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*  SYT1 - Arf guanine nucleotide exchange factor SYT1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) -...
Has no exhange activity on Rab GTPases. Involved in vesicular transport. ... stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Catalyzes both the GDP release by and the GTP ... Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound ... Arf guanine nucleotide exchange factor SYT1Add BLAST. 1226. Amino acid modifications. Feature key. Position(s). Description ...
  http://www.uniprot.org/uniprot/Q06836
*  Anti-Maus rho Guanine Nucleotide Exchange Factor (GEF) 4 Antikörper für Western Blotting (WB)
Top performende anti-Maus rho Guanine Nucleotide Exchange Factor (GEF) 4 Antikörper für Western Blotting (WB) vergleichen & ... Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E- ... anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 Antikörper * anti-Maus rho Guanine Nucleotide Exchange Factor (GEF) 4 ... Weitere Produktkategorien zu rho Guanine Nucleotide Exchange Factor (GEF) 4 Antikörper * 47 anti-rho Guanine Nucleotide ...
  http://www.antikoerper-online.de/neurotrophin-signal%C3%BCbertragung-pathway-29/arhgef4-antibody-11779/mouse-wb-80444/
*  Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats | Hypertension
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell ... Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats. Fan Yi, Min Xia, ... Among ,100 guanine nucleotide exchange factors, Vav subfamily exhibits the high specificity to Rac-mediated NADPH oxidase ... In the present study, we found that, among 3 members of the guanine nucleotide exchange factor-Vav subfamily, Vav2 and Vav3 are ...
  http://hyper.ahajournals.org/content/53/1/90
*  Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix | The EMBO Journal
... it was unable to stimulate the guanine nucleotide exchange activity of Cdc42 (Figure 6C). The same was true for Rac (data not ... guanine nucleotide dissociation inhibitors (GDIs), and guanine nucleotide exchange factors (GEFs), regulate the cycling of ... Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix. Qiyu Feng, Daniel Baird, ... We show that when Cool‐2 exists as a dimer, it functions as a Rac‐specific guanine nucleotide exchange factor (GEF). ...
  http://emboj.embopress.org/content/23/17/3492.long
*  Ras-related C3 botulinum toxin substrate elisa and antibody
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating ... Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in ... Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the ... GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the ...
  https://www.mybiosource.com/protein_family.php?root=ras-related-c3-botulinum-toxin-substrate
*  ELMO1 - Engulfment and cell motility protein 1 - Homo sapiens (Human) - ELMO1 gene & protein
May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. ... May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.2 Publications. ,p>Manually curated information for ... "Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton ... guanyl-nucleotide exchange factor complex Source: WormBaseInferred from direct assayi*12134158 ...
  https://www.uniprot.org/uniprot/Q92556
*  A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. - Semantic...
... we establish that the GTPase activity of the protein is essential for ciliary membrane extension. Taken together, our findings ... arl13b is induced by FoxJ1 and Rfx, and these ciliogenic transcription factors are unable to promote ciliary length increase ... when Arl13b activity is inhibited. Conversely, overexpression of Arl13b was sufficient to restore ciliary length in zebrafish ... A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. * ...
  https://www.semanticscholar.org/paper/A-function-for-the-Joubert-syndrome-protein-Arl13b-Lu-Toh/8e154ef2ed5e78217e8555ed3b0ed801a13f70ef
*  Human ELMO2 peptide (ab22879) | Abcam
May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.. * Tissue specificity ...
  http://www.abcam.com/human-elmo2-peptide-ab22879.html
*  Recombinant Human ELMO1 protein (ab153021) | Abcam
May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.. * Tissue specificity ...
  https://www.abcam.com/recombinant-human-elmo1-protein-ab153021.html
*  Anti-ELMO3 antibody (ab2271) | Abcam
May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.. * Sequence similarities ...
  http://www.abcam.com/elmo3-antibody-ab2271.html
*  Babraham Institute » Members
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.. ... Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment.. Baker MJ ... Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.. Lissanu ...
  https://babraham.ac.uk/our-research/signalling/heidi-welch/members/579/anna-mandel
*  Babraham Institute » Members
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.. ... Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment.. Baker MJ ... The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.. AK Johnsson, Y Dai, M ... Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.. Lissanu ...
  https://www.babraham.ac.uk/our-research/signalling/heidi-welch/members/173/anna-karin-johnsson
*  EPB41L4B - Band 4.1-like protein 4B - Homo sapiens (Human) - EPB41L4B gene & protein
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of ... Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of ... Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-816. ... Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-816. ...
  https://www.uniprot.org/uniprot/Q9H329
*  Effect of Diabetes on Protein Synthesis in the Myocardium | Springer for Research & Development
Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart. Biochem. Biophys. Res. Comm. ... Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Am. J. Physiol. 264: E101-E108, 1993.PubMed ... Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle. Biochimie ... Cardiac myofibrillar ATPase activity in diabetic rats. J. Mol. Cell. Cardiol. 13: 1063-1069, 1981.PubMedCrossRefGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-1-4613-1269-7_5
*  TNK2 - Activated CDC42 kinase 1 - Bos taurus (Bovine) - TNK2 gene & protein
... thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the ... and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors ... Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and ... thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the ...
  http://www.uniprot.org/uniprot/Q17R13
*  HERC1 gene - Genetics Home Reference - NIH
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. ... This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane ... Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is ... required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin- ...
  https://ghr.nlm.nih.gov/gene/HERC1
*  Directional cell migration regulation by small G proteins, nectin-like molecule-5, and afadin. - Semantic Scholar
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and ... PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.. *E Manser, T H Loo, +6 authors L Lim ... Rac1-Dependent Lamellipodial Motility in Prostate Cancer PC-3 Cells Revealed by Optogenetic Control of Rac1 Activity. *Takuma ... small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. ...
  https://www.semanticscholar.org/paper/Directional-cell-migration-regulation-by-small-G-Rikitake-Takai/7aad62767d9f7816eeff3bd3adf0c442b3b7bdc9
*  John R. Pringle | Stanford Medicine Profiles
... evidence suggests that Cdc24p may have a function that is distinct from its Cdc42p guanine-nucleotide-exchange factor activity ... In the yeast Saccharomyces cerevisiae, Cdc24p functions at least in part as a guanine-nucleotide-exchange factor for the Rho- ... Another group of proteins, which includes a Rho-like GTPase (Cdc42), its guanine nucleotide exchange factor (Cdc24), and Bem1, ... which encodes a guanine nucleotide exchange factor for Cdc42p. In all three screens, we identified a new gene, BEM4. Cells from ...
  https://med.stanford.edu/profiles/john-pringle
*  De-AMPylation Unmasked: Modulation of Host Membrane Trafficking | Science Signaling
... to the membranes of Legionella-containing vacuoles and activates Rab1 through its guanine nucleotide exchange factor activity. ...
  http://stke.sciencemag.org/content/4/194/pe42
*  Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics | Cancer Research
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and ... Although many factors are likely to regulate MaSC activities, recent work shows that Slug and Sox9 act cooperatively to ... FAK kinase activity is required for the sphere/acini-forming activity of MaECs, but not their mammary regenerative potential. ... while very low MRU activity was detected in basal MaECs of MFCKO-GFP mice (,1/12818), the MRU activity found in basal MaECs of ...
  http://cancerres.aacrjournals.org/content/73/17/5591.long
*  EIF2B3 - Wikipedia
2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561-6. ... the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and ... required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. ... Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene. GRCh38: Ensembl ...
  https://en.wikipedia.org/wiki/EIF2B3
*  EIF2B4 - Wikipedia
2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561-6. ... the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and ... the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and ... Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that ...
  https://en.wikipedia.org/wiki/EIF2B4
*  The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential...
... as a result of the activity of a guanine nucleotide exchange factor (GEF) (Peyroche et al., 1996). Following the exchange ... 2008). A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi ... 2002). GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in ... 2004). BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and ...
  http://jcs.biologists.org/content/125/5/1318
*  GSK-3: tricks of the trade for a multi-tasking kinase | Journal of Cell Science
Modulation of rabbit reticulocyte guanine nucleotide exchange factor activity by casein kinases 1 and 2 and glycogen synthase ... Apoptotic stimuli such as staurosporine treatment or neurotrophic factor withdrawal increase GSK-3 activity and tyrosine ... Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J. Biol. Chem. ... lymphoid enhancer factor (LEF) family of architectural transcription factors (reviewed in Barker et al., 2000; Brantjes et al ...
  http://jcs.biologists.org/content/116/7/1175?ijkey=aa5e6bf5983d0c651923d106d68885856536fc6a&keytype2=tf_ipsecsha
*  Rho GTPase signaling complexes in cell migration and invasion | JCB
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 33:4021-4035. ... PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and ... Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J. Cell Biol. 216:1543-1556. doi: ... GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6:167-180. doi:10.1038 ...
  http://jcb.rupress.org/content/217/2/447