen peroxide treatment since my Apple G3 was all yellow and greasy also. But when I tried it, it didn't even work! Hydrogen peroxide is a big bully and really mean, and now my G3 is still yellow and greasy and now it is stoopid since I used the hydrogen peroxide.. ...
*  Does using hydrogen peroxide on eczema help? | Reference.com
Using hydrogen peroxide on eczema does not help prevent symptoms. However, there are several other treatments that do help, including medications, moisturizers and nondrug treatments, reports WebMD....
*  NIOSHTIC-2 Publications Search - 00238729 - Oxidant release from pulmonary phagocytes.
This report presents in-vitro and in-vivo data indicating that silica (14808607) may be associated with the production of reactive oxygen species from pulmonary phagocytes. Studies have indicated that in-vitro exposure of alveolar macrophages to 2mg/ml silica increased oxygen consumption by 213%. Half maximal stimulation was observed at 0.56mg/ml silica. The stimulatory effect of silica on respira
*  Should Doctors Be Performing Hydrogen Peroxide Treatments?
ER physician Dr. Travis Stork weighs in on hydrogen peroxide being used intravenously as an alternative treatment for cancer and MS. Is this treatment...
*  The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs | BMC Veterinary Research |...
The skill levels of the dogs reported in this study was determined by the rules set out by the USDAA and may have seemed arbitrary. The groupings proved accurate in these dogs, however, since each successive skill group was significantly faster than the novice group and the group level below it. The labeling of these groups as novice, intermediate and masters could have been labeled instead by their time through the simulated exercise test, however, this would have been less applicable to dogs in actual agility competition.. Agility exercise, as performed by dogs in this study, is of sufficient intensity to induce mild oxidant stress and lipid peroxidation based upon the slightly increased urinary excretion of ISO following the exercise test. The intensity of muscle contraction associated with agility exercise increases production of reactive oxygen species due to increased oxygen consumption, resulting in elevated superoxide anion production in skeletal muscle mitochondria [19]. All dogs in ...
*  Proteins in Antiperoxidation | SpringerLink
Yang Y, Cheng JZ, Singhal SS, Saini M, Pandya U, Awasthi S, Awasthi YC. Role of glutathione S-transferases in protection against lipid peroxidation: Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J Biol Chem 2001;276: 19220-30.PubMedGoogle Scholar ...
*  Thioredoxin, mitochondrial
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008 ...
*  Im really worried. | Ask The Doctor
So last night i was playing with me cat (he's an outside cat) and he attacked me and he dug his claws into my skin and left a deep cut(small though) and around it its all red ( Right after it happened i put Hydrogen Peroxide on it). when
*  Anti oxidants are essential to eliminate toxins from your body
Get our incredible antioxidant Revenol, with the most powerful ingredients to rejeuvenate, protect and clean your body|Neways products by New Ways of Living
*  Why do oxidants appear in urine? | Reference.com
Oxidants, or oxidizing agents, appear in the urine as a result of deliberate adulteration of a clinical urine sample, according to the American Association for Clinical Chemistry. Strong chemical...
*  Oxidants, oxidative stress and the biology of ageing.
Abstract Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive ox..
*  News: protein-protein interactions - Vanderbilt-Ingram Cancer Center
Reactive molecules generated in the body - by toxic drugs, environmental chemicals and even the body's own natural processes - can attack and chemically modify proteins to produce protein "adducts" which may play a role in human diseases. But just how these adducts are involved in toxicity and cellular responses to oxidant damage is unclear. […]. ...
*  Does presence of oxidants early in life help determine life span? | University of Michigan News
Why do we age, and what makes some of us live longer than others? For decades, researchers have been trying to answer these questions by elucidating the molecular causes of aging. Microscope image of
*  oxidants Archives - Neuroscience News
Binghampton researchers report on how the foods we eat can affect our mental well being, and how our dietary needs change as we age.... Read More... ...
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*  In Brief | New Scientist
wondered how mopping up oxidants would affect cancers.. He took a strain of mice that develops brain tumours and fed one group ...